inoa huahana:CMS121
Inoa ʻē aʻe:CMS-121;
1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-;
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121);
ACC,AcetylCoenzymeACarboxylase,ma'i,neuroprotective,keakea,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121
CAS NO.:1353224-53-9
ʻIke: 98.0%Min
Kala: ʻulaʻula melemele māmā
Hoʻopili: 25kg / DRUMS
ʻO 4-(4-(cyclopentyloxy)quinolin-2-yl) benzene-1,2-diol kahi pūhui i kapa ʻia ʻo CMS121. ʻO ka paʻakikī o ka hoʻokumu ʻana o ka pūhui e hōʻike ana he mau waiwai kūʻokoʻa paha kona a me ka hoʻohana ʻana. No ka hoʻomaopopo ʻana i kona koʻikoʻi, kōkua ia e ʻike i nā pūʻulu hana e kū nei a nānā i kā lākou hopena
ʻO CMS121 kahi quin oline i hoʻololi ʻia he neuroprotective, anti-inflammatory, antioxidative, a me nā hana renoprotective. Mālama ʻo ia i nā pae glutathione (GSH) i nā HT22 mouse hippocampal cell in vitro i mua o ka glutamate, hoʻoulu i ka hoʻokaʻawale ʻana o nā cell PC12, pale i ka LPS-induced N9 microglial activation e 82% i ka N9 microglia, a scavenges free radicals i kahi Trolox e like me ka hoʻoikaika ʻana i ka hana. (TEAC). Mālama ʻo CMS121 i ka ischemia a me ka oxytosis i loko o nā pale phenotypic i loko o nā keena HT22 in vitro me nā waiwai EC50 o 7 a me 200 nM no ka pale ʻana i ka iodoacetic acid- a i ʻole ka glutamate-induced cell make, kēlā me kēia. ʻO ia hoʻi he renoprotective, hoʻemi i ka pohō kaumaha o nā puʻupaʻa a hoʻemi i ka hōʻike ʻana o TNF-α, caspase-1, a me ka inducible nit ric oxi de synthase (iNOS) i loko o kahi kiʻi kiʻi SAMP8 o ka maʻi maʻi maʻi maʻi e pili ana i ka ʻelemakule wikiwiki i ka wā e lawelawe ʻia ai i kahi maʻa. o 10 mg/kg i ka lā e hoʻomaka ana i ʻeiwa mahina.
ʻO 4-(4-(cyclopentyloxy)quinolin-2-yl) benzene-1,2-diol kahi pūhui i kapa ʻia ʻo CMS121. ʻO ka paʻakikī o ka hoʻokumu ʻana o ka pūhui e hōʻike ana he mau waiwai kūʻokoʻa paha kona a me ka hoʻohana ʻana. No ka hoʻomaopopo ʻana i kona koʻikoʻi, kōkua ia e ʻike i nā pūʻulu hana e kū nei a nānā i kā lākou hopena. ʻO ka loaʻa ʻana o ke apo quinoline e hōʻike ana i ka hana biologically o ka pūhui. ʻIke ʻia nā molekala i loaʻa mai i ka quinoline no kā lākou mau waiwai olaola like ʻole, me nā hana antibacterial a me nā anti-inflammatory. Hiki i ka hoʻopili ʻana o ka hui cyclopentyloxy ke kōkua i ka solubility o ka pūhui a i ʻole e hoʻonui i kāna hana olaola ma o nā hopena steric. I nā haʻawina ma nā pūnaewele HT22, ua hōʻike ʻo CMS-121 i nā hopena neuroprotective koʻikoʻi, e pale pono ana i kēia mau cell mai ka ischemia a me ka pōʻino oxidative. Eia kekahi, he waiwai anti-inflammatory koʻikoʻi ka CMS-121, e hōʻike ana i kona hiki ke hoʻololi i nā pane inflammatory. Ma ka hana ʻana pēlā, hiki i ka CMS-121 ke hōʻemi i ka ʻāʻī ma nā ʻāpana like ʻole a me nā kino. Loaʻa i ka CMS-121 ka hana lāʻau lapaʻau ikaika ma ke ʻano he mea pale o ka acetyl-CoA carboxylase 1 (ACC1). ʻO kona hopena paʻa ikaika ma ACC1 e lilo ia i mea hoʻohiki hoʻohiki
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