inoa huahana:J-147 Pauda

inoa ʻē aʻe:2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide],J-147, J147

ʻAʻohe CAS:1146963-51-0

ʻIke: 99.0%Min

Kala: ʻO ka pauka keʻokeʻo

Hoʻopili: 25kgs pahu

J-147he neuroprotectant hoʻoikaika waha i loaʻa mua mai ka curcumin, ka mea hana i ka turmeric. ʻAʻole like me ka curcumin, ua hele maikaʻi ʻo ia i ka pale koko-lolo.

ʻO J-147 kahi mea ikaika loa, waha waha, neuroprotective agent no ka hoʻonui ʻana i ka naʻau.
Hiki iā J-147 ke hele maʻalahi i ka pale lolo koko (BBB). Hiki i ka J-147 ke kāohi i ka monoamine oxidase B (MAO B) a me ka dopamine transporter me nā waiwai EC50 o 1.88 μM a me 0.649 μM. Hiki iā J-147 ke mālama i ka maʻi o Alzheimer

ʻO ka J-147 kahi neuroprotectant hoʻoikaika waha i loaʻa mua mai ka curcumin, ka mea hana i ka turmeric. ʻAʻole like me ka curcumin, ua hele maikaʻi ʻo ia i ka pale koko-lolo. Ma waena o lākou, hana ʻo J-147 ma ka hoʻopaʻa ʻana i ka ATP synthase. Hoʻopili ʻia ka overproduction o ATP me ke kaʻina hana ʻelemakule. Ma waho aʻe o ka hoʻonui ʻana i nā pae o nā neurotransmitters NGF a me BDNF, hiki iā J-147 ke hoʻomalu i kēia. Eia hou, J-147 inhibits monoamine oxidase B a me dopamine transporter. Hoʻoikaika i ka ulu ʻana o ka lolo ma o ka hoʻonui ʻana i nā pae o ka nerve growth factor (NGF) a me ka brain-derived neurotrophic factor (BDNF). ʻO ka mea nui loa, hiki iā J-147 ke hoʻoikaika i ka ulu ʻana o nā pūnaʻi nerve hou, hoʻonui i ka hiki ke aʻo a me ka hoʻomanaʻo o ka lolo, a hoʻomaikaʻi i ka hana cognitive.

Hana:

Hiki iā J-147 ke hele maʻalahi i ka pale lolo koko (BBB).
Hiki i ka J-147 ke kāohi i ka monoamine oxidase B (MAO B) a me ka dopamine transporter me nā waiwai EC50 o 1.88 μM a me 0.649 μM.
Hiki iā J-147 ke mālama i ka maʻi o Alzheimer (AD).
Hiki iā J-147 ke mālama i ka maʻi o Alzheimer (AD).

Noi:

ʻO J-147 kahi pūhui synthetic nona ka hana mua e pili ana i ka hoʻonui ʻana i ka mitochondrial, a laila e hoʻonui ai i ka hana ikehu ma ka pae kelepona. Hoʻolālā ʻia ʻo J-147 e hoʻonui i ka hiki o ka lolo e hoʻoponopono a pale iā ia iho mai ka pōʻino pili makahiki ma o ka hoʻomaikaʻi ʻana i ka hana mitochondrial. Hoʻohui ʻia, hōʻike ʻo J-147 i nā waiwai anti-inflammatory a me nā antioxidant, e hoʻonui hou i kona hopena neuroprotective. Hiki iā J-147 ke hoʻoikaika i ka ulu ʻana o nā pūnaʻi aʻalolo hou, hoʻonui i ka hiki ke aʻo a me ka hoʻomanaʻo o ka lolo, a hoʻomaikaʻi i ka hana cognitive.