Inoa mea kūʻai:Nicotinamide riboside chloride pauka
Inoa ʻē aʻe:3-(Aminocarbonyl)-1-PD-ribofuranosyl-pyridinium chloride(1:1);Nicotinamide
Riboside.Cl;3-Carbamoyl-1-beta-D-ribofuranosyl-pyridinium chloride;NR, vitamina NR;Niagen, TRU NIAGEN
CASNO:23111-00-4
Huina mole: C11H15N2O5.Cl
Kaumaha Molekala: 90.70 g/mol
Maʻemaʻe: 98%
Ka helu hehee: 115 ℃-125 ℃
ʻAno: ʻO ke keʻokeʻo a i ka pauka melemele ʻeleʻele
Hoʻohana: Hoʻonui i nā pae NAD +, Kākoʻo i ka ʻelemakule olakino a me ka lolo / cognitive
Nā noi: ma ke ʻano he meaʻai meaʻai, nā meaʻai hana, a me nā mea inu
Manaʻo ʻia: ʻaʻole ʻoi aku ma mua o 180 mg / lā
ʻO Nicotinamide riboside kahi ʻano hou i mahalo nui ʻia o Vitamin B3, me nā waiwai kūʻokoʻa;he mea mua ia o NAD+.
ʻO Nicotinamide riboside (NR), i wehewehe mua ʻia i ka makahiki 1944 ma ke ʻano he kumu ulu (Factor V) no ka maʻi maʻi Haemophilus, a ma 1951, NR, ua noiʻi mua ʻia ma ke ʻano he hopena metabolic i nā ʻiʻo mammalian.
E like me kāu e ʻike ai, aia ʻelua ʻano NR i loaʻa, ʻo Nicotinamide Riboside kekahi, a ʻo kekahi ʻo Nicotinamide Riboside chloride.
Ma ka ʻōlelo kemika, ʻelua mau pūhui ʻokoʻa loa no ka mea he ʻokoʻa kā lākou helu CAS, NR me 1341-23-7 aʻo NR chloride me 23111-00-4.ʻAʻole paʻa ka NR ma ka wela lumi, ʻoiai ʻo NR chloride paʻa.ʻO ka Brand patented kaulana i kapa ʻia ʻo NIAGEN®, i hoʻokuʻu ʻia e Chromadex Inc i 2013, ʻo ia ke ʻano o Nicotinamide riboside chloride, e manaʻo ana e hoʻohuli i nā hōʻailona o ka ʻelemakule mai loko mai o kou kino.ʻO Nicotinamide Riboside i hana ʻia mai Cima Science aia nō hoʻi i ka ʻano pauka chloride.Inā ʻaʻole i kuhikuhi ʻia, e kuhikuhi ʻo NR i ka palapala NR chloride ma ka ʻatikala ma lalo nei.
Nā kumu meaʻai Nicotinamide riboside
ʻO ka nui o ka NR i nā meaʻai he minuke, ke hoʻohālikelike ʻia me nā mea hoʻohui meaʻai.Eia naʻe, he aha nā kumu meaʻai mua i loaʻa i ka nicotinamide riboside (NR)?
Waiu bipi
He ∼12 μmol NAD(+) nā huaora mua o ka waiū bipi/L, a he 60% ka mea i loaʻa ma ke ʻano he nicotinamide, a ʻo 40% ʻo ia ka NR.(ʻO ka waiū maʻamau ka nui o ka NR ma mua o ka waiū kūlohelohe), kahi noiʻi i paʻi ʻia e ke Kulanui o Iowa, ma 2016
hū
Ua ʻōlelo ʻia kahi noiʻi kahiko, "Ua hoʻokaʻawale ʻia kahi mea inhibitory mai ka hū a ua ʻike ʻia ʻo ia ka nicotinamide riboside, aia paha mai NAD (P) i ka wā o ka hoʻomākaukau ʻana i nā mea hū, a i ʻole nā mea hoʻohui hū meaʻai i ka wā o ka digestion in vivo."ʻOiai ʻaʻohe ʻikepili helu ma ka hū
pia
Loaʻa i ka pia ka nui o nā kalapona a me ka inu ʻana i nā mea i loko o kahi ʻano wai e like me ka hopena glycemic;Ua ʻōlelo nā pepa noiʻi like ʻole i ka pia he kumu meaʻai o ka nicotinamide riboside.
Eia kekahi, aia paha ka nui o ka NR e like me ka whey protein, nā halo, a pēlā aku.
No nā kānaka he nui, ʻaʻohe palena o ka waiu no nā kumu ʻē aʻe.Pono paha nā kumu meaʻai o ka nicotinamide riboside, akā ʻoi aku ka maikaʻi ma mua o kahi hoʻohui NR.
No ke aha ʻo Nicotinamide Riboside (NR) i koho ʻia ma ke ʻano he NAD + precursor vitamin invertebrates?
ʻElima mau laina noʻonoʻo e kākoʻo iā ia:
ʻO Haemophilus influenza, he maʻi maʻi maʻi maʻi, ʻaʻohe ala de novo a hiki ʻole ke hoʻohana iā Na a i ʻole Nam, ua hilinaʻi nui ʻia ma NR, NMN, a i ʻole NAD+ no ka ulu ʻana i ke kahe koko.
ʻO ka waiū kahi kumu o NR.
Mālama ʻo NR i nā neurons murine DRG i kahi ex vivo axonopathy assay ma o ka transcriptional induction o ka nicotinamide riboside kinase (NRK) 2 gene.
Hoʻohui nui ʻia ka NR a me nā derivatives e hoʻonui i ka hōʻiliʻili ʻana o NAD + i kahi ʻano hilinaʻi nui i nā laina kelepona kanaka.
ʻO Candida glabrata, kahi haʻuki kūpono e hilinaʻi ana i nā huaora NAD + precursor no ka ulu ʻana, hoʻohana i ka NR i ka wā i hoʻolaha ʻia.
ʻO Nicotinamide Riboside VS Nicotinamide VS Niacin
ʻO ka Niacin (a i ʻole ka waikawa nicotinic), he mea hoʻohuihui mea ola a me ke ʻano o ka huaora B3, kahi meaʻai pono kanaka.Loaʻa iā ia ke ʻano C6H5NO2.
ʻO Nicotinamide a i kapa ʻia ʻo niacinamide he ʻano o ka huaora B3 i loaʻa i ka meaʻai a hoʻohana ʻia ma ke ʻano he meaʻai meaʻai a me ka lāʻau lapaʻau.Loaʻa iā ia ke ʻano C6H6N2O.
ʻO Nicotinamide riboside kahi ʻano pyridine-nucleoside o ka huaora B3 e hana nei ma ke ʻano he precursor i ka nicotinamide adenine dinucleotide a i ʻole NAD +.Loaʻa iā ia ke ʻano C11H15N2O5+.
Nā Pōmaikaʻi Ola ʻo Nicotinamide Riboside
Kōkua ʻo Nicotinamide Riboside i ka hana ikehu
I nā holoholona, hoʻemi ʻia ka hoʻonui ʻana o NR i ka hoʻohana ʻana i ka NAD, ka mea i hoʻomaikaʻi i ka hana mitochondrial, hoʻihoʻi wikiwiki i ka nui o ka ʻiʻo, a mālama i ka ikaika NAD pae a me ka hoʻoikaika kino i nā ʻiole kahiko, e kōkua ana i ka mālama ʻana i ka nui o ka ʻiʻo a me ka hana, kākoʻo i ka hoʻoulu ʻana i ka ikehu.
Hoʻomaikaʻi ʻo Nicotinamide Riboside i ka hana cognitive
Mālama ʻo NR i nā cell nerve i loko o ka lolo ma ka hoʻoulu ʻana i ka SIRT3, Hoʻoulu ka hoʻohui ʻana i nā ala NAD a kōkua i ka pale ʻana i ka degeneration i ka noʻonoʻo.
Hoʻonui ʻo NR i ka hana cognitive a lohi i ka piʻi ʻana o ka maʻi o Alzheimer i nā ʻiole i hāʻawi ʻia iā NR no ʻekolu mahina.
Kāohi ʻo Nicotinamide Riboside i ka nalo lohe
Ma ka ho'āla ʻana i ke ala SIRT3, ua ʻike ʻia kahi haʻawina UNC ua kōkua i ka pale ʻana i nā ʻiole mai ka nalo o ka lohe ʻana i ka walaʻau.
Mālama ʻo Nicotinamide Riboside i ke ake
Hoʻonui waha ʻia ʻo NR i ka NAD i ke kino, e kōkua ana i ka pale ʻana i ke ake.Hoʻopau ʻo NR i ka hōʻiliʻili momona, hoʻohaʻahaʻa i ke kaumaha oxidative, pale i ka mumū, a hoʻomaikaʻi i ka ʻike insulin i loko o ke ake o nā ʻiole.
Eia kekahi, hiki i ka NR ke hoʻolōʻihi i ka lōʻihi, hoʻonui i ka metabolism, kākoʻo i ka hakakā ʻana i ka maʻi kanesa, hoʻemi i nā hōʻailona diabetic, hoʻonui i ka metabolism, hiki ke kōkua i ka pohō kaumaha.
Ua palekana anei ʻo Nicotinamide Riboside?
ʻAe, palekana ʻo NR.
He ʻekolu mau hoʻokolohua lapaʻau i paʻi ʻia e NR e hōʻoia ana he palekana ia no ka ʻai kanaka.
ʻO ka nānā pono ʻana a me ke koʻikoʻi i nā ʻike preclinical a me nā ʻike lapaʻau āpau i loaʻa ma NR e hōʻoiaʻiʻo he palekana a ʻae ʻia.
Mālama ʻo Niagen a me GRAS, me ka hoʻohana ʻana i nā kaʻina hana ʻepekema, ma lalo o ke Federal Food, Drug, and Cosmetic Act (FFDCA).
Nā hoʻāʻo kanaka Nicotinamide Riboside
Nui nā haʻawina pre-clinical i hana ʻia i ka hoʻāʻo ʻana i ka NR i nā ʻōnaehana kumu like ʻole.
I ka makahiki 2015, ua hoʻopau ʻia nā haʻawina lapaʻau kanaka mua, a ua hōʻike nā hopena i ka palekana a me ka hoʻonui ʻana o NR i nā pae o NAD i nā mea manawaleʻa kanaka olakino.
ʻO kahi hoʻokolohua lapaʻau i hoʻopaʻa ʻia e kahi placebo o nicotinamide riboside i nā kāne momona ma ka randomized: palekana, insulin-sensitivity, a me nā hopena lipid-mobilizing.
–Paʻi ʻia ma The American/Journal of Clinical Nutrition
Nā hualoaʻa: 12 wk o NR supplementation i loko o nā doses o 2000 mg/d ʻike ʻia he palekana, akā ʻaʻole ia e hoʻomaikaʻi i ka ʻike insulin a me ka metabolism glucose kino holoʻokoʻa i nā kāne paʻakikī, insulin-resistant.
Hoʻomaʻamaʻa maikaʻi ʻia ka hoʻonui ʻia ʻana o ka nicotinamide riboside a hoʻonui i ka NAD + i nā poʻe ʻelemakule olakino olakino.
–Paʻi ʻia ma Nature Communications
ʻO Nicotinamide Riboside ka mea kūikawā a me ka waha Bioavailable i nā ʻiole a me nā kānaka
–Paʻi ʻia ma Nature Communications
Maanei mākou e wehewehe ai i ka manawa a me ka hopena o ka hopena o ka NR i ke koko NAD metabolism i ke kanaka.Hōʻike ka hōʻike e hiki ke piʻi aʻe ke koko kanaka NAD e like me ka 2.7-fold me ka waha waha hoʻokahi o NR i ka noiʻi pilote o hoʻokahi kanaka a ua hoʻokiʻekiʻe ka NR waha i ka NAD hepatic mouse me ka pharm ʻike a ʻoi aku ka maikaʻi.
