Oleoylethanolamide(OEA)

Inoa mea kūʻai:Oleoylethanolamide, N-Oleoylethanolamide, OEA
inoa ʻē aʻe:N-(2-Hydroxyethyl)-9-Z-octadecenamide, N-oleoyl ethanolamide, Oleoyl monoethanolamide, 9-Octadecenamide , N-(2-Hydroxyethyl)oleamide
ʻAʻohe CAS:111-58-0
Mea Hoʻohālikelike Molecular:C₂₀H₃₉NO₂
Kaumaha Molekala:325.5
Hōʻike:90%,95%, 85% min
ʻAno:pauda kala ʻalika

OleoylethanolamideHe mea hou i ka mākeke meaʻai ma ke ʻano he mea hoʻohui meaʻai kaulana i hoʻohana ʻia i nā ʻano hoʻemi kaumaha.Nui nā poʻe bodybuilding e kūkākūkā ana i ka oleoylethanolamide ma reddit a me nā pūnaewele pūnaewele ʻē aʻe.

ʻO Oleoylethanolamide kahi metabolite kūlohelohe o ka waika oleic i hana ʻia i loko o ka ʻōpū liʻiliʻi i loko o ke kino kanaka.He mea kūlohelohe ia, a kapa ʻia e ka poʻe loea he "endogenous".

ʻO OEA kahi mea hoʻoponopono kūlohelohe o ka ʻai, ke kaumaha a me ka cholesterol.He metabolite kūlohelohe ia i hana ʻia i loko o kou ʻōpū liʻiliʻi.Kōkua ʻo OEA i ka hoʻoponopono ʻana i ka pōloli, ke kaumaha, ka momona o ke kino a me ka cholesterol ma o ka hoʻopaʻa ʻana i kahi mea hoʻokipa i kapa ʻia ʻo PPAR-Alpha (Peroxisome proliferator-activated receptor alpha).ʻO ka mea nui, hoʻonui ʻo OEA i ka metabolism o ka momona o ke kino a haʻi i kou lolo ua piha ʻoe a ʻo ka manawa kēia e hoʻōki i ka ʻai.Ua ʻike ʻia ʻo OEA e hoʻonui i ka hoʻolilo calorie pili ʻole i ka hana.

Oleylethanolamide Moolelo

Ua ʻike ʻia nā hana olaola o Oleoylethanolamide ma mua o 50 mau makahiki i hala.Ma mua o 2001, ʻaʻole nui ka noiʻi ʻana ma OEA.Eia nō naʻe, i kēlā makahiki, ua wāwahi ka poʻe noiʻi Sepania i ka lipid a aʻo i ka hana ʻana, kahi i hoʻohana ʻia ai a me kāna hana.Ua hoʻāʻo lākou i ka hopena o ka OEA ma ka lolo (o nā ʻiole) ma o ka hoʻokomo pololei ʻana iā ia i loko o nā ventricle lolo.ʻAʻole i loaʻa iā lākou kahi hopena i ka ʻai ʻana a hōʻoia ʻaʻole hana ʻo OEA i ka lolo, akā, hoʻomaka ia i kahi hōʻailona ʻokoʻa e pili ana i ka pōloli a me ka ʻai ʻana.

ʻO Oleylethanolamide VS cannabinoid anandamide

Ua aʻo mua ʻia nā hopena o OEA no ka mea ua like ia me nā mea ʻē aʻe, he cannabinoid i kapa ʻia ʻo anandamide.Pili nā Cannabinoids i ka mea kanu Cannabis, a hiki i nā anandamides i loko o ka mea kanu (a me ka marijuana) ke hoʻonui i ka makemake o ke kanaka e ʻai i ka ʻai ma o ka hoʻoulu ʻana i ka pane hānai.Wahi a Wikipedia, ʻo Oleoylethanolamide ka monounsaturated analogue o ka endocannabinoid anandamide.ʻOiai he ʻano kemika ko OEA e like me ka anandamide, ʻokoʻa kona hopena i ka ʻai a me ka hoʻokele kaumaha.ʻAʻole like me ka anandamide, hana kūʻokoʻa ʻo OEA i ke ala cannabinoid, hoʻoponopono i ka hana PPAR-α e hoʻoulu i ka lipolysis.

Nā hanana o nā ʻano ethanolamides fatty-acid: oleoylethanolamide (OEA), palmitoylethanolamide (PEA) a me anandamide (arachidonoylethanolamide, AEA).(Cima Science Co., Ltd ʻo ia wale nō ka mea hana i nā mea waiwai nui o OEA, PEA a me AEA ma Kina, inā makemake ʻoe i ka laʻana a me ke kumukūʻai kumukūʻai, e ʻoluʻolu e hoʻouna iā mākou i leka uila ma ka ʻaoʻao hoʻokaʻaʻike iā mākou.)

Hoʻopili ʻo OEA me ka pilina kiʻekiʻe i ka peroxisome-proliferator-activated receptor-a (PPAR-a), kahi mea hoʻokipa nukle e hoʻoponopono i kekahi mau ʻano o ka metabolism lipid.

Nā kumu kūlohelohe o ka oleoylethanolamide

ʻO Oleoylethanolamide kahi metabolite kūlohelohe o ka waika oleic.No laila, ʻo nā meaʻai i loaʻa i ka ʻakika oleic kahi kumu pololei o OEA.

ʻO ka waika Oleic ka momona mua o nā aila meaʻai e like me ka ʻoliva, canola a me ka sunflower.Hiki ke loaʻa ka ʻaila Oleic i nā aila nut, ka ʻiʻo, ka moa, ka cheese, etc.

ʻO nā kumu meaʻai waiwai i ka ʻakika oleic, ʻo ia hoʻi: ʻAila Canola, ʻAila ʻOlive, ʻAila ʻAvocado, ʻAila Almond, ʻAvocados, High Oleic Safflower Oil.

ʻO kekahi mau mea e pili ana i ka Oleic Acid:

ʻO kekahi o nā momona maʻamau i ka waiū umauma kanaka

He 25% ka momona i ka waiū bipi

Monounsaturated

ʻO ka Omega-9 fatty acid

ʻO ke kumu hoʻohālike kemika C18H34O2(CAS 112-80-1)

Hoʻopili pū me nā triglycerides

Hoʻohana ʻia i nā mea hoʻonaninani kiʻekiʻe ma ke ʻano he moisturizer maikaʻi loa

Loaʻa i ka momona waiu, cheese, ʻaila ʻoliva, ʻaila hua waina, nā nati, avocados, hua manu a me ka ʻiʻo.

Aia paha ke kuleana no ka hapa nui o nā pono olakino o ka ʻaila ʻoliva!

Hoʻokumu i nā paʻakikī super hero me nā protein waiū ʻē aʻe e hakakā ai i nā maʻi maʻi maʻi

Oleoylethanolamide Pono

ʻO ka Oleoylethanolamide (OEA) maikaʻi e lilo i ke kaumaha ma ke ʻano he mea hoʻoponopono makemake a kākoʻo i nā pae cholesterol olakino i nā pākeke.

ʻO OEA ma ke ʻano he mea hoʻopau ʻai

ʻO ka hoʻopau ʻana i ka ʻai he wahi mana nui no ka ʻai ʻana i ka ikehu (meaʻai), koʻikoʻi ka mālama ʻana i ka ʻai i ka mālama ʻana i ke kaumaha o ke kino.Pehea ka OEA e hoomalu ai i kou makemake?Hiki iā ʻoe ke nānā i ke ʻano o nā hana ma lalo nei.

OEA a me ka cholesterol

ʻO ka ʻaila ʻoliva kahi mea momona momona, a kōkua i ka hoʻohaʻahaʻa ʻana i ka "kino" LDL cholesterol a hoʻonui i ka "maikaʻi" HDL.No ke aha mai?A hiki i ka 85% o ka aila ʻoliva he oleic acid, a ʻo ka metabolite olakino nui o ka waika oleic ʻo OEA (ʻo Oleoylethanolamide ka inoa piha).No laila, ʻaʻohe kānalua ua kōkua ʻo OEA i ka cholesterol maikaʻi.

Hōʻike kekahi hulina hou he hopena maikaʻi ka oleoylethanolamide i ka hopohopo, a ʻoi aku ka nui o nā ala a me nā hōʻike e pono ai ke kākoʻo.

Ke kaʻina hana ʻoki ʻana o Oleoylethanolamide

Aia ma lalo iho ka char kahe o Oleoylethanolamide:

ʻO nā ʻanuʻu maʻamau: reactiong → Kaʻina hoʻomaʻemaʻe → Filtration → Hoʻoheheʻe hou ʻia i loko o ka ethanol → hydrogenation → Hoʻopili i ka wai maʻemaʻe → crystallization → kānana → hoʻāʻo → hoʻopaʻa → hopena huahana

Mechanism o ka hana o oleoylethanolamide

No ka maʻalahi, hana ʻo oleoylethanolamide ma ke ʻano he mea hoʻoponopono pōloli.Hiki iā OEA ke hoʻomalu i kāu ʻai ʻana ma ka haʻi ʻana i ka lolo ua piha ke kino, a ʻaʻohe meaʻai e pono ai.ʻAi liʻiliʻi ʻoe i kēlā me kēia lā, a ʻaʻole paha ke kaumaha o kou kino i ka wā lōʻihi.

ʻO nā hana anti-obesity o oleoylethanolamide (OEA) e like me ka mea i hōʻike ʻia ma ke kiʻi.Hoʻopili ʻia ʻo OEA a hoʻoneʻe ʻia i loko o ka ʻōpū liʻiliʻi kokoke mai ka waika oleic i loaʻa i ka meaʻai, e like me ka aila ʻoliva.Hiki i ka meaʻai momona kiʻekiʻe ke kāohi i ka hana OEA i loko o ka ʻōpū.Hoʻemi ʻo OEA i ka ʻai ʻana i ka meaʻai ma ka hoʻōla ʻana i ka homeostatic oxytocin a me ka histamine brain circuitry a me nā ala hedonic dopamine.Aia nā hōʻike e hiki ai i ka OEA ke hōʻemi i ka hedonic cannabinoid receptor 1 (CB1R) hōʻailona, ​​ʻo ka hoʻāla ʻana e pili ana me ka hoʻonui ʻana i ka ʻai.Hoʻemi ʻo OEA i ka lawe ʻana i ka lipid i nā adipocytes e hoʻemi i ka momona momona.ʻO ka wehewehe hou ʻana i nā hopena o ka OEA ma ka ʻai ʻana i ka meaʻai a me ka metabolism lipid e kōkua i ka hoʻoholo ʻana i nā hana physiological i hiki ke kuhikuhi ʻia e hoʻomohala i nā lāʻau lapaʻau ʻoi aku ka maikaʻi.

Hana ʻo OEA e hoʻāla i kahi mea i kapa ʻia ʻo PPAR a hoʻonui i ka puhi momona a hoʻemi i ka waiho ʻana o ka momona.Ke ʻai ʻoe, piʻi ka pae OEA a emi iho kou ʻai i ka wā e haʻi aku ai nā aʻalolo e pili ana i kou lolo ua piha ʻoe.ʻO ka PPAR-α kahi pūʻulu o nā mea hoʻokele nuklea i hoʻoikaika ʻia i ka ligand i komo i ka hōʻike ʻana o ka lipid metabolism a me nā ala ala o ka homeostasis.

Hōʻike ʻo OEA i nā hiʻohiʻona wehewehe āpau o kahi kumu maona:

(1) Kāohi ia i ka hānai ʻana ma ka hoʻolōʻihi ʻana i ka wā i ka ʻai aʻe;

(2) Hoʻoponopono ʻia kona synthesis e ka loaʻa ʻana o ka meaʻai a me

(3) Loaʻa kona mau pae i ka circadian fluctuations.

ʻO nā hopena ʻaoʻao o Oleoylethanolamide

ʻO ka palekana ʻo Oleoylethanolamide kahi hopohopo nui ma waena o nā hōʻailona hoʻohui e makemake e hoʻāʻo i kēia mea hou i loko o kā lākou mau kumu hoʻemi kaumaha.

Ma hope o ka loiloi piha ʻana i nā palapala a me nā ʻikepili i loaʻa, ʻaʻohe hopohopo o ka US Food and Drug Administration (FDA) e pili ana i ka palekana o OEA.ʻO RiduZone ka inoa mua o ka oleoylethanolamide pauka mea hoʻohui mai ka makahiki 2015.

ʻO Oleoylethanolamide kahi metabolite o ka waika oleic, kahi ʻāpana o ka meaʻai olakino olakino.He palekana ke ho'āʻo i nā mea hoʻohui OEA, a ʻaʻohe hopena koʻikoʻi i hōʻike ʻia.

ua hōʻike ʻia nā hopena.

Oleoylethanolamide nā ho'āʻo kanaka

Ma hoʻokahi haʻawina, ua ʻōlelo ʻia he kanalima (n=50) mau kānaka makemake e hoʻemi i ke kaumaha e lawe i ka OEA 2-3 manawa i ka lā, 15-30 mau minuke ma mua o ka ʻai ʻana no 4-12 pule.Aia nā kumuhana i ka poʻe i hoʻohana ʻole i nā huahana kaumaha ma mua, ka poʻe i ʻike i nā hanana pōʻino me nā huahana kaumaha ʻē aʻe, ʻo ka poʻe i hoʻopaʻa ʻia i ka pohō kaumaha ma luna o nā mea paona pohō e like me phentermine, ka poʻe e hoʻāʻo nei e hoʻokō i nā hoʻololi ʻana i ke ʻano o ke ola. ), a me ka poʻe e mālama ʻia nei no nā kūlana olakino e pili ana i ka hoʻomanawanui ʻana o ka glucose, dyslipidemia, hypertension a me nā maʻi cardiovascular.

Ma kahi haʻawina ʻelua, ua aʻo ʻia nā kumuhana 4 me ke kaupaona kumu o 229, 242, 375 a me 193 lbs, e lawe i nā capsules Oleoylethanolamide (hoʻokahi capsule i loaʻa ka 200mg 90% OEA).Lawe nā kānaka i 4 capsules (1 capsule 15-30 mau minuke ma mua o ka ʻai ʻana a pono lākou e lawe i kahi capsule hou ma mua o kā lākou ʻai nui loa o ka lā) i kēlā me kēia lā no 28 mau lā.Ua hoʻokomo mua ʻia ke kumuhana hope ma mua o ka hoʻokomo ʻana i ka lap band.Ua aʻo ʻia nā kumuhana ʻaʻole e hoʻololi i kā lākou ʻai a me nā hana hoʻoikaika kino.

Nā hualoaʻa

Ma ka haʻawina mua, ua nalowale nā ​​kumuhana i ka awelika o 1-2 lbs / pule.ʻAʻohe hopena ʻaoʻao koe wale nō ka mea maʻi i loaʻa i ka nausea transient i hoʻoholo ʻia ma lalo o hoʻokahi pule.Ma ka haʻawina ʻelua, ua hōʻike ʻo 3 o 4 mau mea i ka pohō kaumaha (3, 7, 15 a me 0 lbs).Ua hōʻike ʻia nā kumuhana 4 a pau he 10-15% ka emi ʻana o ka nui o ka ʻāpana, ka lōʻihi o ka wā waena, a ʻaʻohe hopena ʻaoʻao.

Inā makemake ʻoe i nā palapala ʻē aʻe o nā hoʻokolohua kanaka me OEA, e kipa i nā loulou PDF hiki ke hoʻoiho.

Oleoylethanolamide dosage

He liʻiliʻi ka ʻike noiʻi e pili ana i ka supplementation OEA i kēia manawa i loko o ke kanaka, a ʻoiai e manaʻo ʻia he palekana, ʻaʻohe mea i ʻōlelo ʻia.Eia nō naʻe, aia kekahi mau mea hoʻohui ma ka mākeke, a loaʻa paha iā ʻoe kekahi no kāu kuhikuhi.

ʻO ka dosing i kēlā me kēia lā o RiduZone (branded OEA/Oleoylethanolamide 90%) he 200mg (1capsule me OEA wale nō i loko).Inā hui pū ʻia me nā mea hoʻemi kaumaha ʻē aʻe, ʻoi aku ka liʻiliʻi o ka dosing i kēlā me kēia lā, e ʻōlelo ʻo 100mg a i ʻole 150mg.ʻO kekahi mau mea hoʻohui

Manaʻo ʻia e lawe i nā mea hoʻohui oleoylethanolamide 30 mau minuke ma mua o ka ʻaina kakahiaka a me ka ʻaina ahiahi, e manaʻo ʻoe i ka piha ʻana i ka wā ʻai a ma muli o ka ʻai ʻana i ka liʻiliʻi.

E noiʻi i nā palapala no ka oleoylethanolamide

Oleoylethanolamide: he mea pāʻani hou i ka mana metabolism ikehu.Ke kuleana i ka ʻai ʻana i ka meaʻai

Hoʻonui ka Oleoylethanolamide i ka hōʻike o PPAR-Α a hoʻemi i ka ʻai a me ke kaumaha o ke kino i ka poʻe momona: He hoʻokolohua lapaʻau.

ʻO nā Molecules Brain a me ka makemake: ʻO ka hihia o Oleoylethanolamide

Hoʻoponopono ʻo Oleylethanolamide i ka hānai ʻana a me ke kaumaha o ke kino ma o ka hoʻāla ʻana o ka mea hoʻokipa nuklea PPAR-a

Hoʻoulu ʻia o TRPV1 e ka Satiety Factor Oleoylethanolamide

Hoʻoponopono i ka ʻai ʻana e ka oleoylethanolamide

ʻO ka hana o ka oleoylethanolamide ma ka lawe ʻana i ka momona momona i loko o ka ʻōpū liʻiliʻi ma hope o ka ʻai ʻana i ka meaʻai a me ka hoʻemi ʻana o ke kaumaha o ke kino.

Oleoylethanolamide: ʻO ke kuleana o kahi lipid amidein hoʻololi i ka ʻai ʻana

Oleoylethanolamide: He hoa momona i ka hakakā ʻana i ka momona

ʻO Oleoylethanolamide: He ʻano hou no ka lāʻau lapaʻau e hiki ai i ka Cannabinoid Antagonists no ka mālama ʻana i ka makemake.