inoa huahana:ʻO Tianeptine Hemisulfate Monohydrate

Inoa ʻē aʻe: tianeptinesulfate;

(Thiazepin-11-ylAmino)HeptanoicAcidSemisulfateMonohydrateTianeptineSemisulfateMonohydrate;

7-[(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoicacidsulfatehydrate(2:1:2); Tianeptinehemisulfatemonohydrate(THM);

7-[(3-Chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoicacidsulfatehydrate(2:1:2); Tianeptinehemisulfatehydrate;Thiazepin-11-ylAmino)HeptanoicAcidSemisulfate;THM

ʻAʻohe CAS:1224690-84-9

Nā kikoʻī: 98.0%

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ʻO Tianeptine Sulfate/Tianeptine hemisulfate monohydrate he paʻakai maikaʻi o Tianeptine. ʻAʻole ia he hygroscopic no laila ʻoi aku ka maʻalahi o ka mālama ʻana i ka pauka. No ka mea ʻaʻole hiki ke komo a hoʻokuʻu ʻia mai ke kino, hiki i ka paʻakai sulfate ke hoʻokuʻu i ka Tianeptine i nā manawa lōʻihi. Ma mua o ka hoʻohana ʻana i ʻekolu mau manawa me nā hopena kiʻekiʻe wikiwiki a me nā hopena hāʻule wikiwiki, ʻae ka paʻakai sulfate i hoʻokahi dosis e mālama i nā pae plasma i loko o ke kino ʻoi aku ka lōʻihi ma mua o ka paʻakai sodium. ʻO kēia mau hiʻohiʻona i hoʻomaikaʻi ʻia e hana ʻo Tianeptine Sulfate i mea hou.

ʻO ka Tianeptine Sulfate ʻaʻole wale ka hopena antidepressant maikaʻi a me nā hopena ʻino i ʻoi aku ka liʻiliʻi ma mua o nā lāʻau antidepressant tricyclic maʻamau, ʻaneʻane ʻaʻohe hopena ʻino i ka ʻōnaehana cardiovascular, ʻaʻole i ʻeha ke koko, ate a me nā hana puʻupaʻa. ʻAʻole maikaʻi wale ʻo Tianeptine no ke kaumaha a me ka neurosis depressive, ka waiʻona maʻi a me ke kaumaha ma hope o ka ʻona. Hiki i ka hoʻohana lōʻihi ke pale i ka hoʻi hou

ʻO Tianeptine hemisulfate monohydrate, i ʻike ʻia ʻo tianeptine sulfate, he hui kū hoʻokahi i ʻike mua ʻia i nā makahiki 1960 a ua hoʻohana nui ʻia mai ia manawa.

ʻO ka Tianeptine he antidepressant. Aia ka holoholona i ka hippocampus pyramidal cell i hoʻonui i ka spontaneousactivity, a ua kāohi ʻia ka wikiwiki o kāna hana ma hope o ka hoʻihoʻi ʻana; Hoʻonui i nā cortical a me nā hippocampalneuron ma nā wahi o ka 5- serotonin reuptake. ʻO Tianeptine me ka hahai ʻole i nā hopena ʻino: hiamoe a me ka makaʻala; ʻōnaehana cardiovascular; ʻōnaehana cholinergic (me ka ʻole o nā hōʻailona anticholinergic); makemake lāʻau.

ʻO Tianeptine kahi lāʻau lapaʻau i hoʻohana ʻia no ka hoʻomaikaʻi ʻana i ke kaumaha ma nā pae āpau o ka paʻakikī. ʻO ka lāʻau lapaʻau tianeptine ka mea maʻamau i wehewehe ʻia he tricyclic antidepressant. He hui kemika kēia i kapa ʻia no ka mea aia ʻekolu apo o nā ʻātoma.

E like me nā antidepressants tricyclic ʻē aʻe, hoʻopaʻa ʻia ka tianeptine i ka reuptake, a i ʻole ka lawe hou ʻana, o serotonin. ʻO kēia kahi neurotransmitter kuleana no ka maikaʻi o ke kanaka. Hoʻonui ka reuptake i ka loaʻa ʻana o ia mau mea i ka lolo.

ʻO Tianeptine hemisulfate monohydrate, i ʻike ʻia ʻo tianeptine sulfate, he hui kū hoʻokahi i ʻike mua ʻia i ka makahiki 1960 a ua hoʻohana nui ʻia mai ia manawa. . Ma ka hoʻonui ʻana i ka serotonin reuptake, kōkua ka tianeptine hemisulfate monohydrate e hoʻihoʻi i ke koena o nā kemika i loko o ka lolo, hiki ke hōʻemi i nā hōʻailona o ke kaumaha. ʻO kekahi o nā hiʻohiʻona kūʻokoʻa o ka tianeptine hemisulfate monohydrate ka hiki ke hoʻonui i ka neuroplasticity. ʻO ka neuroplasticity e pili ana i ka hiki o ka lolo ke hoʻololi a hoʻololi i ka manawa. Hōʻike nā noiʻi ʻo ka tianeptine hemisulfate monohydrate e hoʻoikaika i ka ulu ʻana o nā neurons hou a hoʻoikaika i nā pilina i loko o ka lolo. Hana kēia waiwai i kahi koho hoihoi no ka mālama ʻana i ke kaumaha, no ka mea hiki ke hāʻawi i nā pōmaikaʻi lōʻihi me ka hoʻomaha ʻana i nā hōʻailona.

Hana:

ʻO ka Tianeptine Sulfate he antidepressant. Aia ka holoholona: ua hoʻonui ka hippocampus pyramidal cell i ka hana spontaneous, a ua kāohi ʻia ka wikiwiki o kāna hana ma hope o ka hoʻihoʻi ʻana; hoʻonui i nā neurons cortical a me hippocampal ma nā wahi o ka 5- serotonin reuptake. Tianeptine me ka hahai ʻole i nā hopena ʻino: hiamoe a me ka makaʻala; ʻōnaehana cardiovascular; ʻōnaehana cholinergic (me ka ʻole o nā hōʻailona anticholinergic); makemake lāʻau.
ʻO ka Tianeptine Sulfate ʻaʻole wale ka hopena antidepressant maikaʻi a me nā hopena ʻino i ʻoi aku ka liʻiliʻi ma mua o nā lāʻau antidepressant tricyclic maʻamau, ʻaneʻane ʻaʻohe hopena ʻino i ka ʻōnaehana cardiovascular, ʻaʻole i ʻeha ke koko, ate a me nā hana puʻupaʻa. ʻAʻole maikaʻi wale ʻo Tianeptine no ke kaumaha a me ka neurosis depressive, ka waiʻona maʻi a me ke kaumaha ma hope o ka ʻona. Hiki i ka hoʻohana lōʻihi ke pale i ka hoʻi hou.

Noi:

ʻO ka Tianeptine hemisulfate monohydrate kahi mea hoʻonui serotonin reuptake enhancer (SSRE), ʻo ia ka mea e hoʻonui ai i ka reuptake o ke serotonin i loko o ka lolo, a laila e hoʻonui ai i ka synaptic plasticity a hoʻomaikaʻi i ke ʻano. Hana ia ma ka hoʻololi ʻana i nā pae serotonin i ka lolo a me ka hoʻoikaika ʻana i ka neuroplasticity. I nā makahiki i hala iho nei, ua lilo ka tianeptine hemisulfate monohydrate i mea kaulana i ka noiʻi olakino, ʻoi loa i ka hoʻomohala ʻana i nā lāʻau antidepressant. Ke hōʻoia nei ka nui o nā noiʻi i kāna hopena therapeutic, e puka mālie ana kāna mau noi noi