Azelaic acid 98%nke HPLC | Ọkwa ọgwụ & ịchọ mma
1. Nchịkọta ngwaahịa
Azelaic acid(CAS123-99-9) bụ dicarboxylic acid na-apụta n'okike nwere usoro ihe omimi C₉H₁₆O₄ na ịdị arọ molekul 188.22 g/mol. Ọkwa ịdị ọcha 98% HPLC anyị kwadoro na-ezute ụkpụrụ USP/EP, ahaziri maka usoro dermatological na ngwa ụlọ ọrụ.
Nkọwapụta igodo
- Ịdị ọcha: ≥98% (HPLC-ELSD kwadoro, mkpokọta adịghị ọcha <0.2%)
- Ọdịdị: White crystalline ntụ ntụ
- Ebe mgbaze: 109-111°C
- Ebe esi mmiri: 286°C na 100 mmHg
- Solubility: 2.14 g / L na mmiri (25 Celsius C), soluble na ethanol / alkaline ngwọta
2. Njirimara chemical
2.1 Nnwale nhazi
- Profaịlụ NMR:
¹H NMR (300 MHz, CDCl₃): δ 1.23 (t, J=7.1Hz, 3H), 1.26-1.39 (m, 6H), 1.51-1.69 (m, 4H), 2.26/2.32 (t, 2H nke ọ bụla), 1.2H, 1.2H COOH) - Chromatogram HPLC:
Oge Njide: 20.5 min (isi kacha elu), adịghị ọcha kacha elu <0.1% na 31.5/41.5 min
2.2 Usoro njikwa ogo
| Oke | Usoro | Usoro nnabata |
|---|---|---|
| Nyocha | HPLC-ELSD (Agilent 1200) Ogidi: Purospher Star RP-C18 Usoro mkpanaaka: Methanol/Mmiri/Acetic Acid gradient | 98.0-102.0% |
| Ọla dị arọ | ICP-MS | ≤10 ppm |
| Ihe mgbaze fọdụrụnụ | GC-FID (kọlụm HP-5MS) Mwepụta ya na HMDS | Ethanol <0.5% |
3. Ngwa ọgwụ
3.1 Mmetụta Dermatological
- Acne vulgaris:
Na-ebelata comedones site na 65% n'ime ule izu iri na abụọ (ude 20%) site na:- Antimicrobial omume megideC. ihe otutu(MIC₅₀ 256 μg/mL)
- Mgbochi Tyrosinase (IC₅₀ 3.8 mM) maka hyperpigmentation post-inflammatory.
- Rosacea:
Gel 15% na-egosi mbelata 72% na erythema (vs 43% placebo) site na:- Antioxidant ROS scavenging (EC₅₀ 8.3 μM)
- MMP-9 nkwụsị na keratinocytes
3.2 Ntuziaka nhazi
| Ụdị usoro onunu ogwu | Akwadoro % | Ndekọ ndakọrịta |
|---|---|---|
| Ude/gel | 15-20% | Zere methylparaben (na-akpata mbibi 42%) |
| Liposomal | 5-10% | Jiri ihe nchekwa phosphate pH7.4 + soybean lecithin |
4. Ngwa ịchọ mma
4.1 Mmekọrịta Ọcha
- Ngwakọta kacha mma:
- 2% AzA + 5% Vitamin C: 31% mbelata melanin vs monotherapy
- 1% AzA + 0.01% Retinol: 2x njikọ njikọ collagen
4.2 data kwụsie ike
| Ọnọdụ | Ọnụego iweda ala |
|---|---|
| 40°C/75% RH (3M) | <0.5% |
| Mkpughe UV | 1.2% (yana nchekwa TiO₂) |
5. Ọrụ mmepụta ihe
- Polymer Precursor:
- Nylon-6,9 njikọ (mmetụta mmeghachi omume> 85% na 220°C)
- Corrosion inhibitor maka ígwè alloys (0.1M ngwọta na-ebelata corrosion site 92%)
6. Safety & Regulatory
6.1 Profaịlụ toxicological
| Oke | Nsonaazụ |
|---|---|
| Oral LD₅₀ (oke) | > 5000 mg / kg |
| Iwe iwe | Dị nro (OECD 404) |
| Ihe ize ndụ anya | Nkeji 2B |
6.2 Nkwekọrịta zuru ụwa ọnụ
- Asambodo:
- US FDA Drug Master faịlụ
- Edebara aha EU REACH
- ISO 9001: 2015 Ogo Sistemu
7. Nkwakọ ngwaahịa & Nchekwa
| Ọnụọgụ | Akpa | Ọnụ ego (EXW) |
|---|---|---|
| 25 n'arọ | HDPE drum + Alu akpa | $4,800 |
| 1 n'arọ | Amber iko karama | $220 |
| 100 g | obere akpa akara okpukpu abụọ | $65 |
Nchekwa: 2-8°C n'ebe akọrọ (okpomọkụ ụlọ na-anabata ma ọ bụrụ <25°C/60% RH)
8. Ajụjụ
Ajụjụ: Enwere m ike iji azelaic acid na niacinamide?
A: Ee, data ụlọ ọgwụ na-egosi 10% AzA + 4% niacinamide na-eme ka nnabata 37% vs AzA naanị.
Ajụjụ: Gịnị bụ ndụ shelf?
A: ọnwa 36 ka echekwara nke ọma. Ogbe-kpọmkwem COA nyere
9. Ntụaka
- data njirimara NMR
- HPLC-ELSD usoro
- Ọmụmụ nkwụsi ike
- Ịrụ ọrụ ụlọ ọgwụ
