L-ERGOTHIONEINE 99% sitere na HPLC
Antioxidant adịchaghị maka ngwa Nutraceutical & Cosmeceutical
1. Nchịkọta ngwaahịa
L-Ergothionine(ERT) bụ amino acid sọlfọ nwere sọlfọ na-enweta n'okike sitere na gbaa ụka microbial, nke a na-ahụkarị na ero dị ka.Tricholoma matsutakenaHericium erinaceus. Ngwaahịa anyị bụ ihe dị elu dị ọcha (≥99% site na HPLC) ntụ ntụ crystalline na CAS Nke 497-30-3, kwadoro site na nyocha chromatographic siri ike. Ọ na-egosipụta nkwụsi ike pụrụ iche na pH 4.0-6.0, na-eme ka ọ dị mma maka serums nlekọta anụ ahụ, lotions, na mgbakwunye ọnụ.
Akụkụ ndị bụ isi:
- Ịdị ọcha: ≥99% (HPLC gbaara ama, COA akọwapụtara nke ọma nyere)
- Usoro ihe omimi: C₉H₁₅N₃O₂S | Arọ molekụla: 229.3 g/mol
- Solubility: 125 mg/mL n'ime mmiri (ultrasonic-enyere aka)
- Asambodo: Ndị na-abụghị GMO, Allergen-Free, Vegan-Friendly
2. Njikwa Ogo & Usoro HPLC
Usoro nyocha anyị dabara na ụkpụrụ ndị ọgbọ nyochara:
- Nkwadebe ihe atụ: 1 mL omenala omenala sie na 94 ° C maka 10 min, vortexed (1600 rpm / 30 min), centrifuged (10,000 × g / 5 min), ma chekwaa na -20 ° C ma ọ bụrụ na ọ dị mkpa.
- Sistemụ HPLC: Dionex Ultimate 3000 nwere ngwanrọ Chromeleon.
- Ogidi: Cortecs UPLC T3 (2.1×150 mm, 1.6 μm particles, 120 Å pore size) .
- Usoro mkpanaaka: elution gradient sitere na 0.1% formic acid ruo 70% acetonitrile/0.1% formic acid, ọnụego erute 0.3 mL / min.
- Nchọpụta: nnabata UV na 254 nm, LOQ 0.15 mmol/L.
Usoro nkwado:
- Ọnụ ọgụgụ: 0.3–10 mmol/L (R²>0.99)
- Nkenkenke: ≤6% RSD (intra-/inter-assay)
- Iweghachite: ~ 100% izi ezi
3. Uru ahụike & Ngwa
3.1 Ihe oriri na-edozi ahụ
- Nchedo Mitochondrial: Na-ebelata nrụgide oxidative site n'iwepụ radicals hydroxyl (IC₅₀: 2.5 μM) na superoxide anions.
- Nkwado Telomere: Na-egbu oge telomere dị mkpụmkpụ na vitro.
- Usoro onunu ogwu: Ọmụmụ ụlọ ọgwụ na-atụ aro 5-20 mg / ụbọchị na-ebuli ọkwa ERT plasma nke ukwuu.
Ngwaahịa akwadoro:
- Capsules: 100 μg–5 mg kwa nri (dịka ọmụmaatụ, LifeExtension's Essential Youth) .
- Ngwakọta mmekọrịta: Na-ejikọta ya na ferulic acid maka nkwalite bioavailability.
3.2 Ojiji Cosmeceutical
- Mgbochi ịka nká: Na-egbochi tyrosinase (40% mbelata na 0.5% itinye uche) ma na-echebe elastin site na mmebi UV.
- Ntuziaka nhazi:
- pH: 4.0–6.0 (nkwụsi ike kacha mma)
- Ntinye uche: 0.5-2.0% na serum / lotions
- Ndakọrịta: Stable na vitamin C, hyaluronic acid, na peptides.
4. Nka na ụzụ nkọwa
| Oke | Nkọwapụta | Ntụaka |
|---|---|---|
| Ọdịdị | White crystalline ntụ ntụ | |
| Ịdị ọcha (HPLC) | ≥99% | |
| Ebe Na-agbaze | 275-280°C (na-emebi emebi) | |
| Nchekwa | 2-8 Celsius C n'ime akpa ikuku | |
| Ndụ shelf | Ọnwa iri abụọ na anọ |
5. Safety & Regulatory Compliance
- Data nchekwa: LD₅₀>2000 mg/kg (ọnụ, oke); enweghị mmetụta ọjọọ na ọnwụnwa mmadụ .
- Asambodo: EU Novel Food Approval (Ergoneine®), FDA GRAS .
- Ijikwa: Jiri NIOSH kwadoro respirators na kemịkal na-eguzogide ọgwụ n'oge nhazi ụlọ ọrụ.
6. Global Supply & Nkwakọ ngwaahịa
- Nhọrọ nkwakọ ngwaahịa: 1 n'arọ, 10 n'arọ, 1000 n'arọ (akpa foil aluminum na desiccant) .
- Oge ndu: 3–5 ụbọchị azụmahịa (mbupu zuru ụwa ọnụ site na DHL/FedEx) .
- Ahịa Efere: USA, EU, Australia, Japan, Brazil .
7. Isi Okwu
- Keywords: "L-Ergothioneine 99%HPLC", "Onye na-eweta Antioxidant eke", "Ergothioneine maka nlekọta anụ ahụ".
- Gụnye CAS 497-30-3, nkwupụta ịdị ọcha na usoro ngwa.
