Oleanolic acid ntụ ntụ

Oleanolic acid nke bụ pentacyclic triterpenoids atọ dịpụrụ adịpụ na osisi Gentianaceae nke Swertia mileensis ahịhịa ma ọ bụ mkpụrụ osisi privet dum, nwere ahụ nweere onwe ya na glycosides n'ọtụtụ osisi.Oleanolic acid nwere ụdị dị iche iche na osisi, na nkezi ọdịnaya bụ 0.2% - 2%.Cucurbitaceae elu ọdịnaya bụ 1.5% ~ hunchback ala 2%, privet mkpụrụ ọdịnaya nke 0.6% ~ 0.7%.Oleanolic acid bụ ụdị pentacyclic triterpenoid compound dịpụrụ adịpụ site na mkpụrụ nke genus Asteraceae, Syzygium sylvestris, ma ọ bụ Ligustrum lucid.Ọ bụ adjuvant ọrịa imeju na ụlọ ọgwụ na-eji maka ọgwụgwọ ọrịa.Nnukwu jaundice ịba ọcha n'anya nwere mmetụta doro anya na ibelata alanine aminotransferase na yellowing.Oolic acid bụ pentacyclic triterpenoids dịpụrụ adịpụ na mkpụrụ nke swertia chinensis ma ọ bụ fructus ligustris sitere na gentianaceae osisi.A na-ahụ oleanolic acid n'ọtụtụ ebe na osisi, yana ọdịnaya zuru oke nke 0.2% ~ 2% [1].Ọdịnaya nke ala calabash bụ 1.5% ~ 2%, yana ọdịnaya nke mkpụrụ osisi fructus ligustris bụ 0.6% ~ 0.7%.Oleanolic acid bụ kristal ọcha acicular (ethanol), enweghị isi na enweghị ụtọ.Adịghị eguzobe na acids na bases.Ebe mgbaze nke 308 ~ 310 ℃, [alpha] 20 d + 73.3 Celsius (c = 0.15, chloroform, insoluble na mmiri, soluble na methanol, ethanol, ethyl ether, acetone na chloroform. Oleanolic acid bụ ekesa triterpenoid na-ekesa n'ọtụtụ ebe, na nri na osisi ọgwụ, nke metụtara betulinic acid Enwere ike ịchọta ya na Phytolacca americana (American pokeweed), na Syzygium spp, galik, wdg.
Achọpụtara Oleanolic acid ka ọ na-egosipụta ọrụ mgbochi HIV siri ike, a na-eji betulinic acid na-ejikọta ya na-emepụta ọgwụ mbụ nke maturation inhibitor.A mụrụ ya nke mbụ wee kewapụ ya n'ọtụtụ osisi, gụnyere Rosa woodsii (akwukwo), Prosopis glandulosa (akwukwo na alaka), Phordendron juniperinum (osisi dum), Syzygium claviflorum (akwụkwọ ozi), Hyptis capitata (osisi dum), na Ternstromia gymnanthera (erial). akụkụ).Ụdị Syzygium ndị ọzọ gụnyere java apple (Syzygium samarangense) na apụl rose nwere ya.

Aha ngwaahịa: Oleanolic acid98%

Nkọwa: 98% nke HPLC

Isi mmalite nke ihe ọkụkụ: Olea Europea Extract

Aha kemịkalụ:(3β)-3-Hydroxyolean-12-en-28-oic acid

CAS Mba:508-02-1

Akụkụ Eji: Akwukwo

Agba: White ntụ ntụ nwere njirimara na uto

Ọnọdụ GMO: GMO efu

Mbukota: na 25kgs fiber drum

Nchekwa: Debe akpa na-emegheghị n'ebe dị jụụ, ebe kpọrọ nkụ, zere ọkụ siri ike

Ndụ shelf: ọnwa 24 site na ụbọchị mmepụta

Gịnị bụoleanolic acid?

Oleanolic acid (OA), a eke hydroxyl pentacyclic triterpenoid acid (HPTA) yiri betulinic acid, ursolic acid;ọ nwere uru dị ka antibacterial, mgbochi mkpali, antitumor omume.

Ebee ka ị ga-ahụoleanolic acid?

Oleanolic acid ejirila omenala maka ọgwụgwọ ọrịa dị iche iche, ị nwere ike ịhụ ya na nri na osisi n'ọtụtụ ebe.

Ụfọdụ mkpụrụ osisi dị ka apụl, pọmigranet, lemon, bilberries, olive nwekwara oleanolic acid.

Ugbu a, Chinese ahịhịaHemsley Chinensis Cognka bụ ngwa ahịa kacha ere maka ịwepụta oleanolic acid.

Hemsley Chinensis Cogn.Okwu mmalite

Hemsleya chinensis Cogn.bụ ahịhịa na-arị elu perennial, bụkwa ọgwụ ọdịnala ndị China.

Ezinụlọ: Cucurbitaceae

Tribus: Gomphogyneae

Genus: Hemsleya

Ụdị: H. amabilis

A na-ekesa ahịhịa a na mpaghara Guangxi, Sichuan, Guizhou, Yunnan, Hubei, wdg. Amụrụ na nsọtụ oke ọhịa na osisi ndagwurugwu n'ogo dị ihe dị ka mita 2,000.

Ihe na-arụ ọrụ: nwere Hemslolide Mal, Ma3, H1;Chikusetsusaponin-Iva;dihydro cucurbitacin F-25-acetate;dilydrocucurbitacin F;oleanolic acid - beta-Hlucosyloleanolate;Hemsamabilinin A;Cu-curbitacin Ⅱb-2-beta-D-glucopyranoside.

Uru ọgwụ:

Hemsleya chinensis Cogn.bụ tumadi maka detoxification, sterilization, mgbochi mkpali, ike afọ na ibelata mgbu.Ugbu a, e nwere extracts ntụ ntụ, ma ọ bụ compound preparations dị ka capsules, mbadamba, eriri afọ ọgwụ ọjọọ eme ihe, wdg, nke a na-ejikarị eme ihe na ụlọ ọgwụ.

Mwepụta nke Oleanolic acid siHemsleya Chinensis Cogn.

Formula nwere Oleanolic acid na mgbakwunye nri

Anyị chọpụtara na oleanolic acid a na-eji na-emeju ahụike na-esite n'ụdị mkpụrụ osisi atọ: mpempe akwụkwọ Loquat, Hemsley Chinensis wepụ, na basil dị nsọ.

• Basil dị nsọ (akwukwo) (0.4% Ursolic acid na Oleanolic acid, 2.0 mg)
• Holy Basil supercritical CO2 wepụ (akwukwo) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid na Oleanolic acid, 1.5 mg)
• Loquat wepụ (mkpụrụ osisi) (na-enye Ursolic acid, Oleanolic Acid) (Kpụrụ ka ọ bụrụ Ursolic acid kwa-eje ozi 125mg)

Oleanolic acid VS Ursolic acid

Oleanolic acid (OA) na ursolic acid (UA) bụ triterpenoids eke nwere usoro kemịkal yiri ya.

A maara ogige triterpenoids ndị a dị na herbs na nri ọgwụ.

Ha nwere ọtụtụ akụrụngwa ọgwụ na-ahụkarị: hepatoprotective, mgbochi mkpali, antimicrobial, hypoglycemic, antimutagenic, ọrụ mgbochi HIV, antioxidant, na mgbochi ọmụmụ.

OA na UA dị iche:

Ọrụ ndu nke Oleanolic acid

1. Mmetụta Mgbochi Tumour/Mgbochi Ọrịa Cancer

Mmetụta mgbochi nke oleanolic acid na hepatocellular carcinoma site na ERK-p53-mediated cell cycle arrest na mitochondrial-based apoptosis

- nke Xin Wang, Hua Bai, wdg. Ndị nyocha

OA gosipụtara mmetụta mgbochi na HCC site na ntinye nke apoptosis na njide okirikiri cell ma na etuto a tụgharịrị na sel HepG2.

OA butere apoptosis site na ụzọ mitochondrial, nke gosipụtara site na mgbochi nke Akt/mammalian target nke ụzọ rapamycin.

OA kpalitere njide okirikiri cell G2/M site na p21-mgbasa ozi ala-usoro nke cyclin B1/cdc2.

OA gosipụtara ihe omume antitumor dị mkpa na HCC na vivo na ụdị in vitro.Data ndị a na-enye nghọta ọhụrụ banyere usoro ndị na-akpata mmetụta antitumor nke OA.

Na mgbakwunye, nyocha na-egosi na OA na nke sitere na Oleanolic acid methyl ester nwekwara mmetụta na ọrịa ara ara, kansa akpa ume, kansa eriri afọ, kansa cervical, mkpụrụ ndụ kansa pancreatic…

2. Ọrụ mgbochi nje

A na-atụ anya na OA nwere ọrụ antimicrobial megide ọtụtụ nje n'ihi na ọ na-arụ ọrụ dị mkpa n'ichebe ọrịa nje na osisi.

OA gosipụtara agafeghị oke ọrụ megide Staphylococcus aureus na Bacillus Thuringiensis na 62.5 µg/mL na Escherichia coli, Salmonella Enterica, na Shigella dysenteriae na 31.2 µg/mL kacha nta inhibitory itinye uche (MIC).

3. Ikike Hepatoprotective

Otu n'ime ihe ndị a ma ama bioactivities nke OA bụ nchebe nke imeju megide nsi na a na-eji ya ugbu a dị ka ọgwụ mgbochi imeju na China.

N'ime oke Wistar albino, ejiri OA sitere na Flaveria Trinervia wee nwee mmetụta nchebe dị ukwuu na nsị imeju nke ethanol kpatara site na iweghachi ọkwa hepatotoxic serum marker enzyme.Ọmụmụ ihe a tụrụ aro ikike antioxidant nke OA dị ka usoro ọzọ enwere ike ime nke ike hepatoprotective ya.

Oleanolic acid na ihe eji eme ya

Ọnwụnwa Clinical Oleanolic Acid

Oleanolic acid (nke sitere na oliv), enwere ihe dị ka nnwale ụlọ ọgwụ 500 debara aha, gosipụtara na ọ nwere mmetụta bara uru na nnwale ụlọ ọgwụ na ọrịa akụrụ na-adịghị ala ala, ọrịa shuga mellitus ụdị 2, na ụfọdụ ọnọdụ mkpali dị ka ọrịa ogbu na nkwonkwo.

Mwepụta kachasị ewu ewu na nnwale ụlọ ọgwụ bụ bardoxolone methyl (CDDO-Me).A na-enyocha CDDO-Me na biopsies tumor, ma ọ nwere ike ịrụ ọrụ na ọgwụgwọ ọrịa akụrụ na-adịghị ala ala, a na-enyocha ya ugbu a na mmetụta na ọbara mgbali elu.

Ọkọlọtọ Pharmacopoeia nke China nke Oleanolic Acid

Oleanolic acid na-akwado usoro onunu ogwu

Dị ka Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose bụ 20 ~ 80mg kwa oge, 60 ~ 240mg kwa ụbọchị.

Oleanolic acid mmetụta

Oleanolic acid ejiri mee ihe dị ka ọgwụ mgbochi hepatoprotective n'elu counter (OTC) ruo ọtụtụ iri afọ na China.

Ọ bụrụ na ịṅụbiga mmanya ókè ma ọ bụ na-ezighị ezi, ọnụ ọgụgụ dị nta nke ndị ọrịa nwere ọnụ akọrọ, afọ ọsịsa, ahụ erughị ala nke elu afọ, ma nwee ike ịla n'iyi mgbe ọgwụgwọ Symptomatic gasịrị.

Biko kpọtụrụ dọkịta gị ma ọ bụ onye na-ere ọgwụ tupu i jiri ngwaahịa a.

Ọrụ:

1.Oleanolic acid bụ dịtụ na-adịghị egbu egbu, antitumor, na hepatoprotective, yana exhibiting antiviral Njirimara.
Achọpụtara 2.Oleanolic acid na-egosipụta ọrụ mgbochi nje HIV siri ike.
3.Oleanolic acid bụ isi ihe na-echebe mkpụrụ ndụ megide nrụgide oxidative na electrophile.
4.Oleanolic acid nwere mmetụta dị ukwuu na trating virus ịba ọcha n'anya, nnukwu icteric ịba ọcha n'anya na-adịghị ala ala ịba ọcha n'anya.
Ngwa:
1. Tinyere na nri ubi, ọ nwere ike na-eme ihe dị ka akụrụngwa nke tii iji belata phlegm;
2. Tinyere n'ọhịa ọgwụ, ọ na-aghọ ọgwụ ọhụrụ na-egbochi ọrịa cancer na obere nsị;
3. Tinyere na ubi ịchọ mma, ọ nwere ike ime ka ọbara gbasaa ma wepụ ihe ọṅụṅụ.