10-Deacetylbaccatin III (10-DAB)

Kufotokozera Kwachidule:

10-Deacetylbaccatins ndi mndandanda wazogwirizana kwambiri zachilengedweorganic mankhwalawolekanitsidwa ndi mtengo wa yew (GeneraMisonkho). 10-Deacetylbaccatin III ndi kalambulabwalo wa mankhwala oletsa khansadocetaxel(Taxotere).

10-deacetylbaccatin III 10-O- acetyltransferaseamasintha 10-deacetylbaccatin kukhalabaccatin III:

10-Deacetylbaccatin III, yomwe imadziwikanso kuti 10-DAB kapena 10-DAB III, ndi mankhwala achilengedwe ogwirizana kwambiri omwe amasiyanitsidwa ndi singano zouma ndi nthambi zing'onozing'ono za mtengo wa yew ku Ulaya (Taxus baccata).10-Deacetylbaccatin III ndi kalambulabwalo wa mankhwala oletsa khansa docetaxel (Taxotere). pacitaxel (taxol); cabazitaxel. 10-10-deacetylbaccatin III inapezeka kuti imalepheretsa kukula kwa L. DONOVANI intracellular amastigotes mkati mwa J774 murine macrophages in vitro pa nanomolar concentrations ndi IC (50) mtengo wa 70 nM.