Product Name:CMS121

Rimwe Zita:CMS-121;

1,2-Benzenediol,4- [4-(cyclopentyloxy)-2-quinolinyl]-;

4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121);

ACC,AcetylCoenzymeACarboxylase,chirwere,neuroprotective,inhibit,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121

CAS NO.:1353224-53-9

Muedzo: 98.0%Maminitsi

Ruvara: Hupfu yeyero

Packing: 25kg / DRUMS

4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol musanganiswa unonziwo CMS121. Kurongeka kwekomboni yacho kunoratidza kuti inogona kunge iine zvimiro zvakasiyana uye zvinogona kushandiswa. Kuti unzwisise kukosha kwayo, zvinobatsira kuona mapoka anoshanda aripo uye kuongorora maitiro avo

CMS121 inotsiviwa quin oline ine neuroprotective, anti-inflammatory, antioxidative, uye renoprotective zviitiko. Iyo inochengetedza glutathione (GSH) mazinga muHT22 mbeva hippocampal masero mu vitro pamberi pe glutamate, induces musiyano wePC12 masero, inodzivirira LPS-induced N9 microglial activation ne82% muN9 microglia, uye inoparadza mahara radicals mune Trolox yakaenzana chiitiko chiitiko. (TEAC) kuongorora. CMS121 inodzivirira ischemia uye oxytosis mune phenotypic skrini muHT22 masero in vitro ine EC50 kukosha kwe7 uye 200 nM yekudzivirira iodoacetic acid- kana glutamate-induced cell death, zvichiteerana. Iyo zvakare inodzivirira, inoderedza uremu hweitsvo uye inoderedza kutaura kweTNF-α, caspase-1, uye inducible nit ric oxi de synthase (iNOS) mune SAMP8 mbeva modhi yechirwere cheitsvo chisingaperi chine chekuita nekuchembera nekukurumidza kana ichiitwa pachiyero. ye10 mg/kg pazuva kutanga pamwedzi mipfumbamwe yezera.

4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol musanganiswa unonziwo CMS121. Kurongeka kwekomboni yacho kunoratidza kuti inogona kunge iine zvimiro zvakasiyana uye zvinogona kushandiswa. Kuti unzwisise kukosha kwayo, zvinobatsira kuona mapoka anoshanda aripo uye kuongorora maitiro avo. Kuvapo kwerin'i yequinoline kunoratidza kuti komboni yacho inogona kunge ichishanda nebiologically. Quinoline-yakatorwa mamorekuru anozivikanwa neawo akasiyana biological properties, kusanganisira antibacterial and anti-inflammatory activities. Kunamirwa kweboka re cyclopentyloxy kunogona kubatsira mukunyungudika kwekomboni kana kuwedzera chiitiko chayo chebhaibheri kuburikidza nekuita steric. Muzvidzidzo zveHT22 masero, CMS-121 yakaratidza zvakakosha neuroprotective mhedzisiro, inonyatso kudzivirira maseru aya kubva kune ischemia uye oxidative kukuvara. Uyezve, CMS-121 ine akakosha anti-kuzvimba zvivakwa, zvichiratidza kugona kwayo kugadzirisa mhinduro dzekuzvimba. Nekuita kudaro, CMS-121 ine mukana wekudzikisa kuzvimba mumhando dzakasiyana siyana uye nhengo. CMS-121 ine yakasimba pharmacological basa se inhibitor yeacetyl-CoA carboxylase 1 (ACC1). Iyo ine simba inhibitory mhedzisiro paACC1 inoita kuti ive komputa inovimbisa

Application:

CMS-121 (CMS121) ibhuku uye ine simba fisetin-based derivative ine anti-aging, neuroprotective, anti-inflammatory, antioxidative, uye renoprotective activities.CMS-121 is a quinolone derivative uye oral active acetyl-CoA carboxylase 1 (ACC1) inhibitor ine inovimbisa pharmacological properties. Tsvakurudzo yakakura yakaitwa kuti iongorore zvingangobatsira zveCMS-121 munzvimbo dzakasiyana-siyana, kusanganisira neuroprotection, anti-inflammatory effects, antioxidant basa, uye maitiro ayo pane zviratidzo zvine chokuita nekukwegura kwakanaka.