Product Name:J-147 Upfu

Rimwe Zita:2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl) -2-[(3-Methoxyphenyl)Methylene]hydrazide],J-147, J147

Nhamba yeCAS:1146963-51-0

Muedzo: 99.0%Maminitsi

Ruvara: Hupfu chena

Kurongedza: 25kgs Zvigubhu

J-147inonyanya kusimba nemuromo inoshanda neuroprotectant inotorwa zvakanyanya kubva ku curcumin, iyo inoshanda musanganiswa muturmeric. Kusiyana necurcumin, inoyambuka ropa-brain barriers zvakabudirira.

J-147 isimba rinoshamisa, rinoshanda nemuromo, neuroprotective agent yekuvandudza kugona.
J-147 inogona nyore kupfuudza ropa reuropi chipingamupinyi (BBB). J-147 inogona kudzivisa monoamine oxidase B (MAO B) uye dopamine transporter ine EC50 tsika dze 1.88 μM uye 0.649 μM, maererano. J-147 ine mukana wekurapa chirwere cheAlzheimer

J-147 inonyanya kusimba nemuromo inoshanda neuroprotectant inotorwa zvakanyanya kubva ku curcumin, iyo inoshanda ingredient mu turmeric. Kusiyana necurcumin, inoyambuka ropa-brain barriers zvakabudirira. Pakati pavo, J-147 inoshanda nekusunga kuATP synthase. Kuwedzeredza kweATP kwakabatana nekukwegura. Pamusoro pekuwedzera kwemazinga eeurotransmitters NGF neBDNF, J-147 inogona kudzora izvi. Mukuwedzera, J-147 inhibits monoamine oxidase B uye dopamine transporter. Inosimudzira kukura kwehuropi nekuwedzera mazinga e nerve growth factor (NGF) uye brain-derived neurotrophic factor (BDNF). Chinonyanya kukosha, J-147 inogona kusimudzira kukura kwemasero matsva etsinga, kuwedzera kugona kwehuropi kudzidza uye ndangariro, uye kunatsiridza kugona kwekuziva.

Basa:

J-147 inogona nyore kupfuudza ropa reuropi chipingamupinyi (BBB).
J-147 inogona kudzivisa monoamine oxidase B (MAO B) uye dopamine transporter ine EC50 tsika dze 1.88 μM uye 0.649 μM, maererano.
J-147 ine mukana wekurapa chirwere cheAlzheimer's (AD).
J-147 ine mukana wekurapa chirwere cheAlzheimer's (AD).

Application:

J-147 inhengo yekugadzira iyo yekutanga nzira yekuita inosanganisira mitochondrial kukwidziridzwa, nekudaro kugonesa kugadzirwa kwesimba pamaserura. J-147 yakagadzirirwa kusimudzira kugona kwehuropi kugadzirisa uye kuzvidzivirira kubva mukukuvadzwa kwezera nekuvandudza mitochondrial basa. Uyezve, J-147 inoratidza akakosha anti-kuzvimba uye antioxidant zvivakwa, zvichiwedzera kuwedzera ayo anogona kuita neuroprotective mhedzisiro. J-147 inogona kukurudzira kukura kwemasero matsva etsinga, kuwedzera kugona kwehuropi kudzidza nekuyeuka, uye kunatsiridza kushanda kwenjere.