Product Name:Galantamine Hydrobromide

Rimwe Zita:Galanthamine hydrobromide;Galantamine HBr; Galanthamine HBr;(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,Hydrobromide

CAS NO:1953-04-4

Zvinodiwa:98.0%

Color:Chenahupfu nehunhu hwema uye kuravira

GMO Mamiriro:GMO Yemahara

Kurongedza: mune 25kgs fiber zvigubhu

Kuchengeta: Chengetedza mudziyo usina kuvhurwa munzvimbo inotonhorera, yakaoma, Chengetedza kure nechiedza chakasimba

Sherufu Hupenyu: Mwedzi makumi maviri nemana kubva pazuva rekugadzirwa

Galantamine inoshandiswa pakurapa nyoro kusvika pakati nepakati chirwere cheAlzheimer uye nezvimwe zvakasiyana-siyana kukanganisa kwendangariro, kunyanya avo vevascular mavambo. Iyo alkaloid inowanikwa nekugadzira kana kubva kuma bulbs nemaruva eGalanthus Caucasicus (Caucasian snowdrop, Voronov's snowdrop), Galanthus woronowii (Amaryllidaceae) uye genera rakabatana seNarcissus (daffodil)), Leucojum (snowatake kusanganisira Lycoris) Red Spider Lily).

Galanthamine yakasikwa yakatorwa kubva ku lycoris radiate, ndeye tertiary alkaloid inotorwa kubva mukudonha kwechando uye nemhando dzine hukama. Inoshanda seyakagadziriswa yemakwikwi acetylcholinesterase (ACHE) inhibitor, nepo ichiita isina simba pabutyrylcholinesterse(BuChE) .inoshandiswa mukurapa kukanganiswa kwepakati nerbous system uye inogona kushandiswa seyakagadziriswa kune nonpolarizing muscle relaxants.Galanthamine hydrobromide is a chena kusvika kuhupfu huchena; zvishoma soluble mumvura; insoluble chloroform, ether uye doro .

Galantamine hydrobromide ibenzazepine inotorwa kubva kuma bulbs nemaruva e narcissus, osmanthus, kana canna. Iyo zvakare yemuromo cholinesterase inhibitor. Se ligand ye nicotinic acetylcholine receptors, yakashandiswa zvakanyanya kuwedzera neurocognitive basa. Basa rayo nderekukwikwidza uye reversibly inhibit acetylcholinesterase, nokudaro zvichiwedzera kuwanda kweacetylcholine. Kana yakanyudzwa muropa, galantamine hydrobromide inonyudzwa nyore nyore munzvimbo dzakasiyana-siyana dzemuviri, kusanganisira uropi. Inosungira kune nicotinic acetylcholine receptors, zvichiita kuti conformational shanduko uye kuwedzera acetylcholine kusunungurwa. Inoshandawo nekukwikwidza uye kudzoreredza mhedzisiro yecholinesterase inhibitors. Nekudzivisa cholinesterase, inodzivirira kuparara kweacetylcholine, nokudaro kuwedzera mazinga uye nguva yeiyi ine simba neurotransmitter. Galantamine inogonawo kunatsiridza kudzidza nekuyeuka, kudzivirira kuzvimba kwehuropi, uye kuchengetedza yakakwira nhanho dzemaurotransmitters nekuchengetedza kutendeseka kwemaneuroni uye synapses.

Basa:

(1) Anti-cholinesterase .

(2) Kurudzira uye inhibit acetylcholinesterase, gadzirisa intracephalic nicotine receptor nzvimbo.

(3) Inorapa infantile paralysis sequelae, sweeny uye myasthenia gravis pseudoparalytica, nezvimwewo.

(4) Kuvandudza kucherechedzwa kwebasa rechiedza, nyoro Alzheimer chirwere chevarwere zvakanyanya, uye kunonoka maitiro ekushanda kuderera kwemasero europi.

(5) Kuvandudza conduction pakati petsinga uye tsandanyama.

Application
1. GalanthamineHydrobromideinonyanya kushandiswa mu myasthenia gravis, poliovirus quiescent stage uye sequela, zvakare mu polyneuritis, funiculitis uye sensorimotor barriers inokonzerwa nenheyo system chirwere kana traumatism;

2. Galanthamine Hydrobromide inoshandiswawo muAlzheimer's disease, ine basa guru rekugadzirisa uye dysmnesia inokonzerwa nekukuvara kwehuropi.