Product Name:YDL223C (HBT1) Upfu

Rimwe Zita:HBT1,YDL223C

CASNo:489408-02-8

Zvinodiwa:99.0%

Color:Chiedza chero chakasimbanehunhu hwema uye kuravira

GMOMamiriro:GMO Yemahara

Kurongedza: mune 25kgs fiber zvigubhu

Kuchengeta: Chengetedza mudziyo usina kuvhurwa munzvimbo inotonhorera, yakaoma, Chengetedza kure nechiedza chakasimba

Sherufu Hupenyu: Mwedzi makumi maviri nemana kubva pazuva rekugadzirwa

HBT1 imorekuru rinongosunga kune imwe saiti paprotein ye AMPA-R kana glutamate iripo, uye kusunga uku kunobatsira kugadzirisa kushanda kweprotein. AMPA receptors inoratidzwa mukati mepakati tsinga sisitimu uye inoita mabasa akakosha mukutaurirana neuronal, kugadzirisa manzwiro, kudzidza, ndangariro, uye synaptic plasticity. AMPA receptors ndiwo anobatsira zvikuru mukunakidza neurotransmission, kupindira nekukurumidza, nekukasira kudzima manyawi pamasynapses mazhinji, uye anobatanidzwa mumhinduro dzekutanga kune glutamate munzvimbo dzesynaptic. AMPA receptors anowanzo kutaurwa pamwe neNMDA receptors pamasynapses, uye pamwe chete vanosimudzira synaptic plasticity maitiro anosanganisirwa mukudzidza, ndangariro, excitotoxicity, uye neuroprotection. Brain-derived neurotrophic factor (BDNF) inonzi neurotrophic factor inoita basa rinokosha mukuchengetedza uye kuwedzera kwemasero uye ine simba uye yakawanda migumisiro pakupararira, kusiyanisa, kurarama uye kufa kwemasero emagetsi uye asina-neuronal. , neurotransmitter modulator inobatsira neuronal plasticity mukudzidza nekuyeuka. Nokudaro, zvakakosha kune hutano uye hutano hwehutano hwehutano.

Mabasa:

1. Yeast genomic knockout strain
   2. Shmoo tip protein, substrate yeHub1p ubiquitin-like protein; mutants akaremara pakuita fungidziro yekusangana, nekudaro
   kuisa Hbt1p mu polarized cell morphogenesis; HBT1 ine paralog, YNL195C, iyo yakasimuka kubva mukudzokororwa kwese kwegenome
   3. Inoshandiswa mumunda wemishonga.
   4. Wedzera njere dzepfungwa.
   5. Wedzera ndangariro uye kugona kutsamira.
   6. Wedzera danho rekukurudzira.
   7. Kuvandudza kutonga kwekortical / subcortical brain mechanism.
   8. Kuvandudza maonero ekunzwa.
   9. Kuvandudza simba rehuropi kugadzirisa matambudziko uye kudzivirira kubva kune chero chemakemikari kana yemuviri.

Applications:

HBT1 inyowani ine simba AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator ine yakaderera agonistic effect kana ichienzaniswa neLY451395 uye OXP1, inokurudzira kugadzirwa kwehuropi-inotorwa. neurotrophic factor (BDNF) uye inoratidza zvishoma agonistic maitiro mumaprimary neurons. HBT1 inosungira kune ligand-binding domain ye AMPA-R mune glutamate dependent manner