Beta-nicotinamide Mononucleotide (NMN), chigadzirwa cheNAMPT maitiro uye kiyi NAD + yepakati, inosimudzira kusashivirira kweglucose nekudzorera NAD + mazinga muHFD-induced T2D mice.NMN inowedzerawo hepatic insulin senitivity uye inodzorera gene expression ine chekuita neoxidative kusagadzikana, kuzvimba kupindura, uye circadian rhythm, chikamu kuburikidza neSIRT1 activation.NMN inoshandiswa pakudzidza inosunga motifs mukati meRNA aptamers uye ribozyme activation process inosanganisira β-nicotinamide mononucleotide (Beta-NMN) -activated RNA fragments.
Nicotinamide mononucleotide (“NMN” uye “β-NMN”) iri nucleotide inotorwa mu ribose uye nicotinamide.Niacinamide (nicotinamide,) imhando yevhitamini B3 (niacin.) Seye biochemical precursor yeNAD +, inogona kubatsira mukudzivirira pellagra.
Chimiro chayo chisina kuiswa, niacin, inowanikwa mune zvakasiyana-siyana zvekudya zvinovaka muviri: Nzungu, Howa (portobello, grilled), Avocados, Green Peas (itsva), uye dzimwe hove nemhuka dzemhuka.
Muzvidzidzo [pamakonzo], NMN yakaratidza kudzoreredza zera-ane hukama nearerial dysfunction nekudzikira oxidative kusagadzikana.
Zita: Beta-Nicotinamide Mononucleotide
CAS ＃: 1094-61-7
Zita rechigadzirwa: Beta-Nicotinamide Mononucleotide;NMN
Rimwe zita:β-D-NMN;BETA-NMN;beta-D-NMN;NMN zwitterion;Nicotinamide Ribotide;Nicotinamide nucleotide;Nicotimide mononucleotide;Nicotinamide mononuclotide
CAS:1094-61-7
Molecular formula: C11H15N2O8P
Molecular uremu: 334.22
Kuchena: 98%
Kuchengetedza Tembiricha: 2-8°C
Kuonekwa: White powder
Shandisa: anti-kuchembera
Basa:
1.Nicotinamide mononucleotide mumasero evanhu inoita basa rinokosha mukugadzirwa kwesimba, iyo inobatanidzwa mu intracellular NAD (nicotinamide adenine dinucleotide, cell energy conversion inokosha coenzyme) synthesis, inoshandiswa mukurwisana nekukwegura, kuwira shuga yeropa uye zvimwe zvigadzirwa zvehutano hwehutano.
2. Nicotinamide Mononucleotide ivhitamini inonyungudika mumvura, Chigadzirwa chacho chichena checrystalline powder, chisina kunhuhwirira kana kuti chinenge chisina kunhuwa, chinovava mukuravira, chinonyungudika zvakasununguka mumvura kana ethanol, inonyungudika muglycerin.
3.Nicotinamide Mononucleotide iri nyore kutora muromo, uye inogona kuparadzirwa zvakanyanya mumuviri, iyo yakawandisa metabolites kana prototype inokurumidza kudzinga kubva muweti.Nicotinamide chikamu checoenzyme I uye coenzyme II, inobata basa rekuburitsa hydrogen mubiological oxidation yekufema cheni, inogona kukurudzira biological oxidation maitiro uye tishu metabolism, kuchengetedza yakajairika matishu (kunyanya ganda, digestive turakiti uye nervous system) kutendeseka kune basa rakakosha. .
Mukuwedzera, nicotinamide ine kudzivirira uye kurapwa kwemoyo block, sinus node basa uye anti-fast experimental arrhythmias, nicotinamide inogona kuvandudza zvakanyanya kurova kwemoyo uye atrioventricular block inokonzerwa neverapamil.
