Arachidonoyl Ethanolamide, arachidonoylethanolamide, N-arachidonoylethanolamine, iyo AEA dhamaantood waxay u dhigmaan anandamide lafteeda.By habka, (5Z,8Z,11Z,14Z) -N- (2-hydroxyethyl) icosa-5,8,11,14-tetraenamide waa anandamide ee magaca kiimikada (magaca IUPAC) waxaana laga yaabaa in loo isticmaalo oo kaliya suugaanta sayniska.Si kastaba ha ahaatee, 94421-68-8 waa aqoonsiga kiimikaad ee gaarka ah (Lambarka Diiwaanka CAS).Maadaama AEA ay tahay ereyga ugu gaaban anandamide, waxaa laga yaabaa inaan u isticmaalno AEA si joogta ah si aan u tixraacno anandamide qoraalada iyo sawirada soo socda.
Magaca Alaabta：BadanBudada Anandamide
La mid ah: Arachidonoyl Ethanolamide, budada AEA, arachidonoylethanolamide, (5Z,8Z,11Z,14Z) -N-(2-hydroxyethyl) icosa-5,8,11,14-tetraenamide, N-arachidonoylethanolamine
CAS No:94421-68-8
Qaybta Dhirta ee la isticmaalo: Caleen
Waxyaabaha ay ka kooban tahay:Apigenin
Qiimaynta: Saliida AEA: 90%
Budada AEA: 50%
Midabka: budada jaalaha ah
saliid huruud ah-brown
Xirmooyinka: 25kgs durbaannada fiber-ka
Kaydinta: Weelka ha furin meel qabow oo qalalan, ka fogow iftiinka xooggan
Life Life:24 bilood laga bilaabo taariikhda wax soo saarka
Sida laga soo xigtay Wikipedia, anandamide waa cannabinoid neurotransmitter oo ku dhaca maskaxda, taas oo macnaheedu yahay in maskaxda bini'aadamku ay awood u leedahay inay soo saarto anandamide iyada oo aan la qaadin cuntooyinka ay ku jiraan AEA.Maskaxda noocyada naasleyda iyo kacao ceeriin ayaa la xaqiijiyay inay ku jiraan xoogaa anandamide ah.
Ilaha cuntada ee anandamide
Ma jiraan ilo dabiici ah oo aad u badan oo toos ah anandamide, iyo shukulaatada iyo truffles ayaa ku yaal dusha sare.Truffle waa mid aad qaali u ah si aad u hesho anandamide, iyo shukulaatada waxay u muuqataa inay tahay ilaha ugu kalsoonaan karo ee tiro badan oo waara oo laga helo cuntooyinka.
Anandamideiyo shokolaatada
Digirta Cacao, isha shukulaatada, sidoo kale waa il qani ah oo anandamide ah.Shukulaatada waxaa ku jira in ka badan 300 oo walxaha kiimikada ah.Caffeine, theobromine, iyo phenylethylamine waa maaddooyin la yaqaan oo kor u qaada niyaddayada.Theobromine waxay dhab ahaantii ka caawisaa kicinta maskaxda si ay u sii daayaan anandamide badan si ay noogu dareento farxad.
Waa maxay sababta anandamide ay aad caan ugu tahay sanadihii ugu dambeeyay?
Kahor intaanan ka jawaabin su'aashan, waxaan u baahanahay inaan sheegno xashiishadda, THC & CBD (Cannabidiol) marka hore.
Cannabis, oo sidoo kale loo yaqaan marijuana, waa geed ubax ah, dadkuna waxay u isticmaalaan daroogada xafladaha ama sigaar cabbin si ay u abuuraan dareen "sare" ama "dhagax".
Walaxda firfircoon ee xashiishadda ee kaa dhigaysa mid sare waa THC, oo leh magaca buuxa sida delta 9-Tetrahydrocannabinol.Marka dadku sigaar cabbaan marijuana, tetrahydrocannabinol ee xashiishadda waxay kicisaa xashiishadda xashiishadda, taasoo dadka ka dhigaysa dareen farxad iyo fayoobi maskaxeed.
Xashiishadu waa sharci-darro waddamo badan maadaama dad badan ay la qabsan doonaan.
Si kastaba ha ahaatee, Uruguay waa waddankii ugu horreeyay ee sharciyeeyay xashiishadda sanadka 2013.
Oktoobar 17 ee 2018, dawladda Kanada waxay ku dhawaaqday in xashiishadda cannabis ay sharci ka noqotay Kanada oo dhan.
Dalka Maraykanka, 10 gobol iyo Degmada Columbia waxay sharciyeeyeen isticmaalka madadaalada ee xashiishadda inkasta oo ay sharci-darro tahay federaalka.
Anandamide vs THC
Cannabis waa isha dhirta ee THC.
Anandamide waa nooca aadanaha ee THC.
Saynisyahanku wuxuu helay AEA 1992 iyo THC 1964.
Anandamide waxa ay maskaxda ka sii daysaa kiimikooyinka niyadda xoojiya, farsamadeeduna bayooloji waxay la mid tahay ta tetrahydrocannabinol ee xashiishadda.
Haa, waxay bartilmaameedsanayaan isla xashiishadda xashiishadda, waxaanan ka hadli doonaa habka AEA dhawaan.
Si kastaba ha ahaatee, awoodda THC aad ayey uga xoog badan tahay AEA.Dareenka qaadashada AEA aad ayuu uga wanagsan yahay kan xashiishadda sigaarka maadaama anandamide uu si dhakhso ah jidhka ugu dheefshiido, malaha 30 daqiiqo gudahood.
Maadaama xashiishka uu mamnuuc ka yahay wadamada badi, kaabista, cuntooyinka, cabitaanada ama waxyaalaha la isku qurxiyo ee ay ku jirto THC waa sharci darro.Dareenkan, anandamide waa mustaqbalka.
Anandamide vs CBD
Geedka marijuana waxa uu leeyahay 400+ xeryahooda, iyo in ka badan 60 cannabinoids oo kala duwan ayaa ku xidhan soo-qabayaasha jidhkeena.
CBD waa qaabka gaaban ee cannabidiol waana mid ka mid ah kuwa 60 cannabinoids.CBD waa phytocannabinoid ee xashiishadda.In ka badan 40% soosaarka xashiishadda waa CBD.
Saynisyahano iyo dhakhaatiirtu waxay ogaadeen in CBD ay awood u leedahay inay hagaajiso heerka anandamide ee maskaxda maskaxda sida dib-u-soo-celinta anandamide iyo xakameynta burburka.Fatty acid amide hydrolase, oo sidoo kale loo yaqaan FAAH gaaban, waa ensaymes burburiya AEA.Taasi waa sida CBD u joojiso FAAH oo ay si dabiici ah u wanaajiso AEA.
CBD waxay sameyn kartaa wax ka badan taas.CBD waxay faa'iido u yeelan kartaa dhammaan Nidaamka Endocannabinoid
Farsamaynta ficilka anandamide
Sidee u shaqeysaa anandamide?Runtii way adag tahay.Waxaa laga yaabaa inaad marka hore u baahato inaad wax ka ogaato nidaamka endocannabinoid, CB1 reseptor, iyo CB2 reseptor.
CB1
THC waxay xiriir sare u leedahay soo-dhoweeyaha CB1, isaga oo si adag ugu xidhan soo-dhoweeyaha.
Intaa waxaa dheer, anandamide waxay saameyneysaa dareenka "sare" iyadoo saameynaysa soo-dhoweynta CB1, kicinta nidaamka abaalmarinta maskaxda iyo soo saarista kiimikooyinka raaxada sida dopamine Hormone.
CB2
Waxaad ka heli kartaa CB2 reseptors unugyada difaaca jirka oo dhan.Soo-dhoweeyaha CB2 ayaa mas'uul ka ah jawaabaha neuroprotective iyo la dagaallanka caabuqa.Saynis yahanadu waxay aaminsan yihiin in CB2 reseptor uu faa'iido u leeyahay xanuunka yaraynta.
Receptors CB1 waxay ku urursan yihiin ugu horrayn maskaxda iyo nidaamka CNS, halka CB2 reseptors inta badan laga helo habka difaaca jirka.
Nidaamka Endocannabinoid (ECS)
Ka hor inta aanad ka hadlin hawlaha nidaamka endocannabinoid (ECS), waa muhiim in la fahmo qaybaheeda.ECS waxay ka kooban tahay cannabinoid reseptors, ligands endogenous (molecules binding) ee kuwa qaata, iyo enzymes kuwaas oo soo saara oo hoos u dhiga ligands.
| ECS qadiimiga | Kordhinta ECS | |
| cannabinoid reseptors | CB1, CB2 | PPAR, GPR, TRPV, Flat, FABP |
| xididdada endogenous | AEA, 2-AG | OEA,PEA,2-DA,NADA,VA,EPEA,BADA,OA,DHEA |
| Enzymes hoos u dhigaya seedaha | FAAH,MAGL | ABHD6,COX-2,ABHD12 |
| Enzymes synthesizing ligands | DAGL,NAT,NAPE-PLD | SHIP1,PTPN22,PLC,GDEI,ABHD4 |
wareegga gudaha (cawlan fudud) wuxuu matalaa nidaamka 'classical' endocannabinoid.Goobada dibadda (cawlan madow) waxaa ku jira qaybo ka mid ah nidaamka endocannabinoid fidsan.Sida aad arki karto, PEA, BADA, iyo OEA ayaa sidoo kale lagu daray nidaamka endocannabinoid.
ECs waxay leeyihiin habdhiska dhexe ee neerfayaasha (CNS) asal ahaan waxaana ka mid ah anandamide (AEA), 2-arachidonoylglycerol (2-AG), noladin ether, virodhamine iyo N-arachidonylodopamine (NADA).Anandamide waa kan ugu horreeya iyo sidoo kale ligand ugu muhiimsan ee nidaamka endocannabinoid.
Anandamide iyo 2-AG
Sida kor ku xusan, anandamide (AEA) iyo 2-arachidonoylglycerol (2-AG) waa labada qaybood ee aasaasiga ah ee nidaamka ECS.ECS waxay caawisaa habaynta hawlaha sida hurdada, habdhiska difaaca, iyo habaynta xanuunka.
Saynis yahanadu waxay heleen Anandamide sanadkii 1992 iyo 2-AG 3 sano kadib.AEA iyo 2-AG waxay leeyihiin qaab dhismeed unugyo isku mid ah oo sidaas darteed isku sifooyin jireed iyo kiimiko.
Anandamide wuxuu inta badan bartilmaameedsadaa CB1 ee maskaxda, halka 2-AG ay bartilmaameedsato CB1 iyo CB2 labadaba (ee habka difaaca jirka).
Anandamide iyo 2-AG labadaba waxaa laga soo saaray arachidonic acid, omega-6 fatty acid, oo leh wadooyin kala duwan iyo enzymes synthesizing.Enzyme sharaf-dhac FAAH (Fatty Acid Amide Hydrolase) ee AEA iyo 2-AG ee MAGL enzyme (Monoacylglycerol Lipase).
Faa'iidooyinka Anandamide
Caddaynta sayniska ayaa soo jeedinaysa anandamide waxaa laga yaabaa inay u fiican tahay ka-hortagga walaaca, caafimaadka maskaxda, habka xusuusta, xakamaynta rabitaanka cuntada, xanuunka xanuunka, ilaalinta neuroprotection, iyo in ka badan.
Anandamide iyo walaac
Dadku waxay Anandamide u magacaabaan "molecule bliss" sababtoo ah AEA waxay awoodaa inay ku dareensiiso farxad.
Caddaynta isku dhafka ah waxay soo jeedinaysaa in nidaamka endocannabinoid uu yahay qayb muhiim ah oo ka mid ah substrates neuronal ee ku lug leh hababka abaalmarinta maskaxda iyo jawaabaha shucuureed ee diiqada.
Xannibaadda dawooyinka ee enzyme fatty acid amide hydrolase (FAAH), oo mas'uul ka ah hoos u dhaca anandamide intracellular, waxay soo saartaa saameynaha anxiolytic-ka ee jiirka iyada oo aan keenin jawaabaha ballaaran ee jawaabaha habdhaqanka ee caadiga ah ee cannabinoid agonists.
Natiijooyinkani waxay soo jeedinayaan in anandamide ay gacan ka geysato xakamaynta dareenka iyo walwalka iyo in FAAH laga yaabo inay noqoto bartilmaameedka fasalka cusub ee daawooyinka anxiolytic.
Macluumaad faahfaahsan oo ku saabsan saamaynta anandamide ee walaaca, fadlan akhri suugaanta hoose:
- Cannabinoid anandamide endogenous waxay saameyn ku leedahay dhiirigelinta iyo walaaca ay muujiso xannibaadda fatty acid amide hydrolase (FAAH).
- Anandamide hydrolysis: bartilmaameed cusub oo loogu talagalay dawooyinka ka hortagga walaaca?
- Dabeecadaha walaaca la dhimay ee ay keentay xannibaadda hidaha iyo dawooyinka ee endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) waxaa dhexdhexaadiya CB1 reseptors.
Anandamide iyo xanuun joojinta
Caddaynta sayniska ome waxay muujinaysaa in xannibaadda FAAH (ensaymka hoos u dhigaya anandamide ee maskaxda) ayaa si weyn u yareeyey jawaabaha nociceptive ee noocyo badan oo xanuun ah.
Ka-hortagga FAAH waxay si weyn u kordhiyaan heerarka anandamide ee maskaxda iyo ugu horreyntii CB1Antinociception-ku-dhex-dhexaadin ah, oo soo jeedinaysa anandamide endogenous, marka laga ilaaliyo hoos u dhaca, ay soo saari karto antinociception iyada oo loo marayo CB1reseptors.
Palmitoylethanolamide (PEA) waa walax endogenous ah oo xoojisa dhaqdhaqaaqa anandamide.Jidhka bini'aadamku wuxuu si dabiici ah u soo saaraa PEA si uu ula dagaallamo bararka iyo xanuunka.In ka badan 800,000 bukaan ayaa ahaa kaniiniyada PEA iyo kaabis cunto si loogu daweeyo xanuunka adduunka.
Si aad wax badan uga barato PEA, fadlan booqo ourBogga PEA.
Anandamide iyo orodyahanka sare
Aan marka hore eegno qeexitaanka waxa sare u ordayaa yahay: dareen farxadeed oo leh walaac hoos u dhaca iyo hoos u dhigida awooda dareenka xanuunka.Jimicsi dheer oo aerobic ah ka dib, waxaad la kulmi doontaa dhacdo aad u wanaagsan inta lagu jiro orodka dheer.
Tobannaankii sano ee la soo dhaafay, cilmi-baarayaashu waxay u maleeyeen in endorphin uu yahay qodobka kaliya ee mas'uul ka ah orodyahannada sare tan iyo heerarka korodhay ee β-endorphins si fudud ayaa looga helaa dhiigga.Sida aad horeba u ogtahay, endorphin waxa uu awood u leeyahay in uu kor u qaado niyaddayada oo uu abuuro dareen farxadeed.
Si kastaba ha ahaatee, saynisyahannadu hadda waxay aaminsan yihiin in ay tahay nidaamka endocannabinoid (ECS) iyo anandamide oo keena sare u kaca orodka.Anandamide waxa uu awoodaa in uu ka gudbo xayndaabka maskaxda iyo dhiiga waxana uu keenaa saamaynta dhexe ee opioids-ka durugsan.Laakiin endorphin ma awoodo.
Haddii aad rabto inaad wax ka ogaato tijaabada ku saabsan heerka sare ee orodyahanka, akhri suugaantan:Sarraynta orodyahanku waxay ku xidhan tahay daaweeyayaasha cannabinoid ee jiirarka
Dhakhaatiirta nafaqada waxay ogaadaan in anandamide sidoo kale laga yaabo inuu yahay maamulaha rabitaanka cuntada ee wanaagsan.Anandamide waxaa laga yaabaa inay kiciso gaajadaada iyo rabitaanka inaad wax badan cunto.Haddii aad jidka ku socoto inaad miisaan lumiso, si taxadar leh uga fikir intaadan qaadan AEA.
Kaabayaasha ay ku jiraan anandamide
Ma waxaad raadinaysaa kaabayaasha anandamide ama kiniinka anandamide?
Nasiib darro, ma jiro mid waqtiga la joogo.Anandamide waa qayb cusub oo aan jirin nooc kaabis cunto ah oo waligood isku dayay qaababkooda hadda.
Waxaa laga yaabaa inaad hesho shirkad lagu magacaabo Sun Potion oo ku iibinaysa budada anandamide ee Amazon.Si kastaba ha ahaatee, taasi maahan runta.Kaliya waa budada cacao ceyriin, laakiin aan la jaan qaadin anandamide.Iyo nuxurka firfircoon ee foomka budada ah waa mid aad u hooseeya, waxaana laga yaabaa inaadan la kulmin waxtarka AEA.
Dabcan, waxaad ogaan kartaa in alaab-qeybiyeyaasha qaarkood ay iibinayaan heerarka tixraaca anandamide ama reagents.Waxyaabaha xun ayaa ah inay kaliya ku iibiyaan 5mg, 25mg, oo kaliya cilmi baaris.Ma jiro xog badan oo saliid AEA ah oo la heli karo gabi ahaanba.
Akhbaarta wanaagsan ayaa ah in soosaarayaasha dheeriga ah ee Mareykanka iyo wadamada Yurub sida Germany, France, Netherland, UK, Spain, Italy, iwm ay ka dalbanayaan muunada AEA ee Wuxi Cima Science Co. .
Tilmaamaha Anandamide
Saliida anandamide badan iyo budada anandamide labaduba waa laga heli karaa Sayniska Cima.
Saliidda Anandamide: 70%, 90%
Budada Anandamide: 50%
