Magaca alaabta:Stearoyl Vanillylamide(SVA)
Magaca kale:C18-VA, N-Vanillyloctadecanamide,Capsaicin AnalogCAS Nlambarka:58493-50-8
Isha Botanical:Piper Longum Linn
Qiimaynta: 98%
Tusaalaha bilaashka ah: La heli karo
Muuqashada: caddaan iyo caddaan ka baxsan
Faa'iidooyinka: Anti-kansarka, ka hortagga gabowga, senolytic
Nolosha shelf: 2 sano
Stearoyl vanillylamide waa mid ka mid ah analoogyada capsaicin ee ugu caansan waana analoog kaabsaycin ah oo si dabiici ah u dhaca oo laga helo noocyada basbaaska cas.Capsaicin waa sababta kulka/dareenka gubashada ee uu keeno basbaas.Si ka duwan noocyada kale ee capsaicin ee isla qaybta, Stearoyl vanillylamide waa mid gaar ah in aanu ahayn steroidal, taasoo la macno ah in aanay soo saarin saamaynta "basbaaska" ama xanaaqa ee capsaicin.
Guud ahaan, sida analoogyada kale ee capsaicin, xaruntani waxay u shaqeysaa iyadoo kor u qaadeysa sii deynta epinephrine iyo norepinephrine.Hormoonnadan ayaa looga baahan yahay inay dhaqaajiyaan falcelinta jirka ee naxariista leh sida dheef-shiid kiimikaad.Sidaa darteed, stearoyl vanillylamide ugu dambeyntii waxay gacan ka geysataa gubashada dufanka bunni ee nudaha adipose ama unugyada subcutaneous.
Waa maxay faa'iidooyinka isticmaalka Stearoyl Vanillylamide?Ku darida stearic acid amide waxay leedahay faa'iidooyin dhowr ah diyaarinta kaabista caafimaadka.Maadaama cilmi-baarisyo badan ay weli socdaan, saynisyahannadu waxay rajeynayaan inay ogaadaan faa'iidooyinka badan ee isticmaalka xaruntan.Kuwa soo socda ayaa ah qaar ka mid ah faa'iidooyinka loo yaqaan isticmaalka Stearoyl vanillylamide:
Waxay si wax ku ool ah u jebisaa baruurta caloosha
Stearoyl vanillylamide wuxuu u shaqeeyaa sidii capsaicin aan xanaaqin oo kicin kara unug adipose-ka bunni ah ama dufan bunni ah (baruurta inta badan waxaa laga helaa mitochondria waxayna soo saartaa kulayl jidhka ah).Dufanka waxaa laga helaa dhammaan xubnaha jirka, oo ay ku jiraan gacmaha, bowdada, caloosha iyo murqaha gluteal.Inkasta oo dadka intooda badani ay si dhakhso ah uga takhalusi karaan baruurta meelaha kale, gubashada dufanka caloosha ayaa loo tixgeliyaa culeys dhab ah.Daraasaduhu waxay muujiyeen in qaadashada Stearoyl vanillylamide ay gacan ka geysan karto burburinta dufanka si gaar ah ugu yaal caloosha.Tan waxaa lagu gaaraa iyada oo la dhaqaajiyo TRPV1, enzyme ka hortagta wax soo saarka dufanka caloosha iyo samaynta baruurta.Si wadajir ah ula capsaicin, Stearoyl vanillylamide waxaa loo tixgeliyaa inay tahay mid ka mid ah wakiilada bartilmaameedsada oo dhaqaajiya TRPV1 (ku-meel-gaar ah oo ku-meel-gaar ah oo suurtagal ah vanilloid) oo ku yaala xuubka plasma (marka laga reebo ligands endogenous, dhexdhexaadiyeyaasha bararka iyo kicinta aan la dooran).Mas'uul ka ah codeynta borotiinka xuubabka isku dhafan sida kanaalka ion.Marka TRPV1 si gaar ah loogu hawlgeliyo fiilooyinka dareenka iyo unugyada aan neerfaha ahayn, waxay keeni doontaa qulqulka calcium iyo sodium, taas oo lagama maarmaan u ah depolarization xuubka (kala-guurka polarity; laga bilaabo taban ilaa togan, taasoo keenta saameyn togan) Shaqada unugyada iyo isgaarsiinta.
Waxay si wax ku ool ah u jebisaa baruurta caloosha
Stearoyl vanillylamide wuxuu u shaqeeyaa sidii capsaicin aan xanaaqin oo kicin kara unug adipose-ka bunni ah ama dufan bunni ah (baruurta inta badan waxaa laga helaa mitochondria waxayna soo saartaa kulayl jidhka ah).Dufanka waxaa laga helaa dhammaan xubnaha jirka, oo ay ku jiraan gacmaha, bowdada, caloosha iyo murqaha gluteal.Inkasta oo dadka intooda badani ay si dhakhso ah uga takhalusi karaan baruurta meelaha kale, gubashada dufanka caloosha ayaa loo tixgeliyaa culeys dhab ah.Daraasaduhu waxay muujiyeen in qaadashada Stearoyl vanillylamide ay gacan ka geysan karto burburinta dufanka si gaar ah ugu yaal caloosha.Tan waxaa lagu gaaraa iyada oo la dhaqaajiyo TRPV1, enzyme ka hortagta wax soo saarka dufanka caloosha iyo samaynta baruurta.Si wadajir ah ula capsaicin, Stearoyl vanillylamide waxaa loo tixgeliyaa inay tahay mid ka mid ah wakiilada bartilmaameedsada oo dhaqaajiya TRPV1 (ku-meel-gaar ah oo ku-meel-gaar ah oo suurtagal ah vanilloid) oo ku yaala xuubka plasma (marka laga reebo ligands endogenous, dhexdhexaadiyeyaasha bararka iyo kicinta aan la dooran).Mas'uul ka ah codeynta borotiinka xuubabka isku dhafan sida kanaalka ion.Marka TRPV1 si gaar ah loogu hawlgeliyo fiilooyinka dareenka iyo unugyada aan neerfaha ahayn, waxay keeni doontaa qulqulka calcium iyo sodium, taas oo lagama maarmaan u ah depolarization xuubka (kala-guurka polarity; laga bilaabo taban ilaa togan, taasoo keenta saameyn togan) Shaqada unugyada iyo isgaarsiinta.
