Magaca Alaabta:Galantamine Hydrobromide
Magac kale:Galanthamine hydrobromide;Galantamine HBr; Galanthamine HBr; (4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,Hydrobromide
CAS NO：1953-04-4
Tilmaamaha:98.0%
Midabka:Caddaanbudo leh ur sifo iyo dhadhan
Xaalada GMO:GMO Bilaash
Xirmooyinka: 25kgs durbaannada fiber-ka
Kaydinta: Weelka ha furin meel qabow oo qalalan, ka fogow iftiinka xooggan
Life Life:24 bilood laga bilaabo taariikhda wax soo saarka
Galantamine waxaa loo isticmaalaa daawaynta cudurka Alzheimers ee fudud ama dhexdhexaad ah iyo dhibaatooyin kale oo kala duwan oo xusuusta ah, gaar ahaan kuwa asalka xididdada dhiigga. Waa alkaloid oo laga helo synthetically ama nalalka iyo ubaxa Galanthus Caucasicus (Caucasian snowdrop, Voronov's snowdrop), Galanthus woronowii (Amaryllidaceae) iyo genera la xidhiidha sida Narcissus (daffodil)), Leucojum (snowflake) iyo Lycorisata oo ay ku jiraan Lily Caaro Cas).
Galanthamine waa dabiici laga soo saaray lycoris radiate, waa alkaloids sare oo ka soo jeeda dhibicda barafka iyo noocyada xiriir dhow la leh. Waxay u shaqeysaa sidii acetylcholinesterase (ACHE) inhibitor ah oo la rogi karo, halka ay ka sii daciifto butyrylcholinesterse (BuChE) caddaan ilaa budo cad ku dhawaad; si yar ugu milmay biyaha; chloroform-ka aan milmi karin, ether iyo aalkolo .
Galantamine hydrobromide waa benzazepine ka soo jeeda nalalka iyo ubaxa narcissus, osmanthus, ama canna. Sidoo kale waa cholinesterase inhibitor afka ah. Sida ligand ee nicotinic acetylcholine reseptors, waxaa si weyn loo isticmaalay si kor loogu qaado shaqada neurocognitive. Shaqadeedu waa in ay si tartan ah oo dib-u-noqosho ah u joojiso acetylcholinesterase, taas oo kordhinaysa xoojinta acetylcholine. Marka la nuugo qulqulka dhiigga, galantamine hydrobromide si diyaar ah ayaa loo nuugo qaybaha kala duwan ee jirka, oo ay ku jiraan maskaxda. Waxay ku xidhan tahay nicotinic acetylcholine reseptors, taasoo keenta isbeddello is-beddel ah iyo kordhinta sii-deynta acetylcholine. Waxa kale oo ay ka shaqeysaa iyada oo la tartamaysa oo dib u soo celinaysa saamaynta cholinesterase inhibitors. Iyadoo la xakameynayo cholinesterase, waxay ka hortagtaa burburka acetylcholine, taas oo kordhinaysa heerarka iyo muddada neurotransmitter-ka awoodda leh. Galantamine waxa kale oo laga yaabaa inay wanaajiso barashada iyo xusuusta, ka hortagto bararka maskaxda, iyo ilaalinta heerarka sare ee neurotransmitters iyadoo la ilaalinayo daacadnimada neerfayaasha iyo synapses
Shaqada:
(1) Anti-cholinesterase.
(2) Kicin oo jooji acetylcholinesterase, nidaami booska qaboojiyaha nicotine intracephalic.
(3) Waxay daawaysaa daba-galka curyaannimada dhallaanka, bararsan iyo myasthenia gravis pseudoparalytica, iwm.
(4) Hagaajinta shaqada aqoonsiga iftiinka, bukaannada cudurka Alzheimers ee fudud, iyo dib u dhigista habka hoos u dhaca shaqada unugyada maskaxda.
(5) Hagaajinta habka u dhexeeya neerfaha iyo muruqa.
Codsiga
1. GalanthamineHydrobromideInta badan waxaa loo isticmaalaa myasthenia gravis, poliovirus quiescent stage iyo sequela, sidoo kale polyneuritis, funiculitis iyo dareenka dareemayaasha oo uu keeno cudur habdhiska dareenka ama traumatism;
2. Galanthamine Hydrobromide waxa kale oo loo isticmaalaa cudurka Alzheimers, waxa uu leeyahay shaqada ugu muhiimsan ee asaasaqa iyo dysmnesia oo ay keento dhaawaca maskaxda organic.
