Oleanolic acid budada

Sharaxaad Gaaban:

Aashitada Oleanolic ayaa lagu ogaadey inay muujiso firfircoonida ka hortagga HIV-ga ee xooggan, isku-dhafka betulinic acid ee laxiriira ayaa loo isticmaalay si loo abuuro dawooyinka korriinka korriinka ee ugu horreeya.Waxaa markii hore la baray oo laga soocay dhowr dhir, oo ay ku jiraan Rosa woodsii (caleemo), Prosopis glandulosa (caleemaha iyo laamaha), Phordendron juniperinum (geedka oo dhan), Syzygium claviflorum (caleemaha), Hyptis capitata (dhirta oo dhan), iyo Ternstromia gymnanthera (aerial) qayb).Noocyada kale ee Syzygium oo ay ku jiraan java tufaaxa (Syzygium samarangense) iyo tufaaxa Rose ayaa ku jira.


  • Qiimaha FOB:US $0.5 - 2000 / KG
  • Tirada Dalbashada Min.1 KG
  • Awooda wax bixinta:10000 KG/Bishii
  • Dekedda:SHANGHAI/BEIJING
  • Shuruudaha Lacag-bixinta:L/C,D/A,D/P,T/T
  • :
  • Faahfaahinta Alaabta

    Tags Product

    Oleanolic acid kaas oo ah saddex triterpenoids pentacyclic oo ka go'doonsan dhirta Gentianaceae ee Swertia mileensis cawska oo dhan ama miro khaas ah, oo leh jidh bilaash ah iyo glycosides dhir badan.Oleanolic acid waxay leedahay tiro balaadhan oo ah dhirta, iyo celceliska content waa 0.2% - 2%.Cucurbitaceae waxa ku jira 1.5% ~ hunchback hoose 2%, miraha gaarka ah ee 0.6% ~ 0.7%.Waa adjuvant cudurka beerka oo bukaan socod eegtada loo isticmaalo infekshanka daweynta.Cagaarshowga cagaarshowga ba'an wuxuu leeyahay saameyn cad oo ku saabsan dhimista alanine aminotransferase iyo jaalaha.Oleanolic acid ayaa si weyn looga helaa dhirta, oo leh maaddo guud oo ah 0.2% ~ 2% [1].Qaybta hoose ee calabash waxay ahayd 1.5% ~ 2%, iyo waxa ku jira miraha fructus ligustris waxay ahayd 0.6% ~ 0.7%.Oleanolic acid waa crystal acicular cad (ethanol), aan ur lahayn oo aan dhadhamin.Asiidhyada iyo saldhigyada aan degganayn.Barta dhalaalka ee 308 ~ 310 ℃, [alpha] 20 d + 73.3 ° (c = 0.15, chloroform, aan milmayn biyaha, milma ee methanol, ethanol, ethyl ether, acetone iyo chloroform. Cuntada iyo dhirta daawooyinka, ee la xidhiidha betulinic acid Waxaa laga heli karaa Phytolacca americana (Pokeweed American), iyo Syzygium spp, toonta, iwm.
    Aashitada Oleanolic ayaa lagu ogaadey inay muujiso firfircoonida ka hortagga HIV-ga ee xooggan, isku-dhafka betulinic acid ee laxiriira ayaa loo isticmaalay si loo abuuro dawooyinka korriinka korriinka ee ugu horreeya.Waxaa markii hore la baray oo laga soocay dhowr dhir, oo ay ku jiraan Rosa woodsii (caleemo), Prosopis glandulosa (caleemaha iyo laamaha), Phordendron juniperinum (geedka oo dhan), Syzygium claviflorum (caleemaha), Hyptis capitata (dhirta oo dhan), iyo Ternstromia gymnanthera (aerial) qayb).Noocyada kale ee Syzygium oo ay ku jiraan java tufaaxa (Syzygium samarangense) iyo tufaaxa Rose ayaa ku jira.

     

    Magaca Alaabta:Oleanolic acid98%

    Tilmaamaha: 98% ee HPLC

    Isha Botanic:Olea Europea Extract

    Magaca Kiimikada:(3β)-3-Hydroxyolean-12-en-28-oic acid

    CAS Maya:508-02-1

    Qaybta La Isticmaalay:Caleemo

    Midabka:Budo cad oo leh ur iyo dhadhamin sifa

    Xaalada GMO:GMO Bilaash

    Xirmooyinka: 25kgs durbaannada fiber-ka

    Kaydinta: Weelka ha furin meel qabow oo qalalan, ka fogow iftiinka xooggan

    Life Life:24 bilood laga bilaabo taariikhda wax soo saarka

     

    Waa maxayoleanolic acid?

    Oleanolic acid (OA), hydroxyl pentacyclic triterpenoid acid (HPTA) oo la mid ah betulinic acid, ursolic acid;waxay leedahay faa'iidooyin sida bakteeriyada, anti-bararka, hawlaha antitumor.

    Qaab dhismeedka acid Oleanolic

    Xagee ka heli kartaaoleanolic acid?

    Oleanolic acid ayaa dhaqan ahaan loo isticmaalo daaweynta cudurrada kala duwan, waxaad ka heli kartaa cuntada iyo dhirta si ballaaran.

    Qaar ka mid ah miraha sida tufaaxa, rummaanka, liin, bilberries, saytuun waxaa ku jira oleanolic acid sidoo kale.

    ilaha oleanolic acid

    Magaca Dhirta Maaddada Oleanolic acid Habka tijaabada
    Ligustrum lucidum Ait 0.8028% HPLC
    Verbena Officinalis L 0.071% -0.086% HPLC
    Prunella vulgaris L 3.47% -4.46% HPLC
    Hemsley Chinensis Cogn. 1.5% ilaa 2% HPLC

    Hadda, geedo Chinese ahHemsley Chinensis Cognweli waa alaabta ceeriin ee ugu ganacsiga badan ee soo saarista oleanolic acid.

    Hemsley Chinensis Cogn.Hordhac

    Hemsleya chinensis Cogn.waa geed fuulitaan sanadle ah, sidoo kale waa dawo dhaqameed Shiinees ah.

    Qoyska: Cucurbitaceae

    Tribus: Gomphogyneae

    Genus: Hemsleya

    Noocyada: H. amabilis

    Dhirta waxaa lagu qaybiyaa gobollada Guangxi, Sichuan, Guizhou, Yunnan, Hubei, iwm. Waxay ku dhasheen cidhifka kaynta iyo geedaha dooxada ee joogga dhererkoodu yahay ilaa 2,000 mitir.

    Maaddooyinka firfircoon: waxaa ku jira Hemslolide Mal, Ma3, H1;Chikusetsusaponin-Iva;dihydro cucurbitacin F-25-acetate;dilydrocucurbitacin F;oleanolic acid-beta-Hlucosyloleanolate;Hemsamabilinin A;Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

    Qiimaha daawada:

    Hemsleya chinensis Cogn.waxay inta badan u tahay sun-saarista, jeermiska, ka hortagga bararka, xoojinta caloosha iyo yaraynta xanuunka.Waqtigan xaadirka ah, waxaa jira budada laga soosaaray, ama diyaargarowga isku dhafan sida kaabsal, kiniinno, kaniiniyada caloosha iyo mindhicirka, iwm, kuwaas oo si weyn loogu isticmaalo waxqabadka kiliinikada.

    Hemsleya chinensis Cogn

    Ka soo saarida Oleanolic acidHemsleya Chinensis Cogn.

    Wax soo saarka Oleanolic acid

    Foomamka ay ku jirto Oleanolic acid ee kaabista cuntada

    Waxaan ogaanay in oleanolic acid-ka loo isticmaalo kaabista caafimaadku ay inta badan ka timaado saddex nooc oo dhirta laga soo saaro: caleen Loquat, soosaar Hemsley Chinensis, iyo soosaar basil quduuska ah.

    • Budada Basil Quduuska ah (caleen) (0.4% Ursolic acid iyo Oleanolic acid, 2.0 mg)
    • Basil Holy Basil supercritical CO2 (caleen) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid iyo Oleanolic acid, 1.5 mg)
    • Loquat Extract (miro) (oo bixisa Ursolic acid, Oleanolic Acid) (oo loo qoondeeyay Ursolic acid halkii adeegba 125mg)

    Oleanolic acid FORMULA

    Oleanolic acid VS Ursolic acid

    Oleanolic acid (OA) iyo ursolic acid (UA) waa triterpenoids dabiici ah oo leh qaab kiimiko la mid ah.

    Iskudhisyada triterpenoidyada waxaa lagu yaqaanaa inay ku jiraan geedo iyo cuntooyinka dawada.

    Waxay leeyihiin waxyaabo badan oo dawooyinka caadiga ah: hepatoprotective, anti-bararka, antimicrobial, hypoglycemic, antimutagenic, waxqabadka anti-HIV, antioxidant, iyo hawlaha dhalmada.

    Oleanolic acid VS Ursolic acid isbarbardhigga

    Farqiga OA iyo UA:

    Magaca Alaabta Oleanolic acid Ursolic acid
    CAS NO. 508-02-1 77-52-1
    Triterpenes Pentacyclic β-Amyrin α-Amyrin
    Ilaha dhirta Caleen Loquat, Basil Quduuska ah, Rosemary, Caleen Saytuun. iwm.
    Tilmaamaha 40%,98% budada 15%,25%,50%,98% budada
    Muuqashada (midabka iyo ur) 40% huruud fudud 98% budo cad oo aan lahayn 15%-50% bunni-jaalle ama jaalle98% budo cad sifada
    Kala soocida IR: (1355 ~ 1392cm-1) laba sare (1245 ~ 1330cm-1) saddex sareNMR: δ(C)12122.1,δ(C13) 143.4 (1355-1392cm-1) saddex sare (1245 ~ 1330cm-1) saddex meelood (C12)125.5,δ(C13) 138.0
    Sooyaalka Oleanolic sodium saltOleanolic acid phosphate disodium salt3-oxo oleanolic acid

    Bardoxolone methyl (CDDO-Me)

    Ursolic sodium cusbo iyo dicarboxylic acid nus ester derivativesUrsolic acid keene derivatives3-carbon ursolic acid

    3-acetoxyursolic acid

    Kansarka ka hortagga suurtagalka ah UA waa ka caansan yahay OA.

    Hawlaha noolaha ee Oleanolic Acid

    1. Ka-hortagga Burada/Saamaynta Ka-hortagga Kansarka

    Saamaynta xakamaynta oleanolic acid ee kansarka hepatocellular iyada oo loo marayo xidhitaanka wareegga unugyada dhexdhexaadka ah ee ERK-p53 iyo apoptosis ku tiirsan mitochondrial

    - waxaa qoray Xin Wang, Hua Bai, iwm. Cilmi-baarayaasha

    OA waxay soo bandhigtay saamaynta xakamaynta ee HCC iyada oo loo marayo kicinta apoptosis iyo xiritaanka wareegga unugyada labadaba burooyinka la tallaalay iyo unugyada HepG2.

    OA waxay keentay apoptosis iyada oo loo marayo dariiqa mitochondrial, taas oo caddaynaysa xannibaadda Akt/naasleyda bartilmaameedka dariiqa rapamycin.

    OA waxay keentay xidhitaanka wareegga unugyada G2/M iyada oo loo marayo p21-dhexdhexaadin hoos u dhigista cyclin B1/cdc2.

    OA waxay muujisay waxqabadyo ka hortag ah oo muhiim ah HCC gudaha vivo iyo moodooyinka gudaha.Xogtaasi waxay bixinaysaa aragti cusub oo ku saabsan hababka ka dambeeya saamaynta antitumor ee OA.

    Intaa waxaa dheer, cilmi-baaristu waxay muujineysaa in OA iyo asalkeeda Oleanolic acid methyl ester ay sidoo kale saameyn ku leeyihiin kansarka naasaha, kansarka sambabada, kansarka kaadiheysta, kansarka ilmo-galeenka, unugyada kansarka ganaca.

    Faa'iidooyinka Oleanolic acid

    1. Dhaqdhaqaaqa ka hortagga jeermiska

    OA waxa la filayaa in ay lahaato firfircoonida ka hortagga jeermiska cudurada faafa ee kala duwan waayo waxa ay door muhiim ah ka ciyaartaa ka difaacida jeermiska cudurada.

    OA waxay muujisay dhaqdhaqaaq dhexdhexaad ah oo ka dhan ah Staphylococcus aureus iyo Bacillus Thuringiensis 62.5 µg/mL iyo Escherichia coli, Salmonella Enterica, iyo Shigella dysenteriae oo ah 31.2 µg/mL ugu yaraan xakamaynta xakamaynta (MIC).

    1. Kartida Hepatoprotective

    Mid ka mid ah bioactivities-ka caanka ah ee OA waa ka-hortagga beerka ee ka hortagga sunta oo hadda loo isticmaalo daawada ka-hortagga cagaarshowga ee Shiinaha.

    Jiirka Wistar albino, OA oo ka socota Flaveria Trinervia ayaa la isticmaalay waxayna ku yeelatay saamayn difaac oo mug leh oo ku saabsan sunta beerka ee ethanol-ku keentay iyada oo dib u soo celinaysa heerarka enzyme hepatotoxic serum calaamadeeyaha.Daraasadani waxay soo jeedisay awoodda antioxidant ee OA inay tahay hannaan kale oo suurtagal ah oo awoodeeda ka hortagga cagaarshowga.

    Oleanolic acid iyo asalkiisa

    Oleanolic acid iyo asalkiisa

    Tijaabooyinka Kiliinikada Acid Oleanolic

    Oleanolic acid (laga soo xigtay saytuunka), waxaa jira ilaa 500 oo tijaabo caafimaad ah oo diiwaangashan, ayaa muujisay inay saameyn faa'iido leh ku leedahay tijaabooyinka bukaan-socodka ee cudurka kelyaha ee daba-dheeraada, sonkorowga mellitus nooca 2, iyo xaaladaha bararka qaarkood sida arthritis.

    Ka-soo-baxyada ugu caansan ee tijaabooyinka bukaan-socodka waa bardoxolone methyl (CDDO-Me).CDDO-Me waxaa lagu qiimeeyay biopsiyada burooyinka, waxaana laga yaabaa inay door ka ciyaarto daaweynta cudurrada kelyaha ee daba-dheeraaday, hadda waxaa lagu qiimeeyaa saameynta dhiig-karka.

     

    Heerka Farmashiyaha Shiinaha ee Oleanolic Acid

    Magaca alaabta Oleanolic acid
    Aqoonsiga (1) Qaado 30mg oo alaabtan ah, ku rid tuubada tijaabada, ku dar 3ml ee chloroform si ay u milanto, ku dar laba dhibcood oo sulfuric acid, rux 5 daqiiqo, lakabka chloroform waa guduud-guduud.
    (2) Qaado qiyaastii 20mg ee alaabtan, ku dar 1ml oo ah anhydride acetic, ku milan kulayl yar, ku dar sulfuric acid midabka guduudka ah, oo mugdi geli ka dib markaad dhigto.
    (3) Qaado qiyaastii 10mg ee alaabtan, ku dar vanillin glacial acetic acid (qaado vanillin 0.5g, ku dar 10ml of glacial acetic acid si ay u milaan, taasi waa) 0.2ml, ku dar 0.8ml ee perchloric acid, oo kuleyl dhowr daqiiqo. biyaha qubeyska.Fuchsia, ku dar 2ml oo ah ethyl acetate, guduud-cas oo lagu milmay ethyl acetate, oo aan midab lahayn.
    (4) Noocyada nuugista infrared-ka ee alaabtan waa inay la socotaa xakamaynta spectrum.
    Go'aaminta qiimaynta Qaado 0.15g oo badeecadan ah, si sax ah u miisaan, ku dar 30ml ethanol, rux, kuleyli biyo diirran si aad u milmaan, u qabooji heerkulka qolka, ku dar 3 dhibcood oo ah xal phenolphthalein ah, samee xal potassium hydroxide leh ethanol ( 0.05mol/L) Titrate isla markiiba oo sax baaritaanka maran.Xalka Potassium hydroxide (0.05 mol/L) 1 ml oo ethanol ah wuxuu u dhigmaa 22.84 mg ee C30H48O3.

    Oleanolic acid waxay ku talinaysaa qiyaasta

    Marka loo eego Heerka Pharmacopoeia ee Shiinaha, Oleanolic acid qiyaasta afka waa 20 ~ 80mg wakhti kasta, 60 ~ 240mg maalintii.

    Dhibaatooyinka soo raaca ee Oleanolic acid

    Oleanolic acid waxa loo isticmaalay dawada hepatoprotective (OTC) ka badan tobanaan sano gudaha Shiinaha.

    Haddii xad-dhaafka ah ama khaldan tahay, tiro yar oo bukaan ah ayaa leh af qallalan, shuban, calool xanuun xagga sare ah, waxayna baaba'aan ka dib daaweynta calaamadaha.

    Fadlan la tasho dhakhtarkaaga ama farmashiistaha ka hor intaadan isticmaalin alaabtan.

    Shaqada:

    1.Oleanolic acid waa wax aan sun ahayn, antitumor, iyo hepatoprotective, iyo sidoo kale soo bandhigay sifooyinka fayraska.
    2.Oleanolic acid ayaa la ogaaday inay muujiso firfircoonida ka hortagga HIV-ga.
    3.Oleanolic acid waa ilaaliyaha ugu weyn ee unugyada ka hortagga cadaadiska oksaydhiyaha iyo electrophile.
    4.Oleanolic acid waxay saameyn weyn ku leedahay raadinta cagaarshowga fayraska, cagaarshow ba'an iyo cagaarshow dabadheeraad ah
    Codsiga:
    1. Codsaday beerta cuntada, waxay u dhaqmi kartaa sida alaabta ceeriin ee shaaha si loo yareeyo xaakada;
    2. Codsaday beerta farmashiyaha, waxay noqonaysaa dawo cusub oo ka hortagga kansarka oo leh sun yar;
    3. Codsaday goobta qurxinta, waxay kicin kartaa wareegga dhiigga waxayna ka saari kartaa cabitaanka.

     

     

     

    Macluumaad dheeraad ah oo ku saabsan TRB

    Shahaadada sharciga
    USFDA,CEP,KOSHER HALAL GMP ISO Certificates
    Tayo lagu kalsoonaan karo
    Ku dhawaad ​​​​20 sano, dhoofinta 40 waddan iyo gobollada, in ka badan 2000 oo dufcadood oo ay soo saartay TRB ma laha wax dhibaato ah oo tayo leh, habka nadiifinta gaarka ah, nadiifinta iyo xakamaynta nadiifka ah waxay la kulmaan USP, EP iyo CP
    Nidaam Tayo Dhameystiran

     

    v Nidaamka Hubinta Tayada

    v Xakamaynta dukumentiga

    v Nidaamka Xaqiijinta

    v Nidaamka Tababarka

    v Protocol-ka Hanti-dhawrka Gudaha

    v Nidaamka Hantidhawrka Suppler

    v Nidaamka Qalabka Qalabka

    v Nidaamka Xakamaynta Qalabka

    v Nidaamka Xakamaynta Waxsoosaarka

    v Nidaamka Calaamadaynta Baakadaha

    v Nidaamka Xakamaynta Shaybaadhka

    v Nidaamka Xaqiijinta Xaqiijinta

    v Nidaamka Amuuraha Xeer-dejinta

    Xakamee dhammaan ilaha iyo hababka
    Si adag loo xakameeyey dhammaan alaabta ceeriin, agabka iyo alaabta baakadaha. Alaabta cayriin ee la door biday iyo agabka iyo alaab-qeybiyaha alaabta baakadaha leh lambarka US DMF.
    Machadyo iskaashi oo xooggan si ay u taageeraan
    Machadka dhirta/machadka microbiology/Academy of Science and Technology/Jaamacad

     


  • Hore:
  • Xiga: