Magaca Alaabta:Tianeptine Hemisulfate Monohydrate

Magac kale: tianeptinesulfate;

(Thiazepin-11-ylAmino)HeptanoicAcidSemisulfateMonohydrateTianeptineSemisulfateMonohydrate;

7-[(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f] [1,2] thiazepin-11-yl) amino] heptanoicacidsulfatehydrate (2: 1: 2); Tianeptinehemisulfatemonohydrate (THM);

7-[(3-Chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f] [1,2] thiazepin-11-yl) amino] heptanoicacidsulfatehydrate (2: 1: 2); Tianeptinehemisulfatehydrate;Thiazepin-11-ylAmino)HeptanoicAcidSemisulfate;THM

CAS Maya:1224690-84-9

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Tianeptine Sulfate/Tianeptine hemisulfate monohydrate waa cusbo hore loo qaaday oo Tianeptine ah. Ma aha hygroscopic sidaa darteed maaraynta budada ayaa aad u fudud. Maadaama aysan ahayn mid si fudud loo nuugo oo aan looga soo saarin jirka, cusbada sulfate-ka waxay u oggolaaneysaa in la sii daayo Tianeptine si dheeraad ah u xakameynaya muddo dheer. Halkii la qaadan lahaa saddex jeer oo leh saameyn degdeg ah oo degdeg ah iyo saameyn degdeg ah, milixda sulfate waxay u oggolaaneysaa hal qiyaas si loo ilaaliyo heerarka balaasmaha ee jirka in ka badan milixda sodium. Sifooyinkan la wanaajiyey ayaa Tianeptine Sulfate ka dhigaya mid cusub oo dheeraad ah.

Tianeptine Sulfate ma aha oo kaliya saameyn wanaagsan oo liddi ku ah niyad-jabka iyo falcelinta xun waxay si weyn uga yar tahay daawooyinka tricyclic antidepressant caadiga ah, ku dhawaad ​​wax saameyn ah kuma yeelan habka wadnaha iyo xididdada dhiigga, shaqada dhiigga, beerka iyo kelyaha ma dhaawacmin, mana laha saameyn dejin. Tianeptine ma aha oo kaliya waxtar u leh niyad-jabka iyo neurosis niyad-jabka, khamriga daba-dheeraada iyo niyad-jabka ka dib khamriga sidoo kale waa wax ku ool ah. Isticmaalka muddada dheer wuxuu ka hortagi karaa soo noqoshada

Tianeptine hemisulfate monohydrate, oo sidoo kale loo yaqaan tianeptine sulfate, waa xarun gaar ah oo markii ugu horreysay la helay 1960-meeyadii oo si ballaaran loo isticmaalay tan iyo markaas.

Tianeptine waa antidepressant. Xayawaanku wuxuu leeyahay unugyada pyramidal ee hippocampus waxay kordhiyeen firfircoonida iskood u shaqeysta, iyo dardargelinta shaqadeeda ayaa la joojiyay ka dib soo kabashada; korodhka kortikal iyo hippocampalneurons ee goobaha 5-serotonin dib u soo celinta. Tianeptine iyada oo aan raacin saamaynta xun: hurdo iyo feejignaan, habdhiska wadnaha; nidaamka cholinergic (aan lahayn calaamadaha anticholinergic); rabitaan daroogo.

Tianeptine waa dawo dhakhtar qoray oo loo isticmaalo in lagu hagaajiyo niyad-jabka dhammaan noocyada darnaanta. Daawada tianeptine waxaa guud ahaan lagu sifeeyaa inay tahay daaweeyaha tricyclic antidepressant. Tani waa iskudhis kiimiko ah oo loo magacaabay sababtoo ah waxay ka kooban tahay saddex siddo oo atamka ah.

Si la mid ah dawooyinka kale ee tricyclic antidepressants, tianeptine waxay xannibaysaa dib-u-qaadista, ama dib-u-noolaynta, ee serotonin. Kani waa neurotransmitter ka mas'uul ah qofka dareenkiisa fayoobi. Dib-u-qaadista ayaa markaa kordhisa helitaanka walxahan oo kale maskaxda.

Tianeptine hemisulfate monohydrate, oo sidoo kale loo yaqaan tianeptine sulfate, waa xarun gaar ah oo markii ugu horreysay la helay 1960-meeyadii oo si ballaaran loo isticmaalay ilaa iyo markaas. Taas oo ka shaqeysa kordhinta dib u soo celinta serotonin, neurotransmitter oo door muhiim ah ka ciyaara nidaaminta niyadda iyo niyadda. . Iyadoo la wanaajinayo dib-u-qaadista serotonin, tianeptine hemisulfate monohydrate waxay caawisaa soo celinta dheelitirka kiimikooyinka maskaxda, taasoo suurtogal ah inay yareyso calaamadaha niyad-jabka. Mid ka mid ah sifooyinka gaarka ah ee tianeptine hemisulfate monohydrate waa awoodda ay u leedahay inay kor u qaaddo neuroplasticity. Neuroplasticity waxaa loola jeedaa awooda maskaxdu inay is beddesho oo ay la qabsato waqti ka dib. Cilmi-baaristu waxay muujineysaa in hemisulfate monohydrate tianeptine ay kor u qaaddo korriinka neerfayaasha cusub waxayna xoojisaa isku xirka maskaxda ee jira. Hantidan ayaa ka dhigaysa mid xiiso leh oo lagu daweeyo niyad-jabka, maadaama laga yaabo inay bixiso faa'iidooyin waqti dheer ah oo ay weheliso nasinta calaamadaha.

Shaqada:

Tianeptine Sulfate waa antidepressant. Xayawaanku wuxuu leeyahay: Unugyada pyramidal-ka hippocampus waxay kordhiyeen firfircoonida iskeed ah, iyo dardargelinta hawsheeda ayaa la joojiyay ka dib soo kabashada; kororka xididada kortikal iyo hippocampal ee goobaha 5- serotonin dib u soo celinta. Tianeptine iyada oo aan raacin saamaynta xun: hurdo iyo feejignaan; nidaamka wadnaha; nidaamka cholinergic (aan lahayn calaamadaha anticholinergic); rabitaan daroogo.
Tianeptine Sulfate ma aha oo kaliya saameyn wanaagsan oo liddi ku ah niyad-jabka iyo falcelinta xun waxay si weyn uga yar tahay daawooyinka tricyclic antidepressant caadiga ah, ku dhawaad ​​wax saameyn ah kuma yeelan habka wadnaha iyo xididdada dhiigga, shaqada dhiigga, beerka iyo kelyaha ma dhaawacmin, mana laha saameyn dejin. Tianeptine ma aha oo kaliya waxtar u leh niyad-jabka iyo neurosis niyad-jabka, khamriga daba-dheeraada iyo niyad-jabka ka dib khamriga sidoo kale waa wax ku ool ah. Isticmaalka muddada dheer wuxuu ka hortagi karaa soo noqoshada.

Codsiga:

Tianeptine hemisulfate monohydrate waa kor u qaada dib u soo celinta serotonin ee xulashada (SSRE), taas oo macnaheedu yahay inay kor u qaadayso dib u soo celinta serotonin ee maskaxda, taas oo kordhinaysa balaastikada synaptik iyo hagaajinta niyadda. Waxay u shaqeysaa iyadoo beddeleysa heerarka serotonin ee maskaxda iyo kor u qaadida neuroplasticity. Sanadihii ugu dambeeyay, tianeptine hemisulfate monohydrate ayaa caan ku noqotay cilmi baarista caafimaadka, gaar ahaan soo saarista dawooyinka lidka diiqadda. Maaddaama daraasado badan oo badan ay xaqiijinayaan saameynteeda daweynta, rajada codsigeeda ayaa si tartiib tartiib ah u soo baxaya