Magaca Alaabta: Tranexamic Acid 98% ee HPLC
Lambarka CAS:1197-18-8
Qaacidada Molecular: C₈H₁₅NO₂
Miisaanka Molecular: 157.21 g/mol
Daahirsanaanta: ≥98% (HPLC)
Muuqaalka: Budada crystalline cad
Kaydinta: +4°C (muddo gaaban), -20°C (muddo dheer)
Codsiga: Daawooyinka, Isqurxinta, Cilmi-baadhista
1. Dulmarka alaabta
Tranexamic Acid (TXA), analooga lysine synthetic, ayaa si weyn loogu isticmaalaa sidii wakiilka antifibrinolytic si loo yareeyo dhiigbaxa goobaha qalliinka iyo dhaawacyada. Alaabtan waxa lagu soo saaray iyada oo la ilaalinayo xakamaynta tayada adag, iyada oo hubinaysa nadiifnimada ≥98% sida ay xaqiijisay chromatography dareeraha waxqabadka sare leh (HPLC). Qaab dhismeedka kiimikada (trans-4- (aminomethyl) cyclohexanecarboxylic acid) iyo xasilloonida sare waxay ka dhigaysaa mid ku habboon codsiyada kala duwan, oo ay ku jiraan:
- Isticmaalka Caafimaadka: Xakamaynta dhiigbaxa, daawaynta dhaawaca maskaxda ee dhaawaca ah (TBI).
- Waxyaabaha la isku qurxiyo: Kareemooyinka maqaarka lagu caddeeyo ee lagu beegsanayo midab-takoorka.
- Cilmi-baaris: Horumarinta habka falanqaynta iyo daraasadaha farmashiyaha.
2. Kiimikada iyo Qalabka Jirka
- Magaca IUPAC: 4-(Aminomethyl) cyclohexane-1-carboxylic acid
- Dhoola cadeynta: NC[C@@H] 1CCC@HC(=O)O
- Furaha InChI: InChi=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7
- Meesha dhalaalaysa: 386°C (dac.)
- Solubility: Biyo ku milma (1N HCl, pH-lagu hagaajiyay bakhtiye), methanol, iyo acetonitrile.
3. Xaqiijinta Tayada
3.1 Falanqaynta HPLC
Habkayaga HPLC waxa uu hubinayaa tiro sax ah iyo sifada wasakhda:
- Tiirka: XBridge C18 (4.6 mm × 250 mm, 5 μm) ama u dhigma.
- Wajiga mobilada: Methanol: acetate buffer (20 mM, pH 4) (75:25 v/v).
- Heerka socodka: 0.8-0.9 mL/min.
- Ogaanshaha: UV at 220 nm ama 570 nm (ka-soo-saarista 1% ninhydrin).
- Habboonaanta Nidaamka:
- Saxnimada: ≤2% CV ee aagga ugu sarreeya (6 nuqul).
- Soo kabashada: 98-102% (80%, 100%, 120% heerar sare loo qaaday).
3.2 Profile wasakh
- wasakh A: ≤0.1%.
- wasakhda B: ≤0.2%.
- Wadarta wasakhda: ≤0.2%.
- Halides (sida Cl⁻): ≤140 ppm.
3.3 Xasilooni
- Xasiloonida pH: La jaanqaadi kara kaydiyeyaasha (pH 2-7.4) iyo xalalka IV ee caadiga ah (tusaale, fructose, sodium chloride).
- Degganaanta kulaylka: Deggan 37°C ilaa 24 saacadood ee maadooyinka noolaha.
4. Codsiyada
4.1 Isticmaalka Caafimaadka
- Daryeelka Dhaawaca: Waxay hoos u dhigtaa dhimashada bukaannada TBI 20% (tijaabo CRASH-3).
- Qalliin: Waxa ay yaraynaysaa luminta dhiigga qalliinka (lafaha, qalliinnada wadnaha).
4.2 Waxyaabaha la isku qurxiyo
- Mechanism: Waxay joojisaa melanogenesis-ka plasmin-ku keeno iyadoo la xirayo goobaha lysine-ku-xidha.
- Qaababka: 3% kiriimyada TXA ee loogu talagalay melasma iyo hyperpigmentation.
- Badbaadada: Isticmaalka jirka la mariyo wuxuu ka fogaadaa khataraha habdhiska (tusaale, thrombosis).
4.3 Cilmi-baarista & Horumarinta
- Hababka Analytical:Synthesis: Daraasadaha is-weydaarsiga daroogada ee xaaladaha acidic.
- UPLC-MS/MS: Falanqaynta balaasmaha (LOD: 0.1 ppm).
- Fluorimetry: Kala soocida NDA/CN (falcelin 5-daqiiqo ah).
5. Baakadaha & Kaydinta
- Baakadaha Aasaasiga ah: Bacaha aluminiumka ee la xidhay oo leh qallajiye.
- Life Life: 24 bilood at -20°C.
- Raritaanka: Heerkulka jawiga (la ansixiyay 72 saacadood).
6. Badbaadada iyo u hoggaansanaanta
- Qabashada: Isticmaal PPE ( galoofyada, muraayadaha) si aad uga fogaato neefsashada/xiriirka.
- Xaalada Sharci: Waafaqsan USP, EP, iyo JPpharmacopeias.
- Sunta: LD₅₀ (afka, jiirka)>5,000 mg/kg; aan kansarka lahayn.
7. Tixraacyo
- Ansixinta ku habboonaanta nidaamka ee HPLC.
- qalooca calibration iyo borotokoolka kala soocida.
- Isbarbardhigga habka UPLC-MS/MS.
- Waxtarka-kharashka ee daryeelka dhaawacyada.
- Dejinta qaabaynta qurxinta.
Erayada Furaha: Tranexamic Acid 98% HPLC, Wakiilka Antifibrinolytic, Maqaarka Cadaynta, Daryeelka Dhaawaca, UPLC-MS/MS, Tijaabada shilalka-3, Daaweynta Melasma
Sharaxaada Meta: Tranexamic Acid daahir-sare ah (≥98% by HPLC) ee isticmaalka caafimaadka, qurxinta, iyo cilmi baarista. Hababka HPLC ee la ansaxiyay, daryeelka dhaawaca jaban ee wax ku oolka leh, iyo qaabab ammaan ah oo la mariyo. CAS 1197-18-8.
