Lebitso la Sehlahisoa:Wogonin Bulk phofo

Mohloli oa Botanic: Scutellaria baikalensis

Nomoro ea CAS:632-85-9

Lebitso le Leng:Vogoni, wagonin, Wogonin hydrate, Vogonin Norwogonin 8-methyl ether

Litlhaloso:≥98% HPLC

'Mala: Phofo e mosehla e nang le monko le tatso e ikhethang

Boemo ba GMO:GMO Mahala

Ho paka: ka meqomo ea fiber ea 25kgs

Polokelo: Boloka setshelo se sa buloa sebakeng se phodileng, se omileng, Qoba hole le leseli le matla

Shelf Life: Likhoeli tse 24 ho tloha ka letsatsi la tlhahiso

Scutellaria baikalensis e na le likarolo tse fapaneng tsa lik'hemik'hale, tse kang flavonoids tse fapa-fapaneng, diterpenoids, polyphenols, amino acid, oli e sa tsitsang, sterol, benzoic acid, joalo-joalo.Metso e ommeng e na le mefuta e fetang 110 ea li-flavonoid tse kang baicalin, baicalein, wogonoside, le wogonin, tseo e leng tsona motsoako o sebetsang oa Scutellaria baikalensis.Tlhahiso e tloaelehileng e kang 80% -90% HPLC Baicalin, 90% -98% HPLC Baicalein, 90% -95% HPLC Wogonoside, le 5% -98% HPLC Wogonin

In Vitro Activity: Wogonin e thibela PMA-induced COX-2 gene expression ka ho thibela c-Jun expression le AP-1 activation liseleng tsa A549[1].Wogonin ke inhibitor ea cyclin-dependent kinase 9 (CDK9) le block phosphorylation ea carboxy-terminal domain ea RNA polymerase II ho Ser.Ka hona, e fokotsa tlhahiso ea RNA mme ka mor'a moo e theoleloa ka potlako protheine ea nakoana ea anti-apoptotic myeloid cell leukemia 1 (Mcl-1) e bakang ho kenngoa ha apoptosis liseleng tsa mofetše.Wogonin e tlama CDK9 ka kotloloho, mohlomong ho pocketa e tlamang ATP mme ha e thibele CDK2, CDK4 le CDK6 ka litekanyetso tse thibelang ts'ebetso ea CDK9.Wogonin e thibela CDK9 ka mokhoa o ikhethileng ha e bapisoa le li-lymphocyte tse tloaelehileng.Wogonin hape ke anti-oxidant e matla e khonang ho senya ?O2?[2].Wogonin e thibela haholo phetisetso ea NFATc1 ho tloha cytoplasm ho ea khubung le ts'ebetso ea eona ea ts'ebetso ea transcriptional.E boetse e thibela haholo karohano ea osteoclast le ho fokotsa ho ngoloa ha osteoclast?e amanang le immunoglobulin?joaloka receptor, tartrate?resistant acid phosphatase le calcitonin receptor[4].Wogonin E Thibela Mosebetsi oa N-acetyltransferase

Ts'ebetsong ea Vivo: Wogonin e hatella kholo ea mofets'e oa xenografts ho vivo.Litaelong tse bolaeang lisele tsa hlahala, wogonin ha e bontše chefo kapa chefo e nyane bakeng sa lisele tse tloaelehileng hape e ne e se na chefo e hlakileng liphoofolong[2].Wogonin e ka etsa hore ho be le apoptosis ho murine sarcoma S180 kahoo e thibela ho hōla ha hlahala ka hare ho vitro le vivo[3].Ente ea intraperitoneal ea 200 mg/kg Wogonin e ka thibela ka botlalo leukemia le lisele tsa CEM.

Liteko tsa lisele:

Lisele tsa A549 ke setso ka poleiti ea seliba sa 24 (1.2 × 105 lisele / seliba) letsatsi la 1 pele ho phekolo ea wogonin.DMSO kapa wogonin e kenngoa liseleng tsa A549 1 h pele ho ts'usumetso ea PMA, 'me lisele li kenngoa ka lihora tse ling tse 6.Lisele li bokelloa ka kalafo ea trypsin 'me linomoro tsa lisele li baloa ka ho sebelisa hemocytometer le mokhoa oa ho kenyelletsa bluepan.