Lebitso la Sehlahisoa:CMS121
Lebitso le Leng:CMS-121;
1,2-Benzenediol,4--[4-(cyclopentyloxy)-2-quinolinyl]-;
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121);
ACC,AcetylCoenzymeACarboxylase, lefu, neuroprotective,inhibit,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121
NOMORO YA CAS:1353224-53-9
Tekanyetso: 98.0% Min
Mmala: Phofo e tshehla e kganyang
Ho paka: 25kg / DRUMS
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol ke motsoako o boetseng o bitsoa CMS121. Ho rarahana ha motsoako ona ho fana ka maikutlo a hore e kanna ea ba le thepa e ikhethang le ts'ebeliso e ka bang teng. Ho utloisisa bohlokoa ba eona, e thusa ho khetholla lihlopha tse sebetsang tse teng le ho sekaseka phello e ka bang teng
CMS121 ke quin oline e nkeloang sebaka e nang le tšebetso ea neuroprotective, anti-inflammatory, antioxidative, le renoprotective. E boloka maemo a glutathione (GSH) ho HT22 mouse hippocampal cell in vitro ka pel'a glutamate, e etsa hore ho be le phapang ea lisele tsa PC12, e thibela LPS-induced N9 microglial activation ka 82% ho N9 microglia, 'me e senya li-radicals tsa mahala sebakeng sa mahloriso a Trolox. (TEAC) tlhahlobo. CMS121 e sireletsa khahlanong le ischemia le oxytosis ho li-phenotypic screens ka liseleng tsa HT22 in vitro tse nang le litekanyetso tsa EC50 tsa 7 le 200 nM bakeng sa ho thibela lefu la iodoacetic acid-kapa glutamate-induced cell, ka ho latellana. E boetse e sireletsa, e fokotsa ho lahleheloa ke boima ba liphio le ho fokotsa polelo ea TNF-α, caspase-1, le inducible nit ric oxi de synthase (iNOS) ka mohlala oa mouse oa SAMP8 oa lefu le sa foleng la liphio le amanang le botsofali bo potlakileng ha bo tsamaisoa ka tekanyo. ea 10 mg/kg ka letsatsi ho qala ka likhoeli tse robong.
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol ke motsoako o boetseng o bitsoa CMS121. Ho rarahana ha motsoako ona ho fana ka maikutlo a hore e kanna ea ba le thepa e ikhethang le ts'ebeliso e ka bang teng. Ho utloisisa bohlokoa ba eona, e thusa ho khetholla lihlopha tse sebetsang tse teng le ho sekaseka phello e ka bang teng. Ho ba teng ha reng ea quinoline ho fana ka maikutlo a hore motsoako ona o ka ba le ts'ebetso ea baeloji. Limolek'hule tse nkiloeng ho quinoline li tsejoa ka mefuta ea tsona ea tlhaho e fapaneng, ho kenyeletsoa mesebetsi ea antibacterial le anti-inflammatory. Ho khomarela sehlopha sa cyclopentyloxy ho ka kenya letsoho ho solubility ea motsoako kapa ho ntlafatsa ts'ebetso ea eona ea likokoana-hloko ka liphello tsa steric. Lithutong tsa lisele tsa HT22, CMS-121 e bonts'itse litlamorao tse kholo tsa neuroprotective, ho sireletsa lisele tsena ka katleho ho tsoa ho ischemia le tšenyo ea oxidative. Ho feta moo, CMS-121 e na le thepa ea bohlokoa e khahlanong le ho ruruha, e bontšang bokhoni ba eona ba ho fetola likarabo tsa ho ruruha. Ka ho etsa joalo, CMS-121 e na le monyetla oa ho fokotsa ho ruruha ha lisele le litho tse fapaneng. CMS-121 e na le ts'ebetso e matla ea pharmacological e le inhibitor ea acetyl-CoA carboxylase 1 (ACC1). Tšusumetso ea eona e matla ea ho thibela ACC1 e e etsa motsoako o ts'episang
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