Lebitso la Sehlahisoa:Evodiamine

Lebitso le Leng:Evodiamine, Isoevodiamine, (+)-Evodiamine, d-Evodiamine,Fructus Evodiae Extract

Nomoro ea CAS:518-17-2

Tekanyetso: 98% Min

'Mala: Phofo e khanyang ea kristale e 'mala o mosehla

Ho paka: ka meqomo ea fiber ea 25kgs

Polokelo: Boloka setshelo se sa buloa sebakeng se phodileng, se omileng, Qoba hole le leseli le matla

Shelf Life: Likhoeli tse 24 ho tloha ka letsatsi la tlhahiso

Evodiamine ke alkaloid e ikhethang ea bioactive le motsoako oa mantlha oa bioactive meriana ea setso ea Machaena. E fumanoa ka monokotsoai oa semela sa Evodia evodia, se hōlang haholo-holo Chaena le Korea. E fumanoa ka monokotsoai oa semela sa Evodia evodia, se hōlang haholo-holo Chaena le Korea. Semela sena se na le mefuta e mengata ea lik'hemik'hale 'me esale se sebelisoa meriana ea setso ea Machaena ho phekola mathata a fapaneng a bophelo bo botle, ho kenyelletsa le mathata a tšilo ea lijo, ho ruruha le bohloko. Evodiamine e sebetsa ka ho shebana le litsela tse fapaneng tsa limolek'hule 'meleng. E tsebahala ka ho hlohlelletsa ts'ebetso ea li-receptor tsa vanillin, tse bapalang karolo ea bohlokoa temohong ea bohloko le thermogenesis. Ho feta moo, ho fumanoe hore e sebelisana le serotonin le li-receptor tsa dopamine, tse fanang ka maikutlo a hore e na le thepa ea ho ntlafatsa maikutlo.

Mosebetsi oa likokoana-hloko: Evodiamine ke alkaloid e arohaneng le litholoana tsa Bentham, tse nang le mesebetsi e fapaneng ea likokoana-hloko tse kang ho thibela ho ruruha, ho thibela botenya, le ho thibela hlahala. In vitro: Evodiamine e bontšitse cytotoxicity khahlano le mela e fapaneng ea lisele tsa mofetše oa motho ka ho etsa hore apoptosis. Ho phaella moo, ke molek'hule ea tlhaho e khahlanong le hlahala e nang le sepheo se sengata e sebetsang khahlanong le hlahala ka mekhoa e fapaneng ea limolek'hule tse kang litsela tse itšetlehileng ka caspase le tse sa itšetleheng, tsela ea sphingomyelin, pontšo ea calcium / JNK, 31 PI3K / Akt / caspase, le Fas. -L/. NF – κ B tsela ea pontšo 32 [1]. Ka vivo: Evodiamine e thibela metabolism ea dapoxetine. Ha ho bapisoa le sehlopha sa taolo, t1/2, AUC (0- ∞), le Tmax pharmacokinetic parameters ea dapoxetine sehlopheng sa evodiamine e ile ea eketseha haholo ka 63.3%, 44.8%, le 50.4%, ka ho latellana. Ho phaella moo, evodiamine e fokolitse haholo t1 / 2 pharmacokinetic parameters le AUC (0- ∞) ea demethylated dapoxetine [2]. Evodiamine e thibela ho hōla ha hlahala ka subcutaneous H22 xenograft model. Evodiamine e kokobetsa VEGF induced angiogenesis in vivo.

In vitro: Evodiamine e bonts'a cytotoxicity khahlano le mela e fapaneng ea lisele tsa mofetše oa motho ka ho susumetsa apoptosis. Ho phaella moo, ke molek'hule ea tlhaho e khahlanong le hlahala e nang le sepheo se sengata e sebetsang khahlanong le hlahala ka mekhoa e fapaneng ea limolek'hule tse kang litsela tse itšetlehileng ka caspase le tse sa itšetleheng, tsela ea sphingomyelin, pontšo ea calcium / JNK, 31 PI3K / Akt / caspase, le Fas. -L/. NF – κ B tsela ea pontšo 32 [1].

Ka vivo: Evodiamine e thibela metabolism ea dapoxetine. Ha ho bapisoa le sehlopha sa taolo, t1/2, AUC (0- ∞), le Tmax pharmacokinetic parameters ea dapoxetine sehlopheng sa evodiamine e ile ea eketseha haholo ka 63.3%, 44.8%, le 50.4%, ka ho latellana. Ho phaella moo, evodiamine e fokolitse haholo t1 / 2 pharmacokinetic parameters le AUC (0- ∞) ea demethylated dapoxetine [2]. Evodiamine e thibela ho hōla ha hlahala ka subcutaneous H22 xenograft model. Evodiamine e kokobetsa VEGF induced angiogenesis in vivo.

MOSEBETSI:

Mesebetsi e khahlanong le ho ruruha, anti-tumor, le hypoglycemic e na le litlamorao tse itseng tsa kalafo kalafong ea 'dementia' ea pele le stroke. E na le analgesic, e theola khatello ea mali 'me e baka ho phahama ho hoholo ha mocheso oa' mele. Tšebeliso ea bongaka ea sehlahisoa sena ke ho hlahisa li-agent tsa bongaka bakeng sa diuretics le mofufutso.

1. Evodia extract e sebelisetsoa ho phekola matšoao a ho tsieleha ka mpeng. Tsena li kenyelletsa ho nyekeloa ke pelo, ho hlatsa le letšollo. Ho boleloa hore e sebetsa ka ho khetheha ho phekola letšollo la hoseng.

2. Evodia e sebelisetsoa ho tsosa takatso ea lijo le ho phekola matšoao a ka mpeng a amanang le ho hloka thahasello lijong.

3. Evodia extract e boetse e na le anti-inflammatory, anti-tumor, anti-viral, astringent, le diuretic properties.

4. Evodiamine e nang le analgesia, ho theola khatello ea mali le ho phahama ha mocheso oa 'mele le liphello tse ling tsa meriana.

5. Evodiamine e na le stomachic, stop retching, oxyrygmia effect le diuretic effect.

6.Evodiamine e na le phello e matla ea ho thibela ho li; le phello e kholo ea likokoanyana ho ascarissuum;

7.Evodiamine hape e ka honyela popelo le ho matlafatsa khatello.

8.Besides, evodiamine e boetse e na le phello e ntle ho lefu la Alzheimer's le stroke.

Kopo: