L-ERGOTHIONEINE 99% NGE-HPLC
I-Antioxidant yePremium yeNutraceutical & Cosmeceutical Applications
1. Isishwankathelo seMveliso
L-Ergothioneine(ERT) yindalo yesalfure equlathe amino acid ephuma kwimicrobial fermentation, efumaneka ikakhulu kumakhowa afanaI-Tricholoma matsutakekwayeHericium erinaceus. Imveliso yethu yi-high-purity (≥99% nge-HPLC) i-crystalline powder kunye ne-CAS No. Ibonisa uzinzo olukhethekileyo kwi-pH 4.0-6.0, iyenza ilungele iiserum zokhathalelo lwesikhumba, izinto zokuthambisa, kunye nezongezelelo zomlomo.
Ezona mpawu:
- Ubunyulu: ≥99% (i-HPLC-eqinisekisiweyo, i-batch-specific COA inikezelwe)
- Ifomula yemolekyuli: C₉H₁₅N₃O₂S | Ubunzima beMolekyuli: 229.3 g/mol
- Ukunyibilika: 125 mg/mL emanzini (i-ultrasonic-assisted)
- Iziqinisekiso: I-Non-GMO, i-Allergen-Free, iVegan-Friendly
2. ULawulo loMgangatho kunye neNdlela yokuSebenza ye-HPLC
Inkqubo yethu yohlalutyo ihambelana neeprothokholi eziphononongwe ngoontanga :
- Ukulungiselela iSampuli: i-1 mL yenkcubeko yenkcubeko ebilisiwe kwi-94 ° C ye-10 min, i-vortexed (1600 rpm / 30 min), i-centrifuged (10,000×g / 5 min), kwaye igcinwe kwi -20 ° C ukuba kuyimfuneko.
- Inkqubo ye-HPLC: Dionex Ultimate 3000 ene-software ye-Chromeleon.
- Ikholamu: Cortecs UPLC T3 (2.1 × 150 mm, 1.6 μm amasuntswana, 120 Å pore ubukhulu) .
- ISigaba seMobile: I-Gradient elution ukusuka kwi-0.1% ye-asidi ye-formic ukuya kwi-70% ye-acetonitrile / i-0.1% ye-asidi ye-asidi, isantya sokuhamba kwe-0.3 mL / min.
- Ukufumanisa: Ukukhutshwa kwe-UV kwi-254 nm, LOQ 0.15 mmol / L.
Imilinganiselo yoQinisekiso:
- Umgca: 0.3–10 mmol/L (R² >0.99)
- Ukuchaneka: ≤6% RSD (intra-/inter-assay)
- Ukubuyisela kwakhona: ~ 100% ukuchaneka
3. IiNzuzo zeMpilo kunye nezicelo
3.1 Usetyenziso lwezondlo
- Ukukhuselwa kweMitochondrial: Ukunciphisa uxinzelelo lwe-oxidative ngokukhupha i-hydroxyl radicals (IC₅₀: 2.5 μM) kunye ne-superoxide anions.
- Inkxaso yeTelomere: Ilibazisa ukufinyezwa kwe-telomere enxulumene nobudala kwi-vitro.
- Umthamo: Izifundo zeklinikhi zibonisa ukuba i-5-20 mg / imini iphakamisa amanqanaba e-ERT e-plasma kakhulu.
Iimveliso eziCetyisiweyo:
- Iicapsules: 100 μg–5 mg ngokukhonza (umz., Ulutsha oluBalulekileyo lweLifeExtension) .
- I-Synergistic Blends: Idibanisa ne-asidi ye-ferulic ukwenzela ukuphuculwa kwe-bioavailability.
3.2 Usetyenziso lweCosmeceutical
- I-Anti-Aging: Inqanda i-tyrosinase (ukunciphisa i-40% kwi-concentration ye-0.5%) kwaye ikhusela i-elastin ekuthotyweni kwe-UV.
- Izikhokelo zokuqulunqa:
- i-pH: 4.0–6.0 (uzinzo olufanelekileyo)
- Ugxininiso: 0.5-2.0% kwiiserum / lotions
- Ukuhambelana: Izinzile kunye ne-vitamin C, i-hyaluronic acid, kunye neepeptides.
4. IiNgcaciso zobuGcisa
| Ipharamitha | Inkcazo | Isalathiso |
|---|---|---|
| Imbonakalo | Umgubo omhlophe wekristale | |
| Ubunyulu (HPLC) | ≥99% | |
| Indawo yokunyibilika | 275–280°C (ibola) | |
| Ugcino | 2–8°C kwisingxobo esingangeni moya | |
| Beka ubomi kwishelufa | Iinyanga ezingama-24 |
5. Ukhuseleko nokuThotyelwa kweMigaqo
- Idatha yoKhuseleko: LD₅₀>2000 mg/kg (ngomlomo, iimpuku); akukho miphumo imbi kwizilingo zabantu .
- Iziqinisekiso: I-EU Novel Food Approval (Ergoneine®), i-FDA GRAS.
- Ukuphatha: Sebenzisa ii-respirators ezivunyiweyo ze-NIOSH kunye neeglavu ezixhathisa iikhemikhali ngexesha lokusetyenzwa kwamashishini.
6. Unikezelo lwehlabathi kunye nokuPakisha
- Iinketho zokupakisha: 1 kg, 10 kg, 1000 kg (iingxowa ze-aluminium foil ezine-desiccant) .
- Ixesha lokukhokela: Iintsuku ze-3-5 zoshishino (ukuthunyelwa kwehlabathi nge-DHL/FedEx) .
- Iimarike ezikhonzwayo: USA, EU, Australia, Japan, Brazil.
7. Amagama aziintloko
- Amagama angundoqo: “L-Ergothioneine 99%I-HPLC", "uMboneleli we-Antioxidant weNdalo", "i-Ergothioneine ye-Skincare".
- Bandakanya i-CAS 497-30-3, amabango ococeko, kunye nemigaqo yesicelo.
