Igama lemveliso:I-Compound 7P

Elinye Igama:Compound7P;2-[(2-methoxyphenyl)[(4-methylphenyl)sulfonyl]amino]-N-(4-methoxy-3-pyridinyl)acetamide ;2-(N-(2-methoxyphenyl)-4- i-methylphenylsulfonamido)-N-(4-methoxypyridin-3-yl)i-acetamide

Inombolo yeCAS:1890208-58-8

Iinkcukacha: 99.0%

Umbala: Umgubo omhlophe onevumba elibonakalayo kunye nencasa

Isimo se-GMO:GMO Mahala

Ukupakisha: kwi-25kgs fiber drums

Ugcino: Gcina isikhongozeli singavulwanga kwindawo epholileyo neyomileyo, Zigcine kude nokukhanya okuqinileyo

Ubomi beShelf: iinyanga ezingama-24 ukusuka kumhla wokuvelisa

I-Compound 7p iboniswe ukukhuthaza ukukhula kwe-GAP-43-positive axons kwimodeli yezilwanyana zokulimala kwe-nerve optic, ebonisa ukuba umsebenzi we-neurite outgrowth we-compound 7p in vitro uguqulela ekuvuseleleni ukuvuselelwa kwe-axon kwi-Vivo.

Kwimodeli yesilwanyana sokulimala kwe-nerve ye-optic, i-7p ibonakaliswe ukukhuthaza ukukhula kwe-gap-43 i-axons emihle, ebonisa ukuba umsebenzi we-in vitro neurite we-compound 7p uguqulela ekukhuthazeni ukuvuselelwa kwe-axon kwi-vivo. yeendlela ezenza ngayo ukuvuselelwa kwe-axon kwi-vivo iya kubonelela ngesiseko esinengqiqo kwiinzame zexesha elizayo zokuphucula izicwangciso zonyango.

ICompound 7P ibhekisa kwikhompawundi ethile yendalo equlathe iiathom zekhabhoni ezisixhenxe. Kwimichiza yezinto eziphilayo, ikhabhoni yinto ebalulekileyo kuba inokwenza izibophelelo ezizinzileyo kunye nezinye iiathomu, kubandakanywa iiathomu zekhabhoni, ukwenza iimolekyuli ezintsonkothileyo. Ezi molekyuli zinokuba neepropati ezahlukeneyo kunye nemisebenzi, okwenza i-carbon-based compounds ibe yibhloko yokwakha ubomi. Kwiimodeli zezilwanyana zokulimala kwe-optic nerve, i-compound 7p yaboniswa ukuba ikhuthaze ukukhula kwe-GAP-43-positive axons, ebonisa ukuba umsebenzi wokukhula kwe-neurite we-compound 7p in vitro uguqulela ekuvuseleleni ukuvuselelwa kwe-axonal kwi-vivo. I-Compound 7P powder iyimpuphu emhlophe emhlophe eveliswa njenge-tandem compound yokuchonga i-dual-acting thromboxane receptor antagonist inhibitors. Enyanisweni, i-compound 7p ibonise ukukhetha kwe-prostaglandin I2 synthase (PTGIS, CYP8A1) ngokumalunga ne-thromboxane synthase (CYP5A1). I-nootropic compound 7P powder ikhuthaza ukukhula kwe-Gap-43-positive axons, ngaloo ndlela ivuselela ukuvuselelwa kwe-axonal emzimbeni. Umgangatho ophezulu we-Complex 7p yenzelwe ukuphucula ulungelelwaniso, ukuphucula isimo sengqondo kunye nokunceda ukulwa nokudinwa. Ikwathintela i-oxidation yengqondo kwaye inceda ukulwa nomonakalo wobuchopho obangelwa kukusela utywala.

Umsebenzi:

Ukuvuselelwa kwe-axon emva kokulimala kwinkqubo ye-nervous central kuphazamiseka ngokuyinxenye kuba ukuba ukuhla okuxhomekeke kwiminyaka yobudala kwi-intrinsic axon ukukhula okunokwenzeka, kwaye enye yezicwangciso zokukhuthaza ukukhula kwe-axon kwi-neuron eyonzakeleyo ibandakanya ukunyanzeliswa kwe-pharmacological yeendlela zokubonisa iimpawu. Isikrini esisekwe kwiseli yephenotypic yamathala eencwadi ekhemikhali kunye nolwakhiwo-olukhokelwayo olukhokelela ekuchongweni kwe-compound 7p. ikhuthaza ukuphuma kwe-neurite ye-neuron ephuculweyo ephuma kwi-hippocampus, i-cerebral cortex, kunye ne-retina. kwimodeli yezilwanyana yokulimala kwe-nerve ye-optic, i-7p ibonakaliswe ukuba ikhulise ukukhula kwe-gap-43 i-axons emihle, ebonisa ukuba i-in vitro neurite outgrowth activity ye-compound 7p iguqulela ekukhuthazeni ukuvuselelwa kwe-axon kwi-vivo. yeendlela ezenza ngayo ukuvuselelwa kwe-axon kwi-vivo iya kubonelela ngesiseko esinengqiqo kwiinzame zexesha elizayo zokuphucula izicwangciso zonyango.
Isicelo:

Ngoku iyeza elinobulumko le-nootropic elizibonakalisa kwelinye lezona racetams ezinamandla kwindalo yonke ye-nootropic. Yenziwe kwiklasi yeekhompawundi ezibizwa ngokuba yi-racetams, kwaye ingasebenzi kwi-acetylcholine kuphela kodwa kunye ne-GABA receptors kwingqondo, oku kunamandla okwenza zombini i-cholinergic kunye ne-glutamate receptors ye-cerebral cortex, kwaye iyisiyobisi se-racetam esiguquguqukayo ngenxa yobuninzi bayo. indlela eyodwa yokwenza. I-Fasoracetam okwangoku ibonisa izibonelelo njenge-anti-depressant, i-ADHD stimulant, kunye ne-anxiolytic, nayo, njengoko ibonakaliswe kwiibhubhoratri kulo lonke uhlanga, inceda ngokusekwa kunye nokugcinwa kweenkumbulo ezintsha.