Igama leMveliso: NADH

Elinye Igama:I-Beta-Nicotinamide Adenine Dinucleotide Ityuwa yeDisodium(NADH) umgubo, i-Beta-d-ribofuranosyl-3-pyridinecarboxamide, i-disodiumsalt; I-BETA-NICOTINAMIDEADENINEDINUCLEOTIDE,INUCEDFORMDISODIUMSALT; I-BETA-NICOTINAMIDE-ADENINEDINUCLEOTIDE,I-RECED,2NA; I-BETA-NICOTINAMIDEADENINEDINUCLEOTIDEREDUCEDDISODIUMSALT;BETA-NICOTINAMIDEADENINEDINUCLEOTIDE,DISODIUMSALT; i-beta-Nicotinamideadeninedinucleotidedisodiumsalthydrate;eta-d-ribofuranosyl-3-pyridinecarboxamide,disodiumsaltbeta-nicotinamideadeninedinucleoti de,disodiumsalt,hydratebeta-nicotinamideadeninedinucleotidedisodiumsalt,trihydrate;NICOTINAMIDEADENINEDINUCLEOTIDE(INHAYISIWE)DISODIUMSALTextrapure

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I-NADH yi-molecule ye-biological ethatha inxaxheba kwi-metabolism yamandla kwiiseli kwaye isebenza njenge-coenzyme ebalulekileyo ekuguquleni iamolekyu zokutya ezifana ne-glucose kunye ne-fatty acids kwi-ATP amandla.

I-NADH (eyehlisiwe i-β-Nicotinamide Adenine Dinucleotide) yi-coenzyme ehambisa iiproton (ngokuchanekileyo, i-hydrogen ions), kwaye ibonakala kwiimpendulo ezininzi ze-metabolic kwiiseli. I-NADH okanye ngokuchanekileyo ngakumbi i-NADH + H + yifomu yayo encitshisiweyo.

I-NADH (eyehlisiwe i-β-Nicotinamide Adenine Dinucleotide) ingancitshiswa, ithwale ukuya kwiiproton ezimbini (ezibhalwe njenge-NADH + H +). I-NAD + yi-coenzyme ye-dehydrogenase, efana ne-alcohol dehydrogenation Chemicalbook enzyme (ADH), esetyenziselwa i-oxidize ethanol.
I-NADH (eyehlisiwe i-β-Nicotinamide Adenine Dinucleotide) idlala indima engenakuthathelwa indawo kwi-glycolysis, i-gluconeogenesis, i-tricarboxylic acid cycle kunye nekhonkco lokuphefumula. Imveliso ephakathi iya kudlula i-hydrogen esusiweyo kwi-NAD, iyenze i-NADH + H +. I-NADH + H + iya kusebenza njengomthwali we-hydrogen kwaye idibanise i-ATP kwikhonkco lokuphefumula ngokusebenzisa ukudibanisa ukungena kweekhemikhali.

I-NADH yi-biomolecule echaphazelekayo kwi-intracellular energy metabolism. I-coenzyme ebalulekileyo ekuguquleni iamolekyu zokutya ezifana ne-glucose kunye ne-fatty acids kumandla e-ATP. I-NADH yindlela encitshisiweyo ye-NAD+ kunye ne-NAD+ yifom ye-oxidized. Yenziwa ngokwamkela ii-electron kunye neeprotons, inkqubo ebalulekileyo kwiimpendulo ezininzi ze-biochemical. I-NADH idlala indima ebalulekileyo kwi-metabolism yamandla ngokubonelela ngee-electron ukukhuthaza ukuphendula kwe-intracellular redox ukuvelisa amandla e-ATP. Ngaphandle kokuthatha inxaxheba kwi-metabolism yamandla, i-NADH iphinda ibandakanyeke kwezinye iinkqubo ezibalulekileyo ze-biological, ezifana ne-apoptosis, ukulungiswa kwe-DNA, ukuhlukana kweeseli, njl. I-NADH idlala indima ebalulekileyo kwi-cell metabolism kunye nemisebenzi yobomi. Akuyena kuphela umdlali obalulekileyo kwi-metabolism yamandla, kodwa iphinda ithathe inxaxheba kwezinye iinkqubo zebhayoloji ezibalulekileyo kwaye inoluhlu olubanzi lwezicelo.

Umsebenzi:

Njenge-coenzyme ye-oxidoreductases, i-NADH (eyehlisiwe i-β-Nicotinamide Adenine Dinucleotide) idlala indima ebalulekileyo kwimveliso yamandla omzimba.
I-1- NADH (eyancitshiswa i-β-Nicotinamide Adenine Dinucleotide) inokukhokelela ekucaceni kwengqondo engcono, ukuphaphama, ukugxila kunye nememori. Inokunyusa ukuqina kwengqondo kwaye inokunyusa isimo sengqondo. Inokunyusa amanqanaba amandla emzimbeni kwaye iphucule imetabolism, amandla engqondo kunye nokunyamezela.
I-2-NADH (eyanciphisa i-β-Nicotinamide Adenine Dinucleotide) inceda abantu abanexinzelelo lweklinikhi, uxinzelelo lwegazi oluphezulu okanye i-cholesterol ephezulu;
I-3- NADH (eyancitshiswa i-β-Nicotinamide Adenine Dinucleotide) iphucula ukusebenza kwezemidlalo;
I-4- NADH (i-β-Nicotinamide Adenine Dinucleotide eyanciphisa) ilibazise inkqubo yokuguga kunye nokugcina ingqibelelo yeeseli ze-nerve ukuxhasa inkqubo ye-nervous;
I-5- NADH (i-β-Nicotinamide Adenine Dinucleotide eyanciphisa) inokunyanga isifo sika-Parkinson, iphucule umsebenzi we-neurotransmitters kwingqondo yezigulane ezine-Parkinson's disease, ukunciphisa ukukhubazeka ngokomzimba kunye neemfuno zeziyobisi;
I-6- i-NADH (i-β-Nicotinamide Adenine Dinucleotide eyanciphisa) iphatha isifo esingapheliyo sokukhathala (CFS), isifo se-Alzheimer kunye nesifo senhliziyo;
I-7- i-NADH (i-β-Nicotinamide Adenine Dinucleotide eyehlisiwe) ikhusela kwimiphumo emibi yeyeza le-AIDS elibizwa ngokuba yi-zidovudine (AZT);
I-8-NADH (eyehlisiwe i-β-Nicotinamide Adenine Dinucleotide) ichasa iimpembelelo zotywala kwisibindi;

Isicelo:

1. I-NADH (eyanciphisa i-β-Nicotinamide Adenine Dinucleotide) i-coenzyme ebalulekileyo kwizinto eziphilayo kwaye isetyenziselwa uphando lwe-biochemical, ukuxilongwa kwekliniki, iyeza leklinikhi kunye nophando lweziyobisi.

2. I-NADH (eyehlisiwe i-β-Nicotinamide Adenine Dinucleotide) iyinxalenye yeziyobisi ze-coenzyme. Ngokweklinikhi, isetyenziselwa kakhulu unyango lwe-adjuvant ye-coronary heart disease, enokuphucula iimpawu ezifana nokuqina kwesifuba kunye ne-angina.
3. I-Beta Nicotinamide Adenine Dinucleotide ithatha inxaxheba kwi-metabolism yamandla kunye ne-metabolism yezinto eziphathekayo emzimbeni, onenzuzo ekulungiseni nasekuhlaziyweni kweeseli. Kunyango lwe-coronary heart disease, i-myocarditis, i-leukopenia embolism.