Igama lomkhiqizo:4-Butylresorcinolimpushana
Ukucaciswa: 98% min
Inombolo ye-CAS:18979-61-8
Omqondofana esiNgisini: N-BUTYLRESEOCINOL;4-N-BUTYLRESORCINOL;4-BUTYLRESORCINOL;4-phenylbutane-1,3-diol;2,4-DIHYDROXY-N-BUTYLBENZEN
Ifomula yemolekyuli: C10H14O2
Isisindo se-molecule: 166.22
Iphoyinti lokuncibilika: 50 ~ 55 ℃
Indawo yokubilisa: 166℃/7mmHg(lit.)
Isilinganiso: 0.1-5%
Iphakheji: 1kg, 25kg
Iyini i-4-Butylresorcinol
Igama lekhemikhali elisemthethweni yi-4-n-butyl resorcinol, kodwa ngokuvamile, wonke umuntu uthanda ukwenza lula ukubhala i-butyl resorcinol.Owokuqala owawengeza emkhiqizweni omhlophe yiPOLA yaseJapan, um~ leyo ethembele ephilisini elenza libe mhlophe emlilweni wasekhaya.
Ibonakala ngokungancibiliki kahle emanzini futhi incibilika ku-ethanol.
Isenzo se-Mechanism ye-4-Butylresorcinol
- I-Tyrosinase idlala indima ebalulekile ekukhiqizweni kwe-melanin ngoba ilawula izinga lokufakwa kwe-melanin.
- I-4-n-butylresorcinol inomphumela ovimbelayo ekukhiqizweni kwe-melanin ngokuvimbela ngokuqondile umsebenzi we-tyrosinase namaseli e-black-speed tumor cell avimbela ukuhlanganiswa kwe-tyrosinase ngaphandle kokubangela noma iyiphi i-cytotoxicity.
- Kwezinye izifundo ze-in vitro, i-4-n-butylresorcinol iboniswe ukuvimbela ukukhiqizwa kwe-melanin, kanye nomsebenzi we-tyrosinase kanye ne-TRP-1.
- I-inhibitor enamandla ye-tyrosinase ne-peroxidase
- I-ejenti ephumelelayo yokwenza mhlophe yesikhumba kanye ne-toner evamile yesikhumba
- I-ejenti emhlophe ephumelelayo yokwenza i-pigmentation yesikhumba
- Isebenza ngempumelelo ekulweni ne-chloasma (isikhumba esine-hyperpigmented esichaziwe elangeni)
- Inomthelela oqinile wokuvikela emonakalweni we-DNA obangelwa i-H2O2.
- Kufakazelwe ukuthi inomphumela we-anti-glycation
Izinzuzo ze-4-Butylresorcinol
Kungani kufanele ukhethe i-4-Butylresorcinol
Okokuqala, sidinga ukwazi ukuthi kungani kune-resorcinol.
I-Lipofuscin ingenye yezinto ezinzima kakhulu ukubhekana nazo ku-melanin.Ngokuvamile, i-hydroquinone isetshenziswa ebuhleni bezokwelapha.
IHydroquinone iyi-ejenti yokwenza mhlophe esebenza kahle kakhulu.Indlela emhlophe ivimbela ngokuphelele umsebenzi we-tyrosinase futhi ivimbela ukwakheka kwe-melanin, futhi umphumela uphawuleka kakhulu.
Kodwa-ke, imiphumela yayo emibi isobala ngokulinganayo, futhi izinzuzo ziyingozi kakhulu kunezinzuzo zokuba mhlophe.
- I-oxidizable kakhulu emoyeni, futhi kufanele isetshenziswe uma uyingeza ezimonyoni.
- kungabangela ukubomvu kwesikhumba;
- Uma ukugxila kudlula u-5%, kuzodala ukuzwela, futhi kunezibonelo zomtholampilo ze-leukoplakia.Okwamanje, i-US Food and Drug Administration ibeka ukuthi imikhiqizo ye-hydroquinone ene-concentration engaphezu kuka-4% iyibanga lezokwelapha futhi ayivunyelwe ukumakethwa.
Osokhemisi nosokhemisi baguqule umuthi onamandla we-hydroquinone ukuze uthole i-4-hydroxyphenyl-beta-D-glucopyranoside, okuyilokho esivame ukukuzwa nge-“arbutin”.Umehluko phakathi kwe-hydroquinone ukuthi i-arbutin inomsila omncane - i-glycoside kune-hydroquinone.Kuyadabukisa ukuthi umphumela wokuba mhlophe uncishiswe kakhulu.
Eminyakeni yamuva nje, izithako ezidume kakhulu zemikhiqizo emikhulu ziyizinto ezihlukahlukene ze-benzenediol.
Kodwa ukuzinza okulula kwe-arbutin kubi kakhulu futhi kusebenza kuphela ebusuku.
Ukuphepha kwe-4-n-butyl resorcinol sekuyinto evelele kakhulu.Ngaphandle kwemiphumela emibi ye-hydroquinone, inomphumela ongcono wokwelapha kunezinye izinto eziphuma ku-resorcinol.
Ocwaningweni lokuvimbela umsebenzi we-tyrosinase, idatha yayo ingcono kakhulu kune-big brother phenethyl resorcinol, okuyizikhathi eziyi-100~6000 ze-ejenti emhlophe engokwesiko njenge-kojic acid arbutin!
Khona-ke ku-melanin B16V yokuhlola ethuthukisiwe eyalandela, iphinde yabonisa inzuzo evamile yokuphuma kwe-resorcinol - ukuvinjelwa kokukhiqizwa kwe-melanin ekugxilweni okungazange kukhiqize i-cytotoxicity.
Ngaphezu kwalokho, kunezilingo eziningi zabantu ku-4-n-butyl resorcinol.Kwezinye iziguli ezingama-32 ezine-chloasma, u-0.3% u-4-n-butylresorcinol ne-placebo wasetshenziswa kuzo zombili izihlathi.Kabili ngosuku ezinyangeni ezi-3, umphumela waba ukuncishiswa kwe-pigment okuphansi kakhulu eqenjini le-4-n-butylresorcinol kuneqembu le-placebo.Kunabantu abenza izivivinyo zokuvimbela i-pigmentation yokufakelwa ngemuva kokushiswa yilanga okwenziwe yilanga, hmm~ umphumela muhle impela ~
Ukuvinjelwa kwe-tyrosinase yomuntu nge-4-butylresorcinol
I-4-butylresorcinol, i-kojic acid, i-arbutin ne-hydroquinone ibonisa kumsebenzi we-L-DOPA oxidase we-tyrosinase.Kunqunywa ukugxiliswa okuhlukahlukene kwama-inhibitor ukuvumela ukubalwa kwamanani e-IC50.Le datha iyisilinganiso sokuhlolwa okuthathu okuzimele.
Ukuvinjelwa kokukhiqizwa kwe-melanin kumamodeli esikhumba e-MelanoDerm nge-4-butylresorcinol
Qhathanisa ne-4-butylresorcinol, i-kojic acid, i-arbutin ne-hydroquinone ekukhiqizeni i-melanin.Ukunqunywa kokuqukethwe kwe-melanin kwamamodeli esikhumba kuboniswe ngemuva kwezinsuku eziyi-13 zokutshala lapho kukhona ukugxila okuhlukahlukene kwe-inhibitor.Le datha iyisilinganiso sokuhlolwa okuhlanu okuzimele.
Ukukhanyisa indawo yobudala nge-4-butylresorcinol
Qhathanisa ne-4-butylresorcinol, i-kojic acid, i-arbutin ne-hydroquinone.Phatha amabala kabili ngosuku amasonto ayi-12 nge-inhibitor efanele.Hlola ukusebenza kahle ngemva kwamaviki angu-4, 8 kanye nayi-12.Idatha imele ingqikithi yezifundo eziyi-14.*P < 0.05: ngokwezibalo kubalulekile uma kuqhathaniswa nezindawo zobudala ezingalashwanga.
Umthamo kanye nokusetshenziswa kwe-4-Butylresorcinol
Umthamo onconyiwe ngu-0.5% -5%.Yize zikhona izifundo eKorea ezinomthelela othize kukhilimu ongu-0.1%, kanti i-India inocwaningo lukakhilimu ongu-0.3% kodwa imakethe ikakhulukazi i-0.5% -5%.Kuvame kakhulu, futhi ifomula yaseJapane ayikacaci, kodwa i-POLA isetshenzisiwe.Futhi imiphumela nokuthengisa kuyamangaza impela.
Njengoba kushiwo ngenhla, i-4-Butylresorcinol ingasetshenziswa kumakhilimu, kodwa ayincibiliki emanzini.Okunye okunjengamafutha okugcoba, okhilimu, namajeli nawo ayatholakala.Kokubili i-POLA ne-Eucerin banemikhiqizo engu-4-Butylresorcinol.
