I-Bulk Anandamide powder

I-Arachidonoyl Ethanolamide, i-arachidonoylethanolamide, i-N-arachidonoylethanolamine, ne-AEA zonke zilingana ne-anandamide ngokwayo.Kodwa-ke, (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide igama lekhemikhali le-anandamide (igama le-IUPAC) futhi lingasetshenziswa kuphela emibhalweni yesayensi.Kodwa-ke, i-94421-68-8 iyi-ID yayo yamakhemikhali eyingqayizivele (Inombolo Yokubhalisa ye-CAS).Njengoba i-AEA kuyigama elifushane kakhulu le-anandamide, singasebenzisa i-AEA njalo ukuze sibhekisele ku-anandamide emibhalweni nasezithombeni ezilandelayo.

Igama Lomkhiqizo:InqwabaI-Anandamide powder

Synonimes:Arachidonoyl Ethanolamide, AEA powder, arachidonoylethanolamide, (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide,N-arachidonoylethanolamine

Inombolo ye-CAS: 94421-68-8

Ingxenye Yesitshalo Esetshenzisiwe:Leaf

Isithako:Apigenin

I-Assay: Amafutha e-AEA: 90%

I-AEA powder: 50%

Umbala:Impushana ephuzi

amafutha ansundu ngokuphuzi

Ukupakisha: ku-25kgs fiber drums

Isitoreji: Gcina isitsha singavulwa endaweni epholile, eyomile, gwema ukukhanya okuqinile

Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqiza

Ngokusho kwe-Wikipedia, i-anandamide iyi-neurotransmitter ye-cannabinoid eyenzeka ebuchosheni, okusho ukuthi ubuchopho bomuntu buyakwazi ukukhiqiza i-anandamide ngaphandle kokudla ukudla okuqukethe i-AEA.Ubuchopho bezinhlobo ezincelisayo kanye nokhokho ongahluziwe kuqinisekiswa ukuthi kuqukethe inani elithile le-anandamide.

Imithombo yokudla ye-anandamide

Ayikho imithombo yemvelo eminingi eqondile ye-anandamide, futhi ushokoledi nama-truffles angaphezulu kwawo.I-Truffle ibiza kakhulu ukuthi ungayithola nge-anandamide, futhi ushokoledi ubonakala uwumthombo onokwethenjelwa wenani elikhulu eliqhubekayo lokudla.

I-Anandamidekanye noshokoledi

Ubhontshisi kakhokho, umthombo kashokoledi, nawo ungumthombo ocebile we-anandamide.Zingaphezu kuka-300 izakhi zamakhemikhali kushokoledi.I-caffeine, i-theobromine, ne-phenylethylamine yizithako ezaziwayo eziphakamisa imizwa yethu.I-theobromine empeleni isiza ukugqugquzela ubuchopho ukuthi bukhulule i-anandamide eyengeziwe ukuze sizizwe sijabule kakhudlwana.

Kungani i-anandamide yanda kangaka eminyakeni yamuva nje?

Ngaphambi kokuphendula lo mbuzo, sidinga ukusho insangu, iTHC & CBD (Cannabidiol) kuqala.

Insangu, eyaziwa nangokuthi insangu, isitshalo esiqhakaza, futhi abantu bayisebenzisa njengesidakamizwa sephathi noma bayibheme ukuze bakhe umuzwa "wokuphakama" noma "ukukhandwa ngamatshe".

Isithako esisebenzayo ku-cannabis esikwenza uphakame iTHC, enegama eliphelele njenge-delta 9-Tetrahydrocannabinol.Lapho abantu bebhema insangu, i-tetrahydrocannabinol ku-cannabis ivuselela i-cannabis receptor, yenze abantu bazizwe bejabule futhi baphile kahle engqondweni.

ICannabis ayikho emthethweni emazweni amaningi njengoba abantu abaningi bezoba imilutha yayo.

Kodwa-ke, i-Uruguay iyizwe lokuqala ukwenza ngokusemthethweni insangu ngonyaka ka-2013.

Ngomhla ziyi-17 kuMfumfu wezi-2018, uhulumeni waseCanada wamemezela ukuthi insangu iba semthethweni kulo lonke elaseCanada.

E-United States, izifundazwe eziyi-10 kanye neSifunda sase-Columbia zigunyaze ngokusemthethweni ukusetshenziswa kwensangu ukuzilibazisa nakuba kusalokhu kungekho emthethweni.

I-Anandamide vs THC

I-Cannabis ingumthombo wesitshalo we-THC.

I-Anandamide inguqulo yomuntu ye-THC.

Usosayensi wathola i-AEA ngo-1992 kanye ne-THC ngo-1964.

I-Anandamide ikhipha amakhemikhali athuthukisa imizwa ebuchosheni, futhi indlela yayo yebhayoloji ifana neye-tetrahydrocannabinol ku-cannabis.

Yebo, baqondise i-cannabis receptor efanayo, futhi sizokhuluma ngomshini we-AEA maduze.

Kodwa-ke, amandla e-THC anamandla kakhulu kune-AEA.Umuzwa wokuthatha i-AEA awumnandi kangako kunowokubhema insangu njengoba i-anandamide igaya umzimba ngokushesha, mhlawumbe phakathi nemizuzu engama-30.

Njengoba insangu inqatshelwe emazweni amaningi, izithasiselo, ukudla, iziphuzo noma izimonyo eziqukethe iTHC akukho emthethweni.Ngalo mqondo, i-anandamide iyikusasa.

I-Anandamide vs CBD

Isitshalo sensangu sinezinhlanganisela ezingama-400+, futhi ama-cannabinoids angaphezu kuka-60 abopha kuma-receptors emzimbeni wethu.

I-CBD iwuhlobo olufushane lwe-cannabidiol futhi ingenye yalawo ma-cannabinoids angama-60.I-CBD iyi-phytocannabinoid ku-cannabis.Ngaphezu kwe-40% ye-cannabis ekhishwe yi-CBD.

Ososayensi nodokotela bathole ukuthi i-CBD iyakwazi ukuthuthukisa izinga le-anandamide kuma-synapses obuchopho njenge-anandamide reuptake kanye ne-breakdown inhibitor.I-fatty acid amide hydrolase, eyaziwa nangokuthi i-FAAH ngamafuphi, iyi-enzyme ephula i-AEA.Yileyo ndlela i-CBD evimbela ngayo i-FAAH futhi ithuthukise i-AEA ngokwemvelo.

I-CBD ingenza okuningi kunalokho.I-CBD ingaba yinzuzo kulo lonke uhlelo lwe-Endocannabinoid

Indlela yokusebenza ye-anandamide

Isebenza kanjani i-anandamide?Kunzima impela.Ungase udinge ukwazi kuqala ngohlelo lwe-endocannabinoid, i-CB1 receptor, kanye ne-CB2 receptor.

I-CB1

I-THC inokuhlobana okuphezulu kwesamukeli se-CB1, ebopha ngokuqinile isamukeli.

Ngaphezu kwalokho, i-anandamide ithinta umuzwa “ophakeme” ngokuthinta isamukeli se-CB1, isebenze uhlelo lomvuzo lobuchopho futhi ikhiqize amakhemikhali enjabulo njenge-dopamine Hormone.

CB2

Ungathola ama-CB2 receptors kumaseli omzimba wakho kuwo wonke umzimba wakho.I-CB2 receptor iphethe izimpendulo ze-neuroprotective kanye nokulwa nokuvuvukala.Ososayensi bakholelwa ukuthi i-CB2 receptor inenzuzo ekudambiseni ubuhlungu.

Ama-receptors e-CB1 agxile kakhulu ebuchosheni nasohlelweni lwe-CNS, kuyilapho ama-receptor e-CB2 atholakala kakhulu kumasosha omzimba.

I-Endocannabinoid System (ECS)

Ngaphambi kokuxoxa ngemisebenzi yohlelo lwe-endocannabinoid (ECS), kubalulekile ukuqonda izingxenye zalo.I-ECS yakhiwe ngama-cannabinoid receptors, ama-ligands angapheli (ama-molecule abophayo) kulawo ma-receptors, nama-enzyme ahlanganisa futhi alulaza imigqa.

umbuthano wangaphakathi (ompunga okhanyayo) umele isistimu ye-endocannabinoid 'yakudala'.Umbuthano wangaphandle (ompunga obumnyama) uhlanganisa izingxenye zohlelo olunwetshiwe lwe-endocannabinoid.Njengoba ungase ubone, i-PEA, SEA, ne-OEA nazo zifakiwe ohlelweni lwe-endocannabinoid.

Ama-EC anomsuka wesistimu yezinzwa emaphakathi (CNS) futhi afaka i-anandamide (AEA), i-2-arachidonoylglycerol (2-AG), i-noladin ether, i-virodhamine ne-N-arachidonylodopamine (NADA).Futhi i-anandamide ingeyokuqala futhi futhi iyi-ligand ebaluleke kakhulu ohlelweni lwe-endocannabinoid.

I-Anandamide ne-2-AG

Njengoba kushiwo ngenhla, i-anandamide (AEA) ne-2-arachidonoylglycerol (2-AG) yimigqa emibili eyinhloko ohlelweni lwe-ECS.I-ECS isiza ukulawula imisebenzi efana nokulala, amasosha omzimba, nokuguquguquka kobuhlungu.

Ososayensi bathola i-Anandamide ngonyaka we-1992 kanye ne-2-AG eminyakeni emi-3 kamuva.I-AEA ne-2-AG inesakhiwo samangqamuzana esifana kakhulu futhi ngaleyo ndlela izici zomzimba nezekhemikhali ezifanayo.

I-Anandamide iqondise kakhulu isamukeli i-CB1 ebuchosheni, kuyilapho i-2-AG iqondise kokubili i-CB1 ne-CB2 receptors (emasosheni omzimba).

Kokubili i-Anandamide ne-2-AG zenziwa ku-arachidonic acid, i-Omega-6 fatty acid, enezindlela ezihlukene kanye nama-enzyme ahlanganisayo.I-enzyme ehlambalazayo i-FAAH (i-Fatty Acid Amide Hydrolase) ye-AEA ne-2-AG nge-MAGL enzyme (i-Monoacylglycerol Lipase).

Izinzuzo ze-Anandamide

Ubufakazi besayensi bubonisa ukuthi i-anandamide ingase ibe yinhle ekulweni nokukhathazeka, impilo yengqondo, ukucubungula inkumbulo, ukulawula ukudla, ukukhulula ubuhlungu, i-neuroprotection, nokuningi.

I-Anandamide nokukhathazeka

Abantu baqamba i-Anandamide ngokuthi “i-molecule ejabulisayo” ngoba i-AEA iyakwazi ukwenza uzizwe ujabule.

Ubufakazi obuguquguqukayo buphakamisa ukuthi uhlelo lwe-endocannabinoid luyingxenye ebalulekile yama-neuronal substrates abandakanyeka ezinqubweni zomvuzo wobuchopho kanye nezimpendulo ezingokomzwelo ekucindezelekeni.

Ukuvinjwa kwe-Pharmacological of the enzyme fatty acid amide hydrolase (FAAH), enesibopho sokuwohloka kwe-anandamide ye-intracellular, kukhiqiza imiphumela efana ne-anxiolytic kumagundane ngaphandle kokubangela ukusabela okubanzi kokuziphatha okujwayelekile kwama-agonists e-cannabinoid asebenza ngokuqondile.

Lokhu okutholakele kusikisela ukuthi i-anandamide inomthelela ekulawulweni kwemizwelo nokukhathazeka nokuthi i-FAAH ingase ibe inkomba yekilasi lenoveli lezidakamizwa ezikhathazayo.

Ukuze uthole ukwaziswa okwengeziwe ngemiphumela ye-anandamide ekukhathazekeni, sicela ufunde izincwadi ezingezansi:

• I-anandamide ye-cannabinoid engapheli inemiphumela ekukhuthazeni nasekukhathazekeni okwembulwa ukuvinjelwa kwe-fatty acid amide hydrolase (FAAH).
• I-Anandamide hydrolysis: inhloso entsha yezidakamizwa ezilwa nokukhathazeka?
• Ukuziphatha okuncishisiwe okufana nokukhathazeka okubangelwa ukuvinjelwa kwezakhi zofuzo kanye nemithi ye-endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) iqondiswa yi-CB1 receptors.

I-Anandamide nokukhulula ubuhlungu

ubufakazi besayensi ome bubonisa ukuthi ukuvinjelwa kwe-FAAH (i-enzyme eyehlisa i-anandamide ebuchosheni) kunciphisa kakhulu izimpendulo ze-nociceptive kumamodeli amaningi obuhlungu.

I-FAAH inhibitors ithuthukisa kakhulu amazinga e-anandamide ebuchosheni futhi ikakhulukazi eyenga i-CB₁i-receptor-mediated antinociception, ephakamisa ukuthi i-anandamide engapheli, lapho ivikelwe ekonakalisweni, ingakhiqiza i-antinociception nge-CB.₁ama-receptors.

I-Palmitoylethanolamide (PEA) iyisithako esingapheli esithuthukisa umsebenzi we-anandamide.Umzimba womuntu ukhiqiza i-PEA ngokwemvelo ukulwa nokuvuvukala nobuhlungu.Iziguli ezingaphezu kuka-800,000 ziye zaba amaphilisi e-PEA kanye nezithako zokudla ukwelapha ubuhlungu emhlabeni.

Ukuze ufunde kabanzi nge-PEA, sicela uvakashele yethuIkhasi le-PEA.

Ukuphakama kwe-Anandamide nomgijimi

Ake siqale sibheke incazelo yokuthi kuyini ukuphakama komgijimi: umuzwa wenjabulo nokukhathazeka okuncishisiwe kanye nekhono elinciphile lokuzwa ubuhlungu.Ngemuva kokuzivocavoca okude kwe-aerobic, uzothola isenzakalo esimnandi ngesikhathi sokugijima isikhathi eside.

Emashumini eminyaka adlule, abacwaningi babecabanga ukuthi i-endorphin ukuphela kwesici esibangela abagijimi abaphezulu njengoba amazinga anyukile ama-β-endorphin atholakala kalula egazini.Njengoba kungenzeka uyazi kakade, i-endorphin inamandla okuthuthukisa isimo sethu sengqondo futhi idale umuzwa wenjabulo.

Kodwa-ke, ososayensi manje bakholelwa ukuthi isistimu ye-endocannabinoid (ECS) kanye ne-anandamide edala ukuphakama komgijimi.I-Anandamide iyakwazi ukuwela umgoqo wegazi nobuchopho futhi inikeze imiphumela emaphakathi yama-opioid asendaweni.Kodwa i-endorphin ayikwazi.

Uma ufuna ukufunda ngokuhlolwa okuphathelene nokuphezulu komgijimi, funda lezi zincwadi:Ukuphakama komgijimi kuncike kuma-cannabinoid receptors kumagundane

Izazi zokudla okunomsoco zithola ukuthi i-anandamide ingase ibe isilawuli esihle sokudla.I-Anandamide ingase ivuse indlala yakho nesifiso sokudla okwengeziwe.Uma usendleleni yokwehlisa isisindo, cabanga ngokucophelela ngaphambi kokuthatha i-AEA.

Izithasiselo eziqukethe i-anandamide

Ngabe ufuna izithasiselo ze-anandamide noma amaphilisi e-anandamide?

Ngeshwa, akekho okwamanje.I-Anandamide iyisithako esiyinoveli kangangokuthi awekho amabhrendi ezithako zokudla aseke ayizama kumafomula awo amanje.

Ungathola inkampani ebizwa ngokuthi i-Sun Potion ithengisa i-anandamide powder ku-Amazon.Nokho, lokho akulona iqiniso.Kuyimpuphu kakhokho eluhlaza kuphela, kodwa hhayi ukukhishwa kwe-anandamide okujwayelekile.Futhi okuqukethwe okusebenzayo kufomu lempushana kuphansi kakhulu, futhi ungase ungakutholi ukuphumelela kwe-AEA.

Kunjalo, ungathola ukuthi abanye abahlinzeki bathengisa izilinganiso zereferensi ye-anandamide noma ama-reagents.Okubi ukuthi bathengisa kuphela ngo-5mg, 25mg, futhi ngokucwaninga kuphela.Alukho ulwazi lwenqwaba kawoyela we-AEA olutholakala sanhlobo.

Izindaba ezinhle ukuthi abakhiqizi bezithasiselo e-United States nasemazweni ase-Europe njengeJalimane, i-France, i-Netherland, i-UK, i-Spain, i-Italy, njll. ba-oda amasampula e-AEA kwa-Wuxi Cima Science Co., Ltd, futhi ukukhiqizwa kwenqwaba yezohwebo kusendleleni. .

Imininingwane ye-Anandamide

Amafutha amaningi e-anandamide kanye ne-anandamide powder kokubili kuyatholakala kwa-Cima Science.

Amafutha e-Anandamide: 70%, 90%

I-Anandamide powder: 50%