Igama lomkhiqizo:I-Archidonic Acid
Ukucaciswa:10% Impushana, 40% Amafutha
Inombolo ye-CAS.: 506-32-1
I-EINECS No.: 208-033-4
Ifomula ye-molecular:C20H32O2
Isisindo samangqamuzana:304.46
Iyini i-Arachidonic Acid?
I-Arachidonic acid (I-ARA) iyingxenye ye-Omega 6 long-chain polyunsaturated fatty acid.
UkusukaI-ARAIsakhiwo, singabona ukuthi iqukethe amabhondi amane e-carbon-carbon double, ibhondi ye-carbon-oksijeni ephindwe kabili, okuyi-acid enamafutha angagcwele kakhulu.
Ingabe i-ARA ingeyama-Essential fatty acids?
Cha, i-Arachidonic Acid ayiwona ama-Essential fatty acids (EFAs).
I-Alpha-linolenic acid kuphela (i-omega-3 fatty acid) ne-linoleic acid (i-omega-6 fatty acid) ama-EFA.
Kodwa-ke, i-arachidonic acid ihlanganiswa ne-Linoleic acid.Uma umzimba wethu untula i-linoleic acid, noma ingakwazi ukuguqula i-linoleic acid ku-ARA, umzimba wethu uzoba mfushane ku-ARA, ngakho-ke i-AA iba ukungenisa ngale ndlela.
Izinsiza Zokudla ze-ARA
Inhlolovo Yokuhlolwa Kwezempilo Nezokudla Kazwelonke 2005-2006
| Izinga | Into yokudla | Umnikelo wokudla (%) | Umnikelo oqongelelwe (%) |
| 1 | Inkukhu nenkukhu izitsha ezixubile | 26.9 | 26.9 |
| 2 | Amaqanda namaqanda okuxubile izitsha | 17.8 | 44.7 |
| 3 | Inyama yenkomo nenyama yenkomo izitsha ezixubile | 7.3 | 52.0 |
| 4 | Amasoseji, ama-frank, ubhekeni, nezimbambo | 6.7 | 58.7 |
| 5 | Ezinye izinhlanzi nezinhlanzi okuxutshwe izitsha | 5.8 | 64.5 |
| 6 | Ama-Burgers | 4.6 | 69.1 |
| 7 | Ukusikeka okubandayo | 3.3 | 72.4 |
| 8 | Ingulube nengulube izitsha ezixubile | 3.1 | 75.5 |
| 9 | Izitsha ezixubile zaseMexico | 3.1 | 78.7 |
| 10 | I-pizza | 2.8 | 81.5 |
| 11 | I-Turkey ne-turkey izitsha ezixubile | 2.7 | 84.2 |
| 12 | I-pasta ne-pasta izitsha | 2.3 | 86.5 |
| 13 | Ama-dessert asekelwe okusanhlamvu | 2.0 | 88.5 |
Singayitholaphi i-ARA empilweni yethu
Uma sihlola uhlu Lwezithako ku-Baby milk powder, i-Arachidonic Acid(ARA) ingatholakala njengesinye sezithako ezibalulekile zokuthuthukiswa kobuhlakani.
Uzoba nombuzo, ingabe i-ARA ibalulekile kuphela ezinganeni?
Cha, izithasiselo eziningi ze-ARA emakethe Yezempilo Yobuchopho kanye nokudla Kwezemidlalo, zisiza ukusekela usayizi wemisipha, amandla, nokulondolozwa kwemisipha ngesikhathi sokuqeqeshwa.
Ingabe i-Arachidonic Acid ingasebenza ekwakheni umzimba?
Yebo.Umzimba uthembele ku-ARA ngokuvuvukala, impendulo evamile futhi edingekayo yokuzivikela komzimba ukulungisa izicubu ezilimele.
Ukuqeqeshwa kwamandla kuzodala impendulo yokuvuvukala okunamandla, okudingekayo ukwakha imisipha emikhulu.
Kusukela esithombeni esingezansi, singabona ama-prostaglandin amabili akhiqizwa ku-ARA yi-PGE2 kanye ne-PGF2α.
Ucwaningo olulodwa olwenziwa nge-skeletal muscle fibers lubonisa ukuthi i-PGE2 yandisa ukuwohloka kwamaprotheni, kuyilapho i-PGF2α ivuselela ukukhiqizwa kwamaprotheni.Olunye ucwaningo luphinde lwathola ukuthi i-PGF2α ingakhuphula ukukhula kwe-fiber muscle.
Okuningiliziwe kwe-Arachidonic Acid Metabolism
I-Prostaglandin Synthesis:
Cishe wonke amangqamuzana ezincelisayo angakhiqiza ama-prostaglandin nezinhlanganisela zawo ezihlobene (i-prostacyclins, i-thromboxanes kanye ne-leukotrienes eyaziwa nangokuthi i-eicosanoids).
Ama-eicosanoid amaningi atholakala ku-ARA angakhuthaza ukuvuvukala, kodwa amanye aphinde asebenze ukuze akuxazulule okulingana nokulwa nokuvuvukala.
Prostaglandins Physiological effects njengoba ngezansi.
I-Prostaglandin ihlanganiswa ngama-enzyme futhi isabela kuma-receptor axhumene ne-G-protein, futhi i-intracellularly mediated yi-cAMP.
I-Arachidonic Acid kanye neMetabolism yayo kufaka phakathi i-Protaglandins (PG), i-Thromboxanes (TX) ne-Leukotrienes (LT)
Ukuphepha kwe-ARA:
Ukudla okunoveli:
2008/968/EC: Isinqumo seKhomishini yangomhla ziyi-12 kuZibandlela wezi-2008 esigunyaza ukubekwa emakethe kawoyela ocebile nge-arachidonic acid avela eMortierella alpina njengesithako sokudla esinoveli ngaphansi koMthethonqubo (EC) No 258/97 wePhalamende laseYurophu kanye noMkhandlu ( ukwaziswa ngaphansi kwenombolo yedokhumenti C(2008) 8080)
GRAS
Ukunqunywa kwesimo esivame ukubonwa njengesiphephile (i-GRAS) samafutha anothile nge-arachidonic acid njengesithako sokudla sokusetshenziswa kwefomula yezingane.
Ukudla Kwensiza Okusha
Uhulumeni wase-China ugunyaza i-Arachidonic Acid Njengesithako Esisha Sokudla Kwensiza.
Isilinganiso se-Arachidonic Acid
Kubantu Abadala: Amazinga okuthathwa kwe-ARA aphakathi kuka-210-250 mg/ngosuku emazweni athuthukile.
Okokwakha umzimba: cishe ama-500-1,500 mg futhi uthathe imizuzu engama-45 ngaphambi kokuzivocavoca
Inzuzo ye-ARA:
OkweBaby
Umongameli we-International Society for the Study of Fatty Acids and Lipids (ISSFAL) - USolwazi Tom Brenna ubonise i-ARA ekhona obisini lwebele lomuntu ngokwesilinganiso esingu-0.47% wesamba esiphelele samafutha.
Esikhathini sezinsana kanye nezingane ezincane, ikhono lomntwana lokuhlanganisa i-ARA liphansi, ngakho-ke kumntwana osenkathini yegolide yokukhula komzimba, ukuhlinzeka nge-ARA ethile ekudleni kuyoba usizo kakhulu ekuthuthukiseni umzimba wakhe.Ukuntuleka kwe-ARA kungase kube nemiphumela emibi kakhulu ekuthuthukiseni izicubu nezitho zomuntu, ikakhulukazi ukuthuthukiswa kobuchopho nesimiso sezinzwa.
Eyabantu Abadala
Ukwakha umzimba
Ucwaningo olungaboni kabili olwenziwa kwabesilisa abanempilo, abancane abangama-30 abaneminyaka emi-2 yokuqeqeshwa kwamandla okungenani amasonto ayisishiyagalombili.
Umhlanganyeli ngamunye wabelwa ukuthi athathe izingcezu ezimbili zamajeli athambile aqukethe amagremu angu-1.5 engqikithi ye-ARA noma amafutha ommbila ngokungahleliwe.Abahlanganyeli bathathe i-softgel cishe imizuzu engama-45 ngaphambi kokuqeqeshwa, noma noma nini lapho kufaneleka ngezinsuku ezingezona zokuqeqesha.
Umphumela wokuhlola we-DXA ubonisa isisindo somzimba senyuke kakhulu eqenjini le-ARA kuphela (+1.6 kilograms; 3%), iqembu le-Placebo cishe alinalo ushintsho.
Womabili amaqembu amabili okuqina kwemisipha akhuphuka kakhulu uma kuqhathaniswa nesisekelo, ukwanda kwakukhulu eqenjini le-AA (8% vs. 4% ukwanda; p = 0.08).
Nge-Fat mass, alukho ushintsho olubalulekile noma umehluko.
Nqoba ukucindezeleka
Abacwaningi bathola ukuthi i-arachidonic acid ingadambisa uphawu lokucindezeleka futhi ihlehlise izimpawu ezingezinhle zobuchopho.
I-Arachidonic acid nayo ibonisiwe ukuthi inganqoba ukucindezeleka ngokuphumelelayo ngokunciphisa igazi.
Ukwelapha isifo samathambo
Kwabadala
Ososayensi benze ucwaningo kumagundane, imininingwane njengoba ingezansi.
Emagundaneni, umsebenzi we-enzyme oguqula i-linoleic acid ku-arachidonic acid iyancipha ngokuguga, futhi ukwengezwa kokudla ku-arachidonic acid kumagundane asebekhulile kubonakala kukhuthaza ukuqonda, nge-P300 amplitude kanye nokuhlolwa kwe-latency, okuye kwaphindaphindiwe ku-240 mg arachidonic. i-asidi (nge-600 mg triglycerides) kwamanye amadoda amadala anempilo.
Njengoba i-arachidonic acid ikhiqizwa kancane ngesikhathi sokuguga, ukwengezwa nge-arachidonic acid kungase kube nokuthuthukiswa kwengqondo kubantu asebekhulile.
I-Side Effect
Njengoba isilinganiso sebhalansi ye-omega-3 ne-omega-6 fatty acids ingu-1: 1 emzimbeni wethu.
Uma sithatha kakhulu isithasiselo se-Arachidonic Acid, i-Omega 6 fatty acid yomzimba wethu izoba phezulu kakhulu kune-Omega-3, sizoba nenkinga yokushoda kwe-Omega-3(isikhumba esomile, izinwele eziphukayo, ukuchama njalo, ukuqwasha, ukuxebuka izinzipho, izinkinga zokugxilisa ingqondo, nokushintsha kwemizwa).
I-Omega-6 fatty acid eningi ingase ibangele isifo senhliziyo nemithambo yegazi, isifuba somoya, isifo sokuzivikela komzimba, amafutha.
Ukuqinisekisa ukuthi ngeke uhlangabezane nale nkinga, sicela uthathe i-Arachidonic acid ngokwesiphakamiso sikadokotela wakho.
