I-Nicotinamide mononucleotide bulk powder
Igama lomkhiqizo:I-Nicotinamide mononucleotide powder
Omqondofana: NMN,β-Nicotinamide Mononucleotide,beta-Nicotinamide Mononucleotide
Inombolo ye-CAS: 1094-61-7
Imininingwane: 99% iminithi
I-Molecular Formula:C11H15N2O8P
Isisindo samangqamuzana: 334.221 g/mol
Iphakheji: 1kg/isikhwama, 25kg/isigubhu
Iyini iNicotinamide Mononucleotide?
I-Nicotinamide mononucleotide, efushanisiwe njenge-NMN, inamagama alandelayo:
β-NMN, BETA-Nicotinamide Mononucleotide;
I-BETA-NMN;I-BETA-NICOTINAMIDE MONONUCLEOTIDE;
BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE;
I-NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE 5′-PHOSPHATE;I-NICOTINAMIDE RIBOTIDE;
I-NICOTINAMIDE MONONUCLEOTIDE
I-NMN ikhona ezintweni eziphilayo ezihlukahlukene kuhlanganise nabantu futhi iyinhlanganisela ebalulekile ekugcineni imisebenzi yomzimba.I-NMN iphinda isetshenziswe ngemva kokugaywa umzimba, futhi i-vitamin B3 ekudleni ingaphinda ihlanganise i-NMN.
Ngaphambi kokuba siqonde i-nicotinamide mononucleotide, sidinga ukwazi ukuthi iyini.I-Nicotinamide mononucleotide (NMN) isandulela esibalulekile se-NAD+, futhi i-NAD+ iyindlela ebalulekile yokulungisa amaseli kubantu.Lapho abantu besezinsaneni nasezinganeni ezincane, ukukhula nokukhula kwabo kuyashesha kakhulu, futhi ngokukhula kweminyaka, ukusebenza komzimba womuntu kuzokwehla kancane kancane.Isibonelo esilula sifana nesidala;uzophuphuthekiswa ngengozi.Amaqhubu adilizwa, okubi nakakhulu ukuthi balimala kabi.Enqubweni yokuguga kwamangqamuzana omuntu, inani le-NAD+ lizoncipha kakhulu uma liqhathaniswa nesikhathi esedlule ngenxa yemetabolism kanye nomzimba ngokwawo.
I-Nicotinamide mononucleotide iyingxenye ebalulekile yokuvuselelwa komuntu.Ososayensi emhlabeni wonke bathole ukuthi i-nicotinamide mononucleotide inomphumela othile ekugugeni.Ocwaningweni olujulile, isihluthulelo se-nicotinamide mononucleotide ukuthi iyisandulela se-NAD+, esizoguqulela i-NAD+, yengeze isici sokulungisa amangqamuzana emangqamuzaneni omuntu, imelane nenqubo yokuguga, futhi ibe nethuba lokuqala kabusha umsebenzi wokukhula kabusha iseli, okuwumsebenzi wokunweba ukuphila kwe-nicotinamide mononucleotide.
I-Nicotinamide mononucleotide ngokwemvelo ikhona kuwo wonke amangqamuzana omzimba wethu futhi iyingxenye ebalulekile yokuzilungisa komzimba.Kuyi-metabolite yokugcina i-NAD+ biosynthesis evamile, futhi le nto ingalawula i-physiology ngesikhathi sokujikeleza komzimba, naku-pathology ethile.Idlala indima ebalulekile ekusebenzeni kwamangqamuzana.
Izithasiselo eziqukethe i-NMN
Kunemikhiqizo eminingi ye-NMN edayiswayo manje.Ezinye zidumile phakathi kwabasebenzisi bokugcina, njenge-NMN Pure, Ultra NMN, njll. ku-Amazon nakwezinye izitolo ze-inthanethi.
Amanye amafomula ane-NNN kuphela kuwo, futhi amanye ahlangene nezinye izithako ezilwa nokuguga ezisebenzayo, njenge-resveratrol, i-pterostilbene, ibonise ukukhishwa kwezimpande, njll.
Womabili amafomu e-capsule nawethebhulethi ayatholakala, ngezansi kukhona amaqiniso ezithako ze-NMN avela kwamanye amalebula e-NMN:
I-125mg ibonakala iyisilinganiso esithandwayo sezithako eziningi ze-NMN, nakuba abanye bebhala i-260mg nge-capsule ngayinye kumalebula abo ngosayizi wokukhonza wama-capsules we-2 noma amaphilisi nsuku zonke.Awukho umthamo onconyiwe osemthethweni njengamanje.
Indlela yokusebenza ye-nicotinamide mononucleotide
I-nicotinamide mononucleotide iguqulwa ibe “i-nicotinamide adenine dinucleotide (NAD)” into ebalulekile kumetabolism yamandla emzimbeni.Ocwaningweni lwegundane, kwaqinisekiswa ukuthi i-nicotinamide mononucleotide ingavula isakhi sofuzo esibizwa nge-acetylase emzimbeni, ngaleyo ndlela ibe nemiphumela efana nokwelula impilo nokwelapha isifo sikashukela.I-NAD iyinto engakhiqizwa umzimba womuntu.Ucwaningo lukhombisile ukuthi okuqukethwe kwe-NAD emzimbeni kuncipha ngokuya ngeminyaka.
Ukwanda kokuvuvukala okuhambisana nokuguga kungase kuphazamise ikhono lomzimba lokukhiqiza i-NMN, okubuye kubangele ukwehla kwe-NAD.
I-NMN iyisandulela se-coenzyme NAD+ ebalulekile emzimbeni.I-Nicotinamide mononucleotide iyindima ebalulekile ekukhiqizeni amandla amangqamuzana omuntu, futhi ibandakanyeka ekuhlanganisweni kwe-intracellular NAD+ (nicotinamide adenine dinucleotide, i-coenzyme yokuguqulwa kwamandla eseli).
I-NMN yaziwa ngokusemthethweni njengento yokuqala yemvelo emhlabeni eqinisekiswa ukuhlola okuqinile kwesayensi ukubuyisela emuva ngempumelelo nokubambezela ukuguga nokwelula impilo.
Ngo-2017, izifundo zibonise ukuthi i-NMN ingaphatha i-NR ne-NMN ataxia, futhi i-NR ayiguquli umsebenzi we-SIRT3 noma ithuthukise umsebenzi wenhliziyo.
Ukunikezwa kwe-NAD + ngeke kume - kuzoqhubeka kudliwe futhi kugcwaliswe, futhi lonke i-NAD + ichibi liphenduka izikhathi ezi-2-4 ngosuku.
Lo mjikelezo ungezindlela zokulungisa, lapho i-enzayimu i-Nampt ivuselela i-NAM iye ku-NMN bese igaywa ku-NAD +.I-Namp iyisinyathelo somkhawulo wejubane ohlelweni lokudoba.
I-Nicotinamide Mononucleotide VS.I-Nicotinamide Riboside
Namuhla, umhlaba ucebile ocwaningweni oluhlukahlukene nge-NR, futhi ukuhlolwa komzimba womuntu kwenza umphumela we-NR kudatha yethiyori ube ngcono kune-NMN.Kodwa-ke, ucwaningo luye lwabonisa ukuthi i-NR iqala ukusebenza emzimbeni womuntu futhi isadinga ukuba nolwazi okwesikhashana.Ukhiye wukuthi kokubili i-NR ne-NMN zingamanduleli we-NAD+, kuyilapho i-Nicotinamide Riboside (NR) iyisandulela se-NMN ne-NAD+, ngakho i-NR iyashintsha.Kuthatha isikhashana ngaphambi kwe-NAD+.Uma kuqhathaniswa nomthelela osheshayo we-NMN, imizuzu engu-15 ye-NR iyigebe elikhulu.
Kungabonakala kumdwebo womjikelezo ongenhla ukuthi i-NAMPT iyisici esibalulekile esikhawulela ukukhiqizwa kwe-NMN.Njengoba iminyaka ikhula, akuwona umzimba womuntu ongafuni ukuba mncane, kodwa umsebenzi we-enzyme we-NAMPT wehla lapho kunikezwa amandla nezakhi.Njengoba umjikelezo we-NAM uncishiswa, isitoko se-NAD+ sincishiswa ngokwemvelo.
I-NR ingaguqulelwa ku-NMN noma iye ku-NAM, kuye ngendima ye-enzyme ye-Nrk1 ukuze kunqunywe ukuthi iyiphi into yekhwalithi efanayo ye-NR ezokhiqiza okwengeziwe.Uma iguqulelwa ku-NAM, iphinde ivinjelwe yi-enzyme ye-NAMPT.Uma kuqhathaniswa nesenzo esiqondile se-NMN sokukhiqiza i-NAD+, umphumela wenani elilinganayo le-NR ngokusobala uba buthaka kakhulu.
Kungani ungathathi i-NAD+?
I-NAD+ ayikwazi ukungeniswa ngokuqondile kumaseli ngokuphathwa ngomlomo ngenxa yesisindo sayo samangqamuzana eseqile.Isengezo se-NAD+ sitholwa kuphela ngokungenisa isandulela se-NAD+ yesisindo samangqamuzana amancane.
Kodwa-ke, i-NMN ingenziwa ibe imikhiqizo ehlukahlukene, okungaba amaphilisi, amaphilisi, noma ama-granules ngenxa yemvelo yayo encibilikayo.Ukuncibilika kwe-NMN emanzini ngu-35mg/ml.
Ngalo mqondo, i-NMN ingcono kakhulu kune-NAD+, futhi iqonde kakhulu kune-nicotinamide riboside.
Izinzuzo zeNicotinamide Mononucleotide
Imiphumela eyinhloko ye-NMN imi kanje:
- i-anti-oxidation
- Ukukhulula ukwehla ngokomzimba
- Ukulungiswa kwe-DNA
- Sekela imiphumela ye-neuroprotective
- Thuthukisa ukusebenza kwenhliziyo futhi uvikele inhliziyo
- Thuthukisa isimo seziguli ze-Alzheimer's
Isici esihluke kakhulu se-NMN ukuthi ingahlehlisa ukuguga futhi yelule impilo.
Imiphumela emibi yeNicotinamide Mononucleotide
Njengoba i-NMN okwamanje yenza ukuhlola kwezilwane kuphela, ukuhlola kwabantu ngezinga elikhulu akukakaqali, ngakho imiphumela engemihle enganqunywa ayikacaci.Kodwa-ke, ngokusho kwendlela yokusebenza ye-NMN, kungachazwa ukuthi iziguli ezinomdlavuza akufanele ziwuthathe ngangokunokwenzeka.Ngoba ukuguqulwa kwe-NMN kukhuthaza ukukhiqizwa kwe-NAD +, kuyilapho amangqamuzana omdlavuza ejwayela ukwenza kancane kancane imisebenzi yomzimba, ukwanda kwe-metabolism kungase kubangele ukusabalala kwamangqamuzana athile omdlavuza.
Uma usebenzisa izithako ze-nicotinamide nucleoside ezifana ne-NMN, ukusebenza kokuzivocavoca kungase kuthinteke.Emagundaneni, amagundane ajovwe ngezithako ze-NAD+ abonise ukusebenza okuncane kakhulu kuneqembu lawo lokulawula.
