Igama lomkhiqizo:I-Celastrol bulk powder

Umthombo we-Botanic:The God Vine(Tripterygium wilfordii hook.f)

I-CASNo:34157-83-0

Umbala: Impushana yekristalu ewolintshi ebomvu enephunga nokunambitha

Ukucaciswa:≥98% HPLC

I-GMOIsimo:GMO Mahhala

Ukupakisha: ku-25kgs fiber drums

Isitoreji: Gcina isitsha singavulwa endaweni epholile, eyomile, gwema ukukhanya okuqinile

Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqiza

I-Celastrol Powderisithako esisebenzayo ku-Tripterygii Radix, okuyimpande eyomile kanye ne-rhizome ye-God Vine.Kunezinhlobo ezine sezizonke, okuyileziI-Tripterygium wilfordii Hook.f, i-Tripterygium hypoglaucum Hutch, i-Tripterygium regelii Sprague et Takeda, kanye ne-Tripterygium forresti Dicls.

I-Diterpenoids: i-triptolide(cas no.38748-32-2), i-Tripdiolide( cas no.38647-10-8), njll.

Triterpenoids: Celastrol(cas no.34157-83-0), Wilforlide A(cas no.84104-71-2), njll.

Ama-Alkaloids:Wilforgine(cas no.37239-47-7), Wolverine (cas no.11088-09-8), wilforidine, njll.

I-Tripterygium iyi-pentazine triterpene etholakala ngokwemvelo e-Tripterygium wilfordii.Isebenza ngempumelelo ekwelapheni i-rheumatoid arthritis.I-Triptolide ivimbela i-proteasome ne-nuclear factor Kb ekusebenzeni.

I-Celastrol (i-Tripterin) iyi-proteasome inhibitor enemisebenzi elwa nokuvuvukala kanye ne-antioxidant.Ivimbela ngempumelelo futhi ngokukhethekileyo umsebenzi ofana ne-chymotrypsin we-20S proteasome nge-IC50 ka-2.5 μM.

I-Tripterine iyi-antioxidant enamandla futhi elwa nokuvuvukala.Kuyi-HSP90 inhibitor entsha (iphazamisa inkimbinkimbi ye-Hsp90/Cdc37), inemiphumela yokulwa nomdlavuza (i-anti-angiogenesis - ivimbela i-vascular endothelial growth factor receptor expression);i-antioxidant (ivimbela i-lipid peroxidation) nomsebenzi wokulwa nokuvuvukala (Ivimbela ukukhiqizwa kwe-iNOS nama-cytokines avuthayo)

BiologicalAumsebenzi:

I-Celastrol (Tripterin) ilawula phansi i-basal kanye ne-DNA-elimaza i-ejenti ebangelwa i-FANCD2 monoubiquitination, okulandelwa ukuwohloka kwamaprotheni.Ukwelashwa kwe-Celastrol kuqeda indawo yokuhlola ye-IR-induced G2 futhi kuthuthukisa umonakalo we-DNA owenziwe yizidakamizwa we-ICL kanye nemiphumela evimbelayo kumaseli omdlavuza wamaphaphu ngokuqeda i-FANCD2.I-Celastrol inemiphumela ebalulekile yokuvimbela kanye ne-apoptosis-inducing kumaseli e-DU145 akhuliswe ku-vitro ngendlela encike esikhathini kanye nomthamo.Umphumela womdlavuza we-Celastrol we-Prostate anti-prostate ngokwengxenye ungokulawula phansi izinga lokuvezwa kweziteshi ze-hERG kumaseli e-DU145, okuphakamisa ukuthi i-Celastrol ingaba isidakamizwa esingaba khona sokulwa nomdlavuza wendlala yesinye, futhi indlela yayo ingaba ukuvimba iziteshi ze-hERG.I-Celastrol ithuthukisa i-colitis yokuhlola kumagundane ashodayo we-IL-10 ngokuvimbela indlela yokusayina ye-PI3K/Akt/mTOR kanye nokulawula ukuzenzela komzimba.I-Celastrol inamandla okuvimbela umsebenzi we-cytochrome P450 futhi ingase ibangele ukusebenzisana kwamakhambi.I-Celastrol yenza i-apoptosis kumaseli e-TNBC, iphakamisa ukuthi i-apoptosis ingase ilamule ngokungasebenzi kahle kwe-mitochondrial kanye nendlela yokusayina ye-PI3K/Akt.I-Celastrol idala i-apoptosis kanye ne-autophagy ngokusebenzisa indlela yokusayina ye-ROS/JNK.I-Celastrol ivimbela ukufa kwe-dopaminergic neuron ku-Parkinson's disease ngokuvula i-apoptosis ye-mitochondrial.

Indima ye-Celastrol ku-chemosensitization yomdlavuza:

I-Chemotherapy isalokhu iyindlela yokwelapha eyinhloko yeziguli ezinomdlavuza.Kodwa-ke, i-chemotherapy ngokuvamile kufanele ihlanganiswe nezinye izidakamizwa ukuze kuncishiswe imiphumela emibi futhi kugwenywe ukumelana nemithi.Imikhiqizo yemvelo iya ngokuya isetshenziswa njengezindlela zokwelapha ezisizayo ngokuhambisana nemithi ekhona yokwelapha ngamakhemikhali ukuze kuthuthukiswe ukusebenza kahle kokwelashwa.Isibonelo esisodwa esithembisayo somuthi onjalo wemvelo inhlanganisela ye-triterpene ebizwa ngokuthi i-celastrol, engase ibe namandla amakhulu okusetshenziswa njengesivamisi samakhemikhali.Ekuqaleni ikhonjwe ku-Thunder God Vine, ilawula kabi ama-molecule e-oncogenic amaningi njenge-NF-κB, i-topoisomerase II, i-Akt/mTOR, i-HSP90, i-STAT3, ne-Notch-1.Lokhu kungaholela ekuphenduleni okulwa nokuvuvukala, kuvimbele ukukhula nokusinda kwesimila, futhi kuqede i-angiogenesis.Lesi sahluko sifingqa kafushane indima engaba khona ye-celastrol njenge-chemosensitizer kanye nezindlela eziyisisekelo zamangqamuzana ezixhumanisa imiphumela yayo ebikiwe ye-chemosensitizing kumdlavuza ohlukahlukene.