I-Lupeol powder 98%

I-Lupeol Powder 98% Isithombe Esifakiwe
  • I-Lupeol powder 98%

Incazelo emfushane:

I-Lupeol powder iyi-triterpene entsha yokudla.I-Lupeol iyisivimbeli esisha se-androgen receptor.

I-Lupeol (i-Clerodol; i-Monogynol B; i-Fagarasterol) iyi-pentacyclic triterpene esebenzayo ene-antioxidant, antitumor kanye nemisebenzi elwa nokuvuvukala.I-Lupeol iyi-androgen receptor inhibitor enamandla futhi ingasetshenziswa ocwaningweni lomdlavuza, ikakhulukazi kumdlavuza wendlala yesinye one-androgen-dependent phenotype (ADPC) kanye ne-castration-resistant phenotype (CRPC).


  • Intengo ye-FOB:US $0.5 - 2000 / KG
  • Inani elincane le-oda:1 KG
  • Ikhono Lokuhlinzeka:10000 KG/ngenyanga
  • Imbobo:SHANGHAI/BEIJING
  • Imigomo Yokukhokha:L/C,D/A,D/P,T/T
  • :
    • Landa njenge-PDF

    Imininingwane Yomkhiqizo

    Omaka bomkhiqizo

    Igama Lomkhiqizo:I-Lupeol Powder98%

    Umthombo we-Botanic:Umango, i-Acacia visco, i-Abronia villosa, ikhofi ye-Dandelion.

    I-CASNo:545-47-1

    Umbala:Okumhlophe kuya kokumhlopheimpushana enephunga sici nokunambitha

    Ukucaciswa:≥98% HPLC

    I-GMOIsimo:GMO Mahhala

    Ukupakisha: ku-25kgs fiber drums

    Isitoreji: Gcina isitsha singavulwa endaweni epholile, eyomile, gwema ukukhanya okuqinile

    Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqiza

    Umsebenzi Webhayoloji:

    I-Lupeol (i-Clerodol; i-Monogynol B; i-Fagarasterol) iyi-pentacyclic triterpenoid esebenzayo, ine-anti-oxidant, anti-mutagenic, anti-tumor kanye nomsebenzi wokulwa nokuvuvukala.I-Lupeol inamandlai-androgen receptor(AR) inhibitor futhi ingasetshenziselwaumdlavuzaucwaningo, ikakhulukazi i-prostateumdlavuzaye-androgen-dependent phenotype (ADPC) kanye ne-castration resistant phenotype (CRPC)[1].

     

    Ku-Vitro Ucwaningo:

    I-Lupeol iyisivimbeli se-AR esinamandla esingathuthukiswa njengesidakamizwa esingase silaphe umdlavuza wendlala yowesilisa (CaP).Ukwelashwa kwe-Lupeol (10–50 μM) ye-48 h kuholele ekuvinjweni kokukhula okuncike kumthamo wamaseli ancike ku-androgen-phenotype (ADPC), okuyi-LAPC4 namaseli e-LNCaP, ane-IC50 ye-15.9 kanye ne-17.3 μM, ngokulandelana.I-Lupeol iphinde yavimbela ukukhula kwe-22Rν_1 nge-IC50 ka-19.1 μM.Ngaphezu kwalokho, i-Lupeol ivimbele ukukhula kwamaseli e-C4-2b nge-IC50 ye-25 μM.I-Lupeol inamandla okuvimbela ukukhula kwamaseli e-CaP kokubili kwe-ADPC kanye ne-CRPC phenotypes.Ama-Androgens aziwa ngokuqhuba ukukhula kwamaseli e-CaP ngokwenza kusebenze i-AR[1]

     

    Ocwaningweni lwe-Vivo:

    I-Lupeol iyisidakamizwa esisebenzayo esinamandla okuvimbela i-tumorigenicity yamaseli e-CaP ku-vivo.Ingqikithi yamazinga e-PSA e-serum ejikelezayo (afihliwe ngamaseli e-tumor afakwe) alinganiswa ekupheleni kocwaningo ngosuku lwe-56. Ngosuku lwe-56 emva kokufakelwa, amazinga e-PSA asukela ku-11.95-12.79 ng/mL abonwa ezilwaneni zokulawula ezinezicubu ze-LNCaP kanye C4-2b izimila, ngokulandelana.Nokho, ozakwabo abalashwe i-Lupeol babonise amazinga ancishisiwe e-PSA e-serum asukela ku-4.25-7.09 ng/mL.Izicubu zesimila ezivela ezilwaneni ezilashwe nge-Lupeol zibonise amazinga ancishisiwe e-PSA e-serum uma kuqhathaniswa nezilawuli[1]

     

     

  • Okwedlule:
  • Olandelayo:

    • IMIKHIQIZO EHLOBANE