I-Neohesperidin Dihydrochalcone (NHDC)

I-NHDC esesimweni esimsulwa itholakala njengento emhlophe engafaniushukela oluyimpuphu.

Inhlanganisela cishe izikhathi eziyi-1500-1800 ezinobumnandi kunoshukela lapho kugxilwe khona embundwini;cishe izikhathi ezingama-340 ubumnandi kunoshukela isisindo-ngesisindo.Amandla ayo ngokwemvelo athintwa yizici ezifana nesicelo lapho isetshenziswa khona, kanye nepHyomkhiqizo.

Njengamanye amnandi kakhuluama-glycosides, njengei-glycyrrhizinnalabo abatholakala kui-stevia, Ukunambitheka okumnandi kwe-NHDC kuqala kancane kunoshukela futhi kuhlala emlonyeni isikhathi esithile.

Ngokungafanii-aspartame, i-NHDC izinzile emazingeni okushisa aphakeme kanye nezimo ezine-acidic noma eziyisisekelo, futhi ingasetshenziswa ezinhlelweni ezidinga impilo ende yeshalofu.I-NHDC ngokwayo ingahlala iphephile ekudleni kuze kube iminyaka emihlanu uma igcinwe ezimeni ezifanele.

Umkhiqizo waziwa kakhulu ngokuba nomthelela oqinile we-synergistic uma usetshenziswa ngokuhlangana neminyeama-sweeteners okwenziwanjengei-aspartame, i-saccharin, i-acesulfame potassium, futhii-cyclamate, kanye notshwala obushukela njengei-xylitol.Ukusetshenziswa kwe-NHDC kukhulisa imiphumela yalezi zinto ezinoshukela ezindaweni eziphansi kunalokho obekungadingeka;amanani amancane amanye ama-sweeteners ayadingeka.Lokhu kunikeza inzuzo yezindleko.

Iyini i-Neohesperidin dihydrochalcone?

I-Neohesperidin dihydrochalcone powder, eyaziwa nangokuthi i-Neohesperidin DC, i-Neo-DHC kanye ne-NHDC ngamafuphi, i-sweetener ethuthukisiwe ekhiqizwa i-neohesperidin.I-NHDC ibhekwa njenge-sweetener enamandla kakhulu, engenamsoco enokunambitheka okumnandi;kungaba ngcono ubumnandi kanye nekhwalithi zokupheka ezahlukene zokudla.

I-Neohesperidin dihydrochalcone iyinhlanganisela ecishe ibe mnandi izikhathi eziyi-1500-1800 kunoshukela embundwini futhi inesisindo esiphindwe izikhathi ezingama-340 kunoshukela.

I-Neohesperidin dihydrochalcone ivame ukusetshenziswa ezimbonini zezithasiselo zokudla kanye nesengezo sokudla.

Thola kanye nomthombo we-Neohesperidin dihydrochalcone

I-Neohesperidin dihydrochalcone yatholakala ngeminyaka yawo-1960s njengengxenye yoMnyango wase-US wephrojekthi yocwaningo lwezolimo ukuthola izindlela zokunciphisa ukubaba kwejusi yewolintshi.I-Neohesperidin iyisakhi esibabayo esikhona ecwecweni kanye ne-pulp yewolintshi elibabayo nezinye izithelo zewolintshi;futhi iyisithako se-flavonoid esisebenzayo sesithelo se-citrus aurantium.Uma iphathwa nge-potassium hydroxide noma esinye isisekelo esiqinile, bese i-hydrogenated, iba yi-Neohesperidin dihydrochalcone (NHDC).

I-NHDC ayenzeki ngokwemvelo.

I-Neo-DHC i-hydrogenated kusuka ku-neohesperidin yemvelo-umthombo wemvelo, kodwa ibe nokuguqulwa kwamakhemikhali, ngakho akuwona umkhiqizo wemvelo.

I-Neohesperidin dihydrochalcone VS amanye ama-sweeteners

Ubumnandi nokunambitheka okuhlukile

Uma iqhathaniswa ne-sucrose, i-neohesperidin DC icishe ibe mnandi izikhathi eziyi-1500-1800 kunoshukela futhi imnandi izikhathi eziyi-1,000 kune-sucrose, kuyilapho i-sucralose iyizikhathi ezingama-400-800 kanti i-ace-k imnandi izikhathi ezingama-200 kunoshukela.

I-Neohesperidin DC inambitheka ngokuhlanzekile futhi inokunambitha okude.Njengamanye ama-glycosides ashukela aphezulu, njenge-glycyrrhizin etholakala ku-stevia kanye nalawo asuka empandeni ye-licorice, ubumnandi be-NHDC buqala kancane kunoshukela futhi buhlala emlonyeni isikhathi eside.

Ukuzinza okuhle nokuphepha okuphezulu

I-NHDC izinzile ngaphansi kwezimo zokushisa eziphezulu, ezine-asidi noma ezine-alkaline ngakho-ke ingasetshenziswa ezinhlelweni ezidinga impilo yeshelufu ende.I-NHDC ingagcina ukudla kuphephile kuze kube iminyaka emihlanu ngaphansi kwezimo ezifanele

Ama-receptors ahlukene

Ukubona komuntu ubumnandi nokunambitheka kuqondiswa yi-T1Rs, umndeni wokuqala wama-GPCRs, ama-TIR aboniswa ngokuguquguquka kolwanga oluthambile nolimi, okuhlanganisa i-TIR1, T1R2, ne-TIR3, evame ukutholakala ngendlela yama-dimers.I-dimer T1R1-TIR3 iyisamukeli se-amino acid, esiveza futhi sibambe iqhaza ekuboneni ukunambitheka.I-dimer T1R2-T1R3 iyisamukeli esimnandi, esibamba iqhaza ekuqapheliseni ukunambitheka okumnandi.

Ama-sweeteners afana ne-sucrose, i-aspartame, i-saccharin, ne-cyclamate asebenza endaweni yesakhiwo esingaphandle kwe-T1R2.I-NHDC kanye ne-cyclamate benza engxenyeni ye-transmembrane ye-T1R3 ukukhiqiza ubumnandi.I-Neohesperidin DC isebenzisana nezinsalela ezithile ze-amino acid endaweni ye-transmembrane ye-T1R3 ukuze iveze ubumnandi bayo futhi ngesikhathi esifanayo, ingaheha umthelela we-synergistic sweetening we-dimer T1R2-T1R3.Njengesithako esimnandi, i-NHDC inomphumela obalulekile wokwenza ubumnandi uma ihlanganiswa nezinye izithako ezinoshukela ezinenani elincane lezithako.

Ngaphandle kwalokho, i-Neohesperidin DC ihlukile kuziswidi zendabuko emisebenzini yayo yokwenza uswidi, ukuthuthukisa iphunga, ukufihla umunyu, nokuguqula ukunambitheka.

Izinzuzo kanye nokusetshenziswa okungenzeka kwe-neohesperidin dihydrochalcone (NHDC)

Izakhiwo Ze-Antioxidant

Eminyakeni yamuva nje, ucwaningo oluningi lubonisa ukuthi i-neohesperidin dihydrochalcone inomsebenzi obalulekile wokuthungatha oncike ekugxiliseni kuma-radicals wamahhala azinzile kanye nezinhlobo ze-oxygen esebenzayo (ROS).Ikakhulukazi, i-NHDC inomphumela onamandla kakhulu wokuvimbela ku-H2O2 ne-HOCl.(izinga lokulahla le-HOCl ne-H2O2 lalingu-93.5% no-73.5% ngokulandelana)

Ngaphezu kwalokho, i-NHDC inganqanda ukuwohloka kwamaprotheni kanye nokuqhekeka kwe-plasmid DNA strand, futhi ivikele ukufa kwe-HIT-T15, i-HUVEC yeseli ekuhlaselweni kwe-HOCl.

I-NHDC inomsebenzi we-antioxidant ohlukile ngokumelene nama-radicals wamahhala ahlukahlukene.Umsebenzi we-antioxidant we-NHDC uhlanganisa nokuthi ungavimbela ngokwengxenye umphumela wokuba nsundu we-pigment deposition ebangelwa i-polyphenol oxidase, engavimbela futhi ngokuphawulekayo ukulawulwa kwe-matrix metalloproteinase (MMP-1) okubangelwa imisebe ye-infrared, ngaleyo ndlela ivikele isikhumba somuntu ukuguga ngaphambi kwesikhathi ngenxa yokuchayeka emisebeni ye-infrared.

Isicelo: I-NHDC ingaba isithasiselo esinamandla sokulwa nokumnyama kanye ne-ejenti emhlophe

Ushukela wegazi ophansi kanye ne-Cholesterol Ephansi

I-NHDC iyisishukela esisebenza kahle, esingenabo ubuthi, esinekhalori ephansi esenelisa isidingo sabantu sobumnandi futhi ngaleyo ndlela sinciphise ukudla okushukela.

Ucwaningo lwakamuva lubonise ukuthi i-NHDC ingavimbela i-α-amylase ezilwaneni ezincelisayo ngamazinga ahlukahlukene bese inciphisa ukumuncwa komzimba kashukela, ngaleyo ndlela yehlise ushukela osegazini, obaluleke kakhulu kwezokwelapha, ikakhulukazi ezigulini ezinesifo sikashukela.

Isicelo: I-NHDC ingasetshenziswa njengesishukela esingenashukela, esingenakhalori.Uma isetshenziswe ngendlela efanele, ingase ithathele indawo i-sucrose futhi inciphise ukudla kwe-sucrose yomuntu.Ilungele abantu abakhuluphele nabangakhuluphali.

Vikela isibindi

UZhang Shuo et al.ithole ukuthi i-NHDC inganciphisa amazinga e-ALT, i-AST ku-serum ne-hydroxyproline ezicutshini zesibindi zamagundane ane-fibrosis yesibindi ebangelwa i-CCI, futhi ibuye ibambezele ukuwohloka kanye ne-necrosis yamaseli kanye ne-fibrosis yesibindi ngamazinga ahlukahlukene.Ngaphezu kwalokho, ukwehla kwe-ALT ne-AST ku-serum kungathuthukisa i-lipid metabolism nokusebenza kwesibindi, kuvimbele ukwakheka kwesibindi esinamafutha kanye ne-endothelial plaque emithanjeni eyinhloko.

Ngaphandle kwalokho, i-NHDC ingadambisa ngempumelelo umonakalo owenziwe yi-CC1, yehlise ukuvuvukala, kanye ne-cell apoptosis.

Isicelo: I-NHDC inethemba lokuthi izosetshenziswa njenge-ejenti ye-hepatoprotective.

Vimbela isilonda esiswini

I-NHDC inganqanda ukukhishwa kwe-asidi esiswini, ngakho-ke ingasetshenziswa njenge-antacid ukuxuba ne-Aluminium Hydroxide Gel noma ezinye izinto ezivamile zokwenza i-asidi ukuze kuthuthukiswe ukumelana ne-asidi yesisu yakamuva.

Suhrez et al.ithole ukuthi i-NHDC inganciphisa kakhulu inkomba yezilonda ebangelwa ukucindezeleka okubandayo (CRS).Umsebenzi wayo uqhathaniswa ne-ranitidine, engavimbela umsebenzi we-histamine futhi inciphise kakhulu ukugcinwa kwe-gastric acid ne-pepsin.

Isicelo: I-NHDC ingase ibe into eluhlaza yomuthi wesisu.

Ukulawula ukungatheleleki

I-NHDC yengezwa ukuze idle njenge-sweetener, hhayi nje ngenxa yokunambitheka kwayo okumnandi kanye nesifiso sokudla kwesilwane, kodwa futhi ngenxa yomphumela wayo we-probiotic otholwe ngu-Daly et al.Lapho i-NHDC yengezwa ekuphakeleni kwezingulube, i-Lactobacillus ekungeneni kwe-caecum yamantshontsho engulube yanda kakhulu ngokwanda kokugxiliswa kwe-lactic acid emgodini wamathumbu.Kungathinta izitshalo zamathumbu e-symbiotic, ukulawula ukuzivikela komzimba, futhi kunciphise izifo zamathumbu.

Isicelo: I-Neohesperidin DC ingasetshenziswa njengesithasiselo sokuphakelayo, i-NHDC ithuthukisa ukunambitheka kwezinto zokudla, ikhulisa ukudla kwezilwane, futhi ithuthukise amagciwane amathumbu, bese ivuselela ukukhula kwawo.

Ukuphepha kwe-Neohesperidin DC

I-NHDC iyisishukela esingavundisi, esingabilisi.Ucwaningo olunamandla ngobuthi oselwenziwe.I-metabolism ye-NHDC emzimbeni womuntu iyafana neyamanye ama-flavonoid glycosides emvelo.I-NHDC ine-metabolism esheshayo, ayivuseleli umzimba womuntu, futhi ayikho imiphumela emibi enobuthi.

I-Neo-DHC ifakwe kungobo yomlando ku-European Pharmacopoeia emashumini amabili eminyaka edlule futhi yagunyazwa njenge-sweetener yi-European Union, kodwa hhayi i-FDA.E-United States, i-neo-DHC ivunyelwe kuphela ukusetshenziswa njengesithuthukisi ukunambitheka.Ngaphandle kwalokho, ukubhaliswa kwe-NHDC kwesimo se-GRAS ku-FDA kusendleleni.

Umthamo onconyiwe we-Neohesperidin dihydrochalcone (NHDC) kanye nemiphumela engemihle.

Kuma-dessert nemikhiqizo yobisi, umthamo: 10-35 ppm (i-sweetener), 1-5 ppm(i-flavour enhancer)

NgoMasking Wokumunyu Kwemithi, umthamo: 10-30 ppm(i-sweetener), 1-5 ppm(isithuthukisi ukunambitheka)

Ngokunambitheka kwesiphakeli, isilinganiso esiphezulu esinconywayo: 30-35 mg NHDC/kg okuphakelayo okuphelele, 5 mg NHDC/L amanzi;3-8 mg NHDC/L amanzi okumunca kanye nokulunyulwa

Izinhloso ezehlukene zinquma umthamo.

Kodwa-ke, uma kuthathwa ngokweqile, noma yisiphi isithako singase sibe yingozi emzimbeni womuntu.Ucwaningo luye lwabonisa ukuthi i-neohesperidin dihydrochalcone (NHDC) ingabangela isicanucanu kanye ne-migraine lapho ukugxila cishe ku-20 ppm noma ngaphezulu.Kunconywa ukuthi ugqoke imaski yokuhlinzwa lapho usebenza ne-NHDC emsulwa

Isitifiketi Sokuhlaziya