Igama: CDP-CHOLINE,CITICOLINE
Igama lekhemikhali: cytidine5'-diphosphatecholine
I-Molecular Formula:C14H26N4O11P2
CAS:987-78-0
Einecs NO:213-580-7
Isisindo sefomula: 488.33
Ukubukeka: Impushana emhlophe ivaliwe.
Ubumsulwa: 98%
Igama lekhemikhali: cytidine5'-diphosphatecholine
I-Molecular Formula:C14H26N4O11P2
CAS:987-78-0
Einecs NO:213-580-7
Isisindo sefomula: 488.33
Ukubukeka: Impushana emhlophe ivaliwe.
Ubumsulwa: 98%
I-Citicoline (INN), eyaziwa nangokuthi i-cytidine diphosphate-choline (CDP-Choline) noma i-cytidine 5′-diphosphocholine i-nootropic.Kuyinto ephakathi esizukulwaneni se-phosphatidylcholine kusuka ku-choline.
Ucwaningo luphakamisa ukuthi izithako ze-CDP-choline zandisa ukuminyana kwe-dopamine receptor, futhi ziphakamisa ukuthi i-CDP-choline supplementation isiza ukuvimbela ukukhubazeka kwenkumbulo okubangelwa izimo ezimbi zemvelo.Ucwaningo lokuqala luthole ukuthi izithako ze-citicoline zisiza ukuthuthukisa ukugxila namandla engqondo futhi zingase zibe usizo ekwelapheni ukuphazamiseka kokunaka.
I-Citicoline iphinde yaboniswa ukuthi iphakamisa i-ACTH ngokuzimela kumazinga e-CRH futhi ikhulise ukukhululwa kwamanye amahomoni e-axis e-HPA afana ne-LH, FSH, GH ne-TSH ekuphenduleni izici ezikhipha i-hypothalamic.Le miphumela kumazinga e-hormone ye-HPA ingase ibe nenzuzo kwabanye abantu kodwa ingase ibe nemiphumela engathandeki kulabo abanezimo zezokwelapha ezihlanganisa i-ACTH noma i-cortisol hypersecretion ehlanganisa i-PCOS, uhlobo lwesifo sikashukela sohlobo lwe-II kanye nesifo esikhulu sokucindezeleka.
Ucwaningo luphakamisa ukuthi izithako ze-CDP-choline zandisa ukuminyana kwe-dopamine receptor, futhi ziphakamisa ukuthi i-CDP-choline supplementation isiza ukuvimbela ukukhubazeka kwenkumbulo okubangelwa izimo ezimbi zemvelo.Ucwaningo lokuqala luthole ukuthi izithako ze-citicoline zisiza ukuthuthukisa ukugxila namandla engqondo futhi zingase zibe usizo ekwelapheni ukuphazamiseka kokunaka.
I-Citicoline iphinde yaboniswa ukuthi iphakamisa i-ACTH ngokuzimela kumazinga e-CRH futhi ikhulise ukukhululwa kwamanye amahomoni e-axis e-HPA afana ne-LH, FSH, GH ne-TSH ekuphenduleni izici ezikhipha i-hypothalamic.Le miphumela kumazinga e-hormone ye-HPA ingase ibe nenzuzo kwabanye abantu kodwa ingase ibe nemiphumela engathandeki kulabo abanezimo zezokwelapha ezihlanganisa i-ACTH noma i-cortisol hypersecretion ehlanganisa i-PCOS, uhlobo lwesifo sikashukela sohlobo lwe-II kanye nesifo esikhulu sokucindezeleka.
Isitifiketi Sokuhlaziya
| Ulwazi Lomkhiqizo | |
| Igama Lomkhiqizo: | I-Citicoline(CDP-Choline) |
| Inombolo ye-CAS: | 987-78-0 |
| Ifomula yamangqamuzana: | I-C14H26N4O11P2 |
| Inombolo yeqoqo. | I-TRB-CDP-20190620 |
| Idethi ye-MFG: | Juni 20, 2019 |
| Into | Ukucaciswa | Imiphumela Yokuhlola |
| Izithako Ezisebenzayo | ||
| I-Assay(%.Kusisekelo Omisiwe) | 98.0%~102.0% yi-HPLC | 100.30% |
| Ukulawula ngokomzimba | ||
| Ukubukeka | I-crystalline powder enhle | Iyahambisana |
| Umbala | Okumhlophe kuya kokumhlophe | Iyahambisana |
| Ukuhlonza | I-NMR | Iyahambisana |
| PH | 2.5~3.5 | 3.3 |
| Ukulahlekelwa Ekumisweni | 1.0% Ubukhulu | 0.041% |
| Amanzi | 1.0% Ubukhulu | 0.052% |
| 5'-CMP | I-NMT1.0% | 0.10% |
| Ukulawula Amakhemikhali | ||
| Izinsimbi ezinzima | I-NMT10PPM | Iyahambisana |
| I-Arsenic(As2O3) | I-NMT1PPM | Iyahambisana |
| I-Sulfate(SO4) | I-NMT 0.020% | Iyahambisana |
| Insimbi(Fe) | I-NMT10PPM | Iyahambisana |
| I-Chloride(Cl) | I-NMT 0.020% | Iyahambisana |
| I-Solvent Residual | Ukuhlangana ne-EU/USP Standard | Iyahambisana |
| I-Microbiological Control | ||
| Inani Lepuleti Eliphelele | 10,00cfu/g Ubukhulu | Iyahambisana |
| Imvubelo & Isikhunta | 100cfu/g Ubukhulu | Iyahambisana |
| E.Coli | Okubi/10g | Iyahambisana |
| I-Salmonella sp. | Okubi/25g | Iyahambisana |
| Staph Aureus | Okubi/10g | Iyahambisana |
| I-Pseudomonas aeruginosa | Okubi/25g | Iyahambisana |
| Ukupakisha kanye Nesitoreji | ||
| Ukupakisha | Pakisha izigubhu zephepha.25Kg/Drum 1Kg isikhwama sepulasitiki ngasinye | |
| Isitoreji | Gcina esitsheni esivalwe kahle kude nomswakama kanye nokukhanya kwelanga okuqondile. | |
| I-Shelf Life | Iminyaka engu-2 uma ivaliwe futhi igcinwe kahle. | |
| Olunye ulwazi lwe-TRB | ||
| Risitifiketi se-egulation | ||
| USFDA,CEP,KOSHER HALAL GMP ISO Izitifiketi | ||
| Ikhwalithi Ethembekile | ||
| Cishe iminyaka engama-20, ukuthekelisa amazwe nezifunda ezingama-40, amaqoqo angaphezu kuka-2000 akhiqizwa yi-TRB awanazo izinkinga zekhwalithi, inqubo yokuhlanza eyingqayizivele, ukungcola kanye nokulawula ubumsulwa kuhlangana ne-USP, EP kanye ne-CP | ||
| Comprehensive Quality System | ||
|
| ▲ Uhlelo Lokuqinisekisa Ikhwalithi | √ |
| ▲ Ukulawula idokhumenti | √ | |
| ▲ Uhlelo Lokuqinisekisa | √ | |
| ▲ Uhlelo Lokuqeqesha | √ | |
| ▲ Iphrothokholi Yokucwaninga Kwangaphakathi | √ | |
| ▲ Uhlelo Lokucwaningwa Kwama-Suppler | √ | |
| ▲ Uhlelo Lwezinsiza Zokusebenza | √ | |
| ▲ Uhlelo Lokulawula Okubalulekile | √ | |
| ▲ Uhlelo Lokulawula Ukukhiqiza | √ | |
| ▲ Uhlelo Lokufaka Amalebula Lokupakisha | √ | |
| ▲ Uhlelo Lokulawula Ilabhorethri | √ | |
| ▲ Uhlelo Lokuqinisekisa Ukuqinisekisa | √ | |
| ▲ Uhlelo Lwezindaba Zokulawula | √ | |
| Lawula Imithombo Yonke Nezinqubo | ||
| Ilawule ngokuqinile yonke impahla eluhlaza, izesekeli nezinto zokupakisha.Impahla esetshenziswayo ekhethwayo kanye nezinsiza kanye nempahla yokupakisha enenombolo yase-US DMF.Abahlinzeki bempahla eluhlaza abambalwa njengesiqiniseko sokuhlinzekwa. | ||
| Izikhungo Zokubambisana Eziqinile ezizokweseka | ||
| I-Institute of botany/Institution of microbiology/Academy of Science and Technology/University | ||
