I-Nicotinamide riboside chloride powder 99%

Igama lomkhiqizo:I-Nicotinamide riboside chloride powder
Elinye igama:3-(Aminocarbonyl)-1-PD-ribofuranosyl-pyridinium chloride(1 :1);Nicotinamide

I-Riboside.Cl;3-Carbamoyl-1-beta-D-ribofuranosyl-pyridinium chloride;I-NR, i-vitamin NR; i-Niagen, i-TRU NIAGEN

I-CASNO:23111-00-4
Ifomula yemolekyuli: C11H15N2O5.Cl
Isisindo samangqamuzana: 90.70 g/mol
Ubumsulwa: 98%
Indawo Encibilikayo:115℃-125℃

Ukubukeka:Kucishiwe Okumhlophe Kuya Kumpushana Ophuzi Okuphaphathekile
Sebenzisa:Inyusa amazinga e-NAD+, Isekela Ukuguga okunempilo kanye nobuchopho/ukuqonda

Izicelo: njengesengezo sokudla, ukudla okusebenzayo, neziphuzo

Umthamo onconyiwe: ungabi ngaphezu kwe-180 mg / ngosuku

I-Nicotinamide riboside iwuhlobo olusanda kwaziswa lwe-Vitamin B3, olunezici eziyingqayizivele;iyisandulela esisemthethweni se-NAD+.

I-Nicotinamide riboside (NR), eyaqala ukuchazwa ngo-1944 njengento yokukhula (Factor V) yomkhuhlane we-Haemophilus, kwathi ngo-1951, i-NR, yaqale yaphenywa njengesiphetho se-metabolic ezicutshini ezincelisayo.

Njengoba ungase uqaphele ukuthi, kunezinhlobo ezimbili ze-NR ezitholakalayo, eyodwa i-Nicotinamide Riboside, kanti enye i-Nicotinamide Riboside chloride.

Uma sikhuluma ngamakhemikhali, ziyizinhlanganisela ezimbili ezihluke ngokuphelele njengoba zinezinombolo ze-CAS ezihlukene, i-NR ene-1341-23-7 kuyilapho i-NR chloride ene-23111-00-4.I-NR ayizinzile ekamelweni lokushisa, kuyilapho i-NR chloride izinzile.I-Brand enelungelo lobunikazi edumile ebizwa nge-NIAGEN®, eyakhishwa yi-Chromadex Inc ngo-2013, iwuhlobo lwe-Nicotinamide riboside chloride, okuhloswe ngayo ukubuyisela emuva izimpawu zokuguga ngaphakathi emzimbeni wakho.I-Nicotinamide Riboside ekhiqizwe kwa-Cima Science nayo ikwifomu le-chloride powder.Uma kungacacisiwe, i-NR izobhekisela efomini le-NR chloride esihlokweni esingezansi.

Imithombo yokudla ye-Nicotinamide riboside

Inani le-NR ekudleni liyiminithi, uma liqhathaniswa nalelo kwizithako zokudla okunomsoco.Nokho, yimiphi imithombo yokudla eyinhloko equkethe i-nicotinamide riboside (NR)?

Ubisi lwenkomo

Ubisi lwenkomo ngokuvamile luba no-~12 μmol NAD(+) amavithamini/L owandulelayo, lapho u-60% wawukhona njenge-nicotinamide, futhi u-40% wawungamanje njenge-NR.(Ubisi olujwayelekile luqukethe i-NR eningi kunobisi oluphilayo), ucwaningo olwanyatheliswa yi-University of Iowa, ngo-2016

Imvubelo

Ucwaningo oludala luye lwathi, "Into eyodwa evimbelayo yahlukaniswa imvubelo futhi kwatholakala ukuthi i-nicotinamide riboside, okungenzeka ukuthi yayisuka ku-NAD (P) ngesikhathi sokulungiswa kwe-yeast extracts, noma kusukela kuzithako zokudla imvubelo ngesikhathi sokugaya ku-vivo."Ngenkathi ingekho idatha yobuningi kumvubelo

Ubhiya

Ubhiya unenani elifanele lama-carbohydrate futhi ukuphuza lawo asesimweni esiwuketshezi njengalokho kuzoba nomthelela we-glycemic;amaphepha ahlukahlukene ocwaningo akhulume ngobhiya njengomthombo wokudla we-nicotinamide riboside.

Futhi, kungase kube namanani omkhondo we-NR afana ne-whey protein, amakhowe, njll.

Kubantu abaningi, ubisi aluvunyelwe ngenxa yezinye izizathu.Imithombo yokudla ye-nicotinamide riboside ingase ibe usizo, kodwa ayisebenzi kahle kunesengezo se-NR.

Kungani iNicotinamide Riboside (NR) iqoka njenge-NAD+ eyiqiniso eyandulela ama-invertebrates amavithamini?

Kunemigqa emihlanu yokucabanga esekela lokhu:

I-Haemophilus influenza, igciwane elibanga umkhuhlane, elingenayo indlela ye-de novo futhi elingakwazi ukusebenzisa i-Na noma i-Nam, lincike kakhulu ku-NR, NMN, noma i-NAD+ ukuze likhule egazini lomsingathi.

Ubisi luwumthombo we-NR.

I-NR ivikela ama-neuron e-murine e-DRG ekuhlolweni kwe-ex vivo axonopathy ngokusebenzisa ukufakwa okubhaliwe kofuzo lwe-nicotinamide riboside kinase (NRK) 2.

I-NR engezwe ngokudlulele kanye nokuphuma kokunye kukhuphula ukunqwabelana kwe-NAD+ ngendlela encike kumthamo emigqeni yamaseli womuntu.

I-Candida glabrata, ukhunta olungosomathuba oluncike kumavithamini owandulela i-NAD+ ukuze lukhule, lisebenzisa i-NR ngesikhathi sokutheleleka okusatshalaliswayo.

I-Nicotinamide Riboside VS Nicotinamide VS Niacin

I-Niacin (noma i-nicotinic acid), iyinhlanganisela yezinto eziphilayo kanye nohlobo lukavithamini B3, isakhi esibalulekile somuntu.Inefomula ethi C6H5NO2.

I-Nicotinamide noma ebizwa ngokuthi i-niacinamide iwuhlobo lukavithamini B3 olutholakala ekudleni futhi lusetshenziswa njengesengezo sokudla kanye nemithi.Inefomula ethi C6H6N2O.

I-Nicotinamide riboside iwuhlobo lwe-pyridine-nucleoside kavithamini B3 esebenza njengesandulela se-nicotinamide adenine dinucleotide noma i-NAD+.Inefomula ethi C11H15N2O5+.

I-Nicotinamide Riboside Izinzuzo Zezempilo

INicotinamide Riboside isiza ukukhiqizwa kwamandla

Ezilwaneni, ukwesekwa kwe-NR kunciphise ukusetshenziswa kwe-NAD, okuthuthukise ukusebenza kwe-mitochondrial, ukuvuselelwa kwemisipha esheshayo, nokugcina amazinga e-NAD amandla kanye nomthamo wokuzivocavoca kumagundane amadala, okusiza ukugcina imisipha nokusebenza, kusekela ukukhiqizwa kwamandla amaningi.

I-Nicotinamide Riboside ithuthukisa ukusebenza kwengqondo

I-NR igcina amangqamuzana ezinzwa ebuchosheni ngokwenza kusebenze i-SIRT3, Ukwengeza kuvuselela izindlela ze-NAD futhi kusiza ukuvimbela ukonakala engqondweni.

I-NR ithuthukise ukusebenza kwengqondo futhi yehlisa ukuqhubeka kwesifo i-Alzheimer's kumagundane anikezwe i-NR izinyanga ezintathu.

I-Nicotinamide Riboside ivimbela ukungezwa

Ngokuvula indlela ye-SIRT3, ucwaningo lwe-UNC lwathola ukuthi lusize ukuvikela amagundane ekulahlekelweni kokuzwa okubangelwa umsindo.

INicotinamide Riboside ivikela isibindi

I-NR ethathwe ngomlomo inyusa i-NAD emzimbeni, esiza ukuvikela isibindi.I-NR yayeka ukunqwabelana kwamafutha, yehlisa ingcindezi ye-oxidative, yavimbela ukuvuvukala, futhi yathuthukisa ukuzwela kwe-insulin esibindini samagundane.

Ngaphezu kwalokho, i-NR inganweba isikhathi eside, Ikhuphule imetabolism, isekele ukulwa nomdlavuza, inciphise izimpawu zesifo sikashukela, ikhulise imetabolism, ingasiza ekwehleni kwesisindo.

Ingabe iNicotinamide Riboside Iphephile?

Yebo, i-NR iphephile.

I-NR inezinhlolo zomtholampilo ezishicilelwe ezintathu eziqinisekisa ukuthi iphephile ukusetshenziswa abantu.

Ukuhlaziya ngokucophelela futhi kugcizelele yonke imininingwane yomtholampilo kanye neyomtholampilo etholakala ku-NR kuqinisekisa ukuthi iphephile futhi ibekezelelwa kahle.

I-Niagen iphephile futhi i-GRAS, isebenzisa izinqubo zesayensi, ngaphansi kwe-Federal Food, Drug, and Cosmetic Act (FFDCA).

I-Nicotinamide Riboside Human Trials

Kunezifundo eziningi zangaphambi komtholampilo ezenziwe zahlola i-NR ezinhlelweni zamamodeli ahlukahlukene.

Ngo-2015, izifundo zokuqala zemitholampilo yabantu zaqedwa, futhi imiphumela yabonisa ukuthi i-NR ikhuphula ngokuphepha nangempumelelo amazinga e-NAD kumavolontiya angabantu abanempilo.

Isilingo somtholampilo esilawulwa yi-placebo se-nicotinamide riboside emadodeni akhuluphele ngokungahleliwe: ukuphepha, ukuzwela kwe-insulin, kanye nemiphumela yokuhlanganisa i-lipid.

-Ishicilelwe ku-American/Journal of Clinical Nutrition

Imiphumela: I-12 wk ye-NR supplementation kumithamo ye-2000 mg/d ibonakala iphephile, kodwa ayithuthukisi ukuzwela kwe-insulin kanye ne-glucose metabolism yomzimba wonke emadodeni akhuluphele, amelana ne-insulin.

Ukwengezwa okungapheli kwe-nicotinamide riboside kubekezelelwa kahle futhi kuphakamisa i-NAD+ kubantu abadala abanempilo ephakathi nendawo nabadala.

-Ishicilelwe ku-Nature Communications

I-Nicotinamide Riboside Itholakala Ngokukhethekile futhi Ngomlomo Kumagundane nakubantu.

-Ishicilelwe ku-Nature Communications

Lapha sichaza isikhathi nemiphumela encike kumthamo we-NR egazini le-NAD metabolism kubantu.Umbiko ukhombisa ukuthi igazi lomuntu i-NAD lingakhuphuka lize liphindwe izikhathi ezingama-2.7 ngomthamo owodwa womlomo we-NR ocwaningweni lomshayeli womuntu oyedwa nokuthi i-NR yomlomo iphakamisa i-NAD ye-hepatic yegundane ngekhemisi ebonakalayo futhi ephakeme.