I-Phosphatidylcholine iqukethe "ikhanda" le-choline kanye ne-glycerol phospholipids.Umsila we-glycerol phospholipids ungaba izinhlobonhlobo zamafutha acid.Ngokuvamile, umsila owodwa ugcwele i-asidi yamafutha, omunye u-unsaturated fatty acid.Kodwa amanye awo womabili angama-unsaturated fatty acids.Isibonelo, i-phosphatidylcholine yamaphaphu esilwane inenani eliphakeme le-dipalmitoyl phosphatidylcholine.
Igama lomkhiqizo: Phosphatidylcholine PC
Elinye Igama:1,2-diacyl-sn-glycero-3-phosphocholine, PC
Ukucaciswa komkhiqizo: Uketshezi / noma okuqinile kwe-waxy: cishe ama-60%
I-Powder / Granule: 10% - 98%,Imininingwane edumile 20%, 50%, 98%
Isampula yamahhala :Iyatholakala
Ukubukeka: Impushana ephuzi noma ephuzi ngokukhanyayo, amafutha noma okuqinile
Indlela Yokuhlola:HPLC
Impilo yeshelufu: iminyaka emi-2
I-Phosphatidylcholine iqukethe "ikhanda" le-choline kanye ne-glycerol phospholipids.Umsila we-glycerol phospholipids ungaba izinhlobonhlobo zamafutha acid.Ngokuvamile, umsila owodwa ugcwele i-asidi yamafutha, omunye u-unsaturated fatty acid.Kodwa amanye awo womabili angama-unsaturated fatty acids.Isibonelo, i-phosphatidylcholine yamaphaphu esilwane inenani eliphakeme le-dipalmitoyl phosphatidylcholine.
I-Phosphatidylcholine iyisici esiyinhloko se-biofilms.Umthombo ulula kakhulu futhi ubanzi.Ungathola i-phosphatidylcholine cishe kunoma yikuphi ukudla empilweni yakho, hhayi nje isikhuphasha seqanda noma ubhontshisi wesoya.Iphinde ibe yi-lecithin emafutheni ezilwane.Ungathola i-phosphatidylcholine ezicutshini zezitshalo nezilwane.Yiqiniso, ukukhiqizwa kwezentengiselwano kwe-phosphatidylcholine kuwumkhiqizo ohlanziwe onokuqukethwe okuphezulu kanye nomphumela oqondile.
I-Phosphatidylcholine iyi-lipophilic hydrophilic substance;utshwala obuphansi obuncibilikayo ku-C1 kuye ku-C4, obungancibiliki ku-acetone nasemanzini.
Nakuba ama-PC ngokuvamile esetshenziselwa ukusekela impilo yobuchopho, angakwazi futhi ukusekela ukusebenza kwesibindi nokulawula amazinga e-cholesterol.
I-Choline inganqamula umgoqo wegazi nobuchopho kalula kakhulu ngohlelo lokusabalalisa olungagcwele unsaturated, futhi lezi zinguquko ze-plasma zingaveza izinguquko ezifanayo emazingeni e-choline yobuchopho.
Ngenxa yokuguqulwa okunganele kwenqubo yokuguqulwa kwe-choline, engagcwaliswa ngokugcwele yi-choline substrate, okuqukethwe kwe-choline ku-plasma kuyanda, okukhuthaza ukwakheka kwe-acetylcholine ne-phosphorylcholine nokukhululwa kwe-acetylcholine.Uma okuqukethwe kwamanye ama-precursors we-phosphatidylcholine kwanda, inqubo yokuguqulwa kwe-choline ku-phosphatidylcholine kanye nokwanda kokuqukethwe kwe-peas kuyanda.Izinga le-synaptic membranes ebuchosheni liyakhula.I-Choline igaywe i-betaine esibindini, okuyindlela enkulu yokuvuselelwa kabusha kwe-methionine ne-S-adenosylmethionine ukuhlinzeka ngeqembu le-methyl.
Iningi le-metabolism yesibindi lenzeka kulwelwesi lweseli oluthatha amamitha-skwele angama-33,000 womzimba womuntu.
Kukhona iminyaka engaphezu kwengu-20 yokuhlolwa komtholampilo okubonisiwe ukuthi i-PC ivikela isibindi emiphumeleni eminingi enobuthi elimaza ulwelwesi lwamangqamuzana, njengokudakwa ngokweqile, izidakamizwa, izinto ezingcolisayo, amagciwane kanye neminye imiphumela enobuthi.
Esinye isisetshenziswa se-PC siyingxenye eyinhloko ye-membrane yeseli namaphaphu, ethutha phakathi kwe-cell membrane nge-phosphatidylcholine transfer protein (PCTP).Iphinde ibambe iqhaza ekudluliselweni kwesignali yeseli ye-membrane kanye nokusebenza kwe-PCTP kwamanye ama-enzyme.
Kukhona iphuzu elididayo lapha.I-Lecithin ayiyona i-phosphatidylcholine.I-Phosphatidylcholine iyisakhi esibalulekile se-lecithin.
Izinzuzo ze-phosphatidylcholine
Vikela isibindi ekulimazeni
Ukuthuthukisa Umsebenzi Wokuqonda
Ukuvimbela imiphumela emibi yezidakamizwa
Umphumela womlingo wokulwa nokuguga wengezwe ezimonyoni
Ukuwohloka kwe-lipid
Ukubhekana ne-ulcerative colitis
Ngokwenani elikhulu lokuhlolwa kwezilwane, ukwesekwa kwe-PC kungandisa i-acetylcholine (i-neurotransmitter ebuchosheni), okuyisilinganiso esibalulekile sokuthuthukisa inkumbulo.Ucwaningo olwengeziwe luyaqhubeka ukubona imiphumela ye-PC nezinye izakhi ekuthuthukiseni inkumbulo kumagundane okuwohloka komqondo.Kuyaziwa ukuthi i-PC nezinye izakhi zinemiphumela ethile emihle nemiphumela ephumelelayo, kodwa ukuhlolwa okwengeziwe kuyadingeka.Ngokujulile, ngo-2017, kwakukhona izifundo ezihlobene namazinga we-phosphatidylcholine nesifo se-Alzheimer's.
Isibindi siyisitho esibalulekile emzimbeni womuntu, futhi eminye imisebenzi ekuphileni kwansuku zonke ingabangela umthwalo omkhulu esibindini, esivamile esibindini esinamafutha kanye ne-cirrhosis.
Ukudla okunamafutha amaningi kungaba nomthelela omubi esibindini.Yiqiniso, isibindi singase sonakaliswe ubuthi botshwala, izidakamizwa, ukungcola, amagciwane, neminye imiphumela enobuthi, futhi ukulungisa kunzima kakhulu.Eminyakeni engu-20 edlule yokuhlolwa komtholampilo, ukutholakala kwe-phosphatidylcholine akuzange kudlale indima ebalulekile enqubweni yokulondoloza impilo.Kungashiwo ukuthi umphumela awugculisi neze, kodwa njengoba i-sildenafil ekuqaleni yayiklanyelwe ukwenza umuthi wokwelapha inhliziyo, eminye imiphumela yatholakala ezingxenyeni zohlelo lwesilingo.Ngokuhlaziya ngokucophelela, singathola umphumela ovikelayo we-PC esibindini ngokuya ngokungena kwe-phosphatidylcholine kanye nomphumela wayo wokuvikela kulwelwesi lweseli.Njengoba ingakwazi ukulungiswa, ingavikelwa kusengaphambili, okuyindima enkulu ye-phosphatidylcholine.
Nakuba i-phosphatidylcholine isetshenziswa njengesengezo sokudla okunomsoco wokuphuza ngomlomo, ayiphazamisi izici zayo ezihlukahlukene.Ngokusho kwezakhiwo zayo ezikhethekile ezingokwenyama nezezinto eziphilayo, zingangena kalula esikhumbeni futhi zikhulise ukungena kweminye imikhiqizo.Ngakho-ke, abakhiqizi abaningi bazimisele kakhulu ukusebenzisa i-phosphatidylcholine kumakhilimu abo okunakekelwa kwesikhumba angaphandle ukuze benze izikhumba ezibushelelezi nezimanzi.I-Phosphatidylcholine iphinde yabonisa imiphumela emihle kakhulu ekwelapheni izinduna, ngokuncipha kwesimo sezulu ngamaphesenti angama-70 ngemuva kwezinsuku ezingama-28.
I-Phosphatidylcholine iyingqamuzana ebalulekile yezinto eziphilayo engatholakala kuwo wonke amangqamuzana omzimba womuntu.Abanye ososayensi baye bazama amagundane ashintshwe izakhi zofuzo ukuze akhiqize umonakalo we-oxidative futhi asheshise ukuguga ukuze afunde imiphumela ye-phosphatidylcholine ekugugeni, ukuthuthukiswa kwengqondo kanye nokuthuthukiswa kwenkumbulo ezigulini ze-Alzheimer's.Yiqiniso, abanye ososayensi bakholelwa ukuthi ukwesekwa kwe-phosphatidylcholine ukwelapha isifo se-Alzheimer akuzange kube nobufakazi obanele.Kodwa ijubane lokudala umhlaba ngaphandle kwe-Alzheimer alikwazi ukuma.Yiqiniso, asikwazi ukuhoxisa ukuthi kungenzeka ukuthi i-phosphatidylcholine inendima, kodwa sidinga ukuhlolwa okwengeziwe nokukhudlwana ukufakazela indima yayo ethile.
Imiphumela emibi ye-phosphatidylcholine
Ikakhulukazi ibonakala esicini sezokwelapha, imikhiqizo equkethe i-PC yezinga lokudla ingathathwa ngokulandela imiyalelo;uma isetshenziswa kwezokwelapha, kufanele ilandele ngokuqinile imiyalelo yodokotela kanye nabakhiqizi bezidakamizwa zokusetshenziswa kwezidakamizwa.Ukuze ugweme lezi zingozi zemiphumela emibi, kuqala ngethamo eliphansi kakhulu, umthamo omkhulu ufinyelelwa kancane kancane.
I-PC yomlomo ingase iholele ekujulukeni ngokweqile.Ukuphuza ngaphezu kwamagremu angu-30 ngosuku kungase kubangele isifo sohudo, isicanucanu, noma ukuhlanza.
Ukujova i-PC ngokuqondile emathunjini amafutha kungase kuholele ekuvuvukeni okukhulu noma i-fibrosis.Kungase futhi kuholele ebuhlungwini, ekushiseni, ekulunyweni, ekuqineni kwegazi, edema, nokuba bomvu kwesikhumba
Izithako ze-PC zingasetshenziswa ku-capsule kanye nefomu eliwuketshezi ngaphandle kwencwadi kadokotela.Zibhekwa njengeziphephile uma zisetshenziswe isikhathi esifushane njengoba kuqondiswe.Umjovo we-PC kumele ulawulwe ochwepheshe bezempilo.
