I-Pyrroloquinoline Quinone disodium Salt(PQQ)

I-Pyrroloquinoline quinone (PQQ), eyaziwa nangokuthi i-Methoxy Platinum, iyi-cofactor ye-redox.Itholakala enhlabathini, i-kiwifruit, ukudla, nobisi lwebele lomuntu.Uma sikhuluma ngokuqondile, igama elithi “pyrroloquinoline quinone” alikho kahle, ngakho-ke abantu abaningi bakhetha ukusebenzisa isifinyezo esithi PQQ.Ijenali yesayensi i-Nature yashicilela iphepha likaKasahara noKato ngo-2003, elalibheka i-PQQ ivithamini entsha.Kodwa-ke, ngemuva kokuqhubeka ngocwaningo lwe-pyrroloquinoline quinone, abacwaningi banqume ukuthi nakuba inezinto ezifana ne-vitamin, iwumzimba ohlobene kuphela.I-PQQ ingasetshenziswa njenge-co-factor noma umgqugquzeli we-enzymatic kunqubo ye-redox.I-PQQ inomphumela othize we-antioxidant ngenxa yokubamba iqhaza kwayo ku-redox.

Igama Lomkhiqizo:I-Pyrroloquinoline Quinone Disodium Usawoti

Inombolo ye-CAS: 122628-50-6/ 72909-34-3

Isisindo samangqamuzana: 374.17/ 330.21

I-Molecular Formula: C14H4N2Na2O8/ C14H6N2O8

Ukucaciswa:PQQ Disodium Salt 99%;PQQ Acid 99%

Ukubukeka: Owolintshi obomvu ukuya ku-Reddish Brown Fine Powder.

Isicelo: Isetshenziselwa kakhulu isithasiselo sokudla kanye ne-nutraceuticals.

Isitoreji: Igcinwe endaweni ekhululekile futhi eyomile, balekela ilanga eliqondile.

I-Quinone ye-Pyrroloquinolineimithombo yokudla

I-PQQ ngokwemvelo ikhona ekudleni okuningi kwemifino, izithelo, nemifino (umkhondo), futhi amazinga aphezulu we-PQQ angatholwa emikhiqizweni kabhontshisi wesoya, njenge-kiwifruit, i-lychee, ubhontshisi oluhlaza, i-tofu, imbewu ye-rapese, isinaphi, itiye eliluhlaza (camellia) , upelepele oluhlaza, isipinashi, njll.

G.U-Haug uthole ukuthi kwakuyi-cofactor yesithathu ye-redox kubhaktheriya ngemva kwe-nicotinamide ne-flavin (nakuba ayecabanga ukuthi kwakuyi-naphthoquinone).U-Anthony no-Zatman baphinde bathola ama-cofactors e-redox angaziwa ku-ethanol dehydrogenase.Ngo-1979, u-Salisbury nozakwabo kanye no-Duine nozakwabo bakhipha lesi sisekelo mbumbulu ku-methanol dehydrogenase ye-dinoflagellate futhi bahlonza isakhiwo sayo samangqamuzana.U-Adachi nozakwabo bathola ukuthi i-Acetobacter nayo iqukethe i-PQQ.

Indlela yokwenza yePyrroloquinoline Quinone

I-Pyrroloquinoline quinone (PQQ) iyingqamuzana elincane le-quinone, elinomphumela we-redox, linganciphisa i-oxidant (antioxidant);bese ibuyiselwa esimweni esisebenzayo nge-glutathione.Ibukeka izinzile ngoba ingadlula izinkulungwane zemijikelezo ngaphambi kokuncipha, futhi yintsha ngoba ihlobene nokwakheka kwamaprotheni amaseli (amanye ama-antioxidants, ama-carotenoid amakhulu njenge-beta-carotene ne-astaxanthin, atholakala ezindaweni ezithile zamaseli, lapho badlala khona izindima eziningi ze-antioxidant ngokulinganayo).Ngenxa yokusondelana, i-PQQ ibonakala idlala indima eduze kwamaprotheni anjenge-carotenoid kulwelwesi lwamaseli.

Le misebenzi ye-redox ingashintsha imisebenzi yamaprotheni kanye nezindlela zokudlulisela isignali.Yize kunezifundo eziningi ezithembisayo ku-vitro (amamodeli aphilayo angaphandle), eminye imiphumela ethembisayo yokwengeza i-PQQ ihlobene kakhulu nokuguqula ezinye izindlela zokudlulisa amasignali noma izinzuzo zazo zibe yi-mitochondria.(Khiqiza okwengeziwe futhi uthuthukise ukusebenza kahle).

Kuyi-coenzyme kubhaktheriya (ngakho kubhaktheriya, kufana namavithamini B), kodwa akubonakali kudlulele kubantu.Njengoba lokhu kungasebenzi kubantu, isihloko sango-2003 ku-Nature, iphephabhuku lesayensi, sithi umbono wokuthi i-PQ iyinhlanganisela yamavithamini usuphelelwe yisikhathi futhi ubhekwa “njengento efana ne-vitamin.”

Mhlawumbe okuphawuleka kakhulu umphumela we-PQQ ku-mitochondria, enikeza amandla (ATP) futhi ilawule umzimba weseli.Abacwaningi bawubone kakhulu umthelela we-PPQ ku-mitochondria futhi bathola ukuthi i-PQQ ingakhuphula inani le-mitochondria futhi ithuthukise nokusebenza kahle kwe-mitochondria.Lesi yisizathu esibalulekile esenza i-PPQ isebenziseke kangaka.Ama-enzyme aqukethe i-PQQ aziwa njenge-glucose dehydrogenase, iphrotheni ye-quinoa esetshenziswa njengenzwa ye-glucose.

Izinzuzo ze-Pyrroloquinoline Quinone

Ukuba ne-mitochondria ngesikhathi esihle kakhulu kubaluleke kakhulu empilweni enempilo kangangokuthi ungathola izinzuzo eziningi ngenkathi uthatha i-ppq.Nazi ezinye zezinzuzo eziphawuleka kakhulu nge-pyrroloquinoline quinone.

Ukwandisa Amandla Eseli

Ngenxa yokuthi i-mitochondria ikhiqiza amandla amangqamuzana, futhi i-PQQ isiza i-mitochondria ukuthi isebenze ngokuphumelelayo, amandla kumaseli akhula ewonke;lena indlela ye-Pyrroloquinoline Quinone mitochondrial.Amandla eselula angasetshenzisiwe adluliselwa kwezinye izingxenye zomzimba.Uma umzimba wakho ungenamandla usuku lonke, noma uzizwa ukhathele noma wozela, khona-ke amandla akhulayo e-PPQ abalulekile kuwe.Olunye ucwaningo lwathola ukuthi ngemva kokuthatha i-PQQ, izifundo ezinezinkinga zamandla ezibikiwe zazinamazinga aphansi kakhulu okukhathala.Uma ufuna okuthile okungakhulisa amandla akho, i-PQQ ingasiza ngalokho.

Ukuvimbela ukwehla kwengqondo

Ngokuthuthuka kwesayensi, ososayensi bathole ukuthi i-nerve growth factor (NGF) ingakhula futhi ilulame.Ngesikhathi esifanayo, i-PQQ iboniswe ukuthi inomthelela omuhle ku-NGF futhi yandisa ukukhula kwezinzwa ngezikhathi ze-40.I-NGF ibalulekile ekwakhekeni nasekugcinweni kwama-neuron amasha, futhi ingabuyisela ama-neuron awonakele angase avimbele ukusebenza kwengqondo.Ama-Neurons amangqamuzana adlulisa ulwazi, ngakho ubuchopho bethu bungakwazi ukuxhumana phakathi kwabo nezinye izingxenye zomzimba.Ukuthuthukisa ikhwalithi nenani lama-neurons kungathuthukisa ukuqonda.Ngakho-ke, i-PQQ inokuthuthukiswa kwesikhashana.

Ukusekela impilo yenhliziyo nemithambo yegazi

I-Pyrroloquinoline quinine inikeza ukwesekwa kwe-antioxidant ne-mitochondrial.Ucwaningo luye lwabonisa ukuthi kokubili i-PQQ ne-CoQ10 isekela ukusebenza kwe-myocardial kanye nokusetshenziswa okufanele komoyampilo weselula.I-Pyrroloquinoline quinone ivimbela ingcindezi ye-oxidative ngokuvuselelwa kwayo.

Okunye Ukusebenza:

Ngaphandle kwezinzuzo ezintathu eziyinhloko ezibalwe ngenhla, i-PQQ inikeza ezinye izinzuzo ezingaziwa kakhulu.I-PQQ ingase ibambe iqhaza ekwehliseni ukuvuvukala komzimba, ithuthukise ukulala kwakho futhi ithuthukise inzalo, kodwa ucwaningo olwengeziwe luyadingeka ukuze kufinyelelwe eziphethweni eziqinisekile.Njengoba ucwaningo luqhubeka, izinzuzo ezengeziwe zokuthatha i-PQQ zingatholwa.

Umthamo we-Pyrroloquinoline Quinone

Njengamanje, akekho uhulumeni noma i-WHO ebeke umthamo we-pyrroloquinoline quinone.Kodwa-ke, abanye abantu nezikhungo benze izivivinyo eziningi zebhayoloji kanye nokuhlolwa kwabantu ngesilinganiso esifanele se-pyrroloquinoline quinone powder.Ngokubheka nokuqhathanisa ukusebenza ngokomzimba kwezifundo, kuphetha ngokuthi umthamo ophelele we-PQQ ngu-20 mg-50 mg.Njalo dlulisela udokotela wakho uma kukhona imibuzo esalindile.Okufana ne-biopqq pyrroloquinoline quinone disodium usawoti.

Imiphumela emibi ye-PQQ

Kusukela ngo-2009, izithasiselo zokudla eziqukethe i-PQQ Na 2 zidayisiwe e-United States ngemuva kwesaziso esisemthethweni yiFood and Drug Administration (FDA), futhi akukho ukusabela okubi okubikiwe.Uma ufuna ukwengeza izithasiselo ze-pyrroloquinoline quinone ekudleni kwakho, kubalulekile ukukhumbula into eyodwa.Njengoba ingadingi i-PQQ eningi kakhulu ukukhiqiza umphumela, imithamo eminingi igcinwa ebangeni elincane.Ngakho-ke, abantu abaningi akudingeki bakhathazeke nganoma yimiphi imiphumela emibi ye-Pyrroloquinoline Quinone.(Lokho uthenge isithasiselo se-pyrroloquinoline quinone PQQimakethe)