I-Oleoylethanolamide(OEA)

Igama lomkhiqizo:Oleoylethanolamide, N-Oleoylethanolamide, I-OEA
Elinye igama:N-(2-Hydroxyethyl)-9-Z-octadecenamide, N-oleoyl ethanolamide, Oleoyl monoethanolamide, 9-Octadecenamide , N-(2-Hydroxyethyl)oleamide
Inombolo ye-CAS:111-58-0
I-Molecular Formula:C₂₀H₃₉NO₂
Isisindo se-Molecular:325.5
Isivivinyo:90%,95%,85% min
Ukubukeka :impushana enombala okhilimu

Oleoylethanolamidekuyinto entsha emakethe yokudla okunempilo njengesithako esithandwayo sokudla esisetshenziswa kumafomula okwehlisa isisindo.Abalandeli abaningi bokwakha umzimba baxoxa nge-oleoylethanolamide ku-reddit nakwezinye izinkundla zokuxhumana.

I-Oleoylethanolamide iyi-metabolite yemvelo ye-oleic acid eyenziwe emathunjini amancane ngaphakathi komzimba womuntu.Iyenzeka ngokwemvelo, futhi ochwepheshe bayibiza ngokuthi "i-endogenous".

I-OEA ingumlawuli wemvelo wesifiso sokudla, isisindo kanye ne-cholesterol.Kuyi-metabolite yemvelo eyenziwa ngamanani amancane emathunjini akho amancane.I-OEA isiza ukulawula indlala, isisindo, amafutha omzimba kanye ne-cholesterol ngokubopha isamukeli eyaziwa ngokuthi i-PPAR-Alpha (i-Peroxisome proliferator-activated receptor alpha).Ngamafuphi, i-OEA inyusa i-metabolism yamafutha omzimba futhi itshela ubuchopho bakho ukuthi usuthi futhi sekuyisikhathi sokuyeka ukudla.I-OEA yaziwa futhi ngokunyusa izindleko zamakhalori ahlobene nokungawuvivinyi.

Umlando we-Oleylethanolamide

Imisebenzi yebhayoloji ye-Oleoylethanolamide yatholwa eminyakeni engama-50 edlule.Ngaphambi kuka-2001, lwalungekho ucwaningo oluningi nge-OEA.Kodwa-ke, ngalowo nyaka, abacwaningi baseSpain baphula i-lipid futhi bafunda ukuthi yenziwa kanjani, isetshenziswa kuphi nokuthi yenzani.Bahlola umphumela we-OEA ebuchosheni (bamagundane) ngokuyijova ngqo kuma-ventricles obuchopho.Abatholanga mphumela ekudleni futhi baqinisekisa ukuthi i-OEA ayenzi ebuchosheni, kodwa kunalokho, iqala isignali ehlukile ethinta indlala nokuziphatha kokudla.

Oleylethanolamide VS cannabinoid anandamide

Imiphumela ye-OEA yafundwa okokuqala ngoba yabelana ngokufana nenye ikhemikhali, i-cannabinoid eyaziwa ngokuthi i-anandamide.Ama-Cannabinoid ahlobene nesitshalo I-Cannabis, futhi ama-anandamide akhona esitshalweni (kanye nensangu) angandisa isifiso somuntu sokudla ukudla okulula ngokuvusa impendulo yokudla.Ngokusho kwe-Wikipedia, i-Oleoylethanolamide iyi-analogue ye-monounsaturated ye-endocannabinoid anandamide.Nakuba i-OEA inesakhiwo samakhemikhali esifana ne-anandamide, imiphumela yayo ekudleni nasekulawuleni isisindo ihlukile.Ngokungafani ne-anandamide, i-OEA isebenza ngokuzimela ngaphandle kwendlela ye-cannabinoid, ilawula umsebenzi we-PPAR-α ukuze ivuse i-lipolysis.

Izakhiwo ze-ethanolamide ehlukahlukene yamafutha-asidi: i-oleoylethanolamide (OEA), i-palmitoylethanolamide (PEA) ne-anandamide (i-arachidonoylethanolamide, i-AEA).(I-Cima Science Co., Ltd ukuphela komkhiqizi wenqwaba yezinto zokusetshenziswa kwe-OEA, i-PEA ne-AEA e-China, uma udinga isampula kanye nesilinganiso samanani, sicela usithumele i-imeyili ekhasini lokuxhumana nathi.)

I-OEA ibophezela ngokuhambisana okuphezulu ku-peroxisome-proliferator-activated receptor-a (PPAR-a), isamukeli senuzi esilawula izici ezimbalwa ze-lipid metabolism.

Imithombo yemvelo ye-oleoylethanolamide

I-Oleoylethanolamide iyi-metabolite yemvelo ye-oleic acid.Ngakho-ke, ukudla okuqukethe i-oleic acid kungumthombo oqondile we-OEA.

I-Oleic acid ingamafutha ayinhloko emafutheni emifino afana nomnqumo, i-canola nobhekilanga.I-Oleic acid ingatholakala emafutheni amantongomane, inyama, izinkukhu, ushizi, njll.

Imithombo yokudla ecebile nge-oleic acid ihlanganisa: Amafutha eCanola, Amafutha E-Olive, Amafutha Kakotapheya, Amafutha E-almond, Ukwatapheya, Amafutha E-Oleic Safflower Aphezulu

Amanye amaqiniso nge-Oleic Acid:

Enye yamafutha avame kakhulu obisini lwebele lomuntu

Yenza u-25% wamafutha obisini lwenkomo

I-monounsaturated

I-Omega-9 fatty acid

Ifomula yamakhemikhali ithi C18H34O2(CAS 112-80-1)

Ihlala ne-triglycerides

Isetshenziswa kuzimonyo ezinenani eliphezulu njenge-moisturizer esebenza kahle kakhulu

Kutholakala emafutheni obisi, ushizi, amafutha omnqumo, amafutha omvini, amantongomane, ukwatapheya, amaqanda nenyama

Ingase ibe nesibopho sezinzuzo eziningi zezempilo zamafutha omnqumo!

Yakha ama-super hero complexes namanye amaprotheni obisi ukulwa namaseli omdlavuza

Izinzuzo ze-Oleoylethanolamide

I-Oleoylethanolamide (OEA) inhle ukunciphisa isisindo njengokulawula ukudla futhi isekela amazinga e-cholesterol enempilo kubantu abadala.

I-OEA njengendlela yokucindezela ukudla

Ukunciphisa isifiso sokudla kuyindawo enkulu yokulawula amandla (ukudla) ukudla, ukulawula isifiso sokudla kubalulekile ekulawuleni isisindo somzimba esinempilo.I-OEA ikulawula kanjani ukudla kwakho?Ungahlola indlela yezenzo ngezansi.

OEA kanye ne-cholesterol

Amafutha omnqumo ayinkanyezi enomsoco, futhi asiza ukwehlisa i-cholesterol “embi” ye-LDL futhi andise i-HDL “enhle”.Kungani?Kufika ku-85% wamafutha omnqumo yi-oleic acid, kanti i-metabolite eyinhloko enempilo ye-oleic acid i-OEA (i-Oleoylethanolamide igama eligcwele).Ngakho-ke, akungabazeki ukuthi i-OEA isiza i-cholesterol enempilo.

Okunye ukucwaninga kabusha kubonisa ukuthi i-oleoylethanolamide inemiphumela emihle ekukhathazekeni, futhi kudingeka imizila eminingi nobufakazi ukuze kusekelwe.

Inqubo yokukhiqiza ye-Oleoylethanolamide

Ukugeleza kwe-Oleoylethanolamide kungezansi:

Izinyathelo ezijwayelekile yilezi: ukusabelag→inqubo yokuhlanza→Ukuhlunga→Incibilika kabusha ku-ethanol→i-hydrogenation →Hlunga Uketshezi Olucacile→icrystallization→Ukuhlunga →Ukuhlola→Ukupakisha →Umkhiqizo Wokugcina

Indlela yokusebenza ye-oleoylethanolamide

Ukukubeka kalula, i-oleoylethanolamide isebenza njengomlawuli wendlala.I-OEA iyakwazi ukulawula ukudla okudlayo ngokutshela ubuchopho ukuthi umzimba ugcwele, futhi akusadingeki ukudla.Udla kancane nsuku zonke, futhi umzimba wakho ungase ungakhuluphali ngokuhamba kwesikhathi.

Izenzo zokulwa nokukhuluphala kwe-oleoylethanolamide (OEA) njengoba kuboniswe esithombeni.I-OEA ihlanganiswa futhi ihlanganiswe emathunjini amancane aseduze kusuka ku-oleic acid etholakala ekudleni, njengamafutha omnqumo.Ukudla okunamafutha amaningi kungavimbela ukukhiqizwa kwe-OEA emathunjini.I-OEA inciphisa ukudla ngokuvula i-homeostatic oxytocin ne-histamine brain circuitry kanye ne-hedonic dopamine pathways.Kunobufakazi bokuthi i-OEA ingase futhi inciphise ukusayinda kwe-hedonic cannabinoid receptor 1 (CB1R), ukwenziwa kwayo kusebenze okuhambisana nokwanda kokudla.I-OEA yehlisa ukuthuthwa kwe-lipid ibe yi-adipocyte ukuze kwehliswe isisindo samafutha.Ukucaciswa okwengeziwe ngemiphumela ye-OEA ekudleni nasekusetshenzisweni kwe-lipid kuzosiza ekunqumeni izindlela zokwakheka komzimba ezingahloselwe ukuthuthukisa izindlela zokwelapha ezisebenza kahle kakhulu zokukhuluphala.

I-OEA isebenza ukwenza into ebizwa nge-PPAR isebenze futhi ngesikhathi esifanayo ikhuphule ukushiswa kwamafutha futhi yehlise ukugcinwa kwamafutha.Uma udla, amazinga e-OEA ayakhula futhi nesifiso sakho sokudla siyehla lapho izinzwa ezixhumene nobuchopho bakho zikutshela ukuthi usuthi.I-PPAR-α iyiqembu le-ligand-activated nuclear receptor elibandakanyeka ekuvezweni kofuzo lwe-lipid metabolism kanye nezindlela ze-energyhomeostasis.

I-OEA ibonisa zonke izici ezichazayo zesici sokusutha:

(1) Ivimbela ukudla ngokwandisa isikhathi sokudla okulandelayo;

(2) Ukuhlanganiswa kwayo kulawulwa ukutholakala kwezakhi kanye

(3) Amazinga ayo abhekana nokuguquguquka kwe-circadian.

Imiphumela emibi ye-Oleoylethanolamide

Ukuphepha kwe-Oleoylethanolamide kuyinkinga enkulu phakathi kwemikhiqizo engezayo efuna ukuzama lesi sithako senoveli kumafomula abo okuncipha kwesisindo.

Ngemva kokubuyekezwa okuphelele kwazo zonke izincwadi nedatha etholakalayo, i-US Food and Drug Administration (FDA) ayizange ibe nokukhathazeka mayelana nokuphepha kwe-OEA.I-RiduZone iyisithako sokuqala se-oleoylethanolamide esine-powder kusukela ngo-2015.

I-Oleoylethanolamide iyi-metabolite ye-oleic acid, eyingxenye yokudla okunempilo kwansuku zonke.Kuphephile ukuzama izithasiselo ze-OEA, futhi ayikho imiphumela emibi embi ebikiwe.

imiphumela ibikiwe.

Izilingo zabantu ze-Oleoylethanolamide

Ocwaningweni olulodwa, abantu abangamashumi amahlanu (n=50) abantu abanentshisekelo yokwehlisa isisindo belulekwa ukuthi bathathe i-OEA izikhathi ezi-2-3/ngosuku, imizuzu eyi-15-30 ngaphambi kokudla amasonto angama-4-12.Izihloko zazihlanganisa nalabo ababengakaze basebenzise imikhiqizo yokulahlekelwa isisindo ngaphambili, labo ababhekana nezenzakalo ezimbi neminye imikhiqizo yokulahlekelwa isisindo, labo ukulahlekelwa kwesisindo sabo kwanda kwamanye ama-ejenti okulahlekelwa kwesisindo afana ne-phentermine, labo abazama ukusebenzisa izinguquko zesitayela sokuphila (ukulawula ingxenye kanye nokuzivocavoca okuvamile. ), kanye nalezo ezilawulwa ngenkuthalo ezimweni zezokwelapha ezihlanganisa ukubekezelela ushukela okhubazekile, i-dyslipidemia, umfutho wegazi ophakeme kanye nezifo zenhliziyo nemithambo yegazi.

Esifundweni sesibili, izifundo ze-4 ezinesisindo sokuqala se-229, i-242, i-375 ne-193 lbs ngokulandelanayo, zayalwa ukuthi zithathe ama-capsules we-Oleoylethanolamide (i-capsule eyodwa equkethe i-200mg 90% OEA).Izifundo zathatha amaphilisi ama-4 (i-capsule engu-1 imizuzu engu-15-30 ngaphambi kokudla futhi kwakufanele bathathe i-capsule eyengeziwe ngaphambi kokudla kwabo okukhulu kosuku) nsuku zonke izinsuku ezingu-28.Isihloko sokugcina besike sabekwa phambili ethangeni.Izifundo zayalwa ukuba zingakwenzi izinguquko ekudleni kwazo nasekuzivivinyeni.

Imiphumela

Ocwaningweni lokuqala, izifundo zilahlekelwe isilinganiso esingu-1-2 lbs/ngeviki.Akubanga nemiphumela engemihle ngaphandle kwesiguli esisodwa ebesinesicanucanu sesikhashana esaxazululeka esikhathini esingaphansi kweviki.Ocwaningweni lwesibili, izihloko ezi-3 kwezi-4 zibike ukuncipha kwesisindo (3, 7, 15 kanye ne-0 lbs ngokulandelana).Zonke izifundo ezi-4 zibike ukwehla okungu-10-15% kusayizi wengxenye, izikhawu ezinde phakathi kokudla, futhi akukho miphumela emibi.

Uma unentshisekelo kweminye imibhalo yezilingo zabantu nge-OEA, sicela uvakashele izixhumanisi ze-PDF ezidawunilodeka.

Umthamo we-Oleoylethanolamide

Kunolwazi olulinganiselwe locwaningo mayelana nokusetshenziswa kwe-OEA kwamanje kubantu, futhi nakuba kuthathwa njengokuphephile, asikho isikali esinconywayo.Kodwa-ke, kukhona izithasiselo ezithile emakethe, futhi ungathola ezinye zereferensi yakho.

I-dosing ngosuku ye-RiduZone (ebizwa nge-OEA/Oleoylethanolamide 90%) yi-200mg (1capsule ene-OEA kuphela kuyo).Uma kuhlanganiswa nezinye izithako zokunciphisa isisindo, umthamo wansuku zonke ubonakala uncane, yithi 100mg noma 150mg.Izithasiselo ezithile

Kunconywa ukuthatha izithako ze-oleoylethanolamide imizuzu engu-30 ngaphambi kokudla kwasekuseni nesidlo sakusihlwa, uzozizwa ugcwele kakhulu ngesikhathi sokudla futhi ngenxa yalokho uzodla kancane.

Izincwadi zokucwaninga nge-oleoylethanolamide

I-Oleoylethanolamide: umdlali omusha ekulawuleni i-metabolism yamandla.Iqhaza ekuthathweni kokudla

I-Oleoylethanolamide inyusa ukubonakaliswa kwe-PPAR-Α futhi yehlisa isifiso sokudla nesisindo somzimba kubantu abakhuluphele: Isivivinyo somtholampilo.

Ama-Brain Molecules and Appetite: Icala le-Oleoylethanolamide

I-Oleylethanolamide ilawula ukudla nesisindo somzimba ngokusebenzisa i-nuclear receptor PPAR-a

Ukusebenza kwe-TRPV1 yi-Satiety Factor Oleoylethanolamide

Ukulawulwa kokudliwa kokudla nge-oleoylethanolamide

Indlela ye-oleoylethanolamide ekuthathweni kwe-fatty acid emathunjini amancane ngemuva kokudla nokunciphisa isisindo somzimba

I-Oleoylethanolamide: Indima ye-bioactive lipid amidein emodulating indlela yokudla

I-Oleoylethanolamide: Umlingani okhuluphele ekulweni nokukhuluphala

I-Oleoylethanolamide: I-Novel Engase Isebenzise I-Pharmacological Alternative kuma-Cannabinoid Antagonists ukulawula Isifiso sokudla