Inoa mea kūʻai:ʻO ka pauda nui ʻo Wogonin

Puna Botanic: Scutellaria baicalensis

ʻAʻohe CAS:632-85-9

Inoa ʻē aʻe: Vogoni, kaʻa, Wogonin hydrate, Vogonin Norwogonin 8-methyl ether

Nā kikoʻī: ≥98% HPLC

Ka waihoʻoluʻu: ʻO ka pauka melemele me ke ʻala a me ka ʻono

Kūlana GMO: ʻAʻole GMO

Hoʻopili: ma 25kgs fiber drums

Ka mālama ʻana: E mālama i ka pahu i wehe ʻole ʻia ma kahi maloʻo a maloʻo, e haʻalele i ka mālamalama ikaika

Ola Ola: 24 mahina mai ka lā i hana ʻia

Aia ka Scutellaria baicalensis i nā ʻano mea kemika, e like me nā flavonoids, diterpenoids, polyphenols, amino acids, volatile oil, sterol, benzoic acid, a pēlā aku.Aia i loko o nā aʻa maloʻo he 110 mau ʻano flavonoids e like me ka baicalin, baicalein, wogonoside, a me wogonin, ʻo ia ka mea nui o ka Scutellaria baicalensis.E like me 80% -90% HPLC Baicalin, 90% -98% HPLC Baicalein, 90% -95% HPLC Wogonoside, a me 5% -98% HPLC Wogonin

In Vitro Activity:Wogonin inhibits PMA-induced COX-2 gene expression ma ke kaohi ʻana i ka c-Jun expression a me ka hoʻoulu ʻana AP-1 i nā cell A549 [1].ʻO Wogonin kahi mea pale o ka cyclin-dependent kinase 9 (CDK9) a block phosphorylation o ka carboxy-terminal domain o RNA polymerase II ma Ser.No laila, ho'ēmi ia i ka RNA synthesis a ma hope iho ka hoʻohaʻahaʻa wikiwiki ʻana o ka pōkole anti-apoptotic protein myeloid cell leukemia 1 (Mcl-1) ka hopena i ka apoptosis induction i loko o nā pūnaʻi maʻi maʻi.Hoʻopili pololei ʻo Wogonin iā CDK9, i ka pocketa hoʻopaʻa ʻia ʻo ATP a ʻaʻole ia e kāohi i ka CDK2, CDK4 a me CDK6 i nā doses e kāohi ai i ka hana CDK9.ʻO Wogonin ka mea makemake i ka CDK9 i ka maʻi maʻi i hoʻohālikelike ʻia me nā lymphocytes maʻamau.ʻO Wogonin kekahi mea anti-oxidant ikaika e hiki ke hoʻopau i ka ?O2?[2].Kākoʻo nui ʻo Wogonin i ka unuhi ʻana o NFATc1 mai ka cytoplasm i ka nucleus a me kāna hana transcriptional activation.Kāohi loa ia i ka hoʻokaʻawale ʻana o ka osteoclast a hoʻemi i ka transcription o osteoclast?associated immunoglobulin?like receptor, tartrate?resistant acid phosphatase and calcitonin receptor[4].Kāohi ʻo Wogonin i ka hana N-acetyltransferase

In Vivo Activity: Hoʻopau ʻo Wogonin i ka ulu ʻana o nā xenografts maʻi maʻi kanaka ma vivo.Ma nā puʻupuʻu make i nā cell tumor, hōʻike ʻo wogonin ʻaʻole a i ʻole ka liʻiliʻi o nā mea ʻawaʻawa no nā cell maʻamau a ʻaʻole hoʻi i ʻike ʻia ka ʻona i nā holoholona[2].Hiki i ka Wogonin ke hoʻoulu i ka apoptosis i ka murine sarcoma S180 ma laila e kāohi ai i ka ulu ʻana o ka maʻi ma ka vitro a me ka vivo [3].ʻO kahi hoʻokomo intraperitoneal o 200 mg/kg Wogonin hiki ke kāohi loa i ka maʻi leukemia a me nā cell CEM

Nā hoʻokolohua kelepona:

He moʻomeheu ʻo A549 i loko o ka pā 24-well (1.2×105 cell/well) 1 lā ma mua o ka mālama ʻana i ka wogonin.Hoʻokomo ʻia ʻo DMSO a i ʻole wogonin i loko o nā pūnaewele A549 1 hola ma mua o ka hoʻoulu ʻana i ka PMA, a hoʻokomo ʻia nā cell no kahi 6 mau hola.E hōʻiliʻili ʻia nā cell e ka lāʻau trypsin a helu ʻia nā helu kelepona ma ka hoʻohana ʻana i kahi hemocytometer a me trypan blue hoʻokuʻu ʻia.