Inoa Huahana: ʻO ka pauka nui ʻo Celastrol
Puna Botanic: Ke Akua Vine(Tripterygium wilfordii hook.f)
CASNo:34157-83-0
Ka waihoʻoluʻu: ʻulaʻula ʻalani pauka aniani me ka ʻala a me ka ʻono
Hōʻike: ≥98% HPLC
GMOKūlana: GMO Free
Hoʻopili: ma 25kgs fiber drums
Ka mālama ʻana: E mālama i ka pahu i wehe ʻole ʻia ma kahi maloʻo a maloʻo, e haʻalele i ka mālamalama ikaika
Ola Ola: 24 mahina mai ka lā i hana ʻia
ʻO ka pauda CelastrolʻO ia ka mea hana i loko o Tripterygii Radix, ʻo ia ke kumu maloʻo a me ka rhizome o ke Akua Vine.ʻEhā mau ʻano nui, ʻo ia hoʻiTripterygium wilfordii Hook.f, Tripterygium hypoglaucum Hutch, Tripterygium regelii Sprague et Takeda, a me Tripterygium forresti Dicls.
Diterpenoids: triptolide(cas no.38748-32-2), Tripdiolide(cas no.38647-10-8), etc.
Triterpenoids: Celastrol(cas no.34157-83-0), Wilforlide A(cas no.84104-71-2), etc.
Alkaloids:Wilforgine(cas no.37239-47-7), Wolverine (cas no.11088-09-8), wilforidine, etc.
ʻO Tripterygium kahi pentazine triterpene i loaʻa maoli ma Tripterygium wilfordii.He mea maikaʻi ia i ka mālama ʻana i ka maʻi rheumatoid.Mālama ʻo Triptolide i ka hana ʻana o ka proteasome a me ka mea nukle Kb.
ʻO Celastrol (Tripterin) kahi mea pale proteasome me nā hana anti-inflammatory a me nā antioxidant.Hoʻopaʻa maikaʻi ia i ka hana chymotrypsin-like o ka proteasome 20S me kahi IC50 o 2.5 μM.
ʻO Tripterine kahi mea antioxidant ikaika a me ka anti-inflammatory agent.He mea hoʻopaneʻe HSP90 hou ia (hoʻopilikia i ka paʻakikī Hsp90/Cdc37), loaʻa nā hopena anti-cancer (anti-angiogenesis - inhibits vascular endothelial growth factor receptor expression);antioxidant (hoʻopaʻa i ka lipid peroxidation) a me ka hana anti-inflammatory (Kaohi i ka hana ʻana o iNOS a me nā cytokine inflammatory)
BiologicalAhana:
ʻO Celastrol (Tripterin) i lalo e hoʻoponopono i ka monoubiquitination FANCD2 i hoʻohui ʻia i ka basal a me ka DNA-damaging agent, a ukali ʻia e ka degradation protein.Hoʻopau ka lapaʻau ʻo Celastrol i ka helu G2 i hoʻokomo ʻia e IR a hoʻonui i ka pōʻino DNA i hoʻokomo ʻia i ka lāʻau ICL a me nā hopena paʻa i nā maʻi maʻi maʻi maʻi ma ka hoʻopau ʻana i ka FANCD2.Loaʻa i ka Celastrol nā hopena paʻa a me ka hoʻoulu ʻana i ka apoptosis ma nā pūnaewele DU145 i hoʻoulu ʻia i loko o ka vitro i ka manawa a me ke ʻano o ka hopena.ʻO ka hopena anti-prostate cancer ka hopena ma muli o ka hoʻoponopono ʻana i ka pae hōʻike o nā ala hERG i loko o nā pūnaewele DU145, e hōʻike ana he lāʻau lapaʻau anti-prostate cancer paha ʻo Celastrol, a ʻo kāna ʻano hana paha e ālai i nā kahawai hERG.Hoʻomaikaʻi ʻo Celastrol i ka colitis hoʻokolohua ma nā ʻiole hemahema IL-10 ma ke kāohi ʻana i ke ala hōʻailona PI3K/Akt/mTOR a me ka upregulating autophagy.Loaʻa i ka Celastrol ka hiki ke pale i ka hana cytochrome P450 a hiki ke hana i nā pilina lāʻau.Hoʻokomo ʻo Celastrol i ka apoptosis ma nā pūnaewele TNBC, e hōʻike ana e hiki ke hoʻopili ʻia ka apoptosis ma o ka mitochondrial dysfunction a me ke ala hōʻailona PI3K/Akt.Hoʻokomo ʻo Celastrol i ka apoptosis a me ka autophagy ma o ke ala hōʻailona ROS / JNK.Kāohi ʻo Celastrol i ka make ʻana o ka neuron dopaminergic i ka maʻi o Parkinson ma ka hoʻoulu ʻana i ka apoptosis mitochondrial.
ʻO ka hana a Celastrol i ka chemosensitization maʻi kanesa:
Hoʻomau ka Chemotherapy i ke koho lapaʻau nui no nā maʻi maʻi maʻi.Eia nō naʻe, pono e hui pū ʻia ka chemotherapy me nā lāʻau ʻē aʻe e hōʻemi i nā hopena ʻino a pale aku i ka pale ʻana i ka lāʻau.Hoʻohana nui ʻia nā huahana kūlohelohe ma ke ʻano he adjuvant therapies i hui pū ʻia me nā regimens chemotherapy e hoʻonui ai i ka pono o ka mālama ʻana.ʻO kahi laʻana hoʻohiki o kēlā lāʻau lapaʻau maoli he pūhui triterpene i kapa ʻia ʻo celastrol, hiki ke hoʻohana nui ʻia ma ke ʻano he sensitizer kemika.Ua ʻike mua ʻia mai Thunder God Vine, hoʻoponopono maikaʻi ʻo ia i nā molekole oncogenic e like me NF-κB, topoisomerase II, Akt/mTOR, HSP90, STAT3, a me Notch-1.Hiki i kēia ke alakaʻi i kahi pane anti-inflammatory, kaohi i ka ulu ʻana a me ke ola ʻana, a hoʻopau i ka angiogenesis.Hōʻuluʻulu pōkole kēia mokuna i ke kuleana o ka celastrol ma ke ʻano he chemosensitizer a me nā ʻano molekala lalo e hoʻopili ana i kāna mau hopena chemosensitizing i hōʻike ʻia i nā maʻi maʻi like ʻole.
