Neohesperidin Dihydrochalcone （NHDC）

Loaʻa ka NHDC ma ke ʻano maʻemaʻe ma ke ʻano he mea keʻokeʻo like ʻolepauda kō.

ʻO kahi pūhui ma kahi o 1500-1800 mau manawa ʻoi aku ka ʻono ma mua o ke kō ma ka paepae paepae;ma kahi o 340 manawa ʻoi aʻe ka ʻono ma mua o ke kaumaha-no-kaumaha.Hoʻopili maoli ʻia kona potency e nā mea like me ka noi i hoʻohana ʻia ai, a me kapHo ka huahana.

E like me nā mea momona ʻē aʻenā glycosides, e like meglycyrrhizina me na mea i loaa mastevia, ʻOi aku ka lohi o ka ʻono ʻono o NHDC ma mua o ke kō a hoʻomau i ka waha no kekahi manawa.

ʻAʻole likeaspartame, Paʻa ka NHDC i nā mahana kiʻekiʻe a me nā kūlana acidic a i ʻole nā ​​kumu kumu, a no laila hiki ke hoʻohana ʻia i nā noi e pono ai ke ola lōʻihi.Hiki iā NHDC ponoʻī ke mālama i ka meaʻai a hiki i ʻelima mau makahiki ke mālama ʻia i nā kūlana maikaʻi loa.

ʻIke ʻia ka huahana no ka loaʻa ʻana o ka hopena synergistic ikaika ke hoʻohana pū ʻia me nā mea ʻē aʻemea ʻono hanae like measpartame, saccharin, acesulfame potassium, acyclamate, a me na waiona kopa e like mexylitol.Hoʻonui ka hoʻohana ʻana i ka NHDC i nā hopena o kēia mau mea ʻono ma nā haʻahaʻa haʻahaʻa ma mua o ka mea i koi ʻia;ʻoi aku ka liʻiliʻi o nā mea ʻono ʻē aʻe e pono ai.Hāʻawi kēia i kahi pōmaikaʻi kumukūʻai.

He aha ka Neohesperidin dihydrochalcone?

ʻO Neohesperidin dihydrochalcone pauka, ʻike pū ʻia ʻo Neohesperidin DC, Neo-DHC a me NHDC no ka pōkole, he mea ʻono i hoʻonui ʻia e neohesperidin.Manaʻo ʻia ʻo NHDC he mea ʻono kiʻekiʻe, ʻaʻohe meaʻai me ka ʻono ʻoluʻolu;hiki iā ia ke hoʻomaikaʻi i ka ʻono a me ka maikaʻi o nā ʻano meaʻai like ʻole.

ʻO ka Neohesperidin dihydrochalcone kahi pūhui i ʻoi aku ka ʻono ma kahi o 1500-1800 mau manawa ma mua o ke kō ma ka paepae paepae a ʻoi aku kona kaumaha ma kahi o 340 mau manawa ʻoi aku ka momona ma mua o ke kō.

Hoʻohana pinepine ʻia ʻo Neohesperidin dihydrochalcone i nā ʻoihana meaʻai meaʻai a me nā mea hoʻohui meaʻai.

E ʻike a me ke kumu o Neohesperidin dihydrochalcone

Ua ʻike ʻia ʻo Neohesperidin dihydrochalcone i ka makahiki 1960 ma ke ʻano he ʻāpana o ka US Department o kahi papahana noiʻi mahiʻai e ʻimi ai i nā ala e hōʻemi ai i ka ʻawaʻawa o ka wai citrus.ʻO Neohesperidin kahi mea ʻawaʻawa i loaʻa i loko o ka ʻili a me ka pulp o ka ʻalani ʻawaʻawa a me nā hua citrus ʻē aʻe;He mea flavonoids hana ia o ka hua citrus aurantium.Ke mālama ʻia me ka potassium hydroxide a i ʻole kekahi kumu ikaika ʻē aʻe, a laila hydrogenated, lilo ia i Neohesperidin dihydrochalcone (NHDC).

ʻAʻole loaʻa ka NHDC ma ke ʻano.

ʻO Neo-DHC ka hydrogenated mai ka neohesperidin maoli—he kumu maoli, akā ua hoʻololi kemika, no laila ʻaʻole ia he huahana kūlohelohe.

Neohesperidin dihydrochalcone VS nā mea ʻono ʻē aʻe

ʻOkoʻa ka ʻono a me ka ʻono

Ke hoʻohālikelike ʻia me ka sucrose, ʻo ka neohesperidin DC ma kahi o 1500-1800 manawa ʻoi aku ka momona ma mua o ke kō a me 1,000 mau manawa ʻoi aku ka momona ma mua o ka sucrose, ʻoiai ʻo ka sucralose he 400-800 mau manawa a ʻo ka ace-k he 200 mau manawa ʻoi aku ka momona ma mua o ke kō.

He ʻono maʻemaʻe ʻo Neohesperidin DC a loaʻa nā ʻono ma hope.E like me nā glycosides kiʻekiʻe kiʻekiʻe, e like me ka glycyrrhizin i loaʻa i ka stevia a me nā mea mai ke aʻa licorice, ʻoi aku ka lohi o ka ʻono o NHDC ma mua o ke kō a paʻa i ka waha no ka manawa lōʻihi.

Paʻa maikaʻi a palekana kiʻekiʻe

Paʻa ka NHDC ma lalo o ka wela kiʻekiʻe, ka acidic a i ʻole nā ​​kūlana alkaline a no laila hiki ke hoʻohana ʻia i nā noi e koi ana i kahi ola lōʻihi.Hiki i ka NHDC ke mālama i ka meaʻai a hiki i ʻelima mau makahiki ma lalo o nā kūlana maikaʻi loa

Loaʻa nā ʻokoʻa

Hoʻopili ʻia ka ʻike kanaka i ka ʻono a me ka ʻono e nā T1R, ka ʻohana mua o GPCR, hōʻike ʻia nā TIR i ka gustatory o ka palale palupalu a me ke alelo, me TIR1, T1R2, a me TIR3, i ʻike pinepine ʻia ma ke ʻano o nā dimer.ʻO ka dimer T1R1-TIR3 kahi mea hoʻokipa amino acid, e hōʻike a komo i ka ʻike ʻono.ʻO ka dimer T1R2-T1R3 kahi mea hoʻokipa momona, e komo ana i ka ʻike ʻono ʻono.

ʻO nā mea ʻono e like me ka sucrose, aspartame, saccharin, a me ka cyclamate e hana ana ma ka ʻāpana o ka hale extracellular o T1R2.Hana ʻo NHDC a me cyclamate i ka ʻāpana transmembrane o T1R3 e hana i ka ʻono.Hoʻopili ʻo Neohesperidin DC me nā koena amino acid kikoʻī i ka ʻāina transmembrane o T1R3 e hoʻoulu i kona ʻono ponoʻī a ma ka manawa like, hiki iā ia ke hoʻoulu i ka hopena ʻono synergistic o ka dimer T1R2-T1R3.Ma keʻano he meaʻono, he hopena koʻikoʻi ko NHDC ke hoʻohuiʻia me nā meaʻono'ē aʻe me ka liʻiliʻi o nā meaʻai.

Ma waho aʻe, ʻokoʻa ʻo Neohesperidin DC mai nā mea ʻono maʻamau i kāna mau hana o ka ʻono, hoʻonui ʻala, huna ʻawaʻawa, a me ka hoʻololi ʻana i ka ʻono.

Nā pōmaikaʻi a me nā hoʻohana ʻana o neohesperidin dihydrochalcone (NHDC)

ʻAno Antioxidant

I kēia mau makahiki i hala iho nei, nui nā haʻawina e hōʻike ana i ka neohesperidin dihydrochalcone he hana scavenging koʻikoʻi koʻikoʻi ma luna o nā radical manuahi a me nā ʻano oxygen reactive (ROS).ʻO ka mea nui, ʻo ka NHDC ka hopena paʻa nui loa ma H2O2 a me HOCl.(ʻo ka scavenging rate o HOCl a me H2O2 he 93.5% a me 73.5% pakahi)

ʻO ka mea hou aku, hiki i ka NHDC ke kāohi i ka hoʻohaʻahaʻa ʻana i ka protein a me ka ʻoki ʻana o ka plasmid DNA strand, a pale i ka HIT-T15, HUVEC cell make mai HOCl attack.

Loaʻa i ka NHDC nā hana antioxidant ʻokoʻa e kūʻē i nā radical manuahi.Hoʻokomo pū ka hana antioxidant o NHDC he hiki ke pale i ka hopena browning o ka waiho ʻana o ka puaʻa i hoʻokumu ʻia e ka polyphenol oxidase, hiki ke pale nui i ka hoʻoponopono ʻana o ka matrix metalloproteinase (MMP-1) i hoʻoulu ʻia e ka radiation infrared, pēlā e pale ai i ka ʻili kanaka mai. ʻelemakule ma mua ma muli o ka ʻike ʻana i ka radiation infrared.

Noi: Hiki i ka NHDC ke lilo i mea hoʻohui anti-browning a me ke keʻokeʻo

Hoʻohaʻahaʻa i ke kō koko a me ka Cholesterol haʻahaʻa

ʻO ka NHDC kahi mea ʻono maikaʻi, ʻaʻohe mea ʻawaʻawa, haʻahaʻa-calorie e hoʻomāʻona i ka pono o ka poʻe no ka ʻono a no laila e hōʻemi i ka ʻai ʻana i ke kō.

Ua hōʻike ʻia nā haʻawina hou e hiki i ka NHDC ke kāohi i ka α-amylase i loko o nā mammals i nā pae like ʻole a laila e hoʻemi i ka komo ʻana o ke kō i ke kino, ma laila e hōʻemi ai i ke kō koko i loko o ke kino, he mea nui loa ia i ka lāʻau lapaʻau, ʻoi aku hoʻi no nā maʻi maʻi maʻi.

Noi: Hiki ke hoʻohana ʻia ka NHDC ma ke ʻano he mea ʻono ʻole ke kō, ʻaʻohe calorie.Ke hoʻohana pono ʻia, hiki ke hoʻololi i ka sucrose a hōʻemi i ka ʻai ʻana o ka sucrose kanaka.He kūpono ia no ka poʻe paʻa a me ka poʻe ʻole.

E pale i ke ake

ʻO Zhang Shuo et al.ʻike ʻia e hiki i ka NHDC ke hoʻemi i nā pae o ALT, AST i loko o ka serum a me ka hydroxyproline i loko o nā ʻiʻo ate o nā ʻiole me ka fibrosis ate i hoʻokomo ʻia e CCI, a hoʻolohi pū hoʻi i ka degeneration a me ka necrosis o nā cell a me nā fibrosis ate i nā pae like ʻole.Eia kekahi, ʻo ka emi ʻana o ALT a me AST i loko o ka serum hiki ke hoʻomaikaʻi i ka metabolism lipid a me ka hana o ka ate, kaohi i ka hoʻokumu ʻana o ka momona momona a me ka endothelial plaque i loko o nā aʻa nui.

Ma waho aʻe, hiki i ka NHDC ke hōʻoluʻolu maikaʻi i ka pōʻino oxidative i hoʻoiho ʻia e CC1, hoʻemi i ka mumū, a me ka apoptosis cell.

Noi: Manaʻolana ka NHDC e hoʻohana ʻia ma ke ʻano he hepatoprotective agent.

Kāohi i ka ʻōpū ʻōpū

Hiki i ka NHDC ke kāohi i ka huna ʻana o ka ʻōpū o ka ʻōpū, no laila hiki ke hoʻohana ʻia e like me ka antacid e hui pū me ka Aluminum Hydroxide Gel a i ʻole nā ​​​​mea hana ʻakika maʻamau e hoʻomaikaʻi ai i ke kūpaʻa ʻana o ka ʻōpū o ka hope.

Suhrez et al.'ike 'ia e hiki i ka NHDC ke ho'emi nui i ka helu helu ma'i ma'i i ho'oulu 'ia e ke ko'iko'i kaohi anu (CRS).Hoʻohālikelike ʻia kāna hana me ka ranitidine, hiki iā ia ke pale i ka hana o ka histamine a hoʻemi nui i ka huna ʻana o ka waikawa gastric a me ka pepsin.

Noi: Lilo paha ka NHDC i mea maka hou no ka laau lapaau.

Hoʻoponopono i ka palekana

Hoʻohui ʻia ʻo NHDC e hānai i mea ʻono, ʻaʻole wale no kona ʻono ʻoluʻolu a me ka hoʻoulu ʻana i ka makemake holoholona, ​​akā no ka hopena probiotic i loaʻa e Daly et al.I ka hoʻohui ʻia ʻana o ka NHDC i ka hānai puaʻa, ua hoʻonui nui ʻia ʻo Lactobacillus i ka puka caecum o nā puaʻa me ka piʻi ʻana o ka ʻakika lactic i loko o ka lua o ka ʻōpū.Hiki iā ia ke hoʻopilikia i ka flora intestinal symbiotic, hoʻoponopono i ka palekana o ke kino, a hoʻemi i nā maʻi ʻōpū.

Noi: Hiki ke hoʻohana ʻia ʻo Neohesperidin DC ma ke ʻano he meaʻai meaʻai, hoʻomaikaʻi ʻo NHDC i ka palatability o ka mea hānai meaʻai, hoʻonui i ka makemake holoholona, ​​​​a hoʻomaikaʻi i ka bacteria intestinal, a laila hoʻoulu i ko lākou ulu.

Neohesperidin DC palekana

ʻO ka NHDC kahi mea ʻono ʻole, ʻaʻole fermentative.ʻO ka noiʻi empirical e pili ana i ka ʻawaʻawa i hana ʻia.ʻO ka metabolism o NHDC i loko o ke kino o ke kanaka ua like ia me nā glycosides flavonoid kūlohelohe.Loaʻa ka NHDC i ka metabolism wikiwiki, ʻaʻohe mea hoʻoulu i ke kino o ke kanaka, ʻaʻohe hopena ʻino.

Ua hoʻopaʻa ʻia ʻo Neo-DHC i ka European Pharmacopoeia i ʻelua mau makahiki i hala aku nei a ʻae ʻia ma ke ʻano he mea ʻono e ka European Union, akā ʻaʻole na ka FDA.Ma ʻAmelika Hui Pū ʻIa, ʻae ʻia ka neo-DHC no ka hoʻohana ʻana ma ke ʻano he mea hoʻonui ʻono.Ma waho aʻe, aia ka hoʻopaʻa inoa NHDC no ke kūlana GRAS ma ka FDA.

ʻO Neohesperidin dihydrochalcone (NHDC) i ʻōlelo ʻia i ka nui a me nā hopena ʻaoʻao.

No nā mea ʻono a me nā huahana waiu, ʻo ke ʻano: 10-35 ppm (mea ʻono), 1-5 ppm (mea hoʻonui ʻono)

No ka Pharmaceutical Bitterness Masking, ke ʻano: 10-30 ppm (mea ʻono), 1-5 ppm (hoʻonui ʻono)

No nā meaʻono hānai, ka nui i manaʻo ʻia: 30-35 mg NHDC/kg hānai piha, 5 mg NHDC/L wai;3-8 mg NHDC/L wai no ka omo ʻana a me ka waiu

Hoʻoholo nā kumu like ʻole i ka dose.

Eia nō naʻe, inā ʻoi aku ka nui o ka lawe ʻana, hiki i kekahi mea hoʻohui ke hoʻopilikia i ke kino o ke kanaka.Ua hōʻike nā haʻawina e hiki i ka neohesperidin dihydrochalcone (NHDC) ke hoʻoulu i ka nausea a me ka migraine i ka wā e pili ana ka ʻike ma kahi o 20 ppm a i ʻole.Manaʻo ʻia e hoʻohana i nā masks surgical i ka wā e hana ai me ka NHDC maʻemaʻe

Palapala hōʻoia