ʻO ka pauka ʻakika Sialika

ʻO ka waikawa Sialic (SA), i ʻike ʻia i ka ʻepekema ʻo "N-acetylneuraminic acid," he waiʻawaʻawa kūlohelohe maoli.Ua hoʻokaʻawale mua ʻia ia mai ka submandibular gland mucin, no laila ka inoa.Aia maʻamau ka waikawa Sialic ma ke ʻano o oligosaccharides, glycolipids a i ʻole glycoproteins.I loko o ke kino o ke kanaka, loaʻa i ka lolo ka nui o ka ʻakika sialic.ʻO ka ʻakika sialic i loko o ka mea hina he 15 mau manawa ma mua o nā mea o loko e like me ke ake a me ka māmā.ʻO ke kumu meaʻai nui o ka sialic acid ka waiū umauma, kahi i loaʻa i ka waiū, nā hua a me ka paʻakai.

I loko o ka lāʻau lapaʻau, kapa ʻia nā glycolipids i loaʻa ka sialic acid he gangliosides, kahi mea koʻikoʻi i ka hana ʻana a me ka hoʻomohala ʻana o ka lolo a me ka ʻōnaehana nerve.I ka manawa like, ua hōʻike ʻia nā haʻawina holoholona e pili ana ka emi ʻana o nā pae ganglioside me ka ʻai mua a me ka hoʻemi ʻana i ka hiki ke aʻo, ʻoiai ʻo ka hoʻohui ʻana me ka sialic acid hiki ke hoʻomaikaʻi i ka ʻano aʻo holoholona.He mea koʻikoʻi paha ka hoʻolako ʻana i ka waikawa sialic no ka hoʻomohala maʻamau o ka hana lolo i nā keiki me ke kaumaha haʻahaʻa.Ma hope o ka hānau ʻana o ka pēpē, pono ka sialic acid i ka waiū umauma e hōʻoia i ko lākou ulu maʻamau.Ua hōʻike ʻia nā noiʻi i ka emi ʻana o ka pae sialic acid i nā makuahine ma hope o ka hānau ʻana.No laila, ʻo ka hoʻomau mau ʻana i ka nui o ka waikawa sialic i ka wā hāpai a ma hope o ka hāpai ʻana e hiki ke kōkua i ka mālama ʻana i nā pae waikona sialic i ke kino.Eia kekahi, pili nui ka ʻike o ka sialic acid me ka DHA, me ka manaʻo e pili nui ia me ka hoʻomohala ʻana o ka lolo a me ka ulu ʻana o ka lolo i nā kamaliʻi, pono ia mau mea ʻelua no ka ulu ʻana o ka lolo.

Ua hōʻike ʻia nā haʻawina ʻo ka manawa gula o ka ulu ʻana o ka lolo kanaka ma waena o nā makahiki 2 a me 2 mau makahiki.He wā koʻikoʻi kēia kaʻina no ka hoʻoponopono ʻana i ka helu o ka lolo, ka piʻi ʻana o ka leo, ka hana pono, a me ka hoʻokumu ʻana i ka ʻoihana neural.No laila, e hoʻolohe maoli nā makuahine akamai i ka lawe ʻana i ka nui o ka waikawa sialic i ka wā hāpai.Ma hope o ka hānau ʻana o ka pēpē, ʻo ka waiū umauma kahi ala kūpono e hoʻohui ai i ka waikawa sialic i ka pēpē, no ka mea ma kahi o 0.3-1.5 mg o ka waikawa sialic no ka milliliter o ka waiū umauma.ʻO ka ʻoiaʻiʻo, hiki i nā mammals āpau, me nā kānaka, ke synthesize i ka waikawa sialic mai ke ake ma o lākou iho.Eia naʻe, ʻaʻole i oʻo ka ulu ʻana o ke akepaʻa o nā keiki hou, a ʻo ka pono no ka ulu wikiwiki ʻana a me ka ulu ʻana o ka lolo hiki ke kaupalena i ka synthesis o ka waikawa sialic, ʻoi aku hoʻi no nā pēpē ʻōpiopio.No laila, he mea nui ka sialic acid i ka waiū umauma no ka hōʻoia ʻana i ka ulu maʻamau a me ka ulu ʻana o ka pēpē.
Ua ʻike nā mea noiʻi o Australia he ʻoi aku ka kiʻekiʻe o nā pēpē i hānai ʻia i ka waiu sialic i loko o ka cortex mua ma mua o nā pēpē hānai hānai.Hiki i kēia ke hoʻoikaika i ka hoʻokumu ʻana i nā synapses, kōkua i ka hoʻomanaʻo o ka pēpē e hana i kahi kumu paʻa paʻa, a hoʻoikaika i ka ulu ʻana o ka ʻōnaehana nerve.

He aha ka Sialic acid

ʻAka Sialikahe pūʻulu o nā mea i loaʻa i ka neuraminic acid (N- a i ʻole O-substituted derivatives neuraminic acid).ʻO ka maʻamau i ke ʻano o ka oligosaccharides, glycolipids a i ʻole glycoproteins.

ʻAka Sialikaʻo ia hoʻi ka inoa no ka lālā maʻamau o kēia hui - N-acetylneuraminic acid (Neu5Ac a i ʻole NANA).

ʻohana ʻakika sialic

Ua ʻike ʻia no kahi kokoke i 50 mau lālā, nā derivatives āpau o ka 9-carbon sugar neuraminic acid.

N-acetylneuraminic acid (Neu5Ac), N-glycolylneuranic

ʻakika (Neu5Gc) a me deaminoneuraminic acid (KDN) kona monomer kumu.

ʻO ka waikawa N-acetylneuraminic wale nō ke ʻano Sialic Acid i loko o ko mākou kino.

ʻAka Sialika a me ka pūnana manu

Ma muli o ka waiwai o ka waika Sialic i ka pūnana manu, ua kapa ʻia ʻo ia he ʻakika pūnana manu, ʻo ia ka hōʻailona koʻikoʻi o ka helu ʻana i ka pūnana manu.

ʻO Sialic Acid ka meaʻai nui i ka pūnana Manu, ma kahi o 3%-15% ma ke kaumaha.

Ma waena o nā meaʻai a pau i ʻike ʻia, aia i loko o ka pūnana Bird ka mea kiʻekiʻe loa o ka waikawa Sialid, ma kahi o 50 mau manawa kiʻekiʻe ma mua o nā meaʻai ʻē aʻe.

Ua like ka pūnana manu me 40 mau hua inā loaʻa ka nui like o ka Sialic Acid.

Nā kumu meaʻai Sialic Acid

ʻO ka maʻamau, ʻaʻohe ʻakika Sialic i nā mea kanu.ʻO ke kumu nui o ka waika Sialic ka waiū kanaka, ka ʻiʻo, ka hua manu, a me ka paʻakai.

Nā mea i loko o ka nui o ka waikona Sialic i nā meaʻai maʻamau (µg/g a i ʻole µg/ml).

Hiki iā mākou ke ʻike he kiʻekiʻe ka Sialic acid i ka waiū kanaka, ʻo ia ka mea nui no ka ulu ʻana o ka lolo o kahi pēpē.

Akā ʻokoʻa ka ʻokoʻa o ka Sialic Acid i nā wā like ʻole o ka waiū kanaka

Kolostrum waiu waiu 1300 +/- 322 mg/l

10 mau lā ma hope 983 +/- 455 mg/l

ʻO ka pauka waiu pēpē mua 197 +/- 31 mg/l

Nā papa waiu i hoʻololi ʻia 190 +/- 31 mg/l

Nā papa waiu i hoʻololi ʻia 100 +/- 33 mg/l

ʻO nā ʻano waiu waiu ukali 100 +/- 33 mg/l

Nā papa waiu waiu soy 34 +/- 9 mg/l

Hoʻohālikelike ʻia me ka waiū umauma, loaʻa i ka pauka waiū pēpē ma kahi o 20% Sialic acid mai ka waiū kanaka, ʻoiai hiki i ka pēpē ke loaʻa he 25% Sialic acid mai ka waiū umauma.

No ka pēpē Preterm, ʻoi aku ka pono o ka waikona Sialic ma mua o kahi pēpē olakino i ka ulu ʻana o ka lolo.

ʻO ka haʻawina ʻo Sialic Acid ma ka pauka waiu

"Ua hōʻike ʻia nā hopena he mea koʻikoʻi ka ʻona sialic acid content i ka hoʻoholo ʻana i ka ʻano.Ua ʻike kekahi pūʻulu i ka hoʻomaikaʻi ʻana i ke aʻo ʻana me ka mālama ʻana i ka sialic acid manuahi i nā rodents.

Nā Manaʻo CAB: Nā Manaʻo i ka Mahiʻai, ʻEpekema Veterinary, Nutrition, a me Natural

Nā Punawai 2006 1, No. 018， He waika sialic i ka waiū meaʻai no ka lolo?， Bing Wang

"ʻO ka hopena ʻoi aku ka kiʻekiʻe o ka lolo ganglioside a me ka glycoprotein sialic acid concentrations i nā pēpē i hānai ʻia i ka waiū kanaka e hōʻike ana i ka hoʻonui ʻana i ka synaptogenesis a me nā ʻokoʻa o ka neurodevelopment."

Am J Clin Nutr 2003;78:1024–9.Pai ʻia ma ʻAmelika.© 2003 American Society for Clinical Nutrition， Brain ganglioside, a me glycoprotein sialic acid i loko o ka umauma i hoʻohālikelike ʻia me nā pēpē i hānai ʻia i ka formula， Bing Wang

"ʻO nā membrane cell neural he 20 mau manawa ʻoi aku ka nui o ka sialic acid ma mua o nā ʻano ʻano membrane ʻē aʻe, e hōʻike ana he kuleana ko ka waikawa sialic i ka hana neural."

ʻO ka European Journal of Clinical Nutrition, (2003) 57, 1351–1369, ʻO ke kuleana a me ka hiki o ka sialic acid i ka meaʻai kanaka, Bing Wang

N-Acetylneuraminic acid Noi

Waiu Pauda

I kēia manawa, ʻoi aku ka nui o ka pauka waiu makuahine hānai, ka pauka waiu pēpē, a me nā mea hoʻohui Nutritional i loaʻa ka Sialic Acid ma ka Makeke.

No na makuahine hānai

No ka pauka waiu pēpē 0-12 mahina

No ka huahana mālama ola

No ka mea inu

Ma muli o ka hiki ke hoʻoheheʻe wai maikaʻi ʻo Sialic acid, nui nā hui e hoʻāʻo nei e hoʻomohala i nā mea inu ʻona Sialic no ke olakino Brain a i ʻole e hoʻohui i nā huahana waiū.

N-Acetylneuraminic acid Palekana

He palekana loa ka N-Acetylneuraminic acid.I kēia manawa, ʻaʻohe lono maikaʻi ʻole i hōʻike ʻia ma ka waikawa Sialic.

Ua ʻae nā aupuni o ʻAmelika, Kina, a me EU i ka waikawa Sialic e hoʻohana ʻia i nā huahana mālama meaʻai a me ke olakino.

USA

Ma 2015, N-Acetyl-D-neuraminic acid (Sialic acid) ua hoʻoholo ʻia ʻo Generally Recognized as Safe (GRAS)

Kina

I ka makahiki 2017, ua ʻae ke Aupuni Kina i ka waikawa N-Acetylneuraminic ma ke ʻano he meaʻai meaʻai hou.

EU

Ka palekana o ka waikawa N-acetyl-d-neuraminic synthetic ma ke ʻano he meaʻai hou ma lalo o ka Regulation (EC) No 258/97

Ma ka 16 ʻOkakopa 2015, ua hāʻawi ʻia ka inoa keiki makua ʻole (EU/3/12/972) e ka European Commission i Ultragenyx UK Limited, United Kingdom, no ka waikawa sialic (ʻike ʻia ʻo aceneuramic acid) no ka mālama ʻana i ka myopathy GNE.

Manaʻo ʻepekema e pili ana i ka hoʻokō ʻana i nā koi olakino e pili ana i ka sialic acid a me ke aʻo ʻana a me ka hoʻomanaʻo (ID 1594) e like me ka Paukū 13 (1) o ka Regulation (EC) No 1924/2006

ʻAiʻai

Manaʻo ʻo CFDA i ka 500mg / lā

Hōʻike ka meaʻai hou i ka 55mg / lā no nā pēpē a me 220mg / lā no nā wahine ʻōpio a me waena.

N-acetylneuraminic acid Hana

Hoʻonui ka hoʻomanaʻo a me ka naʻauao

Ma ka launa pū ʻana me nā membrane cell brain and synapses, hoʻonui ʻo Sialic acid i ka pane ʻana o nā synapses i loko o nā pūnaewele nerve o ka lolo, a laila hoʻoikaika i ka hoʻomohala ʻana o ka hoʻomanaʻo a me ka naʻauao.

Ua hana nā kānaka ʻepekema o Aotearoa i nā ʻano hoʻokolohua e hōʻoia i ke kuleana koʻikoʻi o ka waika pūnana manu i ka ulu ʻana o nā keiki.ʻO ka hope, ua hoʻoholo ka poʻe noiʻi ʻo ka hoʻonui ʻana i ka waika pūnana manu i nā kamaliʻi hiki ke hoʻonui i ka neʻe ʻana o ka waika pūnana manu i loko o ka lolo, a laila e hoʻomaikaʻi ai i ka hiki o ka lolo ke aʻo.

E hoʻomaikaʻi i ka hiki ʻana o ka ʻōpū

Wahi a ke ʻano maʻalahi o ke kino o ke kāne, ua hui pū ʻia nā minerala maikaʻi a me kekahi mau huaora i komo i loko o ka ʻōpū me ka waika pūnana manu i hoʻopiʻi maikaʻi ʻia, no laila ke komo ʻana o ka intestinal o nā huaora a me nā minela.Ua hoʻonui ʻia ka mākaukau mai ia mea.

Hoʻoikaika i ka hoʻomaʻemaʻe antibacterial intestinal

He kuleana koʻikoʻi ka Sialic Acid ma ka protein membrane cell i ka hoʻomaikaʻi ʻana i ka hiki ke hoʻomaopopo i ka cell, detoxification o ka kolera toxin, ka pale ʻana i ka maʻi Escherichia coli pathological, a me ka hoʻoponopono ʻana i ka hapalua o ke ola o ke koko.

Ka lōʻihi

He hopena pale a hoʻopaʻa ʻia ka waikawa sialic i nā cell, a ʻo ka nele o ka waikawa sialic hiki ke alakaʻi i ka emi ʻana o ke ola o ke koko a me ka emi ʻana o ka metabolism glycoprotein.

E hoʻomohala i ka lāʻau lapaʻau hou no ka Sialic Acid

Ho'āʻo nā kānaka ʻepekema e mālama i nā maʻi ʻōpū me ka sialic acid anti-adhesion drugs.Hiki i nā lāʻau anti-adhesive acid Sialic ke mālama i ka Helicobacter pylori e mālama i nā ʻeha ʻōpū a me nā ʻeha duodenal.

ʻO ka waikawa sialic kahi glycoprotein.Hoʻoholo ia i ka ʻike like ʻana a me ka hoʻopaʻa ʻana o nā cell a loaʻa nā hopena anti-inflammatory like me ka aspirin.

ʻO ka waikawa Sialic kahi lāʻau lapaʻau no nā maʻi neurological kikowaena a i ʻole topical a me nā maʻi demyelinating;ʻO ka waika sialic kekahi mea hoʻopaneʻe maʻi.

Hiki i ka waikawa Sialic ke hoʻomohala i nā ʻano lāʻau lapaʻau koʻikoʻi, anti-virus, anti-tumor, anti-inflammatory, a me ka mālama ʻana i ka senile dementia he hopena maikaʻi loa.

ʻO ke kaʻina hana o ka Sialic Acid

ʻO ka hoʻomaka mua ʻana o ka glucose ka nui o ka waiʻona, glycerinum, a me ka magnesium sulfate.A hoʻohana mākou i ka ʻenehana fermented.I loko o kēia kaʻina hana, hoʻohana mākou i ke ala o ka sterilization e mālama i nā mea maʻemaʻe.A laila ma ka hydrolysis, ka hoʻomau, ka maloʻo, a me ka wāwahi.Ma hope o nā kaʻina hana a pau, loaʻa iā mākou ka huahana hope.A e hoʻohana kā mākou QC i ka HPLC e hoʻāʻo i ka maikaʻi o ka waiwai no kēlā me kēia pūʻulu ma mua o ka hāʻawi ʻana i nā mea kūʻai.

Inoa Huahana: Sialic acid ;N-Acetylneuraminic acid

Inoa ʻē aʻe: 5-Acetamido-3,5-dideoxy-D-glycero-D-galactonolosonic acid o-Sialic acid Galactononulosonic acid Lactaminic acid NANA N-Acetylsialic acid

Kumu: Ka pūnana manu ʻai
Manaʻo: 20%–98%
ʻO ke ʻano: ka pauka maikaʻi keʻokeʻo
NĀ CAS NO.: 131-48-6
MW: 309.27
MF: C11H19NO9

Kahi i kumu: Kina

Ka mālama ʻana: E mālama i kahi maloʻo a maloʻo, e mālama i ka mālamalama pololei a me ka wela.
Pono: ʻElua makahiki inā mālama pono ʻia.

HANA:

1. Anti-virus hana.
2. Hana anti-cancer.
3. Anti-inflammation hana.
4. Ka hana pale i ka ma'i bacteriological.
5. Hoʻomalu i ka hiki o ka ʻōnaehana pale.
6. Kāohi i ka hiki ke kū'ē i ka pigmentation.
7. Hoʻololi hōʻailona i loko o nā pūnana nerve.
8. E pāʻani i kahi hana nui i ka ulu ʻana o ka lolo a me ke aʻo ʻana.
9. Ma keʻano he precursor no ka hana ʻana i nā lāʻau lapaʻau he nui.