Khoom npe:CMS121
Lwm Lub Npe: CMS-121;
1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-;
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol (CMS121);
ACC, AcetylCoenzymeACarboxylase, kab mob, neuroprotective, inhibit, anti-inflammatory, mitochondrial, Alzheimer's, antioxidative, acetylation, Inhibitor, H3K9, Acetyl-CoACarboxylase, CMS121, dementia, ACC1, CMS-121
CAS Nr.:1353224-53-9
Kev Ntsuas: 98.0% Min
Xim: Lub teeb daj hmoov
Ntim: 25kg / DRUMS
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol yog ib qho chaw hu ua CMS121. Cov txheej txheem complexity qhia tias nws yuav muaj cov khoom tshwj xeeb thiab muaj peev xwm siv tau. Txhawm rau nkag siab nws qhov tseem ceeb, nws pab txheeb xyuas cov pab pawg ua haujlwm tam sim no thiab txheeb xyuas lawv qhov cuam tshuam
CMS121 yog ib qho kev hloov pauv quin oline uas muaj cov tshuaj tiv thaiv neuroprotective, anti-inflammatory, antioxidative, thiab renoprotective kev ua ub no. Nws tuav glutathione (GSH) qib hauv HT22 nas hippocampal hlwb hauv vitro nyob rau hauv lub xub ntiag ntawm glutamate, induces sib txawv ntawm PC12 hlwb, tiv thaiv LPS-induced N9 microglial activation los ntawm 82% nyob rau hauv N9 microglia, thiab scavenges dawb radicals nyob rau hauv ib tug Trolox sib npaug concentration. (TEAC) assay. CMS121 tiv thaiv ischemia thiab oxytosis hauv phenotypic cov ntxaij vab tshaus hauv HT22 hlwb hauv vitro nrog EC50 qhov tseem ceeb ntawm 7 thiab 200 nM rau kev tiv thaiv iodoacetic acid- lossis glutamate-induced cell tuag, feem. Nws tseem yog renoprotective, txo lub raum yuag poob thiab txo qhov kev qhia ntawm TNF-α, caspase-1, thiab inducible nit ric oxi de synthase (iNOS) nyob rau hauv SAMP8 nas qauv ntawm cov kab mob raum uas cuam tshuam nrog kev laus sai thaum noj ib koob. ntawm 10 mg / kg ib hnub pib thaum muaj hnub nyoog cuaj hlis.
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol yog ib qho chaw hu ua CMS121. Cov txheej txheem complexity qhia tias nws yuav muaj cov khoom tshwj xeeb thiab muaj peev xwm siv tau. Txhawm rau nkag siab nws qhov tseem ceeb, nws pab txheeb xyuas cov pab pawg ua haujlwm tam sim no thiab txheeb xyuas lawv qhov cuam tshuam. Lub xub ntiag ntawm lub nplhaib quinoline qhia tau hais tias qhov sib xyaw ua ke tuaj yeem ua haujlwm lom neeg. Quinoline-derived molecules paub txog lawv cov khoom siv lom neeg sib txawv, suav nrog kev ua haujlwm tiv thaiv kab mob thiab tiv thaiv kab mob. Kev sib txuas ntawm pawg cyclopentyloxy tuaj yeem ua rau cov solubility ntawm cov khoom sib txuas lossis txhim kho nws cov kev ua haujlwm lom neeg los ntawm cov teebmeem steric. Hauv kev tshawb fawb ntawm HT22 hlwb, CMS-121 tau pom cov teebmeem tseem ceeb hauv neuroprotective, tiv thaiv cov hlwb los ntawm ischemia thiab oxidative puas. Tsis tas li ntawd, CMS-121 muaj cov tshuaj tiv thaiv kab mob tseem ceeb, qhia txog nws lub peev xwm los hloov kho cov lus teb. Los ntawm kev ua li ntawd, CMS-121 muaj peev xwm txo tau qhov mob ntawm ntau yam ntaub so ntswg thiab hauv nruab nrog cev. CMS-121 muaj zog pharmacological ua haujlwm raws li inhibitor ntawm acetyl-CoA carboxylase 1 (ACC1). Nws cov nyhuv inhibitory muaj zog ntawm ACC1 ua rau nws muaj txiaj ntsig zoo
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