Khoom npe:Lemairamin (WGX-50)

Lwm Lub Npe:2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-; Lemairamin (WGX-50)

CAS Nr:29946-61-0

Assay: 98.0 ib%Min

Xim: Dawb rau cov hmoov dawb dawb

Ntim:25kg / hnabDRUMS

Lemairamin los yog Wgx50 yog ib qho khoom siv ntuj tsim tawm los ntawm cov kua txob uas tau pom tias muaj txiaj ntsig zoo hauv kev tiv thaiv kab mob Alzheimer. Cov kev tshawb fawb tau pom tias nws tuaj yeem inhibit Aβ-induced neuronal apoptosis, txo cov neuronal calcium toxicity, thiab txo cov tsub zuj zuj ntawm Aβ oligomers nyob rau hauv lub cerebral cortex. Tsis tas li ntawd, wgx50 tau pom tias txhim kho kev txawj ntse hauv nas. Kev tshawb fawb qhia tias wgx50 muaj peev xwm tiv thaiv cov protein-protein sib dhos ntawm amyloid molecules. Zuag qhia tag nrho, wgx50 muaj peev xwm tiv thaiv Alzheimer's kab mob thiab tuaj yeem muab txoj hauv kev tshiab rau kev txhim kho cov tshuaj tsom A.β cov oligomers. Tsis tas li ntawd, WGX-50 nthuav tawm cov haujlwm tseem ceeb los tiv thaiv kab mob, uas ua rau nws muaj kev vam meej rau kev kho mob ntawm cov kab mob. WGX-50 tau pom tias muaj qhov cuam tshuam loj rau ntawm daim tawv nqaij, xws li txo qis wrinkles thiab txhim kho daim tawv nqaij elasticity. Ntxiv rau cov khoom siv ntuj tsim tawm los ntawm cov nroj tsuag Zanthoxylum bungeanum, tam sim no muaj ntau cov khoom siv hluavtaws uas siv ntau yam kev siv thiab tsim nyog rau kev ua lag luam.

Muaj nuj nqi:

1. Cov nyhuv analgesic: Xanthoxylin muaj cov tshuaj tua kab mob thiab tuaj yeem txo qhov mob. Nws tuaj yeem txhawb lub cev cov khoom siv cua sov, hloov txoj kev mob, thiab tso cov tshuaj tua kab mob endogenous, yog li txo qhov tsis xis nyob xws li mob taub hau thiab mob caj dab.
2. Antibacterial nyhuv: Xanthophyllin muaj qee yam tshuaj tua kab mob, uas tuaj yeem cuam tshuam kev loj hlob ntawm cov kab mob thiab cov fungi. Nws yog dav siv hauv kev lag luam khoom noj khoom haus thiab cov khoom siv kho mob kom cov zaub mov tshiab thiab txuas ntxiv nws lub txee lub neej.
3. Txhawb kev zom zaub mov: Xanthoxylum tuaj yeem ua rau lub plab zom mov, ua kom cov kua qaub thiab qaub ncaug nce ntxiv, yog li txhawb txoj kev zom zaub mov. Nws tuaj yeem txo cov teeb meem GI xws li GI cramps thiab kua qaub reflux.
4. Antioxidant nyhuv: Xanthophyllin yog ib qho muaj zog antioxidant uas tuaj yeem tshem tawm cov dawb radicals thiab txo kev puas hlwb los ntawm oxidative kev nyuaj siab. Qhov no pab qeeb cellular aging, tiv thaiv kab mob plawv thiab paj hlwb, thiab tiv thaiv kev loj hlob ntawm cov kab mob ntev.

Daim ntawv thov:

Lemairamin yog ib qho amide compound muab rho tawm los ntawm cov tawv ntoo ntawm Zanthoxylum bungeanum cog. Tam sim no siv raws li kev noj haus ntxiv, nws kuj ua raws li agonist ntawm alpha7 nicotinic acetylcholine receptor (α7nAChR), uas txo cov neuroinflammation nyob rau hauv Alzheimer's kab mob.Tam sim no siv raws li kev noj haus ntxiv, nws kuj ua agonist ntawm alpha7 nicotinic acetylcholine receptor ( α7nAChR), uas txo cov neuroinflamation hauv Alzheimer's kab mob, thiab yog hluavtaws kiag li.Wgx50 tau qhia txhawb nqa cov kev tshawb fawb hauv preclinical, suav nrog inhibiting Aβ-induced neuronal apoptosis, txo cov neuronal calcium toxicity, txo cov tsub zuj zuj ntawm Aβ oligomers hauv cerebral cortex, thiab txhim kho kev txawj ntse hauv nas.