Khoom npe:J-147 hmoov

Lwm Lub Npe:2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide,J-147j147, ib

CAS Nr:1146963-51-0

Kev Ntsuas: 99.0% Min

Xim: Dawb hmoov

Ntim: 25kgs Nruas

J-147yog ib qho muaj zog tshwj xeeb ntawm qhov ncauj active neuroprotectant muab tau los ntawm curcumin, cov khoom muaj nyob hauv turmeric. Tsis zoo li curcumin, nws hla cov ntshav-hlwb barrier zoo heev.

J-147 yog qhov tshwj xeeb tshaj yog muaj zog, hais lus nquag, tus neeg saib xyuas neuroprotective rau kev txawj ntse.
J-147 tuaj yeem nkag siab dhau ntawm cov hlab ntsha hauv hlwb (BBB). J-147 tuaj yeem inhibit monoamine oxidase B (MAO B) thiab dopamine transporter nrog EC50 qhov tseem ceeb ntawm 1.88 μM thiab 0.649 μM, feem. J-147 muaj peev xwm kho tau tus kab mob Alzheimer

J-147 yog ib qho tshwj xeeb muaj zog qhov ncauj active neuroprotectant muab tau los ntawm curcumin, cov khoom muaj nyob rau hauv turmeric. Tsis zoo li curcumin, nws hla cov ntshav-hlwb barrier zoo heev. Ntawm lawv, J-147 ua haujlwm los ntawm kev khi rau ATP synthase. Overproduction ntawm ATP yog txuam nrog cov txheej txheem kev laus. Ntxiv rau qhov nce qib ntawm cov neurotransmitters NGF thiab BDNF, J-147 tuaj yeem tswj tau qhov no. Tsis tas li ntawd, J-147 inhibits monoamine oxidase B thiab dopamine transporter. Txhawb kev loj hlob ntawm lub hlwb los ntawm kev nce qib ntawm cov paj hlwb loj hlob (NGF) thiab hlwb-derived neurotrophic factor (BDNF). Qhov tseem ceeb tshaj plaws, J-147 tuaj yeem txhawb kev loj hlob ntawm cov paj hlwb tshiab, txhim kho lub hlwb kev txawj ntse thiab kev nco, thiab txhim kho kev txawj ntse.

Muaj nuj nqi:

J-147 tuaj yeem nkag mus rau cov hlab ntsha hauv hlwb (BBB).
J-147 tuaj yeem inhibit monoamine oxidase B (MAO B) thiab dopamine transporter nrog EC50 qhov tseem ceeb ntawm 1.88 μM thiab 0.649 μM, feem.
J-147 muaj peev xwm rau kev kho mob Alzheimer's disease (AD).
J-147 muaj peev xwm rau kev kho mob Alzheimer's disease (AD).

Daim ntawv thov:

J-147 yog ib qho khoom siv hluavtaws uas nws lub luag haujlwm tseem ceeb ntawm kev ua haujlwm cuam tshuam nrog kev txhim kho mitochondrial, yog li ua kom lub zog tsim tawm ntawm qib cellular. J-147 yog tsim los txhim kho lub hlwb lub peev xwm kho thiab tiv thaiv nws tus kheej los ntawm kev puas tsuaj rau lub hnub nyoog los ntawm kev txhim kho mitochondrial muaj nuj nqi. Tsis tas li ntawd, J-147 nthuav tawm cov tshuaj tiv thaiv kab mob thiab cov tshuaj tiv thaiv antioxidant, ntxiv dag zog rau nws cov teebmeem neuroprotective. J-147 tuaj yeem txhawb kev loj hlob ntawm cov paj hlwb tshiab, txhim kho lub hlwb kev kawm muaj peev xwm thiab nco, thiab txhim kho kev txawj ntse.