Khoom npe:Evodiamine

Lwm Lub Npe:Evodiamine, Isoevodiamine, (+)-Evodiamine, d-Evodiamine,Fructus Evodiae Extract

CAS Nr:518-17-2 ib

Kev Ntsuas: 98% Min

Xim: Lub teeb daj crystalline hmoov

Ntim: hauv 25kgs fiber ntau nruas

Cia: Khaws lub thawv tsis qhib hauv qhov chaw txias, qhuav, Khaws kom deb ntawm lub teeb muaj zog

Lub neej txee: 24 lub hlis txij li hnub tsim khoom

Evodiamine yog ib qho tshwj xeeb bioactive alkaloid thiab lub ntsiab bioactive muaj nyob rau hauv cov tshuaj suav tshuaj. Pom muaj nyob rau hauv cov txiv hmab txiv ntoo ntawm Evodia evodia nroj tsuag, uas loj hlob feem ntau nyob rau hauv Tuam Tshoj thiab Kauslim Teb.Evodiamine yog ib tug tshwj xeeb bioactive alkaloid thiab lub ntsiab bioactive muaj nyob rau hauv tsoos suav tshuaj. Pom nyob rau hauv berries ntawm Evodia evodia nroj tsuag, uas loj hlob feem ntau nyob rau hauv Tuam Tshoj thiab Kauslim teb. Cov nroj tsuag no muaj ntau yam tshuaj lom neeg thiab tau siv los ntawm cov tshuaj suav tshuaj los kho ntau yam teeb meem kev noj qab haus huv, suav nrog kev zom zaub mov, mob, thiab mob. Evodiamine ua haujlwm los ntawm kev tsom mus rau ntau txoj hauv kev molecular hauv lub cev. Nws yog lub npe hu ua kom lub zog ntawm vanillin receptors, uas ua lub luag haujlwm tseem ceeb hauv kev nkag siab qhov mob thiab thermogenesis. Tsis tas li ntawd, nws tau pom muaj kev cuam tshuam nrog serotonin thiab dopamine receptors, qhia tias nws muaj peev xwm ua kom lub siab zoo.

Kev ua yeeb yam lom neeg: Evodiamine yog ib qho alkaloid cais los ntawm cov txiv hmab txiv ntoo ntawm Bentham, uas muaj ntau yam kev ua ub no xws li tshuaj tiv thaiv kab mob, tiv thaiv rog, thiab tiv thaiv qog. Hauv vitro: Evodiamine tau qhia cytotoxicity tawm tsam ntau tus tib neeg cov kab mob qog noj ntshav los ntawm inducing apoptosis. Tsis tas li ntawd, nws yog lub hom phiaj ntau lub hom phiaj los tiv thaiv qog nqaij hlav uas tawm tsam cov qog nqaij hlav los ntawm ntau yam molecular mechanisms xws li caspase dependent thiab tsis nyob ntawm txoj kev, sphingomyelin txoj kev, calcium / JNK signaling, 31 PI3K / Akt / caspase, thiab Fas -L/. NF – κ B signaling pathway 32 [1]. Hauv vivo: Evodiamine inhibits cov metabolism ntawm dapoxetine. Piv nrog rau pawg tswj hwm, t1/2, AUC (0- ∞), thiab Tmax pharmacokinetic tsis tau ntawm dapoxetine hauv pawg evodiamine tau nce 63.3%, 44.8%, thiab 50.4%, feem. Tsis tas li ntawd, evodiamine txo qis t1/2 pharmacokinetic tsis thiab AUC (0- ∞) ntawm demethylated dapoxetine [2]. Evodiamine inhibits qog loj hlob hauv subcutaneous H22 xenograft qauv. Evodiamine attenuates VEGF induced angiogenesis hauv vivo.

Hauv vitro: Evodiamine nthuav tawm cytotoxicity tawm tsam ntau tus tib neeg cov kab mob qog noj ntshav los ntawm inducing apoptosis. Tsis tas li ntawd, nws yog lub hom phiaj ntau lub hom phiaj los tiv thaiv qog nqaij hlav uas tawm tsam cov qog nqaij hlav los ntawm ntau yam molecular mechanisms xws li caspase dependent thiab tsis nyob ntawm txoj kev, sphingomyelin txoj kev, calcium / JNK signaling, 31 PI3K / Akt / caspase, thiab Fas -L/. NF – κ B signaling pathway 32 [1].

Hauv vivo: Evodiamine inhibits cov metabolism ntawm dapoxetine. Piv nrog rau pawg tswj hwm, t1/2, AUC (0- ∞), thiab Tmax pharmacokinetic tsis tau ntawm dapoxetine hauv pawg evodiamine tau nce 63.3%, 44.8%, thiab 50.4%, feem. Tsis tas li ntawd, evodiamine txo qis t1/2 pharmacokinetic tsis thiab AUC (0- ∞) ntawm demethylated dapoxetine [2]. Evodiamine inhibits qog loj hlob hauv subcutaneous H22 xenograft qauv. Evodiamine attenuates VEGF induced angiogenesis hauv vivo.

FUNCTION:

Kev tiv thaiv kab mob, tiv thaiv qog, thiab kev ua haujlwm hypoglycemic muaj qee yam kev kho mob ntawm kev kho mob thaum ntxov senile dementia thiab mob stroke.Nws muaj analgesic, txo cov ntshav siab thiab induces ib qho tseem ceeb ntawm lub cev kub los. Kev siv tshuaj kho mob ntawm cov khoom no yog tsim cov tshuaj kho mob rau diuretics thiab hws.

1. Evodia extract yog siv los kho cov tsos mob ntawm kev mob plab. Cov no muaj xws li xeev siab, ntuav, thiab raws plab. Nws tau hais tias nws muaj txiaj ntsig tshwj xeeb hauv kev kho mob raws plab thaum sawv ntxov.

2. Evodia yog siv los txhawb kev qab los noj mov thiab kho cov tsos mob plab uas cuam tshuam nrog kev tsis txaus siab ntawm zaub mov.

3. Evodia extract kuj muaj cov tshuaj tiv thaiv kab mob, tiv thaiv qog, tiv thaiv kab mob, astringent, thiab diuretic zog.

4. Evodiamine nrog analgesia, txo cov ntshav siab thiab lub cev kub thiab lwm yam tshuaj muaj txiaj ntsig.

5. Evodiamine muaj mob plab, nres retching, oxyrygmia nyhuv thiab diuretic nyhuv.

6.Evodiamine muaj zog inhibitory nyhuv ntawm li; thiab muaj cov tshuaj tua kab tseem ceeb ntawm ascarissuum;

7.Evodiamine kuj tuaj yeem ua rau lub tsev me me thiab txhawb lub siab.

8.Ntawm no, evodiamine kuj muaj txiaj ntsig zoo rau Alzheimer's kab mob thiab mob stroke.

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