4-Butylresorcinol ntụ ntụ

Aha ngwaahịa:4-Butylresorcinolntụ ntụ

Nkọwa: 98% min

Nọmba CAS:18979-61-8

Okwu ndị bekee: N-BUTYLRESEOCINOL;4-N-BUTYLRESORCINOL;4-BUTYLRESORCINOL;4-phenylbutane-1,3-diol;2,4-DIHYDROXY-N-BUTYLBENZEN

Usoro ihe omimi: C₁₀H₁₄O₂

Arọ molikula: 166.22

Ebe mgbaze: 50 ~ 55 ℃

Ebe esi mmiri: 166 ℃/7mmHg (ọkụ)

Usoro onunu ogwu: 0.1-5%

Ngwugwu: 1kg, 25kg

Nkọwa

Kedu ihe bụ 4-Butylresorcinol

Aha kemịkalụ gọọmentị bụ 4-n-butyl resorcinol, mana n'ozuzu, onye ọ bụla na-enwe mmasị ime ka ederede butyl resorcinol dị mfe.Nke mbụ tinye ya na ngwaahịa na-acha ọcha bụ Japanese POLA, um ~ nke na-adabere na pill ịcha ọcha na ọkụ ụlọ.

A na-eji ya na-adịghị mma solubility na mmiri na soluble na ethanol.

Mechanism edinam nke 4-Butylresorcinol

• Tyrosinase na-arụ ọrụ dị oke mkpa na mmepụta melanin n'ihi na ọ na-achịkwa ọnụego nke itinye melanin.
• 4-n-butylresorcinol nwere mmetụta inhibitory na mmepụta melanin site na igbochi ọrụ nke tyrosinase na B16 nwa-ọsọ sel tumor na-egbochi njikọ nke tyrosinase na-enweghị ihe ọ bụla cytotoxicity.
• N'ime ụfọdụ ọmụmụ in vitro, e gosipụtara 4-n-butylresorcinol iji gbochie mmepụta melanin, yana ọrụ tyrosinase na TRP-1.
• Ihe mgbochi siri ike nke tyrosinase na peroxidase
• Ihe na-eme ka akpụkpọ ahụ dị mma na toner nkịtị
• Onye na-acha ọcha dị irè maka pigmentation nke akpụkpọ ahụ
• Dị irè megide chloasma (akpụkpọ anụ hyperpigmented ekpughere na anyanwụ)
• Ọ nwere mmetụta nchebe siri ike na mmebi DNA nke H2O2 kpatara.
• E gosipụtara na ọ nwere mmetụta mgbochi glycation

Uru nke 4-Butylresorcinol

Ihe mere ị ga-eji họrọ 4-Butylresorcinol

Nke mbụ, anyị kwesịrị ịma ihe kpatara na e nwere resorcinol.

Lipofuscin bụ otu n'ime ihe ndị siri ike ịnagide melanin.N'ozuzu, a na-eji hydroquinone mee ihe na mma ahụike.

Hydroquinone bụ ihe na-eme ka ịcha ọcha dị nnọọ irè.Usoro ịcha ọcha na-egbochi ọrụ tyrosinase kpamkpam ma na-egbochi ịmepụta melanin, mmetụta ya dịkwa ịrịba ama.

Otú ọ dị, mmetụta ya na-apụta ìhè n'otu aka ahụ, uru ya na-emerụkwa ahụ karịa uru nke ịcha ọcha.

• Ọ bụ nke ukwuu oxidizable na ikuku, na a ghaghị iji ya mee ihe mgbe ị na-agbakwunye ya na ihe ịchọ mma.
• nwere ike ime ka akpụkpọ ahụ na-acha ọbara ọbara;
• Ọ bụrụ na itinye uche karịa 5%, ọ ga-eme ka uche pụta ìhè, ma enwere ihe atụ ụlọ ọgwụ nke leukoplakia.Ugbu a, nchịkwa nri na ọgwụ ọjọọ nke US kwuru na ngwaahịa hydroquinone nwere ntinye uche karịrị 4% bụ ọkwa ahụike na anaghị ekwe ka erere ya.

Ndị na-ahụ maka ọgwụ na ndị na-ere ọgwụ agbanweela hydroquinone ọgwụ dị ike iji nweta 4-hydroxyphenyl-beta-D-glucopyranoside, nke bụ ihe anyị na-anụkarị banyere "arbutin".Ihe dị iche n'etiti hydroquinone bụ na arbutin nwere obere ọdụ - glycoside karịa hydroquinone.Ọ bụ ihe nwute na mmetụta na-acha ọcha na-ebelata nke ukwuu.

N'afọ ndị na-adịbeghị anya, ihe ndị kachasị ewu ewu nke isi ụdị bụ ụdị dị iche iche nke benzenediol.

Mana nkwụsi ike nke arbutin adịghị mma ma na-arụ ọrụ naanị n'abalị.

Nchekwa nke 4-n-butyl resorcinol aghọwo ihe pụtara ìhè.Na-enweghị mmetụta dị n'akụkụ nke hydroquinone, ọ nwere mmetụta ọgwụgwọ dị mma karịa ihe ndị ọzọ resorcinol.

N'ime nnwale mgbochi ọrụ tyrosinase, data ya dị mma karịa nnukwu nwanne phenethyl resorcinol, nke bụ oge 100 ~ 6000 nke onye na-acha ọcha ọdịnala dị ka kojic acid arbutin!

Mgbe ahụ na nyocha nke melanin B16V na-esote, o gosikwara otu uru nke resorcinol na-emepụta ihe - mgbochi nke mmepụta melanin na mkpokọta nke na-emepụtaghị cytotoxicity.

Na mgbakwunye, enwere ọtụtụ nnwale mmadụ na 4-n-butyl resorcinol.N'ime ụfọdụ ndị ọrịa 32 nwere chloasma, 0.3% 4-n-butylresorcinol na placebo na-eji na ntì abụọ ahụ.Ugboro abụọ n'ụbọchị maka ọnwa 3, nsonaazụ ya bụ mbelata pigmenti dị ala nke ukwuu na otu 4-n-butylresorcinol karịa na otu placebo.Enwere ndị mmadụ na-eme nnwale inhibition pigmentation mgbe anwụ na-acha, hmm ~ nsonaazụ ya dị mma nke ukwuu ~

Mgbochi nke tyrosinase mmadụ site na 4-butylresorcinol

4-butylresorcinol, kojic acid, arbutin na hydroquinone na-egosi na ọrụ L-DOPA oxidase nke tyrosinase.Kpebisiri ike site na ntinye uche dị iche iche nke ndị na-emechi ihe iji nye ohere maka ngụkọta nke ụkpụrụ IC50.Nke a data bụ nkezi nke atọ onwe nnwale.

Mgbochi nke melanin na-emepụta na ụdị akpụkpọ anụ MelanoDerm site na 4-butylresorcinol

Tulee ya na 4-butylresorcinol, kojic acid, arbutin na hydroquinone na mmepụta melanin.E gosipụtara mkpebi nke ọdịnaya melanin nke ụdị akpụkpọ ahụ mgbe ụbọchị iri na atọ gachara n'ihu ọnụ ọgụgụ ndị na-egbochi ihe dị iche iche.Nke a data bụ nkezi nke ise onwe nnwale.

Ọkpụkpụ afọ na-amụba site na 4-butylresorcinol

Tulee ya na 4-butylresorcinol, kojic acid, arbutin na hydroquinone.Na-emeso ntụpọ ahụ ugboro abụọ n'ụbọchị maka izu iri na abụọ na ndị na-egbochi ya.Nyochaa ịdị irè mgbe izu 4, 8 na 12 gachara.Data na-anọchite anya isi isiokwu iri na anọ.*P <0.05: dị ịrịba ama vs. ntụpọ afọ njikwa a na-agwọghị.

Usoro onunu ogwu na ojiji nke 4-Butylresorcinol

Usoro akwadoro bụ 0.5%-5%.Ọ bụ ezie na e nwere ọmụmụ na Korea nke nwere mmetụta ụfọdụ na 0.1% ude, na India nwere researches 0.3% ude ma ahịa bụ tumadi 0,5% -5%.Ọ na-adịkarị, na usoro Japanese ka edoghị anya, mana ejirila POLA.Na nsonaazụ na ahịa dị oke egwu.

Dị ka e kwuru n'elu, 4-Butylresorcinol nwere ike iji ude, ma ọ bụ insoluble na mmiri.Ndị ọzọ dị ka lotions, ude, na gels dịkwa.Ma POLA na Eucerin nwere ngwaahịa 4-Butylresorcinol.