Nnukwu Anandamide ntụ ntụ

Arachidonoyl Ethanolamide, arachidonoylethanolamide, N-arachidonoylethanolamine, na AEA niile dabara na anandamide n'onwe ya.Site n'ụzọ, (5Z,8Z,11Z,14Z) -N- (2-hydroxyethyl) icosa-5,8,11,14-tetraenamide bụ aha kemịkalụ anandamide (aha IUPAC) na enwere ike iji ya na akwụkwọ sayensị.Agbanyeghị, 94421-68-8 bụ ID kemịkalụ ya pụrụ iche (nọmba ndekọ CAS).Ebe AEA bụ okwu kacha nso maka anandamide, anyị nwere ike iji AEA ugboro ugboro na-ezo aka anandamide na ederede na onyonyo ndị a.

Aha ngwaahịa:NnukwuAnandamide ntụ ntụ

Synonyms: Arachidonoyl Ethanolamide, AEA ntụ ntụ, arachidonoylethanolamide, (5Z,8Z,11Z,14Z) -N- (2-hydroxyethyl) icosa-5,8,11,14-tetraenamide, N-arachidonoylethanolamine

Nọmba CAS: 94421-68-8

A na-eji akụkụ osisi: Akwụkwọ

Ngwa: Apigenin

Nyocha: mmanụ AEA: 90%

AEA ntụ ntụ: 50%

Agba: Yellowish ntụ ntụ

mmanụ agba aja aja

Mbukota: na 25kgs fiber drum

Nchekwa: Debe akpa na-emegheghị n'ebe dị jụụ, ebe kpọrọ nkụ, zere ọkụ siri ike

Ndụ shelf: ọnwa 24 site na ụbọchị mmepụta

Dị ka Wikipedia si kwuo, anandamide bụ ihe na-eme cannabinoid neurotransmitter na ụbụrụ, nke pụtara na ụbụrụ mmadụ nwere ike ịmepụta anandamide n'ejighị nri nwere AEA.A kwenyere na ụbụrụ nke ụdị anụ mamma na cacao raw nwere ụfọdụ anandamide.

Ebe nri anandamide

Enweghị ọtụtụ ebe sitere n'okike maka anandamide, na chocolate na truffles dị n'elu ha.Truffle dị oke ọnụ iji nweta anandamide, chocolate yiri ka ọ bụ ebe a pụrụ ịdabere na ya maka nnukwu ihe oriri na-adigide.

Anandamidena chọkọletị

Cacao agwa, isi iyi nke chọkọletị, bụkwa isi iyi nke anandamide.Enwere ihe karịrị ihe mejupụtara kemịkalụ 300 na chocolate.Caffeine, theobromine, na phenylethylamine bụ ihe amara nke na-ebuli ọnọdụ anyị elu.Theobromine n'ezie na-enyere aka kpalie ụbụrụ ịhapụ ọzọ anandamide iji mee ka anyị nwee obi ụtọ karị.

Gịnị kpatara anandamide ji na-ewu ewu n'afọ ndị na-adịbeghị anya?

Tupu anyị azaa ajụjụ a, anyị kwesịrị ibu ụzọ kwuo cannabis, THC & CBD (Cannabidiol).

Cannabis, nke a makwaara dị ka wii wii, bụ osisi ifuru, ndị mmadụ na-ejikwa ya dị ka ọgwụ oriri oriri ma ọ bụ na-ese ya iji mepụta mmetụta "elu" ma ọ bụ "nkume".

Ihe na-arụ ọrụ na cannabis na-eme ka ị dị elu bụ THC, nke nwere aha zuru oke dị ka delta 9-Tetrahydrocannabinol.Mgbe ndị mmadụ na-ese wii wii, tetrahydrocannabinol na cannabis na-akpali ndị na-anabata cannabis, na-eme ka ndị mmadụ nwee mmetụta nke obi ụtọ na ịdị mma nke uche.

Cannabis bụ iwu na-akwadoghị n'ọtụtụ mba ebe ọ bụ na ọtụtụ mmadụ ga-eri ahụ.

Agbanyeghị, Uruguay bụ obodo mbụ nyere iwu cannabis iwu n'afọ 2013.

Na Ọkt 17 nke 2018, gọọmentị Canada kwupụtara na cannabis ghọrọ iwu na Canada niile.

Na United States, steeti iri na District nke Columbia akwadola ka a na-eji cannabis eme ihe ntụrụndụ n'ụzọ iwu kwadoro n'agbanyeghị na ọ ka bụ iwu na-akwadoghị.

Anandamide vs THC

Cannabis bụ isi iyi nke THC.

Anandamide bụ ụdị mmadụ nke THC.

Ọkà mmụta sayensị chọpụtara AEA na 1992 na THC na 1964.

Anandamide na-ewepụta kemịkalụ na-eme ka ọnọdụ obi dịkwuo mma na ụbụrụ, yana usoro ndu ya yiri nke tetrahydrocannabinol na cannabis.

Ee, ha na-elekwasị anya otu onye na-anabata cannabis, anyị ga-ekwukwa maka usoro AEA n'oge na-adịghị anya.

Agbanyeghị, ike nke THC siri ike karịa AEA.Mmetụta ị were AEA adịghị ụtọ karịa nke ị smokingụ sịga ebe ọ bụ na anandamide metabolize ngwa ngwa n'ime ahụ, ikekwe n'ime 30 mins.

Ebe ọ bụ na amachibidoro cannabis n'ọtụtụ mba, mgbakwunye, nri, ihe ọ beụ ,ụ ma ọ bụ ihe ịchọ mma nwere THC bụ iwu na-akwadoghị.N'echiche a, anandamide bụ ọdịnihu.

Anandamide vs CBD

Osisi wii wii nwere ogige 400+, yana ihe karịrị 60 cannabinoids dị iche iche na-ejikọta ndị na-anabata ya n'ahụ anyị.

CBD bụ obere ụdị cannabidiol ma bụrụ otu n'ime 60 cannabinoids.CBD bụ phytocannabinoid na cannabis.Ihe karịrị 40% nke mkpụrụ osisi cannabis bụ CBD.

Ndị ọkà mmụta sayensị na ndị dọkịta chọpụtara na CBD nwere ike imeziwanye ọkwa anandamide na synapses nke ụbụrụ dị ka anandamide reuptake na breakdown inhibitor.Fatty acid amide hydrolase, nke a makwaara dị ka FAAH maka mkpụmkpụ, bụ enzyme nke na-akụda AEA.Nke ahụ bụ ka CBD si egbochi FAAH ma na-emeziwanye AEA n'ụzọ nkịtị.

CBD nwere ike ime ọtụtụ ihe karịa nke ahụ.CBD nwere ike ịba uru maka sistemụ endocannabinoid niile

Usoro ọrụ nke anandamide

Kedu ka anandamide si arụ ọrụ?Ọ gbagwojuru anya n'ezie.Ị nwere ike ibu ụzọ mara banyere usoro endocannabinoid, onye na-anabata CB1, na onye na-anabata CB2.

CB1

THC nwere mmekọrịta dị elu maka onye na-anabata CB1, na-ejikọta ya na onye na-anabata ya.

Na mgbakwunye, anandamide na-emetụta mmetụta "dị elu" site na imetụta onye na-anabata CB1, na-eme ka usoro ụgwọ ọrụ ụbụrụ rụọ ọrụ na ịmepụta kemịkalụ ụtọ dị ka dopamine Hormone.

CB2

Ị nwere ike ịhụ ndị na-anabata CB2 n'ime sel ndị na-alụso ọrịa ọgụ na ahụ gị dum.Onye na-anabata CB2 na-ahụ maka nzaghachi neuroprotective na ọgụ megide mbufụt.Ndị ọkà mmụta sayensị kwenyere na onye na-anabata CB2 bara uru na-ebelata ihe mgbu.

Ndị na-anabata CB1 na-etinyekarị uche na ụbụrụ na sistemu CNS, ebe a na-ahụ ndị na-anabata CB2 na sistemu ahụ ji alụso ọrịa ọgụ.

Sistemụ Endocannabinoid (ECS)

Tupu ịkọwa ọrụ nke usoro endocannabinoid (ECS), ọ dị mkpa ịghọta akụkụ ya.ECS na-agụnye ndị na-anabata cannabinoid, endogenous ligands (molecule molecules) maka ndị na-anabata ya, na enzymes nke na-emepụta ma na-eweda ligands.

ya n'ime okirikiri (ìhè isi awọ) na-anọchi anya 'klaasị' endocannabinoid usoro.Okirikiri dị n'èzí (isi awọ gbara ọchịchịrị) gụnyere akụkụ nke sistemu endocannabinoid agbatị.Dị ka ị na-ahụ, PEA, SEA, na OEA na-etinyekwa na usoro endocannabinoid.

Ndị EC nwere usoro nhụjuanya nke etiti (CNS) na-agụnye anandamide (AEA), 2-arachidonoylglycerol (2-AG), noladin ether, virodhamine na N-arachidonylodopamine (NADA).Na anandamide bụ nke mbụ na nke kachasị mkpa na usoro endocannabinoid.

Anandamide na 2-AG

Dịka e kwuru n'elu, anandamide (AEA) na 2-arachidonoylglycerol (2-AG) bụ njikọ abụọ bụ isi na usoro ECS.ECS na-enyere aka ịhazi ọrụ dị ka ihi ụra, usoro ahụ ji alụso ọrịa ọgụ, na mgbanwe mgbu.

Ndị ọkà mmụta sayensị chọpụtara Anandamide n'afọ 1992 na 2-AG afọ 3 ka e mesịrị.AEA na 2-AG nwere usoro ihe omimi yiri nke ahụ ma si otú ahụ otu ihe anụ ahụ na kemịkal.

Anandamide na-elekwasị anya na onye na-anabata CB1 na ụbụrụ, ebe 2-AG na-elekwasị anya ma CB1 na CB2 ndị nabatara (na usoro ahụ ji alụso ọrịa ọgụ).

Ma Anandamide na 2-AG sitere na arachidonic acid, Omega-6 fatty acid, nwere ụzọ dị iche iche na enzymes synthesizing.Enzyme na-eweda ala FAAH (Fatty Acid Amide Hydrolase) maka AEA na 2-AG site na MAGL enzyme (Monoacylglycerol Lipase).

Uru Anandamide

Ihe akaebe sayensị na-egosi anandamide nwere ike ịdị mma maka mgbochi nchegbu, ahụike uche, nhazi ebe nchekwa, njikwa agụụ, ihe mgbu, neuroprotection, na ndị ọzọ.

Anandamide na nchegbu

Ndị mmadụ na-akpọ Anandamide "molecule bliss" n'ihi na AEA nwere ike ime ka ị nwee obi ụtọ.

Ihe akaebe na-atụgharị na-egosi na usoro endocannabinoid bụ akụkụ dị mkpa nke mkpụrụ ndụ neuronal na-etinye aka na usoro ụgwọ ọrụ ụbụrụ na nzaghachi mmetụta uche na nrụgide.

Mgbochi ọgwụ ọgwụ nke enzyme fatty acid amide hydrolase (FAAH), nke na-ahụ maka mmebi intracellular anandamide, na-emepụta mmetụta anxiolytic dị ka oke na oke na-enweghị ime ka ụdị nzaghachi omume dị iche iche nke cannabinoid agonists na-eme kpọmkwem.

Nchọpụta ndị a na-egosi na anandamide na-enye aka na nhazi nke mmetụta uche na nchekasị na FAAH nwere ike ịbụ ihe mgbaru ọsọ maka klas ọhụrụ nke ọgwụ anxiolytic.

Maka ozi zuru ezu maka mmetụta anandamide na nchekasị, biko gụọ akwụkwọ ndị dị n'okpuru:

• Cannabinoid anandamide endogenous nwere mmetụta na mkpali na nchekasị nke na-ekpughe fatty acid amide hydrolase (FAAH) mgbochi.
• Anandamide hydrolysis: ebumnuche ọhụrụ maka ọgwụ mgbochi nchegbu?
• Mbelata omume dị ka nchekasị kpatara site na mkpụrụ ndụ ihe nketa na ọgwụ mgbochi nke endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) bụ onye na-anabata CB1.

Anandamide na nkwụsị mgbu

ihe akaebe sayensị ome na-egosi na mgbochi nke FAAH (enzyme nke na-emebi anandamide na ụbụrụ) belatara nzaghachi nociceptive nke ukwuu n'ọtụtụ ụdị mgbu.

Ndị na-egbochi FAAH na-ebuli ọkwa anandamide dị n'ụbụrụ yana isi CB kpatara₁antinociception na-anabata onye na-anabata ya, na-atụ aro na anandamide endogenous, mgbe echebe ya pụọ ​​​​na mmebi, nwere ike mepụta antinociception site na CB.₁ndị na-anabata ya.

Palmitoylethanolamide (PEA) bụ ihe eji eme ihe na-akwalite ọrụ anandamide.Ahụ mmadụ na-emepụta PEA iji lụso mbufụt na mgbu ọgụ.N'ime ndị ọrịa 800,000 bụ ọgwụ PEA na ihe mgbakwunye nri iji gwọọ mgbu n'ụwa.

Iji mụtakwuo maka PEA, biko gaa na nke anyịPea ibe.

Anandamide na onye na-agba ọsọ dị elu

Ka anyị buru ụzọ leba anya na nkọwapụta nke elu onye na-agba ọsọ bụ: mmetụta nke euphoria na mgbakasị ahụ belatara yana ike belata ahụ mgbu.Mgbe ịmechara mgbatị ahụ ogologo oge, ị ga-ahụ ihe na-atọ ụtọ n'oge ịgba ọsọ ogologo oge.

N'ime iri afọ gara aga, ndị nchọpụta chere na endorphin bụ naanị ihe na-akpata ndị na-agba ọsọ dị elu ebe ọ bụ na mmụba nke β-endorphins na-adị mfe n'ọbara.Dị ka ị maraworị, endorphin nwere ike ịkwalite ọnọdụ anyị ma mepụta mmetụta euphoric.

Otú ọ dị, ndị ọkà mmụta sayensị kwenyere ugbu a na ọ bụ usoro endocannabinoid (ECS) na anandamide na-eme ka onye na-agba ọsọ dị elu.Anandamide nwere ike ịgafe ihe mgbochi ụbụrụ ọbara ma na-eme ka mmetụta dị n'etiti opioids dị n'akụkụ.Ma endorphin enweghị ike.

Ọ bụrụ na ị chọrọ ịmụta maka nnwale gbasara ịgba ọsọ, gụọ akwụkwọ a:Onye na-agba ọsọ dị elu na-adabere na ndị na-anabata cannabinoid na ụmụ oke

Ndị na-ahụ maka nri na-ahụ maka nri na-achọpụta na anandamide nwekwara ike bụrụ ezigbo njikwa agụụ.Anandamide nwere ike kpalite agụụ gị na agụụ iri nri karịa.Ọ bụrụ na ị na-aga ifelata, chee echiche nke ọma tupu ị were AEA.

Mmeju nwere anandamide

Ị na-achọ ihe mgbakwunye anandamide ma ọ bụ ọgwụ anandamide?

N'ụzọ dị mwute, ọ dịghị nke maka oge a.Anandamide bụ ngwa ngwa ọhụrụ nke na ọ nweghị ụdị mgbakwunye nri anwalela ya na usoro ha ugbu a.

Ị nwere ike ịhụ ụlọ ọrụ aha ya bụ Sun Potion na-ere anandamide ntụ ntụ na Amazon.Otú ọ dị, nke ahụ abụghị eziokwu.Ọ bụ naanị ntụ ntụ cacao raw, mana ọ bụghị mkpokọta anandamide.Na ọdịnaya na-arụ ọrụ n'ụdị ntụ ntụ dị ala, ma ị nwere ike ọ gaghị enweta uru AEA.

N'ezie, ị nwere ike ịhụ na ụfọdụ ndị na-ebubata na-ere ụkpụrụ ntụaka anandamide ma ọ bụ reagents.Ihe ọjọọ bụ na ha na-ere naanị na 5mg, 25mg, na naanị maka nyocha naanị.Enweghị nnukwu ozi mmanụ AEA dị ma ọlị.

Ozi ọma ahụ bụ na ndị na-emepụta ihe mgbakwunye na United States na mba Europe dị ka Germany, France, Netherland, UK, Spain, Italy, wdg na-enye iwu AEA sample si Wuxi Cima Science Co., Ltd, na nnukwu mmepụta azụmahịa na-aga n'ihu. .

Nkọwapụta Anandamide

Nnukwu mmanụ anandamide na ntụ ntụ anandamide dị na Cima Science.

Mmanụ Anandamide: 70%, 90%

Anandamide ntụ ntụ: 50%