Aha ngwaahịa:Galantamine hydrobromide

Aha ọzọ:Galanthamine hydrobromide; Galantamine HBr; Galanthamine HBr; (4aS,6R,8aS-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,Hydrobromide

CAS NO:1953-04-4

Nkọwapụta:98.0%

Agba:Ọchantụ ntụ na njirimara isi na uto

Ọnọdụ GMO: GMO efu

Mbukota: na 25kgs fiber drum

Nchekwa: Debe akpa na-emegheghị n'ebe dị jụụ, ebe kpọrọ nkụ, zere ọkụ siri ike

Ndụ shelf: ọnwa 24 site na ụbọchị mmepụta

A na-eji Galantamine na-agwọ ọrịa Alzheimer dị nro na nke na-adịghị ala ala yana nsogbu ebe nchekwa ndị ọzọ dị iche iche, karịsịa ndị sitere na vaskụla. Ọ bụ alkaloid nke a na-enweta site na sịntetically ma ọ bụ site na bulbs na okooko osisi nke Galanthus Caucasicus (Caucasian snowdrop, Voronov's snowdrop), Galanthus woronowii (Amaryllidaceae) na ihe ndị metụtara ya dị ka Narcissus (daffodil)), Leucojum (snowflake) na Lycorisata gụnyere (lycorisata). Ududo ududo Lily).

Galanthamine bụ eke ewepụtara na lycoris radiate, bụ tertiary alkaloid ewepụtara na snow dobe na chiri anya ụdị. Ọ na-arụ ọrụ dị ka onye na-emechi asọmpi acetylcholinesterase (ACHE), ebe ọ na-esiwanye ike na butyrylcholinesterse (BuChE) .a na-eji ya agwọ ọrịa nke usoro nhụjuanya nke etiti ahụ ma nwee ike iji ya mee ihe dị ka ihe ngwọta maka ndị na-eme ka anụ ahụ na-eme ka ahụ ghara ịdị ike. Galanthamine hydrobromide bụ ihe ngwọta. ọcha ka ọ fọrọ nke nta ka ọ bụrụ ntụ ntụ; obere soluble na mmiri; chloroform, ether na mmanya na-adịghị ike.

Galantamine hydrobromide bụ benzazepine nke ewepụtara site na bulbs na ifuru nke narcissus, osmanthus, ma ọ bụ canna. Ọ bụkwa ihe mgbochi cholinesterase nke ọnụ. Dị ka ligand maka ndị na-anabata nicotinic acetylcholine, ejirila ya mee ihe iji kwalite ọrụ neurocognitive. Ọrụ ya bụ ịsọ mpi na ngbanwe na-egbochi acetylcholinesterase, si otú ahụ na-abawanye mkpokọta acetylcholine. Mgbe etinyere ya n'ọbara, galantamine hydrobromide na-abanye ngwa ngwa n'akụkụ dị iche iche nke ahụ, gụnyere ụbụrụ. Ọ na-ejikọta na nicotinic acetylcholine receptors, na-eme mgbanwe mgbanwe na mmụba acetylcholine ntọhapụ. Ọ na-arụkwa ọrụ site na ịsọ mpi na ịtụgharị mmetụta nke ndị na-egbochi cholinesterase. Site na igbochi cholinesterase, ọ na-egbochi nkwụsị nke acetylcholine, si otú ahụ na-abawanye ọkwa na ogologo oge nke neurotransmitter dị ike. Galantamine nwekwara ike imeziwanye mmụta na ebe nchekwa, gbochie mbufụt nke ụbụrụ, ma nọgide na-enwe ọkwa dị elu nke neurotransmitters site n'ịkwado iguzosi ike n'ezi ihe nke neurons na synapses.

Ọrụ:

(1) Anti-cholinesterase.

(2) Na-akpali ma na-egbochi acetylcholinesterase, na-achịkwa ọnọdụ nnabata nicotine intracephalic.

(3) Na-agwọ ọrịa mkpọnwụ nwa ọhụrụ sequelae, sweeny na myasthenia gravis pseudoparalytica, wdg.

(4) Melite ọrụ njirimara nke ìhè, ndị ọrịa ọrịa Alzheimer dị nro nke ukwuu, na-egbu oge usoro ọrụ mbelata nke mkpụrụ ndụ ụbụrụ.

(5) Meziwanye nhazi n'etiti akwara na akwara.

Ngwa
1. GalanthamineHydrobromidea na-ejikarị na myasthenia gravis, poliovirus quiescent ogbo na sequela, nakwa na polyneuritis, funiculitis na sensorimotor mgbochi kpatara ọrịa ụjọ ma ọ bụ traumatism;

2. Galanthamine Hydrobromide na-ejikwa na ọrịa Alzheimer, nwere isi ọrụ maka dement na dysmnesia kpatara organic ụbụrụ mebiri.