Aha ngwaahịa:Evodiamine

Aha ọzọ:Evodiamine, Isoevodiamine, (+) -Evodiamine, d-Evodiamine,Fructus Evodiae wepụ

CAS Mba:518-17-2

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Evodiamine bụ ihe pụrụ iche bioactive alkaloid na ihe bụ isi bioactive mgwa ọgwụ Chinese omenala. Achọtara na mkpụrụ osisi Evodia evodia, nke na-eto na China na Korea. Achọtara na tomato nke osisi Evodia evodia, nke na-etolite na China na Korea. Osisi a bara ụba na kemịkalụ dị iche iche ma ejirila ya na omenala ndị China na-agwọta nsogbu ahụike dị iche iche, gụnyere nsogbu mgbaze, mbufụt, na mgbu. Evodiamine na-arụ ọrụ site n'ịgbado ụzọ dị iche iche molecular n'ime ahụ. A maara na ọ na-akpali ịgbalite ndị na-anabata vanillin, nke na-arụ ọrụ dị mkpa na nghọta mgbu na thermogenesis. Na mgbakwunye, a chọpụtala na ya na ndị na-anabata serotonin na dopamine na-emekọrịta ihe, na-atụ aro na ọ nwere ikike na-eme ka ọnọdụ ahụ dịkwuo mma.

Ọrụ ndu: Evodiamine bụ alkaloid dịpụrụ adịpụ na mkpụrụ nke Bentham, nke nwere ihe omume dị iche iche dị ndụ dị ka mgbochi mkpali, mgbochi oke ibu, na mgbochi tumor. In vitro: Evodiamine egosila cytotoxicity megide ahịrị mkpụrụ ndụ kansa mmadụ dị iche iche site n'ịkwalite apoptosis. Tụkwasị na nke ahụ, ọ bụ ngwongwo mgbochi tumor nke na-arụ ọrụ mgbochi tumor site na usoro mkpụrụ ndụ dị iche iche dị ka nke na-adabere na caspase na ụzọ ndị na-adịghị adabere, ụzọ sphingomyelin, calcium/JNK signaling, 31 PI3K/Akt/caspase, na Fas. -L/. NF - κ B ụzọ akara 32 [1]. Na vivo: Evodiamine na-egbochi metabolism nke dapoxetine. E jiri ya tụnyere otu njikwa, t1/2, AUC (0-∞), na Tmax pharmacokinetic paramita nke dapoxetine na otu evodiamine mụbara nke ukwuu site na 63.3%, 44.8%, na 50.4%, n'otu n'otu. Na mgbakwunye, evodiamine belatara nke ukwuu t1/2 pharmacokinetic parameters na AUC (0-∞) nke demethylated dapoxetine [2]. Evodiamine na-egbochi uto tumor na ụdị H22 xenograft subcutaneous. Evodiamine na-ebelata VEGF butere angiogenesis na vivo.

In vitro: Evodiamine na-egosiputa cytotoxicity megide ahịrị mkpụrụ ndụ kansa mmadụ dị iche iche site na ịkpata apoptosis. Tụkwasị na nke ahụ, ọ bụ ngwongwo mgbochi tumor nke na-arụ ọrụ mgbochi tumor site na usoro mkpụrụ ndụ dị iche iche dị ka nke na-adabere na caspase na ụzọ ndị na-adịghị adabere, ụzọ sphingomyelin, calcium/JNK signaling, 31 PI3K/Akt/caspase, na Fas. -L/. NF - κ B ụzọ akara 32 [1].

Na vivo: Evodiamine na-egbochi metabolism nke dapoxetine. E jiri ya tụnyere otu njikwa, t1/2, AUC (0-∞), na Tmax pharmacokinetic paramita nke dapoxetine na otu evodiamine mụbara nke ukwuu site na 63.3%, 44.8%, na 50.4%, n'otu n'otu. Na mgbakwunye, evodiamine belatara nke ukwuu t1/2 pharmacokinetic parameters na AUC (0-∞) nke demethylated dapoxetine [2]. Evodiamine na-egbochi uto tumor na ụdị H22 xenograft subcutaneous. Evodiamine na-ebelata VEGF kpatara angiogenesis na vivo.

Ọrụ:

Mgbochi mkpali, mgbochi tumor, na hypoglycemic omume nwere ụfọdụ ọgwụgwọ mmetụta na ọgwụgwọ nke n'oge senile dementia na ọrịa strok. Ọ nwere analgesic, lowers ọbara mgbali ma na-ebute a ịrịba ịrị elu nke ahu okpomọkụ mmetụta. Ọrụ ụlọ ọgwụ nke ngwaahịa a bụ imepụta ndị na-ahụ maka ahụike maka diuretics na ọsụsọ.

1. A na-eji wepụ Evodia agwọ ọrịa mgbaàmà nke nhụjuanya afọ. Ndị a na-agụnye ọgbụgbọ, ọgbụgbọ, na afọ ọsịsa. A na-ekwu na ọ dị irè karịsịa n'ịgwọ afọ ọsịsa ụtụtụ.

2. A na-eji Evodia eme ka agụụ na-agụ ma na-emeso mgbaàmà afọ nke metụtara enweghị mmasị na nri.

3. Evodia wepụ nwekwara mgbochi mkpali, mgbochi tumo, mgbochi viral, astringent, na diuretic Njirimara.

4. Evodiamine na analgesia, mbelata ọbara mgbali na ahụ okpomọkụ ịrị elu na ndị ọzọ pharmacological mmetụta.

5. Evodiamine nwere afo, kwụsị retching, oxyrygmia mmetụta na diuretic mmetụta.

6.Evodiamine nwere mmetụta mgbochi siri ike na li; na mmetụta dị ịrịba ama ụmụ ahụhụ na ascarissuum;

7.Evodiamine nwekwara ike ibelata akpanwa wee bulie nrụgide.

8.Besides,evodiamine nwekwara mmetụta dị mma na ọrịa Alzheimer na ọrịa strok.

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